|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prevalence and evolution of drug resistance HIV-1 variants in Henan, China显示文摘To understand the prevalence and evolution of drug resistant HIV strains in Henan China after the implementation of free antiretroviral therapy for AIDS patients. 45 drug nave AIDS patients, 118 AIDS patients who received three months antiretroviral therapy and 124 AIDS patients who received six months antiretroviral treatment were recruited in the southern part of Henan province. Information on general condition, antiretroviral medicines, adherence and clinical syndromes were collected by face to face interview. Meanwhile, 14ml EDTA anticoagulant blood was drawn. CD4/CD8 T cell count, viral load and genotypic drug resistance were tested. The rates of clinical improvement were 55.1% and 50.8% respectively three months and six months after antiretroviral therapy. The mean CD4 cell count after antiretroviral therapy was significantly higher than in drug nave patients. The prevalence rate of drug resistant HIV strains were 13. 9%, 45.4% and 62.7% in drug nave patients, three month treatment patients and six month treatment patients, respectively. The number of resistance mutation codons and the frequency of mutations increased significantly with continued antiretroviral therapy. The mutation sites were primarily at the 103, 106 and 215 codons in the three-month treatment group and they increased to 15 codon mutations in the six-month treatment group. From this result, the evolution of drug resistant strains was inferred to begin with the high level NNRTI resistant strain, and then develop low level resistant strains to NRTIs. The HIV strains with high level resistance to NVP and low level resistance to AZT and DDI were highly prevalent because of the AZT+DDI+NVP combination therapy. These HIV strains were also cross resistant to DLV, EFV, DDC and D4T. Poor adherence to therapy was believed to be the main reason for the emergence and prevalence of drug resistant HIV strains. The prevalence of drug resistant HIV strains was increased with the continu- ation of antiretroviral therapy in the southern part of Henan province. Measures, that could promote high level adherence, provide new drugs and change ART regimens in failing patients, should be implemented as soon as possible. | Jing Yun LI Han Ping LI Lin LI Hong LI Zhe WANG Kun YANG Zuo Yi BAO Dao Min ZHUANG Si Yang LIU Yong Jian LIU Hui XING Yi Ming SHAO | 2005 | Cell Research2005，15，11： | 34 |
| 2 | Functional micro‐concrete 3D hybrid structures f abricated by two‐photon polymerization显示文摘Arbitrary micro-scale three-dimensional(3D)structures fabrication is a dream to achieve many exciting goals that have been pursued for a long time.Among all these applications,the direct 3D printing to fabricate human organs and integrated photonic circuits are extraordinary attractive as they can promote the current technology to a new level.Among all the 3D printing methods available,two-photon polymerization(2PP)is very competitive as it is the unique method to achieve sub-micron resolution to make any desired tiny structures.For the conventional 2PP,the building block is the photoresist.However,the requirement for the building block is different for different purposes.It is very necessary to investigate and improve the photoresist properties according to different requirements.In this paper,we presented one hybrid method to modify the mechanical strength and light trapping efficiency of the photoresist,which transfers the photoresist into the micro-concretes.The micro-concrete structure can achieve±22%strength modification via a silica nano-particles doping.The structures doped with gold nano-particles show tunable plasmonic absorption.Dye doped hybrid structure shows great potential to fabricate 3D micro-chip laser. | Yang Li Lianwei Chen Fang Kong Zuyong Wang Ming Dao Chwee Teck Lim Fengping Li Minghui Hong | 2017 | 光电工程2017，44，4： | 2 |
| 3 | Endoscopic papillary large‐balloon dilation following limited sphincterotomy for the removal of refractory bile duct stones: Experience of 169 cases in a single C hinese center显示文摘 | Xiao Ming Yang Bing Hu Ya Min Pan Dao Jian Gao Tian Tian Wang Jun Wu Xin Ye | 2013 | Journal of Digestive Diseases2013，，3： | 2 |
| 4 | Intraductal radiofrequency ablation for refractory benign biliary stricture: P ilot feasibility study显示文摘 | Bing Hu Dao‐Jian Gao Jun Wu Tian‐Tian Wang Xiao‐Ming Yang Xin Ye | 2014 | Digestive Endoscopy2014，，4： | 2 |
| 5 | Indentation across size scales and disciplines: Recent developments in experimentation and modeling显示文摘 | Andrew Gouldstone Nuwong Chollacoop Ming Dao | 2007 | Acta Materialia2007，55，12： | 1 |
| 6 | Protection mechanisms of the iron-plated armor of a deep-sea hydrothermal vent gastropod显示文摘 | YAO Haimin DAO Ming IMHOLT T | 2010 | PNAS2010，107，3： | 1 |
| 7 | Enhanced ferroelectric polarization with less wake-up effect and improved endurance of Hf_(0.5)Zr_(0.5)O_(2)thin films by implementing W electrode显示文摘This paper reports the improvement of electrical,ferroelectric and endurance of Hf_(0.5)Zr_(0.5)O_(2)(HZO)thinfilm capacitors by implementing W electrode.The W/HZO/W capacitor shows excellent pristine 2 P_(r)values of 45.1 gC/cm^(2)at±6 V,which are much higher than those of TiN/HZO/W(34.4μC/cm^(2))and W/HZO/TiN(26.9μC/cm^(2))capacitors.Notably,the maximum initial 2 P_(r)value of W/HZO/W capacitor can reach as high as 57.9μC/cm^(2)at±7.5 V.These strong ferroelectric polarization effects are ascribed to the W electrode with a fairly low thermal expansion coefficient which provides a larger in-plane tensile strain compared with TiN electrode,allowing for enhancement of o-phase formation.Moreover,the W/HZO/W capacitor also exhibits higher endurance,smaller wake-up effect(10.1%)and superior fatigue properties up to 1.5×10^(10)cycles compared to the TiN/HZO/W and W/HZO/TiN capacitors.Such improvements of W/HZO/W capacitor are mainly due to the decreased leakage current by more than an order of magnitude compared to the W/HZO/TiN capacitor.These results demonstrate that capping electrode material plays an important role in the enhancement of o-phase formation,reduces oxygen vacancies,mitigates wake-up effect and improves reliability. | Dao Wang Yan Zhang Jiali Wang Chunlai Luo Ming Li Wentao Shuai Ruiqiang Tao Zhen Fan Deyang Chen Min Zeng Jiyan Y.Dai Xubing B.Lu J-M.Liu | 2022 | Journal of Materials Science & Technology2022，，9： | 1 |
| 8 | Numerical Simulation of Plastic Deformation and Fracture Effects in Two Phase γ-TiAl+α2 Ti3Al Lamellar Microstructures显示文摘 | Dao Ming Asaro Robert J | 1995 | Phlosophical Magazine A1995，71，3： | 1 |
| 9 | The Mechanism of CagA and VacA in Gastric Cancer under the Tumor Microenvironment and Vitro Factors显示文摘Gastric cancer is closely related to the stomach microbiota,especially Helicobacter pylori.Numerous reports and clinical studies have shown that microbial behavior in the stomach may lead to pathological changes in the gastrointestinal tract of the host,which ultimately leads to the production and development of gastric cancer.This review outlines the major pathogenic processes of Helicobacter pylori in the stomach,specifically focusing on Cag A,Vac A,inflammatory pathways and oxidative stress.In addition,we describe the effects of some non-Helicobacter pylori factors,such as other microbiota,alcohol,and tobacco,on the carcinogenesis induced by Helicobacter pylori.The effects of family history are also taken into account.We hope that understanding the stomach microbiota will make it possible to more easily prevent,detect and treat gastric cancer. | Zhu Jiang Dai Hui Wen Fang Jing Qiu Zhang Qi Wu Jia Ming Xu Han Jian Zhu Jin Gao Zhuang Zhuang Liu Dong Tang Dao Rong Wang | 2020 | Journal of Nutritional Oncology2020，5，2： | 1 |
| 10 | Numerical Simulations of Stress-strain Behaviour in Two-Phase α2+γLamellarTiAlAlloys 显示文摘 | Dao Ming Asaro Robert J | 1995 | Materials Science and Engineering A1995，，： | 1 |
| 11 | Ballistic perform- ance of nanocrystalline and nanotwinned ultra/me crystal steele 显示文摘 | FrontOxt J ZHANG Yu-ming DAO Ming LU Jian G(alvez F Jrusalem A | 2012 | Acta Materialia2012，60，3： | 1 |
| 12 | PREPARATION AND CHARACTERIZATION OF A NEW HEXAHYDROPYRROLIZINE DERIVATIVE OF FULLERENE显示文摘PREPARATION AND CHARACTERIZATION OF A NEW HEXAHYDROPYRROLIZINE DERIVATIVE OF FULLERENE￥HoneXianHAN;YuLiangLI;YongFangLI;MingY... | Hone Xian HAN Yu Liang LI Yong Fang LI Ming Yong HAN Zi WU Yi Ming MO Fend Lian BAI Dao Ben ZHU | 1995 | Chinese Chemical Letters1995，6，3： | 1 |
| 13 | Synthesis and cytotoxic activity of heterocycle-substituted phthalimide derivatives显示文摘一系列代替 heterocycle 的 phthalimide 衍生物被综合。有杂环的戒指的在结构上多样的衍生物包括呋喃, imidazo [ 1,2-a ] pyridine , 1,3,4-thiadiazine , imidazo [ 2,1-b ][ 1,3,4 ] thiadiazine , pyrazole , 1,2,4-triazolo [ 3,4-b ][ 1,3,4 ] thiadiazine , thiazole 和 thiazoline ,被与包含氧,氮和硫原子的各种各样的 nucleophiles 中间的伪- bromoketone 的反应获得。他们的细胞毒素的活动也在 vitro 与五根人的癌症房间线被作比较。 | Ya Jun Yang Ya Nan Yang Jian Shuang Jiang Zi Ming Feng Hong Yan Liu Xian Dao Pan Pei Cheng Zhang | 2010 | Chinese Chemical Letters2010，21，8： | 1 |
| 14 | A STUDY OF THE INTERACTION AND FORMATION CONSTANTS OF NAPHTHALENE DERIVATIVES WITH CYCLODEXTRIN BY FLUORESCENCE AND CIRCULAR DICHROISM SPECTRA显示文摘The molecular recognition of the α,β-CD and 6A,6C(D)-o,o′-(4,4′-diphenyloxide-disulfonyl)-β-CD to naphthalene derivatives was studied by fluorescence and circulardichroism spectra.The formation constants of the inclusion complexes were estimatedbased on the variation of fluorescent intensity and the modified Benesi-Hildebrand equa-tions. | You Ming ZHANG Lian Xiang ZHANG Department of Chemistry,Northwest Normal University,Lanzhou,730070Bao Jian SHEN Lin Hui TONG Dao Sen JIN Lanzhou Institute of Chemical Physics,Academia Sinica,Lanzhou,730000 | 1993 | Chinese Chemical Letters1993，4，10： | 1 |
| 15 | Numerical simulation of plastic deformation and fracture effects in two phase γ-TiAl + α2-Ti3Al lamellar microstructures显示文摘 | Kad B K Dao Ming Asaro R J | 1995 | Philosophical Magazine A1995，71，3： | 1 |
| 16 | Endoscopic papillary large‐balloon dilation following limited sphincterotomy for the removal of refractory bile duct stones: Experience of 169 cases in a single C hinese center显示文摘 | Xiao Ming Yang Bing Hu Ya Min Pan Dao Jian Gao Tian Tian Wang Jun Wu Xin Ye | 2013 | Journal of Digestive Diseases2013，，3： | 1 |
| 17 | The Role of the PNI and NLR in Nutritional Risk Screening and Assessment of Gastric Cancer Patients显示文摘Background The use of nutritional risk screening and assessment is becoming increasingly common in cancer patients.The Nutritional Risk Screening 2002(NRS 2002)is a nutritional risk screening programe with good utility.The patient generated-subjective global assessment(PG-SGA)is a method used to assess the nutritional status of cancer patients.The prognostic nutritional index(PNI)and neutrophil to lymphocyte ratio(NLR)are considered to be predictors of the prognosis following treatment for patients with a variety of cancers.However,the relationship between the PNI and NLR in the nutritional screening and assessment in patients with gastric cancer is unknown.Methods A retrospective analysis was performed on 378 patients with gastric cancer who underwent surgery at the First Affiliated Hospital of Guangxi Medical University from August 2019 to December 2020.NRS 2002 and PG-SGA were performed within 24 hours of admission,and indicators such as the serum albumin level,body mass index(BMI),PNI and NLR were measured.Results In the grouping based on the NRS2002,patients in the positive group(NRS 2002≥3)had a higher platelet value,a higher median NLR,and a lower PNI than those in the negative group(NRS 2002<3)(295.50±118.49×10^(9)/L vs.269.36±93.52×10^(9)/L,2.38 vs.1.77,42.36±5.96 vs.46.64±4.29).Based on the PG-SGA grouping,the serum albumin level and lymphocyte count were highest in the mild group(PG-SGA:score 2-3),(36.94±3.51 g/L and 1.91±0.7610^(9)/L)and lowest within the severe group(PG SGA score≥9)(34.09±4.18 g/L and 1.51±0.6410^(9)/L).The BMI was highest in the mild group(23.35±3.00 kg/m^(2))and lowest in the severe group(20.63±2.97 kg/m^(2)),and the PNI was also highest in the mild group(46.50±5.17)and lowest in the severe group(41.64±5.53).However,the NLR was lowest in the mild group(median 1.91)and highest in the severe group(median 2.44).Conclusion The PNI and NLR in gastric cancer patients are closely related to the results of the nutritional risk screening and assessment,suggesting that they may be useful to guide the nutritional interventions for gastric cancer patients. | Hui Chao Ruan Xiang Hua Wu Dao Lai Huang Xiao Bin Fu Chao Zhang Kun Zhou Guan Yu Zhu Dang Liu Jin Tao Cai Ming Hao Tan | 2022 | Journal of Nutritional Oncology2022，7，4： | 1 |
| 18 | Indentation across size scales and disciplines: Recent developments in experimentation and modeling显示文摘 | Andrew Gouldstone Nuwong Chollacoop Ming Dao Ju Li Andrew M. Minor Yu-Lin Shen | 2006 | Acta Materialia2006，，： | 1 |
| 19 | The Effect of Ti-Zr Deoxidation on the Mechanical Properties of High Strength Low Alloy Steels显示文摘 | Lu Wei Yu Meng Ling Dong Wang Hong Hong Wang Dao Yuan Yao Yong Kuan Wu Kai Ming | 2011 | Advanced Materials Research2011，，146： | 1 |
| 20 | Isolation and func-tional characterization of HvDREB1-a gene encoding a dehydration-responsive element binding protein in Hordeum vulgare显示文摘 | Zhao Shi Xu Zhi Yong Ni Zhi Yong Li Lian Cheng Li Ming Chen Dong Yao Gao Xiu Dao Yu Pei Liu You Zhi Ma | 2009 | J Plant Res2009，122，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员