5篇
您的检索式：作者名="Zhuola Liu"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases显示文摘Matrix metalloproteinases(MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to degrade and remodel of extracellular matrix. However, recent studies have shown that MMPs are implicated in initiation and progression of kidney fibrosis through tubular cell epithelial–mesenchymal transition(EMT) as well as activation of resident fibroblasts, endothelial-mesenchymal transition(Endo MT) and pericyte-myofibroblast transdifferentiation. Interstitial macrophage infiltration has also been shown to correlate with the severity of kidney fibrosis in various chronic kidney diseases. MMPs secreted by macrophages, especially MMP-9, hasbeen shown by us to be profibrotic by induction of tubular cells EMT. EMT is mainly induced by transforming growth factor-β(TGF-β). However, MMP-9 was found by us and others to be up-regulated by TGF-β1 in kidney tubular epithelial cells and secreted by activated macrophages, resulting in EMT and ultimately kidney fibrosis. Therefore, MMP-9 may serve as a potential therapeutic target to prevent kidney fibrosis in chronic kidney disease. This review, by a particular focus on EMT, seeks to provide a comprehensive understanding of MMPs, especially MMP-9, in kidney fibrosis. | Hong Zhao Yanting Dong Xinrui Tian Thian Kui Tan Zhuola Liu Ye Zhao Yun Zhang David CH Harris Guoping Zheng | 2013 | World Journal of Nephrology2013，2，3： | 21 |
| 2 | E-cadherin/β-catenin complex and the epithelial barrier显示文摘 | Tian Xinrui Liu Zhuola Niu Bo | 2011 | J Biomed Bioteehnol2011，2011，56： | 1 |
| 3 | E-Cadherin/ β -Catenin Complex and the Epithelial Barrier显示文摘 | Xinrui Tian Zhuola Liu Bo Niu Jianlin Zhang Thian Kui Tan So Ra Lee Ye Zhao David C. H. Harris Guoping Zheng Sanford I. Bernstein | 2011 | Journal of Biomedicine and Biotechnology2011，，： | 1 |
| 4 | E-Cadherin/ β -Catenin Complex and the Epithelial Barrier显示文摘 | Xinrui Tian Zhuola Liu Bo Niu Jianlin Zhang Thian Kui Tan So Ra Lee Ye Zhao David C. H. Harris Guoping Zheng Sanford I. Bernstein | 2011 | Journal of Biomedicine and Biotechnology2011，，： | 1 |
| 5 | Research Progress on Chemical Constituents and Pharmacological Effect of Semen Cuscutae显示文摘In this paper,by summarizing the literature in recent years,it is considered that the chemical constituents of S.cuscutae are mainly flavonoids.The main pharmacological effects include improving osteoporosis,improving ovarian function,improving drug-induced reproductive toxicity,regulating spermatogenic cell apoptosis,resisting liver fibrosis,resisting inflammation,improving cardiovascular function,protecting fetus,protecting synapses and so on.By summarizing the chemical constituents and pharmacological effects of S.cuscutae,this study aims to better study the mechanism of anti-osteoporosis based on the fact that S.cuscutae has the function of tonifying liver and kidney. | Zhuola Chunhui LIU | 2021 | Medicinal Plant2021，12，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员