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| 1 | Climate change and social vulnerability: toward a sociology and geography of food insecurity显示文摘 | Hans Bohle G Thomas Downing E Michael Watts J | 2004 | Global Environmental Change2004，，1： | 1 |
| 2 | AMPK and PPARdelta agonists are exercise mimetics显示文摘 | Vihang A Narkar Michael Downes Ruth T Yu | 2008 | Cell2008，134，3： | 1 |
| 3 | FXR and PXR: Potential therapeutic targets in cholestasis显示文摘 | Johan W. Jonker Christopher Liddle Michael Downes | 2011 | Journal of Steroid Biochemistry and Molecular Biology . 2011 (3-5)2011，，： | 1 |
| 4 | Growth of callus and suspension culture cells from cotton varieties (Gossypium hirsutum L.) resistant and susceptible toxanthomonas malvacearum (E. F. Sm.) dows显示文摘 | John Ruyack Michael R. Downing Judy Su Chang Earl D. Mitchell | 1979 | In Vitro1979，，5： | 1 |
| 5 | A factor analytic study of communication satisfaction显示文摘 | CAL W DOWNS HAZEN MICHAEL D | 1977 | Journal of business communication1977，14，3： | 1 |
| 6 | Effects of Storage Time on the Mechanical Properties of Rabbit Peripapillary Sclera After Enucleation显示文摘 | Michael Girard Jun-Kyo Francis Suh Richard T. Hart Claude F. Burgoyne J. Crawford Downs | 2007 | Current Eye Research2007，，5： | 1 |
| 7 | Nuclear receptor expression links the circadi- an clock to metabolism显示文摘 | XIAOYONG YANG DOWNES MICHAEL RUTH T Y U | 2006 | Cell2006，126，： | 1 |
| 8 | Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis显示文摘 | Maria M. Mihaylova Debbie S. Vasquez Kim Ravnskjaer Pierre-Damien Denechaud Ruth T. Yu Jacqueline G. Alvarez Michael Downes Ronald M. Evans Marc Montminy Reuben J. Shaw | 2011 | Cell2011，，4： | 1 |
| 9 | AMPK and PPARδ Agonists Are Exercise Mimetics显示文摘 | Vihang A. Narkar Michael Downes Ruth T. Yu Emi Embler Yong-Xu Wang Ester Banayo Maria M. Mihaylova Michael C. Nelson Yuhua Zou Henry Juguilon Heonjoong Kang Reuben J. Shaw Ronald M. Evans | 2008 | Cell2008，，3： | 1 |
| 10 | Climate change and social vulnerability: toward a sociology and geography of food insecurity 显示文摘 | Hans G Bohle Thomas E Downing Michael J Watts | 1994 | Global Environmental Change1994，4，1： | 1 |
| 11 | Anatomical Profiling of Nuclear Receptor Expression Reveals a Hierarchical Transcriptional Network显示文摘 | Angie L. Bookout Yangsik Jeong Michael Downes Ruth T. Yu Ronald M. Evans David J. Mangelsdorf | 2006 | Cell2006，，4： | 1 |
| 12 | Hypoparathyroidism and other causes of hypocalcimia显示文摘 | Robert W Downs JR Michael AL | 1990 | Lippincott1990，22，： | 1 |
| 13 | Impact of extended-infusion piperacillin-tazobactam in a Canadian community hospital显示文摘Background:Studies have demonstrated improved clinical outcomes with extended infusion(EI)piperacillin/tazobactam(TZP)compared to standard infusion(SI).However,there is less evidence on its benefits in noncritically-ill patients.Hospital-wide EI TZP was implemented at our site on February 21,2012.Our objectives were to compare clinical,safety and economic outcomes between EI and SI TZP.Methods:A retrospective cohort study of all adult patients who received EI TZP(3.375 g IV q8h infused over 4 hours and SI TZP for≥48 hours during 3 years pre-and postimplementation was conducted.The primary study outcome was 14-day mortality while secondary outcomes included length of hospital stay(LOS),nursing plus pharmacy cost,occurrence of Clostridioides difficile infection,readmission within 30 days and change in Pseudomonas aeruginosa minimum inhibitory concentration(MIC)distribution for TZP.The primary outcome and binary secondary outcomes were analyzed using a logistic regression model.LOS was examined using time to event analysis.Cost was examined using linear regression modelling.Results:Overall,2034 patients received EI TZP and 1364 patients received SI TZP.EI TZP was associated with lower odds of mortality(OR 0.76,95%CI 0.63-0.91),lower odds of C.difficile infection(OR 0.59,95%CI 0.41-0.84)and 8%lower cost(estimate 0.92,95%CI 0.87-0.98)compared to SI TZP.Conclusions:Hospital-wide implementation of EI TZP was associated with lower odds of 14-day mortality and incidence of C.difficile infection with cost savings at our institution. | April J.Chan Gerald Lebovic Michael Wan Yan Chen Elizabeth Leung Bradley J.Langford Jenny Seah Linda R.Taggart Mark Downing | 2023 | Infectious Medicine2023，2，1： | 0 |
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