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| 1 | Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases显示文摘Matrix metalloproteinases(MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to degrade and remodel of extracellular matrix. However, recent studies have shown that MMPs are implicated in initiation and progression of kidney fibrosis through tubular cell epithelial–mesenchymal transition(EMT) as well as activation of resident fibroblasts, endothelial-mesenchymal transition(Endo MT) and pericyte-myofibroblast transdifferentiation. Interstitial macrophage infiltration has also been shown to correlate with the severity of kidney fibrosis in various chronic kidney diseases. MMPs secreted by macrophages, especially MMP-9, hasbeen shown by us to be profibrotic by induction of tubular cells EMT. EMT is mainly induced by transforming growth factor-β(TGF-β). However, MMP-9 was found by us and others to be up-regulated by TGF-β1 in kidney tubular epithelial cells and secreted by activated macrophages, resulting in EMT and ultimately kidney fibrosis. Therefore, MMP-9 may serve as a potential therapeutic target to prevent kidney fibrosis in chronic kidney disease. This review, by a particular focus on EMT, seeks to provide a comprehensive understanding of MMPs, especially MMP-9, in kidney fibrosis. | Hong Zhao Yanting Dong Xinrui Tian Thian Kui Tan Zhuola Liu Ye Zhao Yun Zhang David CH Harris Guoping Zheng | 2013 | World Journal of Nephrology2013，2，3： | 21 |
| 2 | Application of Box Behnken design in optimization for polysaccharides extraction from cultured mycelium of Cordyceps sinensis显示文摘 | Dong CH Xie X Q Wang X L | 2009 | Food Bioprod Process2009，87，2： | 1 |
| 3 | Significant left atrial appendage activation delay complicating aggressive septal ablation during cathe-ter ablation of persistent atrial fibrillation显示文摘 | Jiang CX Sang CH Dong JZ | 2010 | Pacing Clin Electro- physial2010，33，6： | 1 |
| 4 | Nutritional requirements of mycelial growth of cordyceps sinensis in submerged culture 显示文摘 | Dong CH Yao YJ | 2005 | J Appl Microbiol2005，99，3： | 1 |
| 5 | Atmospheric Corrosion Monitoring of a Weathering Steel under an Elec-trolyte Film in Cyclic Wet-Dry Condition 显示文摘 | THEE Ch HAO Long DONG Jun-hua | | 0，，09： | 1 |
| 6 | Postoperative adjuvant transcatheter arterial chemoembolization for reseetable mul- tiple hepatocellular carcinoma beyond the Milan critefia:a retrospective analysis 显示文摘 | Dong ZR Zhang PF Wang CH | 2015 | Am J Cancer IRes2015，5，1： | 1 |
| 7 | A R2R3 type MYB transcription factor is involved in the cold regula- tion of CBF genes and in acquired freezing tolerance显示文摘 | Agarwal M Hao Y Kapoor A Dong CH | 2006 | J Biol Chem2006，281，37： | 1 |
| 8 | Recent advances in the management of recurrent bile duct stones 显示文摘 | OH CH DONG SH | 2015 | Korean J Gastroenterol2015，66，5： | 1 |
| 9 | Hepatic oval cell lines generate hepatocellular carcinoma following transfection with HBx gene and treatment with aflatoxin B1 in vivo显示文摘 | Li CH Wang YJ Dong W | 2011 | Cancer Lett2011，311，1： | 1 |
| 10 | Serum polyfluoroalkyl concentrations,asthma outcomes,and immunological markers in a ease- control study of Taiwanese children 显示文摘 | Dong GH Tung KY Tsai CH | 2013 | Environ Health Perspeet2013，121，： | 1 |
| 11 | In vitro evaluation of antioxidant activities of aqueous extracts from natural and cultured mycelia of Cordyceps sinensis显示文摘 | Dong CH Yao YJ | 2008 | Lwt-Food Science and Technology2008，41，4： | 1 |
| 12 | Transplantation of bone marrowderivedmesenchymal stem cells after regional hepatic irradiationameliorates thioacetamide- induced liver fibrosis in rats显示文摘 | Shao CH Chen SL Dong TF | 2014 | JSurg Res2014，186，1： | 1 |
| 13 | Preoperative depletion of C3 improves the survival of guinea pig to rat cardiac xenograft recipients显示文摘 | Sun CH Oaks MK Dong NN | 1997 | J Invest Surg1997，10，12： | 1 |
| 14 | A fixed approach for catheter ab- lation of chronic atrial fibrillation 显示文摘 | Sang CH Dong JZ Liu XP | 2010 | Heart Rhythm2010，7，： | 1 |
| 15 | Correlation between structure and resistivity variations of the live human skull显示文摘 | TANG CH YOU F SH DONG X ZH | 2008 | IEEE Transactions on Biomedical Engineering2008，55，9： | 1 |
| 16 | 显示文摘 | Dong Y Q Tong Y Y Li Z Ch | 2009 | Maeromolecules2009，42，8： | 1 |
| 17 | Isolation, characterization of melanin derived from Ophlocordyceps sinensis, an entomogenous fungus endemic to the Tibetan Plateau 显示文摘 | Dong CH Yao YJ | 2012 | Journal of Bioscience and Bioengineering2012，113，4： | 1 |
| 18 | Screening melamine adulterant in milk powder with laser Raman spectrometry 显示文摘 | YAN CH DONG Y Y WU J H | 2010 | Journal of Food Composition and Analysis2010，，23： | 1 |
| 19 | Development of a side-view chamber for studying cell-surface adhesion under flow conditions 显示文摘 | CAO J USAMI SH DONG CH | 1997 | Annals of Biomedical Engineering1997，25，： | 1 |
| 20 | An in situ-forming, solid lipid/PLGA hybrid implant for long-acting antipsychotics显示文摘 | DONG SY WANG S ZHENG CH | 2011 | Soft Matter2011，7，12： | 1 |
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