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| 1 | Role of antispasmodics in the treatment of irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is a long-lasting,relapsing disorder characterized by abdominal pain/discomfort and altered bowel habits.Intestinal motility impairment and visceral hypersensitivity are the key factors among its multifactorial pathogenesis,both of which require effective treatment.Voltage-gated calcium channels mediate smooth muscle contraction and endocrine secretion and play important roles in neuronal transmission.Antispasmodics are a group of drugs that have been used in the treatment of IBS for decades.Alverine citrate,a spasmolytic,decreases the sensitivity of smooth muscle contractile proteins to calcium,and it is a selective 5-HT1A receptor antagonist.Alverine,in combination with simethicone,has been demonstrated to effectively reduce abdominal pain and discomfort in a large placebo-controlled trial.Mebeverine is a musculotropic agent that potently blocks intestinal peristalsis.Non-placebo-controlled trials have shown positive effects of mebeverine in IBS regarding symptom control;nevertheless,in recent placebo-controlled studies,mebeverine did not exhibit superiority over placebo.Otilonium bromide is poorly absorbed from the GI tract,where it acts locally as an L-type calcium channel blocker,an antimuscarinic and a tachykinin NK2receptor antagonist.Otilonium has effectively reduced pain and improved defecation alterations in placebocontrolled trials in IBS patients.Pinaverium bromide is also an L-type calcium channel blocker that acts locally in the GI tract.Pinaverium improves motility disorders and consequently reduces stool problems in IBS patients.Phloroglucinol and trimethylphloroglucinol are non-specific antispasmodics that reduced pain in IBS patients in a placebo-controlled trial.Antispasmodics have excellent safety profiles.T-type calcium channel blockers can abolish visceral hypersensitivity in animal models,which makes them potential candidates for the development of novel therapeutic agents in the treatment of IBS. | Anita Annaházi Richárd Róka András Rosztóczy Tibor Wittmann | 2014 | World Journal of Gastroenterology2014，20，20： | 15 |
| 2 | Epidemiologic characteristics of Helicobacter pylori infection in southeast Hungary显示文摘BACKGROUND Epidemiologic studies have revealed a decrease in the prevalence of Helicobacter pylori(H.pylori)infection in Western Europe.AIM To obtain data regarding the prevalence of H.pylori in Csongrád and Békés Counties in Hungary,evaluate the differences in its prevalence between urban and rural areas,and establish factors associated with positive seroprevalence.METHODS One-thousand and one healthy blood donors[male/female:501/500,mean age:40(19–65)years]were enrolled in this study.Subjects were tested for H.pylori IgG antibody positivity via enzyme-linked immunosorbent assay.Subgroup analysis by age,gender,smoking habits,alcohol consumption,and urban vs nonurban residence was also performed.RESULTS The overall seropositivity of H.pylori was 32%.It was higher in males(34.93%vs 29.2%,P=0.0521)and in rural areas(36.2%vs 27.94%,P=0.0051).Agricultural/industrial workers were more likely to be positive for infection than office workers(38.35%vs 30.11%,P=0.0095)and rural subjects in Békés County than those in Csongrád County(43.36%vs 33.33%,P=0.0015).CONCLUSION Although the prevalence of H.pylori infection decreased in recent decades in Southeast Hungary,it remains high in middle-aged rural populations.Generally accepted risk factors for H.pylori positivity appeared to be valid for the studied population. | Lenke Bálint Andrea Tiszai Gábor Kozák Ilona Dóczi Veronika Szekeres Orsolya Inczefi Georgina Ollé Krisztina Helle Richárd Róka András Rosztóczy | 2019 | World Journal of Gastroenterology2019，25，42： | 5 |
| 3 | 交叉处的理论构建:是扩大影响的秘诀还是一条无果之路?显示文摘Zahra和Newey(2009)提出了创造性的理论构建工作在管理研究中的重要性,并且认为'跨学科研究'是开展这一工作的最佳途径。但我们认为,管理研究越是沿着'通过跨学科研究来创建新理论'这条路走下去,就越有可能损害另外一个有价值的目标,也就是把管理学科建设成为一个在研究主题及理论和方法上明显区别于其他学科的合法学科领域。我们也不赞成'管理学科应将重点放在发展新理论上'这一隐含假设。 | Lívia Markóczy David L.Deeds 苗莉 | 2011 | 管理世界2011，27，3： | 3 |
| 4 | COVID-19-associated diarrhea显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)recently emerged as a highly virulent respiratory pathogen that is known as the causative agent of coronavirus disease 2019(COVID-19).Diarrhea is a common early symptom in a significant proportion of patients with SARS-CoV-2 infection.SARS-CoV-2 can infect and replicate in esophageal cells and enterocytes,leading to direct damage to the intestinal epithelium.The infection decreases the level of angiotensinconverting enzyme 2 receptors,thereby altering the composition of the gut microbiota.SARS-CoV-2 elicits a cytokine storm,which contributes to gastrointestinal inflammation.The direct cytopathic effects of SARS-CoV-2,gut dysbiosis,and aberrant immune response result in increased intestinal permeability,which may exacerbate existing symptoms and worsen the prognosis.By exploring the elements of pathogenesis,several therapeutic options have emerged for the treatment of COVID-19 patients,such as biologics and biotherapeutic agents.However,the presence of SARS-CoV-2 in the feces may facilitate the spread of COVID-19 through fecal-oral transmission and contaminate the environment.Thus gastrointestinal SARS-CoV-2 infection has important epidemiological significance.The development of new therapeutic and preventive options is necessary to treat and restrict the spread of this severe and widespread infection more effectively.Therefore,we summarize the key elements involved in the pathogenesis and the epidemiology of COVID-19-associated diarrhea. | Klara Megyeri Áron Dernovics Zaid I I Al-Luhaibi András Rosztóczy | 2021 | World Journal of Gastroenterology2021，27，23： | 2 |
| 5 | Detailed esophageal function and morphological analysis shows high prevalence of gastroesophageal reflux disease and Barrett’s esophagus in patients with cervical inlet patch显示文摘 | A. Rosztóczy F. Izbéki I. B. Németh S. Dulic K. Vadászi R. Róka K. Gecse T. Gy?keres G. Lázár L. Tiszlavicz T. Wittmann | 2011 | Diseases of the Esophagus2011，，6： | 2 |
| 6 | A physically based,non-dimensional parameter for discriminating between locations of freezing rain and ice pellets显示文摘 | Czys R R Scott R W Tang K C | | 0，，04： | 1 |
| 7 | A physically based, non- dimensional parameter for discriminating between locations of Freezing Rain and ice pellets 显示文摘 | Czys R R Scott R W Tang K C | 1996 | Wea Forecasting1996，11，： | 1 |
| 8 | Safety analysis of reactivity initiated accidents in a HPLWR reactor by the coupled ATHLET-KIKO3D code显示文摘 | MAR(A)CZY C KERESZTURI A TROSZTEL I | | 0，，02： | 1 |
| 9 | Takinga View: Corporate Speculation, Governance and Compensation显示文摘 | Géczy C B A Minton and C Schrand | 2007 | Journal of Finance Vol 62 No 52007，，： | 1 |
| 10 | Production of a defensin-like antifungal protein NFAP from Neosartorya fischeri in Pichia pastoris and its antifungal activity against filamentous fungal isolates from human infections显示文摘 | Máté Virágh Dóra V?r?s Zoltán Kele Laura Kovács ádám Fizil Gergely Lakatos Gergely Maróti Gyula Batta Csaba Vágv?lgyi László Galgóczy | 2014 | Protein Expression and Purification2014，，： | 1 |
| 11 | A physically based nondimensional parameter for discriminating between locations offreezing rain and ice pellets显示文摘 | Czys R R Scott R W Tang K C | 1996 | Wea Forecasting1996，11，4： | 1 |
| 12 | A pilot study of fecal serine- protease activity: a pathophysiologlc factor in diarrhea-predominant irritable bowel syndrome 显示文摘 | Roka R Roszto' czy A Leveque M | 2007 | Clin Gastroenterol Hepatol2007，5，5： | 1 |
| 13 | A physical based nondimensional parameter for discriminating between locations of freezing rain and ice pellets显示文摘 | Czys R R Scott R W Tang K C | 1996 | Wea Forecasting1996，11，： | 1 |
| 14 | Quantitative element mapping of Mg alloys by laser ablation ICP-MS and EPMA显示文摘 | Latko czy Ch Muller Y Schmutz P | 2005 | Applied Surface Science2005，252，1： | 1 |
| 15 | Exercise capacity, arrhythmic risk profile, and pulmonary function is not influenced by intracoronary injection of Bone Marrow Stem Cells in patients with acute myocardial infarction显示文摘 | Ewa Straburzyńska-Migaj Ma?gorzata Popiel Stefan Grajek Agnieszka Katarzyńska-Szymańska Maciej Lesiak Piotr Br?borowicz Krzysztof Sawiński Anna Czy? Lidia Gil Maria Koz?owska-Skrzypczak Mieczys?aw Komarnicki | 2011 | International Journal of Cardiology2011，，2： | 1 |
| 16 | Complexes of Y, La, and lanthanides withm-aminobenzoic acid显示文摘 | Zofia Rz?czyńska Wanda Brzyska | 1989 | Monatshefte für Chemie Chemical Monthly1989，，3： | 1 |
| 17 | Responses of warm-based, midwest cumulus congestus to dyn am ic seedingtrials 显示文摘 | Czys R R Changnon S A W estcott N E | 1995 | J Appl Meteor1995，34，： | 1 |
| 18 | Complete QED NLO contributions to the reaction e + e ? → μ + μ ? γ and their implementation in the event generator PHOKHARA显示文摘 | F. Campanario H. Czy? J. Gluza M. Gunia T. Riemann G. Rodrigo V. Yundin | 2014 | Journal of High Energy Physics2014，，2： | 1 |
| 19 | Why Firms Use Currency Derivatives显示文摘 | Géczy C B.A.Minton C.Schrand | | 0，，04： | 1 |
| 20 | 《宗教论》显示文摘 | CZY生(杨昌济) | 1915 | 甲寅杂志1915，1，： | 1 |
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