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| 1 | Phytochromes Regulate SA and JA Signaling Pathways in Rice and Are Required for Developmentally Controlled Resistance to Magnaporthe grisea显示文摘野类型的米饭植物的旧叶子(Oryza sativa L。cv。Nipponbare ) 比新叶子对强风真菌(Magnaporthe grisea ) 更抵抗。相反,米饭 phytochrome 三元组异种(phyAphyBphyC ) 的旧、新的叶子产生强风真菌。我们表明那个致病相关的班 1 (PR1 ) 蛋白质很快并且强烈在 M 期间被导致。grisea 感染和后面的外长的 jasmonate (JA ) 或水杨酸酸(SA ) 在旧叶子,然而并非在新叶子的暴露野类型。相反, PR1 蛋白质的累积显著地在 phyAphyBphyC 异种的旧、新的叶子被稀释。这些结果建议 phytochromes 在米饭为 PR1 蛋白质的正式就职被要求。PR1a 和 PR1b 的基础抄写层次是实质地更高的在象与 phyAphyBphyC 异种相比野类型,也建议那 phytochromes 为 PR1 基因的基础表示被要求。而且,知道在 SA 依赖或 JA 依赖的防卫小径工作的基因的抄本层次到叶年龄和功能的 phytochromes 被调整。一起拿,我们的调查结果证明 phytochromes 为年龄相关的抵抗在米饭被要求到 M。grisea 并且可以间接地由调整 SA 依赖、 JA 依赖的防卫小径增加 PR1 基因表示。 | Xian-Zhi Xie Yan-Jiu Xue Jin-Jun Zhou Bin Zhang Hong Chang Makoto Takano | 2011 | Molecular Plant2011，4，4： | 28 |
| 2 | 四种能源植物种子萌芽期的耐盐性研究显示文摘通过对盐胁迫下种子发芽率、相对发芽率、发芽势和相对胚根长度指标的测定,分析了4种能源植物的耐盐浓度、耐盐半致死浓度、耐盐极限浓度,并根据各指标隶属函数值,综合评价了各种植物的耐盐性。结果显示:随着处理盐浓度的增加,4种植物的发芽势、发芽率和胚根长度均呈下降趋势。在3-6 g·L^-1NaC l浓度下,亚麻、油菜种子的相对发芽率变化不大,但大豆下降较多。当盐浓度6 g·L^-1时,4种植物的相对胚根长度均明显减少;其中减少最多的是油葵,其次是亚麻,再次是大豆;油菜胚根长度减少的最少;在12 g·L^-1的盐浓度下4种能源植物的相对胚根长度均降至11%以下。亚麻的耐盐浓度最高,为6%,是大豆、油菜和油葵的耐盐浓度的2倍以上。耐盐半致死浓度最大的为亚麻和油菜(9 g·L^-1),大豆次之(6 g·L^-1),油葵最低(3 g·L^-1)。抗盐隶属函数综合分析表明,在各种盐浓度下,4种植物萌芽期的耐盐性最强的是亚麻,其次是油菜,再次是大豆和油葵。 | 高永 杨静慧 李宏平 李建科 黄俊轩 张伟玉 Takano Yujisakai | 2010 | 大豆科学2010，29，6： | 13 |
| 3 | Prediction of lymph node metastasis and sentinel node navigation surgery for patients with early-stage gastric cancer显示文摘Accurate prediction of lymph node(LN) status is crucially important for appropriate treatment planning in patients with early gastric cancer(EGC). However,consensus on patient and tumor characteristics associated with LN metastasis are yet to be reached. Through systematic search,we identified several independent variables associated with LN metastasis in EGC,which should be included in future research to assess which of these variables remain as significant predictors of LN metastasis. On the other hand,even if we use these promising parameters,we should realize the limitation and the difficulty of predicting LN metastasis accurately. The sentinel LN(SLN) is defined as first possible site to receive cancer cells along the route of lymphatic drainage from the primary tumor. The absence of metastasis in SLN is believed to correlate with the absence of metastasis in downstream LNs. In this review,we have attempted to focus on several independent parameters which have close relationship between tumor and LN metastasis in EGC. In addition,we evaluated the history of sentinel node navigation surgery and the usefulness for EGC. | Atsuo Shida Norio Mitsumori Hiroshi Nimura Yuta Takano Taizou Iwasaki Muneharu Fujisaki Naoto Takahashi Katsuhiko Yanaga | 2016 | World Journal of Gastroenterology2016，22，33： | 13 |
| 4 | 水稻抗稻瘟病防御系统中草酸氧化酶的鉴定显示文摘以水稻(Oryzasativa)OSK3蛋白激酶为诱饵,利用酵母双杂交系统中从水稻cDNA文库中筛选与其互作的蛋白,与植物抗病性相关的草酸氧化酶编码基因是所获得的阳性克隆之一,经检测报告基因lacZ的表达验证了互作的真实性。认为属于H2O2产生酶类的草酸氧化酶在水稻OSK3蛋白激酶介导的抗病途径中,可能是位于抗病信号传导链下游的蛋白。 | 冯洁 Takano Makoto | 2004 | 农业生物技术学报2004，12，3： | 12 |
| 5 | 光敏色素影响赤霉素调控的水稻幼苗光形态建成特征显示文摘赤霉素(gibberellin,GA)是一种重要的植物激素,它与光敏色素协同调节拟南芥植株的光形态建成特征.但是GA对水稻幼苗光形态建成和暗形态建成的影响,特别是在此过程中光敏色素与GA之间的相互作用仍不清楚.本研究利用野生型和光敏色素突变体(phyA和phyB)水稻作为研究材料,分析了GA生物合成抑制剂多效唑(PAC)对黑暗和光照下生长的水稻幼苗胚芽鞘、地上部分和主根延伸以及光调控基因LHCB表达的影响.据此推测,在暗生长条件下,PAC处理能够抑制野生型水稻幼苗胚芽鞘的生长,诱导LHCB基因的表达;phyA突变体对PAC处理的反应不如野生型敏感;phyB突变体和野生型反应基本相同.在光照条件下,PAC处理能够抑制水稻幼苗地上部分的生长,phyB突变体对PAC处理的反应不如野生型和phyA突变体敏感.此外,phyB介导的光信号负调控PAC诱导的主根延伸反应.据此推测,GA是维持水稻幼苗暗形态建成、抑制光形态建成所必需的;另一方面,phyA和phyB或正或负调控PAC所诱导的光形态建成反应.本研究结果揭示了光敏色素和GA在水稻幼苗生长发育中的相互作用,为进一步研究光和GA协同调控水稻发育的分子机制奠定了基础. | 刘婧 柳艳梅 TAKANO Makoto 王宝山 谢先芝 | 2010 | 科学通报2010，55，24： | 9 |
| 6 | IgM反应是熊去氧胆酸和苯扎贝特治疗原发性胆汁性胆管炎的预后生物标志物显示文摘【据《J Gastroenterol Hepatol》2019年11月报道】题:IgM反应是熊去氧胆酸和苯扎贝特治疗原发性胆汁性胆管炎的预后生物标志物(作者Takano K等)原发性胆汁性胆管炎(PBC)患者对熊去氧胆酸(UDCA)不敏感,有可能发展为肝硬化和肝衰竭。苯扎贝特可作为这些患者的二线药物选择。该研究旨在评价UDCA联合苯扎贝特治疗UDCA难治性PBC的远期疗效,并探讨影响预后的因素。 | 李艳艳 高润平 TAKANO K SAEKI C OIKAWA T | 2020 | 临床肝胆病杂志2020，36，3： | 8 |
| 7 | Neoatherosclerosis:Coronary stents seal atherosclerotic lesions but result in making a new problem of atherosclerosis显示文摘Chronic inflammation of the native vessel wall with infiltration of lipid-laden foamy macrophages through impaired endothelium results in atherosclerosis. Percutaneous coronary intervention, including metallic stent implantation, is now widely utilized for the treatment of atherosclerotic lesions of the coronary artery. Baremetal stents and the subsequently developed drugeluting stents seal the atherosclerosis and resolve lumen stenosis or obstruction of the epicardial coronary artery and myocardial ischemia. After stent implantation, neointima proliferates within the stented segment. Chronic inflammation caused by a foreign body reaction to the implanted stent and subsequent neovascularization, which is characterized by the continuous recruitment of macrophages into the vessel, result in the transformation of the usual neointima into an atheromatous neointima. Neointima with an atherosclerotic appearance, such as that caused by thin-cap fibroatheromas, is now recognized as neoatherosclerosis, which can sometimes cause in-stent restenosis and acute thrombotic occlusion originating from the stent segment following disruption of the atheroma. Neoatherosclerosis is emerging as a new coronary stent-associated problem that has not yet been resolved. In this review article, we will discuss possible mechanisms, clinical challenges, and the future outlook of neoatherosclerosis. | Hidenori Komiyama Masamichi Takano Noritake Hata Yoshihiko Seino Wataru Shimizu Kyoichi Mizuno | 2015 | World Journal of Cardiology2015，7，11： | 7 |
| 8 | Biliary drainage strategy of unresectable malignant hilar strictures by computed tomography volumetry显示文摘AIM:To identify criteria for predicting successful drainage of unresectable malignant hilar biliary strictures(UMHBS) because no ideal strategy currently exists.METHODS:We examined 78 patients with UMHBS who underwent biliary drainage.Drainage was considered effective when the serum bilirubin level decreased by ≥ 50% from the value before stent placement within 2 wk after drainage, without additional intervention.Complications that occurred within 7 d after stent placement were considered as early complications.Before drainage, the liver volume of each section(lateral and medial sections of the left liver and anterior and posterior sections of the right liver) was measured using computed tomography(CT) volumetry.Drained liver volume was calculated based on the volume of each liver section and the type of bile duct stricture(according to the Bismuth classification).Tumor volume, which was calculated by using CT volumetry, was excluded from the volume of each section.Receiver operating characteristic(ROC) analysis was performed to identify the optimal cutoff values for drained liver volume.In addition, factors associated with the effectiveness of drainage and early complications were evaluated.RESULTS:Multivariate analysis showed that drained liver volume [odds ratio(OR) = 2.92, 95%CI:1.648-5.197; P < 0.001] and impaired liver function(with decompensated liver cirrhosis)(OR = 0.06, 95%CI:0.009-0.426; P = 0.005) were independent factors contributing to the effectiveness of drainage.ROC analysis for effective drainage showed cutoff values of 33% of liver volume for patients with preserved liver function(with normal liver or compensated livercirrhosis)and 50%for patients with impaired liver function(with decompensated liver cirrhosis).The sensitivity and specificity of these cutoff values were82%and 80%for preserved liver function,and 100%and 67%for impaired liver function,respectively.Among patients who met these criteria,the rate of effective drainage among those with preserved liver function and impaired liver function was 90%and 80%,respectively.The rates of effective drainage in both groups were significantly higher than in those who did not fulfill these criteria(P<0.001 and P=0.02,respectively).Drainage-associated cholangitis occurred in 9 patients(12%).A smaller drained liver volume was associated with drainage-associated cholangitis(P<0.01).CONCLUSION:Liver volume drainage≥33%in patients with preserved liver function and≥50%in patients with impaired liver function correlates with effective biliary drainage in UMHBS. | Ei Takahashi Mitsuharu Fukasawa Tadashi Sato Shinichi Takano Makoto Kadokura Hiroko Shindo Yudai Yokota Nobuyuki Enomoto | 2015 | World Journal of Gastroenterology2015，21，16： | 6 |
| 9 | Invasive group B streptococcal infection in a patient with post splenectomy for hypersplenism secondary to liver cirrhosis and portal hypertension显示文摘BACKGROUND:Splenectomy in patients with liver cirrhosis(LC)is expected to become more common owing to its efficacy on portal hemodynamics.In this report we describe an alarming case of group B streptococcus(GBS)infection after splenectomy in a patient with LC.METHODS:A 72-year-old woman with a history of LC was admitted to our emergency department because of respiratory failure.The patient had received left lateral segmentectomy of the liver and splenectomy three months before admission.Pulmonary examination revealed significant wheezing during inspiration and expiration,but no crackles and stridor.Chest radiography and CT showed no infiltrates.A presumptive diagnosis of bronchial asthma caused by upper respiratory infection was made.Four days after admission,GBS infection was confirmed by blood culture and penicillin G was administered.Antibiotics were given intravenously for a total of 12 days.RESULTS:The patient was discharged on the 12th day after admission.CONCLUSIONS:Although efficacy of splenectomy in patients with LC has been reported,immune status should be evaluated for a longer period.Patients who have undergone splenectomy are highly susceptible to bacteria;moreover,LC itself is an independent risk factor for mortality in patients with sepsis.Since prophylaxis against GBS has not been established,immediate action should be taken.Emergency physicians should be aware of invasive GBS infection in the context of the critical risk factors related to splenectomy and LC,particularly the expected increase of splenectomy performed in LC patients. | Tomoya Okazaki Toru Hifumi Arisa Manabe Hikari Matsumura Satoshi Egawa Hideyuki Hamaya Nastuyo Shinohara Koshiro Takano Hajime Shishido Yuko Abe Kenya Kawakita Masanobu Hagiike Yasuhiro Kuroda | 2016 | World Journal of Emergency Medicine2016，7，1： | 6 |
| 10 | Risk factors for perforation during endoscopic retrograde cholangiopancreatography in post-reconstruction intestinal tract显示文摘BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP) in patients with surgically altered anatomy has been a major challenge to gastrointestinal endoscopists with low success rates for reaching the target site as well as high complication rates. The knowledge of ERCP-related risk factors is important for reducing unexpected complications.AIM To identify ERCP-related risk factors for perforation in patients with surgically altered anatomy.METHODS The medical records of 187 patients with surgically altered anatomy who underwent ERCP at our institution between April 2009 and December 2017 were retrospectively reviewed. An analysis of patient data, including age, sex, type of reconstruction, cause of surgery, aim of ERCP, success rate of reaching target site,success rate of procedure, adverse events, type of scope, time to reach the target site, and duration of procedure, was performed. In patients with Billroth-Ⅱ reconstruction, additional potential risk factors were the shape of the inserted scope and whether the anastomosis was antecolic or retrocolic.RESULTS All patients(n = 187) had surgical anatomy, such as Billroth-Ⅰ(n = 22), Billroth-Ⅱ(n = 33), Roux-en-Y(n = 54), Child, or Whipple reconstruction(n = 75). ERCP was performed for biliary drainage in 43 cases(23%), stone removal in 29 cases(16%),and stricture dilation of anastomosis in 59 cases(32%). The scope was unable to reach the target site in 17 cases(9%), and an aimed procedure could not be accomplished in 54 cases(29%). Adverse events were pancreatitis(3%),hyperamylasemia(10%), cholangitis(6%), cholestasis(4%), excessive sedation(1%), perforation(2%), and others(3%). Perforation occurred in three cases, all of which were in patients with Billroth-Ⅱ reconstruction; in these patients, further analysis revealed loop-shaped insertion of the scope to be a significant risk for perforation(P = 0.01).CONCLUSION Risk factors for perforation during ERCP in patients with surgically altered anatomy were Billroth-Ⅱ reconstruction and looping of the scope during BillrothⅡ procedure. | Shinichi Takano Mitsuharu Fukasawa Hiroko Shindo Ei Takahashi Sumio Hirose Yoshimitsu Fukasawa Satoshi Kawakami Hiroshi Hayakawa Hiroshi Yokomichi Makoto Kadokura Tadashi Sato Nobuyuki Enomoto | 2019 | World Journal of Clinical Cases2019，7，1： | 6 |
| 11 | Ultrasound-guided vs endoscopic ultrasound-guided fine-needle aspiration for pancreatic cancer diagnosis显示文摘AIM: To clarify the effectiveness and safety of endo- scopic ultrasound-guided fine-needle aspiration (EUS-FNA) for the diagnosis of pancreatic cancer (PC). METHODS: Patients who were diagnosed with unresectable, locally advanced or metastatic PC between February 2006 and September 2011 were selected for this retrospective study. FNA biopsy for pancreatic tumors had been performed percutaneously under extracorporeal ultrasound guidance until October 2009; then, beginning in November 2009, EUS-FNA has been performed. We reviewed the complete medical records of all patients who met the selection criteria for the following data: sex, age, location and size of the targeted tumor, histological and/or cytological findings, details of puncture procedures, time from day of puncture until day of definitive diagnosis, and details of severe adverse events. RESULTS: Of the 121 patients who met the selection criteria, 46 had a percutaneous biopsy (Group A) and 75 had an EUS-FNA biopsy (Group B). Adequate cytological specimens were obtained in 42 Group A patients (91.3%) and all 75 Group B patients (P=0.0192), and histological specimens were obtained in 41 Group A patients (89.1%) and 65 Group B patients (86.7%). Diagnosis of malignancy by cytology was positive in 33 Group A patients (78.6%) and 72 Group B patients (94.6%) (P=0.0079). Malignancy by both cytology and pathology was found in 43 Group A (93.5%) and 73 Group B (97.3%) patients. The mean period from the puncture until the cytological diagnosis in Group B was 1.7 d, which was significantly shorter than that in Group A (4.1 d) (P < 0.0001). Severe adverse events were experienced in two Group A patients (4.3%) and in one Group B patient (1.3%). CONCLUSION: EUS-FNA, as well as percutaneous needle aspiration, is an effective modality to obtain cytopathological confirmation in patients with advanced PC. | Masato Matsuyama Hiroshi Ishii Kensuke Kuraoka Seigo Yukisawa Akiyoshi Kasuga Masato Ozaka Sho Suzuki Kouichi Takano Yuko Sugiyama Takao Itoi | 2013 | World Journal of Gastroenterology2013，19，15： | 5 |
| 12 | Vulnerable atherosclerotic plaque features:findings from coronary imaging显示文摘Pathological studies have suggested that features of vulnerable atherosclerotic plaques likely to progress and lead to acute cardiovascular events have specific characteristics.Given the progress of intravascular coronary imaging technology,some large prospective studies have detected features of vulnerable atherosclerotic plaques using these imaging modalities.However,the rate of cardiovascular events,such as acute coronary syndrome,has been found to be considerably reduced in the limited follow-up period available in the statin era.Additionally,not all disrupted plaques lead to thrombus formation with clinical presentation.If sub-occlusive or occlusive thrombus formation does not occur,a thrombus on a disrupted plaque will organize without any symptoms,forming a'healed plaque'.Although vulnerable plaque detection using intracoronary imaging is focused on'thin-cap fibroatheroma'leading to plaque rupture,superficial plaque erosion is increasingly recognized;however,the underlying mechanism of thrombus formation on eroded plaques is not well understood.One of intravascular imaging,optical coherence tomography(OCT)has the highest image resolution and has enabled detailed characterization of the plaque in vivo.Here,we reviewed the status and limitations of intravascular imaging in terms of detecting vulnerable plaque through mainly OCT studies.We suggested that vulnerable plaque should be reconsidered in terms of eroded plaque and healed plaque and that both plaque and circulating blood should be assessed in greater detail accordingly. | Osamu Kurihara Masamichi Takano Yasushi Miyauchi Kyoichi Mizuno Wataru Shimizu | 2021 | Journal of Geriatric Cardiology2021，18，7： | 5 |
| 13 | Epidemiological study of gastroenteropancreatic neuroendocrine tumors in Japan显示文摘 | Tetsuhide Ito Hironobu Sasano Masao Tanaka R. Yoshiyuki Osamura Iwao Sasaki Wataru Kimura Koji Takano Takao Obara Miyuki Ishibashi Kazuwa Nakao Ryuichiro Doi Akira Shimatsu Toshirou Nishida Izumi Komoto Yukio Hirata Kazuhiko Nakamura Hisato Igarashi Rober | 2010 | Journal of Gastroenterology2010，，2： | 4 |
| 14 | Coronary atherosclerosis is already ongoing in pre-diabetic status: Insight from intravascular imaging modalities显示文摘Diabetes mellitus is a powerful risk factor of coronary artery disease(CAD), leading to death and disability. In recent years, given the accumulating evidence that prediabetes is also related to increasing risk of CAD including cardiovascular events, a new guideline has been proposed for the treatment of blood cholesterolfor primary prevention of cardiovascular events. This guideline recommends aggressive lipid-lowering statin therapy for primary prevention in diabetes and other patients. The ultimate goal of patient management is to inhibit progression of systemic atherosclerosis and prevent fatal cardiovascular events such as acute coronary syndrome(ACS). Because disruption of atherosclerotic coronary plaques is a trigger of ACS, the high-risk atheroma is called a vulnerable plaque. Several types of novel diagnostic imaging technologies have been developed for identifying the characteristics of coronary atherosclerosis before the onset of ACS, especially vulnerable plaques. According to coronary angioscopic evaluation, atherosclerosis severity and plaque vulnerability were more advanced in prediabetic than in nondiabetic patients and comparable to that in diabetic patients. In addition, pharmacological intervention by statin therapy changed plaque color and complexity, and the dynamic changes in plaque features are considered plaque stabilization. In this article, we review the findings of atherosclerosis in prediabetes, detected by intravascular imaging modalities, and the therapeutic implications. | Osamu Kurihara Masamichi Takano Yoshihiko Seino Wataru Shimizu Kyoichi Mizuno | 2015 | World Journal of Diabetes2015，6，1： | 4 |
| 15 | Complete response with sorafenib and transcatheter arterial chemoembolization in unresectable hepatocellular carcinoma显示文摘Patients with advanced hepatocellular carcinoma(HCC) showing portal vein tumor thrombosis(PVTT) have an extremely poor prognosis. According to treatment guidelines, the only option for HCC patients with PVTT is sorafenib chemotherapy. However, in Asia, various treatments have been attempted and possible prolongation of overall survival has been repeatedly reported. We herein report the first case of a patient with an initially unresectable advanced HCC with PVTT who underwent curative hepatectomy after sorafenib and transcatheter arterial chemoembolization(TACE) showing complete histological response. Two months after induction with sorafenib, a significant decrease in serum alpha-fetoprotein level was observed and computed tomography imaging showed a significant decrease in tumor size. Because of remaining PVTT, TACE and curative resection were performed. The combination of sorafenib and TACE may be an effective treatment for HCC patients with PVTT. | Michitoshi Takano Takashi Kokudo Yoshihiro Miyazaki Yumiko Kageyama Amane Takahashi Katsumi Amikura Hirohiko Sakamoto | 2016 | World Journal of Gastroenterology2016，22，42： | 4 |
| 16 | Effect of Double Air Injection on Performance Characteristics of Centrifugal Compressor显示文摘In the operation of a centrifugal compressor of turbocharger, instability phenomena such as rotating stall and surge are induced at a lower flow rate close to the maximum pressure ratio. In this study, for the suppression of surge phenomenon resulting in the extension of the stable operating range of centrifugal compressor to lower flow rate, the compressed air at the compressor exit was re-circulated and injected into the impeller inlet by using the double injection nozzle system. The experiments were performed to find out the optimum circumferential position of the second nozzle relative to the fixed first one and the optimum inner diameter of the injection nozzles, which are able to most effectively reduce the flow rate of surge inception. Moreover, in order to examine the universality of these optimum values, the experiments were carried out for two types of compressors. | Toshiyuki Hirano Mizuki Takano Hoshio Tsujita | 2015 | Journal of Thermal Science2015，24，1： | 3 |
| 17 | Clinical usefulness of ursodeoxycholic acid for Japanese patients with autoimmune hepatitis显示文摘AIM To evaluate the therapeutic effects of ursodeoxycholic acid(UDCA) on autoimmune hepatitis(AIH).METHODS A total 136 patients who were diagnosed with AIH were included in our study. All of the patients underwent a liver biopsy, and had at least a probable diagnosis on the basis of either the revised scoring system or the simplified scores. Initial treatment included UDCA monotherapy(Group U, n = 48) and prednisolone(PSL) monotherapy(Group P, n = 88). Group U was further classified into two subgroups according to the effect of UDCA: Patients who had achieved remission induction with UDCA monotherapy and showed no sign of relapse(Subgroup U1, n = 34) and patients who additionally received PSL during follow-up(Subgroup U2, n = 14). We compared the clinical and histological findings between each groups, and investigated factorscontributing to the response to UDCA monotherapy.RESULTS In Group U, 34 patients(71%) achieved and maintained remission over 49(range: 8-90) mo(Subgroup U1) and 14 patients(29%) additionally received PSL(Subgroup U2) during follow-up. Two patients in Subgroup U2 achieved remission induction once but additionally required PSL administration because of relapse(15 and 35 mo after the start of treatment). The remaining 12 patients in Subgroup U2 failed to achieve remission induction during follow-up, and PSL was added during 7(range: 2-18) mo. Compared with Subgroup U2, Subgroup U1 had significantly lower alanine aminotransferase(ALT) levels at onset(124 IU/L vs 262 IU/L, P = 0.023) and a significantly higher proportion of patients with mild inflammation(A1) on histological examination(70.6% vs 35.7%, P = 0.025). When multivariate analysis was performed to identify factors contributing to the response to UDCA monotherapy, only a serum ALT level of 200 IU/L or lower was found to be associated with a significant difference(P = 0.013).CONCLUSION To prevent adverse events related to corticosteroids, UDCA monotherapy for AIH needs to be considered in patients with a serum ALT level of 200 IU/L or lower. | Yuichi Torisu Masanori Nakano Keiko Takano Ryo Nakagawa Chisato Saeki Atsushi Hokari Tomohisa Ishikawa Masayuki Saruta Mikio Zeniya | 2017 | World Journal of Hepatology2017，9，1： | 3 |
| 18 | Hemorrhagic shock due to submucosal esophageal hematoma along with mallory-weiss syndrome:A case report显示文摘BACKGROUND Esophageal submucosal hematoma is a rare condition.Although the exact etiology remains uncertain,vessel fragility with external factors is believed to have led to submucosal bleeding and hematoma formation;the vessel was ruptured by a sudden increase in pressure due to nausea,and the hematoma was enlarged by antiplatelet or anticoagulant therapy.Serious conditions are rare,with a better prognosis.We present the first known case of submucosal esophageal hematoma-subsequent hemorrhagic shock due to Mallory-Weiss syndrome.CASE SUMMARY A 73-year-old female underwent endovascular treatment for an unruptured cerebral aneurysm.The patient received aspirin and clopidogrel before surgery and heparin during surgery,and was well during the surgery.Several hours after returning to the ICU,she complained of chest discomfort,vomited 500 m L of fresh blood,and entered hemorrhagic shock.Esophageal submucosal hematoma with Mallory-Weiss syndrome was diagnosed through an endoscopic examination and computed tomography.In addition to a massive fluid and erythrocyte transfusion,we performed a temporary compression for hemostasis with a Sengstaken-Blakemore(S-B)tube.Afterwards,she became hemodynamically stable.On postoperative day 1,we performed an upper gastrointestinal endoscopy and confirmed no expansion of the hematoma nor any recurring bleeding;therefore,we removed the S-B tube and clipped the gastric mucosal laceration at the esophagogastric junction.We started oral intake on postoperative day 10.The patient made steady progress,and was discharged on postoperative day 33.CONCLUSION We present the first known case of submucosal esophageal hematoma subsequent hemorrhagic shock due to Mallory-Weiss syndrome. | Jiro Oba Daisuke Usuda Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Hayabusa Takano Shintaro Shimozawa Yuta Hotchi Kenki Usami Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita | 2022 | World Journal of Clinical Cases2022，10，27： | 3 |
| 19 | NIH 3T3 cells malignantly transformed by mot-2 showinactivation and cytoplasmic sequestration of the p53protein显示文摘INTRODUCTIONInvolvementandinactivationofp53,atumorsuppressorandcellulartranscriptionfactorincellularimmortalizationhasbeenwelldocumented[1-4].Variousactivitiesofp53proteininvolveitsfunctionaldomains,viz.,anamino--terminustransactivationdomain(aminoac... | WADHIVA RENU SYIJICHI TAKANO YOUJIMITSUI SUNIL C KAUL( Chugai Research Institute for Molecular Medicine,153-2 Nagai, Niihari-Mura, Ibaraki 300-41, Japan)( National Institute of Bioscience and Hunan-Technology, AIST, 1-1 Higashi, Tsukusa, Ibaraki 305-85 | 1999 | Cell Research1999，9，4： | 3 |
| 20 | Multi-modal Gesture Recognition using Integrated Model of Motion, Audio and Video显示文摘Gesture recognition is used in many practical applications such as human-robot interaction, medical rehabilitation and sign language. With increasing motion sensor development, multiple data sources have become available, which leads to the rise of multi-modal gesture recognition. Since our previous approach to gesture recognition depends on a unimodal system, it is difficult to classify similar motion patterns. In order to solve this problem, a novel approach which integrates motion, audio and video models is proposed by using dataset captured by Kinect. The proposed system can recognize observed gestures by using three models. Recognition results of three models are integrated by using the proposed framework and the output becomes the final result. The motion and audio models are learned by using Hidden Markov Model. Random Forest which is the video classifier is used to learn the video model. In the experiments to test the performances of the proposed system, the motion and audio models most suitable for gesture recognition are chosen by varying feature vectors and learning methods. Additionally, the unimodal and multi-modal models are compared with respect to recognition accuracy. All the experiments are conducted on dataset provided by the competition organizer of MMGRC, which is a workshop for Multi-Modal Gesture Recognition Challenge. The comparison results show that the multi-modal model composed of three models scores the highest recognition rate. This improvement of recognition accuracy means that the complementary relationship among three models improves the accuracy of gesture recognition. The proposed system provides the application technology to understand human actions of daily life more precisely. | GOUTSU Yusuke KOBAYASHI Takaki OBARA Junya KUSAJIMA Ikuo TAKEICHI Kazunari TAKANO Wataru NAKAMURA Yoshihiko | 2015 | Chinese Journal of Mechanical Engineering2015，28，4： | 3 |
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