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| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 3 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 4 | 氮氧化物吸附催化器与选择性催化还原装置组合排放控制系统用的先进催化剂显示文摘与仅采用一种技术的系统相比,由氮氧化物(NO_x)吸附催化器(NAC)和选择性催化还原(SCR)装置组合的排放控制系统能够对稀燃条件下的NO_x控制提供更大的优势。然而,组合系统也对新的催化剂设计提出了挑战。与仅采用NAC的系统相比,NO_x再生时,NAC+SCR组合系统中NAC生成的氨(NH_3)是所需的特性。组合系统中的SCR需要与单独的SCR技术一样耐热,同时必须能抵抗上游的NAC周期性脱硫时出现的高温稀/浓状态反复变化。研究中,特别为组合系统研发了先进的NAC和SCR催化剂。改进的NAC催化剂展示出更宽广的运行温度窗口,并在减少铂族金属涂敷量的情况下获得了更高的NH_3生成活性。先进的SCR具有优异的低温NO_x还原效率,即便在高温稀/浓状态反复交替后依然具有极好的耐久性。采用改进的NAC和SCR催化剂后,系统性能显著提高。新研发的催化剂的优势也在车辆上得到了验证。 | Chen H Y Weigert E C Fedeyko J M Cox J P Andersen P J 许蕾 | 2012 | 国外内燃机2012，44，2： | 3 |
| 5 | Fulid infiltration and volume changes during mid-crustal mylonite of Proterozz granite, King Island, Tasmamia 显示文摘 | Streit J E Cox S F | 1998 | Journal of Metamorphic Geology1998，16，： | 2 |
| 6 | A theory of the term structure of interest rates显示文摘 | Cox J C Ingersoll J E Ross S A | 1985 | Econometrica1985，53，2： | 2 |
| 7 | Cecal carriage of Clostri-dinm perfringens in broiler chickens given mucosal starter culture 显示文摘 | Craven S E Stem N J Cox N A | 1999 | Avian Diseases1999，43，： | 1 |
| 8 | Learning curves and breast cancer lymphatic mapping: Institutional volume index 显示文摘 | Cox C Shivers S | 2001 | J Surg Res2001，97，： | 1 |
| 9 | Time Synchronization for ZigBee Networks显示文摘 | Jovanov E Milenkovic A | 2005 | System Theory2005，37，3： | 1 |
| 10 | An intertemporal general equilibrium model of asset prices 显示文摘 | Cox J C Ingersoll J E Ross S A | 1985 | Econometrica1985，53，： | 1 |
| 11 | A theory of the term structure of interest rates显示文摘 | Cox J C Ingersoll J E Ross S A | 1985 | Econometrica1985，53，： | 1 |
| 12 | 显示文摘 | Aller E Brown D S Cox G G | 1995 | J Org Chem1995，60，： | 1 |
| 13 | Molecular and biological characterization of human monoclonal antibodies bingding to the spike and nucleocapsid proteins of Severe Acute Respiratory Syndrome Coronavirus显示文摘 | Van den Brink E N Meulen J Cox F | 2005 | J Virol2005，79，： | 1 |
| 14 | Effect in range difference position estimation due to stations position errors显示文摘 | MANOLAKIS D E COX M E | 1998 | IEEE1998，34，1： | 1 |
| 15 | Avian encephalomyelitis virus in reared pheasants:a case study 显示文摘 | Welchman D D Cox W J Gough R E | 2009 | Avian Pathology2009，38，3： | 1 |
| 16 | Effect of yeast-supplemented feed on Salmonella and Campylobacter populations in broilers显示文摘 | LINE J E BAILEY J S COX N A | 1998 | Poultry Science1998，77，3： | 1 |
| 17 | Analysis of 1,3-butadiene and other selected gas-phase components in cigarette mainstream and sidestream smoke by gas chromatography-mass selective detection显示文摘 | Brunnemann K D Kagan M R Cox J E | 1990 | Carcinogenesis1990，11，10： | 1 |
| 18 | The IgA system:a comparison of structure and function in different species显示文摘 | Snoeck V Peters IR Cox E | 2006 | Vet Res2006，37，： | 1 |
| 19 | A theory of the term structure of interest rates显示文摘 | Cox J C Ingersoll J E Ross S A | | 0，，02： | 1 |
| 20 | Prevention and Control of Influenza with Vaccines Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010显示文摘 | Fiore Anthony E Uyeki Timothy M Broder Karen Finelli Lyn Euler Gary L Singleton James A Iskander John K Wortley Pascale M Shay David K Bresee Joseph S Cox Nancy J | 2010 | MMWR. Morbidity and Mortality Weekly Report2010，，： | 1 |
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