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| 1 | Caveolin-1 gene silencing promotes the activation of PI3K/AKT dependent on Erα36 and the transformation of MCF10A^(CE)显示文摘ERα36,a variant of estrogen receptor-α,acts as a dominant-negative factor in both estrogen-dependent and estrogen-independent transactivation signaling pathways,and is a key factor in the promotion,progression and prognosis of breast cancers.Caveolin-1,a 22-to 24-kD integral membrane protein,may function as a tumor suppressor in inhibiting of many growth-promoting signaling pathways.It was shown that downregulation of Caveolin-1 strengthens the interaction of ERα and Caveolin-1.In conclusion,Caveolin-1 gene silencing activated the PI3K/AKT signaling pathway in an ERα36-dependent way.Our finding may provide a promising therapeutic target of breast cancer. | FENG Shuang1,WANG Yang1,WANG Xi1,WANG ZhaoYi3,CUI YuYing1,LIU Jing4,ZHAO ChunHui1,JIN Mei1,2 & ZOU Wei1,2 1 College of Life Science,Liaoning Normal University,Dalian 116029,China 2 Liaoning Key Laboratory of Biotechnology and Molecular Drug R&D,Dalian 116029,China 3 Cancer Center,Creighton University,2500 California Plaza,Omaha,NE 68178,USA 4 First Clinical Hospital of Dalian Medical University,Dalian 116011,China | 2010 | Science China(Life Sciences)2010，53，5： | 16 |
| 2 | Clostridium difficile infections in China显示文摘Clostridium difficile (C. difficile) infection has become one of the major hospital-associated infections in West-ern countries in the last two decades. However, there is limited information on the status of C. difficile infection inChinese healthcare settings. Given the large and increasing elderly population and the well-recognized problem ofover-prescribing of broad spectrum antibiotics in China, it is critical to understand the epidemiology and potentialrisk factors that may contribute to C. difficile infection in China. A literature review of available published studies,including those in Chinese language-based journals, was conducted. A review of the currently available literaturesuggested the presence of C. difficile infections in China, but also suggested that these infections were not particu-larly endemic. This finding should lead to better designed and greatly expanded studies to provide a more reliableepidemiologically-based conclusion on the actual status of C. difficile infection in China, including the identifica-tion of any associated risk factors. Such information is ultimately valuable to develop appropriate strategies to pre-vent C. difficile infection and the vast negative impact of such infections in China and other developing countries. | Ke Jin a,b,c,Shixia Wang c,d,Zuhu Huang a,b,c,Shan Lu b,c,daDepartment of Infectious Diseases,bJiangsu Province Key Laboratory in Infectious Diseases,cChina-US Vaccine ResearchCenter,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China d Department of Medicine,University of Massachusetts Medical School,Worcester,MA 01655,USA. | 2010 | The Journal of Biomedical Research2010，24，6： | 14 |
| 3 | Defects in Mesenchymal Stem Cell Self-Renewal and Cell Fate Determination Lead to an Osteopenic Phenotype in Bmi-1 Null Mice(摘要)显示文摘 | Zhang, HW Ding, J Jin, JL Guo, J Liu, JN Karaplis, A Goltzman, D Miao, DS | 2010 | 南京医科大学学报(自然科学版)2010，30，8： | 13 |
| 4 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 5 | A DELLA protein complex controls the arbuscular mycorrhizal symbiosis in plants显示文摘 | Nan Yu Dexian Luo Xiaowei Zhang Junzhong Liu Wanxiao Wang Yue Jin Wentao Dong Jiyun Liu Huan Liu Weibing Yang Longjun Zeng Qun Li Zuhua He Giles E D Oldroyd Ertao Wang | 2014 | Cell Research2014，24，1： | 9 |
| 6 | 地理信息系统技术在伤寒发热监测中应用显示文摘目的运用地理信息系统(GIS)技术,了解各居民点发热流行率和评价以医疗机构为哨点的伤寒发热监测系统的敏感性。方法收集医学人口普查数据、疾病监测系统信息数据、现场采集居民居住点全球卫星定位数据等资料,建立GIS系统和以人口为基数的发热监测系统;对所有发热就诊病人进行身份和居住地址确认,并制作各居民点年发热就诊率GIS分布图。结果共采集3776个居民居住的全球定位系统(GPS)定位点,人群发热就诊率为1.11‰,发热就诊人次占总门诊人次的16.3%,监测区内的发热就诊病人占所有发热就诊病人的83.5%。在3种类型的医疗机构中,门诊量以个体门诊类最多,但其发热就诊人次占总门诊人次的比率最低(12.6%)。监测区内发热1d或以上的病人地址和身份(ADDRESS-ID)确认率达到95%。根据居民点年发热就诊率GIS分布图,发热就诊率最高的居民点达到17.81‰,最低为0;发热就诊率高的居民点多集中在城市。结论利用GIS技术可直观准确的了解疾病流行率的分布,可迅速直观的寻找出监测系统中的薄弱环节和推断出可能存在的问题。 | 杨进 董柏青 张杰 廖和壮 梁大斌 吴兴华 司国爱 杨宏徽 Jin Kyung Park R Leon Ochiai Camilo J Acosta Moharmmad Ali John D Clemens | 2007 | 中国公共卫生2007，23，9： | 8 |
| 7 | Acupuncture Treatment for Idiopathic Trigeminal Neuralgia:A Longitudinal Case-Control Double Blinded Study显示文摘Objective: To evaluate the treatment effect of acupuncture on patients with idiopathic trigeminal neuralgia(ITN) by case-control longitudinal blinded study. Methods: Sixty ITN patients and 30 healthy subjects were included. The ITN patients were randomly assigned to acupuncture group(15 cases), sham-acupuncture group(15 cases) and carbamazepine group(30 cases), respectively. Clinical orofacial evaluation(including pain intensity and medication doses), research diagnostic criteria for temporomandibular disorders(RDC/TMD) and Helkimo indexes(for functional evaluation of the masticatory system), and quantitative sensory testing for sensory thresholds(gustative, olfactory, cold, warm, touch, vibration and superficial and deep pain) were evaluated before treatment, immediately after treatment, and 6 months after treatment. Results: The mean pain intensity by the Visual Analogue Scale only decreased in the acupuncture group at the last evaluation(P=0.012). Patients in the sham-acupuncture group had an increase in carbamazepine doses according to the prescriptions(P<0.01). There was a reduction in secondary myofascial pain and mandibular limitations at the acupuncture and sham-acupuncture groups, however only the acupuncture group kept the changes after 6 months(P<0.01, P=0.023). There was a decrease in mechanical thresholds in the acupuncture group(tactile, P<0.01; vibration, P=0.027) and an increase in deep pain thresholds in both acupuncture and sham-acupuncture groups(P=0.013). Conclusion: Acupuncture can be an option in the treatment of ITN due to its analgesic effect in both ITN and secondary myofascial pain associated with it. | Michelle Cristina Ichida Mariana Zemuner Jorge Hosomi Hong Jin Pai Manoel Jacobsen Teixeira JoséTadeu Tesseroli de Siqueira Silvia R D T de Siqueira | 2017 | Chinese Journal of Integrative Medicine2017，23，11： | 6 |
| 8 | Exploring Seasonal and Circadian Rhythms in Structural Traits of Field Maize from LiDAR Time Series显示文摘Plant growth rhythm in structural traits is important for better understanding plant response to the ever-changing environment.Terrestrial laser scanning(TLS)is a well-suited tool to study structural rhythm under field conditions.Recent studies have used TLS to describe the structural rhythm of trees,but no consistent patterns have been drawn.Meanwhile,whether TLS can capture structural rhythm in crops is unclear.Here,we aim to explore the seasonal and circadian rhythms in maize structural traits at both the plant and leaf levels from time-series TLS.The seasonal rhythm was studied using TLS data collected at four key growth periods,including jointing,bell-mouthed,heading,and maturity periods.Circadian rhythms were explored by using TLS data acquired around every 2 hours in a whole day under standard and cold stress conditions.Results showed that TLS can quantify the seasonal and circadian rhythm in structural traits at both plant and leaf levels.(1)Leaf inclination angle decreased significantly between the jointing stage and bell-mouthed stage.Leaf azimuth was stable after the jointing stage.(2)Some individual-level structural rhythms(e.g.,azimuth and projected leaf area/PLA)were consistent with leaf-level structural rhythms.(3)The circadian rhythms of some traits(e.g.,PLA)were not consistent under standard and cold stress conditions.(4)Environmental factors showed better correlations with leaf traits under cold stress than standard conditions.Temperature was the most important factor that significantly correlated with all leaf traits except leaf azimuth.This study highlights the potential of time-series TLS in studying outdoor agricultural chronobiology. | Shichao Jin Yanjun Su Yongguang Zhang Shilin Song Qing Li Zhonghua Liu Qin Ma Yan Ge LingLi Liu Yanfeng Ding Frédéric Baret Qinghua Guo | 2021 | Plant Phenomics2021，3，1： | 5 |
| 9 | High-Throughput Measurements of Stem Characteristics to Estimate Ear Density and Above-Ground Biomass显示文摘Total above-ground biomass at harvest and ear density are two important traits that characterize wheat genotypes.Two experiments were carried out in two different sites where several genotypes were grown under contrasted irrigation and nitrogen treatments.A high spatial resolution RGB camera was used to capture the residual stems standing straight after the cutting by the combine machine during harvest.It provided a ground spatial resolution better than 0.2 mm.A Faster Regional Convolutional Neural Network(Faster-RCNN)deep-learning model was first trained to identify the stems cross section.Results showed that the identification provided precision and recall close to 95%.Further,the balance between precision and recall allowed getting accurate estimates of the stem density with a relative RMSE close to 7%and robustness across the two experimental sites.The estimated stem density was also compared with the ear density measured in the field with traditional methods.A very high correlation was found with almost no bias,indicating that the stem density could be a good proxy of the ear density.The heritability/repeatability evaluated over 16 genotypes in one of the two experiments was slightly higher(80%)than that of the ear density(78%).The diameter of each stem was computed from the profile of gray values in the extracts of the stem cross section.Results show that the stem diameters follow a gamma distribution over eachmicroplot with an average diameter close to 2.0mm.Finally,the biovolume computed as the product of the average stem diameter,the stem density,and plant height is closely related to the above-ground biomass at harvest with a relative RMSE of 6%.Possible limitations of the findings and future applications are finally discussed. | Xiuliang Jin Simon Madec Dan Dutartre Benoit de Solan Alexis Comar Frédéric Baret | 2019 | Plant Phenomics2019，1，1： | 5 |
| 10 | 左心室舒张功能的遗传性和其他影响因素:以家庭为基础的人口研究显示文摘确定遗传因素影响舒张功能多普勒指数的程度,是评估左心室舒张功能障碍与预后关系的一个重要因素。因此,研究人员从一般人群中选出家庭样本,对其家族左心室舒张特性和舒张功能集合评分的遗传度进行评估。方法:随机抽取316个家庭样本,包括452名父母和600名后代,平均年龄分别为58.5和33.3岁, | 刘莉 叶鹏 Kloch-Badelek M Knez J Tikhonoff V Thijs L Sakiewicz W Ryabikov A Stolarz-Skrzypek K Jin Y Malyutina S Casiglia E Narkiewicz K Czarnecka D Kawecka-Jaszcz K Staessen JA Kuznetsova T | 2014 | 中华高血压杂志2014，22，10： | 2 |
| 11 | Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy显示文摘 | Sinha Rohit Anthony You Seo-Hee Zhou Jin Siddique Mobin M Bay Boon-Huat Zhu Xuguang Privalsky Martin L Cheng Sheue-Yann Stevens Robert D Summers Scott A Newgard Christopher B Lazar Mitchell A Yen Paul M | 2012 | EN2012，，7： | 2 |
| 12 | Regulatory role for a novel human thioredoxin peroxidase in NF-kappa B activation显示文摘 | Jin D Zoon HJ Rhee SG | 1997 | J Biol Chem1997，272，30： | 2 |
| 13 | Httperf-a tool for measuring web server performance 显示文摘 | Mosberger D Jin T | 1998 | ACM SIGMETRICS Performance Evaluation Review1998，26，3： | 1 |
| 14 | Optimal control of a tethered subsatellite of three degrees of freedom显示文摘 | Jin D P Hu H Y | 2006 | Nonlinear Dynamics2006，46，12： | 1 |
| 15 | C-fos-deficient mouse hippocampal CA3 pyramidal neurons exhibit both enhanced basal and kainic acid-induced excitability显示文摘 | Zhang J Lou D Chavkin C Xu M | 2002 | Neurosci Lett2002，331，3： | 1 |
| 16 | A switching vector median filter based on the CIELAB color space for color image restoration 显示文摘 | Jin L H Li D H | 2007 | Signal Processing2007，87，： | 1 |
| 17 | Bowel wall thickening in patients with Crohn's disease: CT patterns and correlation with inflammatory activity显示文摘 | Choi D Jin LS Ah CY | 2003 | Clin Radiol2003，58，： | 1 |
| 18 | Differential expression of galectin-3 in pituitary tumors 显示文摘 | Riss D Jin L Bayliss J | 2003 | Cancer Res2003，63，9： | 1 |
| 19 | Investigation of the heat partitioning in high efficiency deep grinding显示文摘 | Jin T Stephenson D J | 2003 | International Journal of Machine Tools & Manufacture2003，43，： | 1 |
| 20 | Effect of chymase inhibition on the arteriovenous fistula stenosis in dogs显示文摘 | Jin D Ueda H Takai S | 2005 | J Am Soc Nephrol2005，16，4： | 1 |
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