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| 1 | The nuclear signaling of NF-KB: current knowledge, new insights, and future perspectives显示文摘 | Fengyi Wan Michael J Lenardo | 2010 | Cell Research2010，20，1： | 72 |
| 2 | Record-Setting Ocean Warmth Continued in 2019显示文摘Human-emitted greenhouse gases(GHGs)have resulted in a long-term and unequivocal warming of the planet(IPCC,2019).More than 90%of the excess heat is stored within the world's oceans,where it accumulates and causes increases in ocean temperature(Rhein et al.,2013;Abram et al.,2019). | Lijing CHENG John ABRAHAM Jiang ZHU Kevin ETRENBERTH John FASULLO Tim BOYER Ricardo LOCARNINI Bin ZHANG Fujiang YU Liying WAN Xingrong CHEN Xiangzhou SONG Yulong LIU Michael EMANN | 2020 | Advances in Atmospheric Sciences2020，37，2： | 7 |
| 3 | Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions显示文摘Brain tumors are dynamic complex ecosystems with multiple cell types.To model the brain tumor microenvironment in a reproducible and scalable system,we developed a rapid three-dimensional(3D)bioprinting method to construct clinically relevant biomimetic tissue models.In recurrent glioblastoma,macrophages/microglia prominently contribute to the tumor mass.To parse the function of macrophages in 3D,we compared the growth of glioblastoma stem cells(GSCs)alone or with astrocytes and neural precursor cells in a hyaluronic acid-rich hydrogel,with or without macrophage.Bioprinted constructs integrating macrophage recapitulate patient-derived transcriptional profiles predictive of patient survival,maintenance of stemness,invasion,and drug resistance.Whole-genome CRISPR screening with bioprinted complex systems identified unique molecular dependencies in GSCs,relative to sphere culture.Multicellular bioprinted models serve as a scalable and physiologic platform to interrogate drug sensitivity,cellular crosstalk,invasion,context-specific functional dependencies,as well as immunologic interactions in a species-matched neural environment. | Min Tang Qi Xie Ryan C.Gimple Zheng Zhong Trevor Tam Jing Tian Reilly L.Kidwell Qiulian Wu Briana C.Prager Zhixin Qiu Aaron Yu Zhe Zhu Pinar Mesci Hui Jing Jacob Schimelman Pengrui Wang Derrick Lee Michael H.Lorenzini Deobrat Dixit Linjie Zhao Shruti B.hargava Tyler E.Miller Xueyi Wan Jing Tang Bingjie Sun Benjamin F.Cravatt Alysson R.Muotri Shaochen Chen Jeremy N.Rich | 2020 | Cell Research2020，30，10： | 6 |
| 4 | Significance of CD90 + Cancer Stem Cells in Human Liver Cancer显示文摘 | Zhen Fan Yang David W. Ho Michael N. Ng Chi Keung Lau Wan Ching Yu Patricia Ngai Patrick W.K. Chu Chi Tat Lam Ronnie T.P. Poon Sheung Tat Fan | 2008 | Cancer Cell2008，，2： | 5 |
| 5 | Biodegradable magnesium pins enhanced the healing of transverse patellar fracture in rabbits显示文摘Displaced fractures of patella often require open reduction surgery and internal fixation to restore the extensor continuity and articular congruity.Fracture fixation with biodegradable magnesium(Mg)pins enhanced fracture healing.We hypothesized that fixation with Mg pins and their degradation over time would enhance healing of patellar fracture radiologically,mechanically,and histologically.Transverse patellar fracture surgery was performed on thirty-two 18-weeks old female New Zealand White Rabbits.The fracture was fixed with a pin made of stainless steel or pure Mg,and a figure-of-eight stainless steel band wire.Samples were harvested at week 8 or 12,and assessed with microCT,tensile testing,microindentation,and histology.Microarchitectural analysis showed that Mg group showed 12%higher in the ratio of bone volume to tissue volume at week 8,and 38.4%higher of bone volume at week 12.Tensile testing showed that the failure load and stiffness of Mg group were 66.9%and 104%higher than the control group at week 8,respectively.At week 12,Mg group was 60.8%higher in ultimate strength than the control group.Microindentation showed that,compared to the Control group,Mg group showed 49.9%higher Vickers hardness and 31%higher elastic modulus at week 8 and 12,respectively.At week 12,the new bone of Mg group remodelled to laminar bone,but those of the control group remained woven bone-like.Fixation of transverse patellar fracture with Mg pins and its degradation enhanced new bone formation and mechanical properties of the repaired patella compared to the Control group. | Dick Ho Kiu Chow Jiali Wang Peng Wan Lizhen Zheng Michael Tim Yun Ong Le Huang Wenxue Tong Lili Tan Ke Yang Ling Qin | 2021 | Bioactive Materials2021，6，11： | 3 |
| 6 | Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study显示文摘 | Yahya Shehabi Lucy Chan Suhaini Kadiman Anita Alias Wan Nasrudin Ismail Mohd Ali T. Ismail Tan Tien Meng Khoo Saedah Binti Ali Mat Ariffin Saman Ahmad Shaltut Cheng Cheng Tan Cow Yen Yong Michael Bailey | 2013 | Intensive Care Medicine2013，，5： | 3 |
| 7 | Upper Ocean Temperatures Hit Record High in 2020显示文摘The long-term warming of the ocean is a critical indicator of both the past and present state of the climate system. It also provides insights about the changes to come, owing to the persistence of both decadal variations and secular trends,which the ocean records extremely well(Hansen et al., 2011;IPCC, 2013;Rhein et al., 2013;Trenberth et al., 2016;Abram et al., 2019). | Lijing CHENG John ABRAHAM Kevin ETRENBERTH John FASULLO Tim BOYER Ricardo LOCARNINI Bin ZHANG Fujiang YU Liying WAN Xingrong CHEN Xiangzhou SONG Yulong LIU Michael EMANN Franco RESEGHETTI Simona SIMONCELLI Viktor GOURETSKI Gengxin CHEN Alexey MISHONOV Jim REAGAN Jiang ZHU | 2021 | Advances in Atmospheric Sciences2021，38，4： | 2 |
| 8 | Methanolic extract of Abrus precatorius promotes breast cancer MDA-MB-231 cell death by inducing cell cycle arrest at G0/G1 and upregulating Bax显示文摘Objective:To determine the anti-proliferative activity of Abrus precatorius(A.precatorius)leaf extracts and their effect on cell death.Methods:A.precatorius leaves were extracted successively with hexane,ethyl acetate and methanol by Soxhlet extraction.Aqueous extract was prepared by decoction at 50 ℃.Extracts of A.precatorius leaves were used to treat selected cancer and normal cell lines for72 h.Furthermore,3-(4,5-dimethyl thiazol-2-yl)2,5-diphenyl tetrazolium bromide assay was performed to determine cell viability.Analysis of cell cycle arrest,apoptosis assay and apoptosis protein expressions were determined by flow cytometry.Results:Methanolic extract of A.precatorius leaves showed the lowest IC50 on MDA-MB-231 cells at(26.40±5.40)μg/mL.Flow cytometry analysis revealed that cell arrest occurred at G0/G1 phase and the apoptosis assay showed the occurrence of early apoptosis at 48 h in MDAMB-231 cells treated with methanolic extract of A.precatorius leaves.Methanolic extract of A.precatorius leaves induced apoptosis by upregulation of Bax,p53 and caspase-3 and downregulation of Bcl-2.Conclusions:Methanolic extract of A precatorius leaves promotes MDA-MB-231 cell death by inducing cell cycle arrest and apoptosis possibly via the mitochondrial-related pathway. | Wan Suriyani Wan-Ibrahim Norzila Ismail Siti Farhanah Mohd-Salleh Aidy Irman Yajid Michael Pak-KaiWong Mohd Nizam Md Hashim | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，6： | 2 |
| 9 | Photochemistry of a major commercial polybrominated diphenyl ether flame retardant congener: 2,2′,4,4′,5,5′-Hexabromodiphenyl ether (BDE153)显示文摘 | Sierra Rayne Peter Wan Michael Ikonomou | 2006 | Environment International2006，，5： | 2 |
| 10 | Generalized Hyers-Ulam Stability of a General Mixed Additive-cubic Functional Equation in Quasi-Banach Spaces显示文摘In this paper, we establish a general solution and the generalized Hyers-Ulam-Rassias stability of the following general mixed additive-cubic functional equation f (kx+y) + f (kx-y) = kf (x+y) + kf(x-y)+2f(kx)-2kf (x) in the quasi-Banach spaces. | Tian Zhou XU John Michael RASSIAS Wan Xin XU | 2012 | Acta Mathematica Sinica,English Series2012，28，3： | 2 |
| 11 | Monocyte-derived Wnt5a regulates inflammatory ymphangiogenesis显示文摘 | Roberto Sessa Don Yuen Stephanie Wan Michael Rosner Preethi Padmanaban Shaokui Ge April Smith Russell Fletcher Ariane Baudhuin-Kessel Terry P Yamaguchi Richard A Lang LuChen | 2016 | Cell Research2016，26，2： | 2 |
| 12 | Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis显示文摘 | Lok Yung Chan Hoi Hin Kwok Renee Wan Yi Chan Malik Joseph Sriyal Peiris Nai Ki Mak Ricky Ngok Shun Wong Michael Chi Wai Chan Patrick Ying Kit Yue | 2011 | Journal of Ethnopharmacology2011，，3： | 2 |
| 13 | Significance of CD90 + Cancer Stem Cells in Human Liver Cancer显示文摘 | Zhen Fan Yang David W. Ho Michael N. Ng Chi Keung Lau Wan Ching Yu Patricia Ngai Patrick W.K. Chu Chi Tat Lam Ronnie T.P. Poon Sheung Tat Fan | 2008 | Cancer Cell2008，，2： | 1 |
| 14 | Another Record: Ocean Warming Continues through 2021 despite La Nina Conditions显示文摘The increased concentration of greenhouse gases in the atmosphere from human activities traps heat within the climate system and increases ocean heat content(OHC). Here, we provide the first analysis of recent OHC changes through 2021 from two international groups. The world ocean, in 2021, was the hottest ever recorded by humans, and the 2021 annual OHC value is even higher than last year’s record value by 14 ± 11 ZJ(1 zetta J = 1021 J) using the IAP/CAS dataset and by16 ± 10 ZJ using NCEI/NOAA dataset. The long-term ocean warming is larger in the Atlantic and Southern Oceans than in other regions and is mainly attributed, via climate model simulations, to an increase in anthropogenic greenhouse gas concentrations. The year-to-year variation of OHC is primarily tied to the El Nino-Southern Oscillation(ENSO). In the seven maritime domains of the Indian, Tropical Atlantic, North Atlantic, Northwest Pacific, North Pacific, Southern oceans,and the Mediterranean Sea, robust warming is observed but with distinct inter-annual to decadal variability. Four out of seven domains showed record-high heat content in 2021. The anomalous global and regional ocean warming established in this study should be incorporated into climate risk assessments, adaptation, and mitigation. | Lijing CHENG John ABRAHAM Kevin ETRENBERTH John FASULLO Tim BOYER Michael EMANN Jiang ZHU Fan WANG Ricardo LOCARNINI Yuanlong LI Bin ZHANG Zhetao TAN Fujiang YU Liying WAN Xingrong CHEN Xiangzhou SONG Yulong LIU Franco RESEGHETTI Simona SIMONCELLI Viktor GOURETSKI Gengxin CHEN Alexey MISHONOV Jim REAGAN | 2022 | Advances in Atmospheric Sciences2022，39，3： | 1 |
| 15 | Differential, time-dependent effects of perivenous application of fibrin glue on medial thickening in porcine saphenous vein grafts显示文摘 | Wan S Arifi AA Michael CW | 2006 | Eur J Cardiothorac Surg2006，29，： | 1 |
| 16 | Significance of CD90 + Cancer Stem Cells in Human Liver Cancer显示文摘 | Zhen Fan Yang David W. Ho Michael N. Ng Chi Keung Lau Wan Ching Yu Patricia Ngai Patrick W.K. Chu Chi Tat Lam Ronnie T.P. Poon Sheung Tat Fan | 2008 | Cancer Cell2008，，2： | 1 |
| 17 | Drying kinetics and product quality of dried Chempedak显示文摘 | Chien Hwa Chong Chung Lim Law Michael Cloke Ching Lik Hii Luqman Chuah Abdullah Wan Ramli Wan Daud | 2008 | Journal of Food Engineering2008，，4： | 1 |
| 18 | IFNγsignaling integrity in colorectal cancer immunity and immunotherapy显示文摘The majority of colorectal cancer patients are not responsive to immune checkpoint blockade(ICB).The interferon gamma(IFNγ)signaling pathway drives spontaneous and ICB-induced antitumor immunity.In this review,we summarize recent advances in the epigenetic,genetic,and functional integrity of the IFNγsignaling pathway in the colorectal cancer microenvironment and its immunological relevance in the therapeutic efficacy of and resistance to ICB.Moreover,we discuss how to target IFNγsignaling to inform novel clinical trials to treat patients with colorectal cancer. | Wan Du Timothy L.Frankel Michael Green Weiping Zou | 2022 | Cellular & Molecular Immunology2022，19，1： | 1 |
| 19 | Computer simulations and parametric studies of GFRP bridge deck systems显示文摘 | WAN Baolin RIZOS Dimitris C PETROU Michael F | 2005 | Composite Structures2005，69，： | 1 |
| 20 | The Relative Effectiveness of Inoculation, Bolstering, and Combined Approaches in Crisis Communication显示文摘 | Hua-Hsin Wan Pfou Michael | 2004 | Journal of Public Relations Research2004，16，3： | 1 |
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