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| 1 | Effects of flavonoids from Allium mongolicum Regel on growth performance and growth-related hormones in meat sheep显示文摘This study was conducted to investigate the effects of different doses of flavonoids from Allium mongolicum Regel on the production performance and neuroendocrine hormones in meat sheep and to determine the optimum dosage of Allium mongolicum Regel flavonoids to add to the basal diet of dry lotfeeding meat sheep. Sixty meat sheep(initial body weight = 39.9 ± 3.2 kg; 6-month-old) were randomly assigned to 4 groups(15 sheep per group). The sheep in the control group were fed a basal diet, and the 3 experimental groups were fed the basal diet supplemented with flavonoids at 11.22 and 33 mg/kg. Blood samples were collected via the jugular vein at d 0.15, 30, 45, and 60 to determine the neuroendocrine hormone levels. The fasting weight of the sheep was measured during the experimental period, and feed offered and refusals were recorded daily. The basal diet supplemented with flavonoids from 11 to 33 mg/kg significantly increased the daily weight gain and average daily feed intake(P<0.05) and significantly decreased the feed conversion ratio(P<0.05), but there were no differences among the supplementation groups(P>0.05). Starting on d 30, the growth hormone(GH) and insulin-like growth factor-1(IGF-1)levels in the sera of the sheep in the supplementation groups increased significantly(P<0.05), and the increases occurred in a time-dependent manner. Compared with control group, after d 30, the serum corticosterone(CORT) levels were reduced in the sheep that consumed the basal diet supplemented with22 mg/kg flavonoids(P<0.05), but among the other experimental groups, there was a non-significant effect(P>0.05). The serum adrenocorticotropic hormone(ACTH) levels were increased by the supplementation of flavonoids, but compared with the control group, the effect was not significant. The basal diet supplemented with flavonoids at levels from 11 to 33 mg/kg had a significant effect on the production performance and neuroendocrine hormone levels of meat sheep, and the effect occurred in a time-dependent manner. The effect was especially obvious after 30 d of feeding. | Muqier Sarula Qi Terigele Wang Renwei Chen Cuifang Wang Changjin Ao | 2017 | Animal Nutrition2017，，1： | 18 |
| 2 | Efficacy of thalidomide on trinitrobenzene sulfonate-induced colitis in young rats and its mechanism显示文摘 | Xu Jiahua Zheng Cuifang Huang Ying Liang Yingjie | 2014 | Chinese Medical Journal2014，，12： | 9 |
| 3 | Exosome-based small RNA delivery:Progress and prospects显示文摘RNA interfering(RNAi), mediated by small interfering RNAs and microRNAs, is currently one of the most promising tools of gene therapy. Small RNAs are capable of inducing specific post-transcriptional gene silencing, providing a potentially effective platform for the treatment of a wide array of diseases. However, similar to other nucleic acid-based drugs,the major hurdle of RNAi therapy is lack of efficient and non-immunogenic delivery vehicles. Currently, viruses, synthetic polymers, and lipid-based carriers are among the most widely studied vehicles for small RNA delivery. However, many drawbacks are reported to be associated with these delivery vehicles. There is a pressing need to replace them with more efficient and better-tolerated approaches. Exosomes secreted from the endocytic compartment of live cells, are a subtype of endogenous extracellular vesicles that transfer genetic and biochemical information among different cells, thus playing an important role in cellcell communication. Recently, accumulating attention has been focused on harnessing exosomes as nanaocarriers for small RNAs delivery. Due to their natural role in shuttling endogenous nucleic acid in our body, exosomes may exhibit higher delivery efficiency, lower immunogenicity, and better compatibility than existing foreign RNA carriers. Importantly,exosomes own intrinsic homing capacity that can guide small RNAs across natural membranous barriers. Moreover, such a capacity can be further improved by adding appropriate targeting moieties. In this manuscript, we briefly review the progress and challenges of RNAi therapy, and discuss the potential of exosomes' applications in small RNA delivery with focus on the most recent advances in exosome-based small RNA delivery for disease therapy. | Mei Lu Haonan Xing Zhe Xun Tianzhi Yang Pingtian Ding Cuifang Cai Dongkai Wang Xiaoyun Zhao | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，1： | 8 |
| 4 | Preparation of Negative Thermal Expansion ZrW_2O_8 Powders and Its Application in Polyimide/ZrW_2O_8 Composites显示文摘Negative thermal expansion (NTE) ZrW2O8 powders were prepared by step-by-step solid-state reaction with ZrO2 and WO3 powders. The coefficient of thermal expansion (CTE) of the as-prepared ZrW2O8 was around -5.08×10-6 K-1 at 20–700℃. Different amounts of ZrW2O8 powders were added in BTDA-ODA polyamic acid to form polyimide/ZrW2O8 composites (PI/ZrW2O8). With the increment of ZrW2O8, experimental results show that ZrW2O8 powders can significantly enhance the thermal stability of the composites, and reduce the thermal expansion. A 50 wt pct ZrW2O8 addition can give rise to a 31% reduction of CTE. It is suggested that the PI/ZrW2O8 composites have potential applications in high performance microelectronic devices. | Juan Yang Vongsen Yang Qinqin Liu Cuifang Xu Xiaonong Cheng | 2010 | Journal of Materials Science & Technology2010，26，7： | 6 |
| 5 | Review of 4Pi Fluorescence Nanoscopy显示文摘Since the 1990s,continuous technical and scientific advances have defied the diffraction limit in microscopy and enabled three-dimensional(3D)super-resolution imaging.An important milestone in this pursuit is the coherent utilization of two opposing objectives(4Pi geometry)and its combination with superresolution microscopy.Herein,we review the recent progress in 4Pi nanoscopy,which provides a 3D,non-invasive,diffraction-unlimited,and isotropic resolution in transparent samples.This review includes both the targeted and stochastic switching modalities of 4Pi nanoscopy.The schematics,principles,applications,and future potential of 4Pi nanoscopy are discussed in detail. | Xiang Hao Yiming Li Shuang Fu Yanghui Li Yingke Xu Cuifang Kuang Xu Liu | 2022 | Engineering2022，8，4： | 2 |
| 6 | Palladium-Catalyzed Cascade Double C--N Bond Activation: A New Strategy for Aminomethylation of 1,3-Dienes with Aminals显示文摘 | Cuifang Qiao Anrong Chen Bingjian Gao Yang Liu Hanmin Huang | 2018 | Chinese Journal of Chemistry2018，36，10： | 2 |
| 7 | Formalin-induced astrocyte glutamate-glutamine cycle involved in rat spinal cord central sensitization显示文摘BACKGROUND:Central sensitization,a state of increased excitability of nociceptive neurons in the spinal dorsal horn following peripheral tissue injury and/or inflammation,is an important mechanism underlying hyperalgesia and neuropathic pain.Participation of the glutamate-glutamine cycle in central sensitization of the spinal cord remains poorly understood. OBJECTIVE:To determine whether the astrocyte-neuronal glutamate-glutamine cycle is involved in formalin-induced central sensitization in the spinal cord. DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment was performed at the Institute of Orthopedics,Second Hospital,Lanzhou University,China from September 2007 to August 2008. MATERIALS:Methionine sulfoximine(MSO,0.1 mmol/L),glutamine(0.25 mmol/L),and formalin were used for this study. METHODS:A total of 43 male,Sprague Dawley rats,aged 4 months,were randomly assigned to a sham operation group(n = 6) and a model group(n = 37).Rats in the model group received intrathecal infusion in the spinal cord.7 days later,37 model rats were randomly divided into PBS, MSO,glutamine,MSO + glutamine and formalin subcutaneous injection alone groups.The PBS, MSO,glutamine,MSO + glutamine groups were respectively intrathecally injected with PBS,MSO, glutamine,MSO + glutamine(50μL each),and then infused with 10μL of saline.Rats from the sham operation group were not subjected to intrathecal infusion in the spinal cord.At 15 minutes after intrathecal injection,a rat model of formalin-induced inflammatory pain was established by subcutaneous injection of 5%formalin(50μL) in the left hindpaw. MAIN OUTCOME MEASURES:Changes in spontaneous nociceptive behavior(licking/biting or flinching) were observed following formalin injection into the rat hindpaw. RESULTS:Compared with the PBS group,duration of licking/biting was significantly shortened,and flinching frequency was significantly diminished in the MSO group(P<0.05).Compared with the MSO group,duration of licking/biting was significantly prolonged,and flinching frequency was significantly increased in the MSO + glutamine group(P<0.05).There was no significant difference in inflammatory pain behaviors among the sham operation,PBS,glutamine,MSO + glutamine,and formalin subcutaneous injection alone groups(P>0.05). CONCLUSION:The astrocyte-neuronal glutamate-glutamine cycle in the spinal cord was shown to be involved in central sensitization induced by formalin subcutaneous injection into the hindpaw. | Haili Shen Yufeng XieO Hua Han Yayi Xia Youcheng Zhang Cuifang Wang Jing Wang | 2009 | Neural Regeneration Research2009，4，11： | 2 |
| 8 | A review of water resources utilization and protection in Southwest China显示文摘Yunnan and Guizhou are two provinces in Southwest China where in recent years drought disasters have occurred due to natural and human factors. This paper reviewed literature and summarized the related achievements of water resources utilization and protection in Yunnan and Guizhou provinces. This included characters and utilization of precipitation, rivers, and karst ground water in the two provinces, and also the various explanations of drought(climate and human factors) and strategies for coping with droughts. Our concluding remarks highlight three lines of future studies: inequalities and equitable use of water distribution, better evaluation systems, and raising awareness through conservation practices. | CuiFang Wu Steve Déry WanCai Wu XueBin Liu JinHui Xiong WenQi Gao | 2015 | Research in Cold and Arid Regions2015，7，6： | 2 |
| 9 | Fluid shear stress inhibits TNF- alpha-induced osteoblast apoptosis via ERK5 signaling pathway 显示文摘 | Bin G Cuifang W Bo Z | 2015 | Biochemical and Biophysical Research Communications2015，466，1： | 1 |
| 10 | Tablets of paliperidone using compression-coated technology for controlled ascending release显示文摘The aim of this work was to prepare ascending release compression-coated(CC) tablets with paliperidone(PAL) using a simple manufacturing technique and short manufacturing process.The release behavior and mechanisms in vitro of the final tablets was investigated and evaluated. The PAL CC tablets were comprised of a core layer of high viscosity hydroxypropyl cellulose(HPC-H) and a coating layer of high viscosity hydroxypropyl methylcellulose(HPMCK100 M). Several factors such as materials and core tablet compositions were studied for their influence in the formulation procedure. The drug release mechanism was studied using gravimetric analysis. The data could be fitted to the Peppas model. The ascending drug release results were expressed in terms of the slope of the release curve at different time points.Results showed that the formulation could achieve a good ascending drug release when the weight ratio of PAL was 5:1(core:layer). The fraction of HPC and HPMC was 33 %, and the combination of Eudragit RL-PO was 10%. The ascending release mechanism was due to solvent penetration into the PAL CC tablets, and subsequent drug dissolution from the gelatinous HPC and HPMC matrix erosion. The release mechanism was therefore a combination of diffusion and erosion. This work demonstrated that the compression-coated tablets could achieve controlled ascending release over 24 h for the oral administration systems. | Yingying Tang Huan Teng Yanan Shi Haibing He Yu Zhang Tian Yin Cuifang Cai Xing Tang | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，2： | 1 |
| 11 | Global stability for an HIV-1 infection model with Beddington–DeAngelis incidence rate and CTL immune response显示文摘 | Cuifang Lv Lihong Huang Zhaohui Yuan | 2013 | Communications in Nonlinear Science and Numerical Simulation2013，，： | 1 |
| 12 | High-precision laser alignment technique based on spiral phase plate 显示文摘 | Luo Ding Kuang Cuifang Hao Xiang | 2012 | Optics and Lasers in Engineering2012，50，7： | 1 |
| 13 | Dual-modulation difference stimulated emission depletion microscopy to suppress the background signal显示文摘Stimulated emission depletion(STED)nanoscopy is one of the most well-developed nanoscopy techniques that can provide subdiffraction spatial resolution imaging.Here,we introduce dual-modulation difference STED microscopy(dmdSTED)to suppress the background noise in traditional STED imaging.By applying respective time-domain modulations to the two continuous-wave lasers,signals are distributed discretely in the frequency spectrum and thus are obtained through lock-in demodulation of the corresponding frequencies.The background signals can be selectively eliminated from the effective signal without compromise of temporal resolution.We used nanoparticle,fixed cell,and perovskite coating experiments,as well as theoretical demonstration,to confirm the effectiveness of this method.We highlight dmdSTED as an idea and approach with simple implementation for improving the imaging quality,which substantially enlarges the versatility of STED nanoscopy. | Wensheng Wang Chuankang Li Zhengyi Zhan Zhimin Zhang Yubing Han Cuifang Kuang Xu Liu | 2022 | Advanced Photonics2022，4，4： | 1 |
| 14 | Cross-talk- free multiplexed immunoassay using a disposable electro- chemiluminescent immunosensor array coupled with a non-array detector显示文摘 | Li Cuifang Fu Zhifeng Li Zongyun | 2011 | Biosens Bioelectron2011，27，： | 1 |
| 15 | 显示文摘 | SUNYa-na ZHULei CUIFang(孙娅娜 朱蕾 崔芳) | 2012 | 食品科技2012，36，12： | 1 |
| 16 | Effect of WOW process parameters on morphologyand burst release of FITC dextran loaded PLGA microspheres 显示文摘 | MAO Shirui XU Jing CAI Cuifang | 2007 | Interna- tional Journal of Pharnlaceutics2007，334，12： | 1 |
| 17 | A straight-ness measurement system using a single-mode fiber-coup led laser module显示文摘 | Feng Qibo Zhang Bin Kuang Cuifang | 2004 | Optics and Laser Technol-ogy2004，36，： | 1 |
| 18 | Effect of WOW process parameters on morphologyand burst release of FITC dextran loaded PLGA microspheres显示文摘 | MAO Shirui XU Jing CAI Cuifang | 2007 | Int J Pharm2007，334，12： | 1 |
| 19 | Development of equipment for simultaneously measuring two-dimensional rotation angles of the linear guide track显示文摘 | Kuang Cuifang Feng Qibo Liu Bin | 2005 | Journal of Optoelectronics·Lasers2005，，08： | 1 |
| 20 | Identification Simulation for Dynamical System Based on Genetic Algorithm and Recurrent Multilayer Neural Network显示文摘 | Zhang Cuifang Jin Fan | 2003 | Joural of Southwest Jiaotong University2003，11，1： | 1 |
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