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| 1 | Mechanistic analysis of nonoxygenated hypothermic machine perfusion's protection on warm ischemic kidney uncovers greater eNOS phosphorylation and vasodilation 显示文摘 | Chatauret N Coudroy R Delpech PO | 2014 | Am J Transplant2014，14，11： | 1 |
| 2 | Mechanistic analysis of nonoxygenated hypothermic machine perfusion% protection on warm isehemie kidney uncovers greater eNOS phosphorylation and vasodilation显示文摘 | Chatauret N Coudroy R Delpech PO | 2014 | Am J Transplant2014，14，11： | 1 |
| 3 | Contribution of cubilin and amnionless to processing and membrane tar- geting of cubilin-amnionless complex显示文摘 | Coudroy G Gburek J Kozyraki R | 2005 | J Am Soc Nephrol2005，16，8： | 1 |
| 4 | Mechanistic analysis of nonoxygenated hypothermic machine perfusion's protection on warm ischemic kidneyuncovers greater eNOS phosphorylation and vasodilation显示文摘 | Chatauret N Coudroy R Delpech PO | 2014 | Am J Transplant2014，14，11： | 1 |
| 5 | Evolution of respiratory system compliance and potential for lung recruitment in COVID-19–induced acute respiratory distress syndrome显示文摘Background:Coronavirus disease 2019(COVID-19)has been frequently complicated by severe acute respiratory distress syndrome(ARDS)with prolonged invasive ventilation.While respiratory system compliance and lung recruitability have been described within the first days after ICU admission,data about their longitudinal changes are still limited.Therefore,we conducted this study to assess the evolution of respiratory system compliance and lung recruitability in patients with COVID-19–related ARDS.Method:We conducted a prospective single-center study in patients admitted for COVID-19–related ARDS during the first wave of the pandemic,from March 16,2020 to April 10,2020.Respiratory system compliance was calculated daily at clinical positive end-expiratory pressure(PEEP)during passive breathing.The potential for lung recruitment was assessed by measuring the volume derecruited between PEEP 15 cmH2 O and 5 cmH2 O,and using the calculation of the recruitment-to-inflation ratio(R/I ratio).Recruitable lung was considered when the R/I ratio was at least 0.5.The primary outcome was the evolution of respiratory mechanics over time.The secondary outcome was the evolution of lung recruitability over time.Results:Thirty-two patients were included in this study.The respiratory mechanics were assessed 222 times(7±5 times per patient).Respiratory system compliance at clinical PEEP was 29.1 mL/cmH2 O(interquartile range[IQR]:24.1–33.9 mL/cmH2 O)and decreased significantly over time(P<0.0001).Lung recruitability was assessed in 22 out of the 32 patients(60 assessments).The median volume derecruited between PEEP 15 cmH2 O and 5 cmH2 O was 246.8 mL(IQR:180.8–352.2 mL)and the median R/I ratio was 0.56(IQR:0.39–0.73).Neither changed significantly over time.The proportion of patients with recruitable lung was 50.0%(6/12)within the first 3 days after intubation,69.2%(9/13)between day 4 and day 7,and 66.7%(8/12)after day 7(P=0.7934).Conclusions:In our cohort,respiratory system compliance was low and decreased over time.The potential for lung recruitment was high and persisted despite prolonged mechanical ventilation,suggesting that maintaining high PEEP levels in the later course of COVID-19 could be adequate. | Maeva Rodriguez Sylvain Le Pape François Arrivé Jean-Pierre Frat Arnaud WThille Rémi Coudroy | 2022 | Journal of Intensive Medicine2022，2，4： | 0 |
| 6 | High-flow nasal cannula oxygen therapy in acute hypoxemic respiratory failure and COVID-19-related respiratory failure显示文摘Although standard oxygen face masks are first-line therapy for patients with acute hypoxemic respiratory failure,high-flow nasal cannula oxygen therapy has gained major popularity in intensive care units.The physiological effects of high-flow oxygen counterbalance the physiological consequences of acute hypoxemic respiratory failure by lessening the deleterious effects of intense and prolonged inspiratory efforts generated by patients.Its simplicity of application for physicians and nurses and its comfort for patients are other arguments for its use in this setting.Although clinical studies have reported a decreased risk of intubation with high-flow oxygen compared with standard oxygen,its survival benefit is uncertain.A more precise definition of acute hypoxemic respiratory failure,including a classification of severity based on oxygenation levels,is needed to better compare the efficiencies of different non-invasive oxygenation support methods(standard oxygen,high-flow oxygen,and non-invasive ventilation).Additionally,the respective role of each non-invasive oxygenation support method needs to be established through further clinical trials in acute hypoxemic respiratory failure,especially in severe forms. | Jean-Pierre Frat Laura Marchasson François Arrivé Rémi Coudroy | 2023 | Journal of Intensive Medicine2023，3，1： | 0 |
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