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| 1 | Tumor infiltrating lymphocytes in triple negative breast cancer receiving neoadjuvant chemotherapy显示文摘AIM To determine influence of neoadjuvant-chemotherapy(NAC) over tumor-infiltrating-lymphocytes(TIL) intriple-negative-breast-cancer(TNBC).METHODS TILs were evaluated in 98 TNBC cases who came to Instituto Nacional de Enfermedades Neoplasicas from 2005 to 2010. Immunohistochemistry staining for CD3, CD4, CD8 and FOXP3 was performed in tissue microarrays(TMA) sections. Evaluation of H/E in full-face and immunohistochemistry in TMA sections was performed in pre and post-NAC samples. STATA software was used and P value < 0.05 was considered statistically significant. RESULTS Higher TIL evaluated in full-face sections from pre-NAC tumors was associated to pathologic-complete-response(pCR)(P = 0.0251) and outcome(P = 0.0334). TIL evaluated in TMA sections showed low level of agreement with full-face sections(ICC = 0.017-0.20) and was not associated to pCR or outcome. TIL in post-NAC samples were not associated to response or outcome. PostNAC lesions with pC R had similar TIL levels than those without pCR(P = 0.6331). NAC produced a TIL decrease in full-face sections(P < 0.0001). Percentage of TIL subpopulations was correlated with their absolute counts. Higher counts of CD3, CD4, CD8 and FOXP3 in pre-NAC samples had longer disease-free-survival(DFS). Higher counts of CD3 in pre-NAC samples had longer overallsurvival. Higher ratio of CD8/CD4 counts in pre-NAC was associated with pCR. Higher ratio of CD4/FOXP3 counts in pre-NAC was associated with longer DFS. Higher counts of CD4 in post-NAC samples were associated with pCR.CONCLUSION TIL in pre-NAC full-face sections in TNBC are correlated to longer survival. TIL in full-face differ from TMA sections, absolute count and percentage analysis of TIL subpopulation closely related. | Carlos A Castaneda Elizabeth Mittendorf Sandro Casavilca Yun Wu Miluska Castillo Patricia Arboleda Teresa Nunez Henry Guerra Carlos Barrionuevo Ketty Dolores-Cerna Carolina Belmar-Lopez Julio Abugattas Gabriela Calderon Miguel De La Cruz Manuel Cotrina Jorge Dunstan Henry L Gomez Tatiana Vidaurre | 2016 | World Journal of Clinical Oncology2016，7，5： | 6 |
| 2 | Clinicopathological predictors of long-term benefit in breast cancer treated with neoadjuvant chemotherapy显示文摘AIM To investigate the survival impact of clinicopathological factors, including pathological complete response(p CR) and tumor-infiltrating lymphocytes(s TIL) levels according to subtypes, in breast cancer(BC) patients who received neo-adjuvant chemotherapy(NAC).METHODS We evaluated 435 BC patients who presented and received NAC at the Instituto Nacional de Enfermedades Neoplasicas from 2003 to 2014. s TIL was analyzed as the proportion of tumor stroma occupied by lymphocytes, and was prospectively evaluated on hematoxylin and eosin-stained sections of the preN AC core biopsy. p CR was considered in the absence of infiltrating cancer cells in primary tumor and axillary lymph nodes. Analysis of statistical association between clinical pathological features, s TIL, p CR and survival were carried out using SPSSvs19.RESULTS Median age was 49 years(range 24-84 years) and the most frequent clinical stage was ⅢB(58.3%). Luminal A, Luminal B, HER2-enriched and(triple-negative) TN phenotype was found in 24.6%, 37.9%, 17.7% and 19.8%, respectively. p CR was observed in 11% and median percentage of s TIL was 40%(2%-95%) in the whole population. p CR was associated to Ct1-2(P = 0.045) and to high s TIL(P = 0.029) in the whole population. There was a slight trend towards significance for s TIL(P = 0.054) in Luminal A. s TIL was associated with grade Ⅲ(P < 0.001), no-Luminal A subtype(P < 0.001), RE-negative(P < 0.001), PgR-negative(P < 0.001), HER2-positive(P = 0.002) and p CR(P = 0.029) in the whole population. Longer disease-free survival was associated with grade Ⅰ-Ⅱ(P = 0.006), cN 0(P < 0.001), clinical stage Ⅱ(P = 0.004), ER-positive(P < 0.001), Pg R-positive(P < 0.001), luminal A(P < 0.001) and p CR(P = 0.002). Longer disease-free survival was associated with grade Ⅰ-Ⅱ in Luminal A(P < 0.001), N0-1 in Luminal A(P = 0.045) and TNBC(P = 0.01), clinical stage Ⅱ in Luminal A(P = 0.003) and TNBC(P = 0.038), and pC R in TNBC(P < 0.001). Longer overall survival was associated with grade Ⅰ-Ⅱ(P < 0.001), ER-positive(P < 0.001), PgR-positive(P < 0.001), Luminal A(P < 0.001), cN 0(P = 0.002) and p CR(P = 0.002) in the whole population. Overall survival was associated with clinical stage Ⅱ(P = 0.017) in Luminal A, older age(P = 0.042) in Luminal B, and pC R in TNBC(P = 0.005).CONCLUSION Predictive and prognostic values of clinicopathological features, like p CR and s TIL, differ depending on the evaluated molecular subtype. | Marco Galvez Carlos A Castaneda Joselyn Sanchez Miluska Castillo Lia Pamela Rebaza Gabriela Calderon Miguel De La Cruz Jose Manuel Cotrina Julio Abugattas Jorge Dunstan Henry Guerra Omar Mejia Henry L Gomez | 2018 | World Journal of Clinical Oncology2018，9，2： | 4 |
| 3 | Rapid detection of lamivudine-resistant hepatitis B virus polymerase gene variants显示文摘 | Jardi R Buti M Rodriguez FF Cotrina M Costa X Pascual C Esteban R Guardia J | | 0，，： | 1 |
| 4 | Astrocytic gap junctions remain open during ischemic conditions 显示文摘 | Cotrina ML Kang J Lin JH | 1998 | J Neurosci1998，18，7： | 1 |
| 5 | Astrocytes and ischemic injury 显示文摘 | TAKANO T OBERHEIM N COTRINA M L al | 2009 | Stroke2009，40，3： | 1 |
| 6 | Astrocytic gap junctions remain open during ischemic conditions显示文摘 | Cotrina ML Kang J Lin JH | | 0，，07： | 1 |
| 7 | Astrocytes and ischemic injury显示文摘 | Takano T Oberheim N Cotrina ML | 2009 | Stroke2009，40，3： | 1 |
| 8 | Programmed cell death in the developing somites is promoted by nerve growth factor via its p75 (NTR) receptor显示文摘 | Cotrina ML Gonzalez-Hoyuela M Barbas JA | 2000 | Dev Biol2000，228，2： | 1 |
| 9 | Astrecytic gap junctions remain open during ischemic conditions 显示文摘 | Cotrina ML Kang J Lin JH | 1998 | J Neurosci1998，18，7： | 1 |
| 10 | Modeling surfaces from planar irregular meshes 显示文摘 | Cotrina J Pla N | 2000 | Computer Aided Geometric Design2000，17，1： | 1 |
| 11 | Role of hepatitis B, C, and D viruses in dual and triple infection: Influence of viral genotypes and hepatitis B precore and basal core promoter mutations on viral replicative interference显示文摘 | Rosendo Jardi Francisco Rodriguez Maria Buti Xose Costa Montserrat Cotrina Roman Galimany Rafael Esteban Jaime Guardia | 2001 | Hepatology2001，，2： | 1 |
| 12 | Expression and function of astrocytic gap junctions in aging显示文摘 | Cotrina ML Gao Q Lin JH | 2001 | Brain Res2001，901，12： | 1 |
| 13 | Is hepatitis B virus subtype testing useful in predicting virological response and resistance to lamivudine?显示文摘 | Buti M Cotrina M Valdes A | | 0，，： | 1 |
| 14 | Astrocytes and ischemic injury显示文摘 | Takano T Oberheim N Cotrina ML | 2009 | Stroke2009，40，： | 1 |
| 15 | Gap junction- mediated propagation and amplification of cell injury显示文摘 | Lin JH Weigel H Cotrina ML | 1998 | Nai Neurocsci1998，1，： | 1 |
| 16 | Diverse roles of Eph receptors and ephrins in the regulation of cell migration and tissue assembly显示文摘 | Poliakov A Cotrina M Wilkinson DG | 2004 | Dev Cell2004，7，4： | 1 |
| 17 | Regular triangulations of dynamic sets of points 显示文摘 | Marc Vigo Nuria Pla Josep Cotrina | 2002 | Computer Aided Geometric Design2002，19，2： | 1 |
| 18 | Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cells显示文摘 | Lin JH Takano T Cotrina ML | | 0，，11： | 1 |
| 19 | Gap-junction-mediated propagation and amplification of cell injury显示文摘 | Lin JH Weigel H Cotrina ML | 1998 | Nat Neurosci1998，1，6： | 1 |
| 20 | Astrocytes and ischemic injury显示文摘 | Takano T Oberheim N Cotrina ML | | 0，，3： | 1 |
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