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| 1 | Outbreak of Dengue Fever in Central China,2013显示文摘In 2013,the first dengue fever(DF) outbreak in central China was reported in the central of Henan province,northern temperate regions,although they have been sequentially recorded in Southern China.106 suspected DF cases were reported and 73 patients were confirmed dengue virus type 3(DEN-3) infections.62/392(15.8%) local health persons showed DEN antibodies positive.To this day Henan is the northernmost province in China which has been reported about outbreak of DF and what is important is that it warns us the endemic range of DF has been expanded geographically in China. | HUANG Xue Yong MA Hong Xia WANG Hai Feng DU Yan Hua SU Jia LI Xing Le TANG Xiao Yan MA Hong Peng ZU Bing Can ZHANG Qiao Hong CHEN Hao Min XU Bian Li | 2014 | Biomedical and Environmental Sciences2014，27，11： | 30 |
| 2 | Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China:a hospital.based,multicenter,cross-sectional survey显示文摘Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall expenditure.Results: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 CNY.The overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagnosed at a later stage were likely to spend more,whereas those with a lower household income and those who underwent surgery spent less(all P < 0.05).Conclusions: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic,and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective. | Hui-Yao Huang Ju-Fang Shi Lan-Wei Guo Ya-Na Bai Xian-Zhen Liao Guo-iangLiu A-Yan Mao Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Le Wang Bing-Bing Song Ling-Bin Du Lin Zhu Ji-Yong Gong Qi Zhou Yu-Qin Liu Rong Cao Ling Mai Li Lan Xiao-Hua Sun Ying Ren Jin-Yi Zhou Yuan-Zheng Wang Xiao Qi Pei-An Lou Dian Shi Ni Li Kai Zhang Jie He Min Dai | 2017 | Chinese Journal of Cancer2017，36，8： | 25 |
| 3 | Cancer incidence and mortality in Zhejiang Province,Southeast China,2016:a population-based study显示文摘Backgrounds:Cancer is one of the main causes of death worldwide,seriously threatening human health and life expectancy.We aimed to analyze the cancer incidence and mortality rates during 2016 in Zhejiang Province,Southeast China.Methods:Data were collected from 14 population-based cancer registries across Zhejiang Province of China.Cancer incidence and mortality rates stratified by sex and region were analyzed.The crude rate,age-standardized rate,age-specific and region-specific rate,and cumulative rate were calculated.The proportions of 10 common cancers in different groups and the incidence and mortality rates of the top five cancers in different age groups were also calculated.The Chinese national census of 2000 and the world Segi population was used for calculating the age-standardized incidence and mortality rates.Results:The 14 cancer registries covered a population of 14,250,844 individuals,accounting for 29.13%of the population of Zhejiang Province.The total reported cancer cases and deathswere 55,835 and 27,013,respectively.The proportion ofmorphological verification(MV%)was 78.95%of the population,and percentage of incident cases identified through death certificates only(DCO%)was 1.23%with a mortality-to-incidence ratio(M/I ratio)of 0.48.The crude incidence rate in Zhejiang cancer registration areas was 391.80/105;the age-standardized incidence rate of the Chinese standard population(ASIRC)and the age-standardized incidence rate of theworld standard population(ASIRW)were 229.76/105 and 220.96/105,respectively.The incidence rate in men was higher than that inwomen.The incidence rate increased rapidly after 45 years of age and peaked in individuals aged 80 to 84 years.The top 10 incidence rates of cancers were lung cancer,female breast cancer,thyroid cancer,colorectal cancer,stomach cancer,liver cancer,prostate cancer,cervical cancer,esophageal cancer,and pancreatic cancer(from highest to lowest).The crude mortality rate in Zhejiang cancer registration areas was 189.55/105;the age-standardized mortality rate of the Chinese standard population(ASMRC)and the agestandardized mortality rate of the world standard population(ASMRW)were 94.46/105 and 93.42/105,respectively.The mortality rate in men was higher than that in women,and the male population in rural areas was higher than that in urban areas.The cancer mortality rate increased rapidly after 50 years of age and peaked in individuals aged 85+years.The top 10 mortality rates of cancers were lung cancer,liver cancer,stomach cancer,colorectal cancer,pancreatic cancer,esophageal cancer,female breast cancer,prostate cancer,lymphoma,and leukemia(from highest to lowest).Conclusions:Lung cancer,female breast cancer,thyroid cancer,colorectal cancer,prostate cancer,liver cancer,and stomach cancer were the most common cancers in Zhejiang Province.Effective prevention and control measures should be established after considering the different characteristics of cancers in urban and rural areas. | You-Qing Wang Hui-Zhang Li Wei-Wei Gong Yao-Yao Chen Chen Zhu Le Wang Jie-Ming Zhong Ling-Bin Du | 2021 | Chinese Medical Journal2021，，16： | 18 |
| 4 | ABO sequence analysis in an AB type with anti-B patient显示文摘ABO blood group system is the first to be discovered and the most clinically important in transfusion medicine.1The ABO gene encodes a glycosyltransferase which synthesize the oligosaccharide epitopes.The difference between the consensus A gene (A101 allele) usually used as the reference and the consensus B gene (B101 allele) are 7 in-frame single nucleotide polymorphisms (SNPs),among which only 4 alleles cause amino acid mutations in the enzyme.When A allele was inherited from one parent and B allele was inherited from the other which produced the AB blood group,this is known as trans-AB.Cis-AB is characterized as mutant ABO alleles encoding a glycosyltransferase capable of synthesizing both A and B antigens which is very rare. | Chen Qing Xiao Jianyu Wang Shuya Li Jiahuang Du Leilei Lu Le Huang Chengyin Li Min Li Ping | 2014 | Chinese Medical Journal2014，，5： | 17 |
| 5 | Controllable preparation of particles with microfluidics显示文摘This paper reviews recent development and achievements in controllable preparation of nanoparticles, micron spherical and non-spherical particles, using microfluidics. A variety of synthesis strategies are presented and compared, including single-phase and multiphase microflows. The main structures of microfluidic devices and the fundamental principles of microflows for particle preparation are summarized and identifled. The controllability of particle size, size distribution, crystal structure, morphology, physical and chemical properties, is examined in terms of the special features of microfluidic reactors. An outlook on opinions and predictions concerning the future development of powder technology with microfluidics is specially provided. | Guangsheng Luo Le Du Yujun Wang Yangcheng Lu Jianhong Xu | 2011 | Particuology2011，9，6： | 15 |
| 6 | Molecular mechanism of icariin on rat asthmatic model显示文摘在气喘的老鼠和 LPS 的干预的航线发炎上的 icariin 的背景效果导致了发炎与 icariin 的 machanism 被介入。我们的学习试图在 Th1/Th2 cytokine 表示和它的 mechanism.Methods 的 导致ovalbumin 的不平衡上观察 icariin 的效果六十只男 SD 老鼠随机被划分成控制组( PBS ),气喘组( ovalbumin (卵) -induced),dexamethasone 组,和 OVA+icariin 低、中等、高的剂量组( 5 , 10 , 20 mg/kg ,分别地)。每个组有十只老鼠。卵促进感受性的模型是一个老鼠气喘模型。连接酶的 immunosorbent 试金( ELISA )方法被用来在 interleukin-4 ( IL-4 )上观察 icariin 的效果,在老鼠染色的肺 tissue.Immunohistochemical 的 inerferon Y ( IFN-Y )被使用在 T 房间(T赌注)和 gatabinding 蛋白质上检测 icariin 的干预效果 3 ( GATA-3 )在里面老鼠肺的织物。实时 RT-PCR 被用来在老鼠在 T 赌注和 GATA-3 mRNA 表示上观察 icariin 的干预效果肺的织物和怒气淋巴细胞。西方的弄污被用来在老鼠在T赌注, GATA-3 和原子 factor-Kappa B ( NF-B ) p65 蛋白质表情上观察 icariin 干预效果从肺的织物的 ELISA 结果显示出的肺的 tissue.Results 那 IL-4 表情显著地被减少( P 0.05 ),当 IFN-y 表示增加了时然而并非当我们把 OVA+icariin 中等、高的剂量组与气喘作比较时,显著地组织。当染色的 T 赌注没在 OVA+icariin 高剂量组变化时,肺的织物染色的 Immunohistochemical 证明 GATA-3 显著地减少了。在肺的组织和脾淋巴细胞, T 赌注和 GATA-3 mRNA 表情显著地被减少(P 0.05 ) 在 icariin,治疗与气喘模型组相比组织。在在气喘组的老鼠怒气淋巴细胞的 GATA-3 和 T 赌注 mRNA 比在控制组高。在肺的织物的 GATA-3 mRNA 表示显著地减少了( P 0.05 )当T赌注 mRNA 表示减少了然而并非显著地,在 icariin 处理组,与气喘相比,在肺的织物的group.T赌注和 GATA-3 蛋白质表情与气喘相比显著地增加了时,组织,它意味着 icariin 能禁止 GATA-3 蛋白质,然而并非T赌注的增加。支气管,血容器和圆周当 NF-B p65 房间被减少时,肺的织物在 OVA+icariin 高剂量组有煽动性的房间的渗入,并且在这个组的 NF-B p65 的表示是不到在里面气喘组。当细胞质的 p65 蛋白质 increased.Conclusions Icariin 的表示能在气喘的老鼠调整 Th1/Th2 cytokines 的不平衡时,全部的 p65 蛋白质的表示与 icariin 处理减少了肺的织物。Icariin 能调整 Th1/Th2 的不平衡在气喘的老鼠的联系抄写因素 T 赌注和 GATA-3 肺的织物和怒气淋巴细胞。Icariin 能在气喘的老鼠禁止 NF-B p65 蛋白质的激活肺的织物。 | XU Chang-qing LE Jing-jing DUAN Xiao-hong DU Wei-jing LIU Bao-jun WU Jing-feng CAO Yu-xue DONG Jing-cheng | 2011 | Chinese Medical Journal2011，，18： | 13 |
| 7 | PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins显示文摘Mutations in RNA-binding proteins (RBPs) localized in ribonucleoprotein (RNP) granules, such as hnRNP A1 and TDP-43, promote aberrant protein aggregation, which is a pathological hallmark of various neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Protein posttranslational modifications (PTMs) are known to 佗gulate RNP granules. In this study, we investigate the function of poly(ADP-ribosyl)ation (PARylation), an important PTM involved in DNA damage repair and cell death, in RNP granule-related neurodegeneration. We reveal that PARylation levels are a major regulator of the assembly-disassembly dynamics of RNP granules containing disease-related RBPs, hnRNP A1 and TDP-43. We find that hnRNP A1 can both be PARylated and bind to PARylated proteins or poly(ADP-ribose)(PAR). We further uncover that PARylation of hnRNP A1 at K298 controls its nucleocytoplasmic transport, whereas PAR-binding via the PAR-binding motif (PBM) of hnRNP Al regulates its association with stress granules. Moreover, we reveal that PAR not only dramatically enhances the liquid-liquid phase separation of hnRNP A1, but also promotes the co-phase separation of hnRNP A1 and TDP-43 in vitro and their interaction in vivo. Finally, both genetic and pharmacological inhibition of PARP mitigates hnRNP Al- and TDP-43-mediated neurotoxicity in cell and Drosophila models of ALS. Together, our findings suggest a novel and crucial role for PARylation in regulating the dynamics of RNP granules, and that dysregulation in PARylation and PAR levels may con tribute to ALS disease pathoge nesis by promoting protei n aggregation. | Yongjia Duan Aiying Du Jinge Gu Gang Duan Chen Wang Xinrui Gui Zhiwei Ma Beituo Qian Xue Deng Kai Zhang Le Sun Kuili Tian Yaoyang Zhang Hong Jiang Cong Liu Yanshan Fang | 2019 | Cell Research2019，29，3： | 13 |
| 8 | A phase I study of different doses and frequencies of pegylated recombinant human granulocyte-colony stimulating factor(PEG rhG-CSF) in patients with standard-dose chemotherapy-induced neutropenia显示文摘Objective: The recommended dose of prophylactic pegylated recombinant human granulocyte-colony stimulating factor(PEG rhG-CSF) is 100 μg/kg once per cycle for patients receiving intense-dose chemotherapy.However, few data are available on the proper dose for patients receiving less-intense chemotherapy. The aim of this phase I study is to explore the proper dose and administration schedule of PEG rhG-CSF for patients receiving standard-dose chemotherapy.Methods:Eligible patients received 3-cycle chemotherapy every 3 weeks.No PEG rhG-CSF was given in the first cycle.Patients experienced grade 3 or 4 neutropenia would then enter the cycle 2 and 3.In cycle 2,patients received a single subcutaneous injection of prophylactic PEG rhG-CSF on d 3,and received half-dose subcutaneous injection in cycle 3 on d 3 and d 5,respectively.Escalating doses(30,60,100 and 200μg/kg)of PEG rhG-CSF were investigated.Results:A total of 26 patients were enrolled and received chemotherapy,in which 24 and 18 patients entered cycle 2 and cycle 3 treatment,respectively.In cycle 2,the incidence of grade 3 or 4 neutropenia for patients receiving single-dose PEG rhG-CSF of 30,60,100 and 200 μg/kg was 66.67%,33.33%,22.22% and 0,respectively,with a median duration less than 1(0–2)d.No grade 3 or higher neutropenia was noted in cycle 3 in all dose cohorts.Conclusions:The pharmacokinetic and pharmacodynamic profiles of PEG rhG-CSF used in cancer patients were similar to those reported,as well as the safety.Double half dose administration model showed better efficacy result than a single dose model in terms of grade 3 neutropenia and above.The single dose of 60 μg/kg,100 μg/kg and double half dose of 30 μg/kg were recommended to the phase Ⅱ study,hoping to find a preferable method for neutropenia treatment. | Yan Qin Xiaohong Han Lin Wang Ping Du Jiarui Yao Di Wu Yuanyuan Song Shuxiang Zhang Le Tang Yuankai Shi | 2017 | Chinese Journal of Cancer Research2017，29，5： | 11 |
| 9 | Salvianolic Acid B Down-regulates Matrix Metalloproteinase-9 Activity and Expression in Tumor Necrosis Factor-α-induced Human Coronary Artery Endothelial Cells显示文摘 | Le Ma Yun-Qian Guan Zhong-Dong Du | 2015 | Chinese Medical Journal2015，，19： | 11 |
| 10 | Culprit vessel only versus "one-week" staged percutaneous coronary intervention for multivessel disease in patients presenting with ST-segment elevation myocardial infarction显示文摘ObjectiveTo 探索 “ 的影响; one-week”上演 multivessel 经皮的冠的干预(一种总线标准)对死亡和主要不利心脏的事件(向)上的犯人唯一的一种总线标准 .MethodsWe ;回顾地与 multivessel 疾病分析了 447 个病人经历了圣片断举起在在经历在2008年7月26日和9月25日之间的一种总线标准前的 12 h 以内的心肌的梗塞( STEMI ), 2011 。在在梗塞动脉的一种总线标准的结束以后,仍然医院里的 201 个病人同意为 “ 与超过 70% 狭窄在非梗塞动脉经历一种总线标准; one-week”上演 multivessel 一种总线标准。246 病人 only 的一个总数;为犯人容器的收到的干预。后续在 2014 年 9 月 9 日结束了。这研究从任何原因在死亡检验了差别(即,心脏并且 noncardiac ) 并且在到一条犯人唯一的一种总线标准治疗途径的二治疗 groups.ResultsCompared 之间的向, “ one-week”上演 multivessel 一种总线标准强烈与更大的好处被联系为 55 月所有原因死亡[41 (16.7%) vs.13 (6.5%) , P = 0.004 ] 并且向[82 (33.3%) 对 40 (19.9%) , P = 0.002 ] 率。另外,在心肌的梗塞的数字有重要差别[43 (17.5%) 对 20 (10.0%) , P = 0.023 ] ,冠动脉绕过 grafting [CABG;20 (8.1%) 对 6 (3.0%) , P = 0.021 ] ,并且一种总线标准[31 (12.6%) 对 12 (6.0%) , P = 0.018 ] 。与 “ 相比经历犯人唯一的一种总线标准的病人; one-week”一种总线标准有 stent 血栓事件的一样的数字[7 (2.8%) 对 3 (1.5%) , P = 0.522 ].ConclusionsCompared 到一条犯人唯一的一种总线标准治疗途径, “ one-week”上演多容器一种总线标准为 STEMI 和多容器一种总线标准是一只保险箱和有效选择。 | Li-Xiang MA Zhen-Hua LU Le WANG Xin DU Chang-Sheng MA | 2015 | Journal of Geriatric Cardiology2015，12，3： | 10 |
| 11 | In situ preparation of hydrophobic CaCO_3 nanoparticles in a gas-liquid microdispersion process显示文摘This study presents a novel process of in situ surface modification of CaCCh nanoparticles using a multipleorifice dispersion microreactor.CO_2/Ca(OH)_2 precipitation reaction was employed to prepare CaCO_3nanoparticles with sodium stearate surfactant.Synthesized CaCCh products were characterized by thermogravimetric analysis(TGA),infra-red(IR),X-ray diffraction(XRD),transmission electron microscopy(TEM) and Brunauer-Emmet-Teller analysis(BET).The effect of various operation parameters on nanoparticles and the dosage of sodium stearate were determined.The results showed that the preparation process could be precisely controlled with efficient mass transfer process.The particles were highly hydrophobic with a contact angle of 117 and monodisperse with an average size of 30 nm.The adsorptions of sodium stearate and calcium ion on solid particles during the in situ surface modification process were investigated. | Le Du Yujun Wang Guangsheng Luo | 2013 | Particuology2013，11，4： | 8 |
| 12 | Surgical outcome and patient satisfaction after Z-epicanthoplasty and blepharoplasty显示文摘AIM: To evaluate surgical outcomes of modified Z-epicanthoplasty with blepharoplasty that we previously reported from the patient's perspective using patient-reported outcome measures(PROMs) and patient satisfaction scores.METHODS: A total of patients(n=180) who underwent the surgery between January 2013 and June 2016 were randomly selected. Standardized patient satisfaction forms(total score, 40) and validated PROMs questionnaires(total score, 12) were sent to patients for completion. PROMs assesses the severity of scarring, pain and asymmetry, as well as functional and appearance issues.RESULTS: All patients were female, ranging from 18 to 35 years old(mean=24). The response rate was 73.3%(n=132). The majority of patients reported good or excellent outcomes based on PROM analysis. Patients reported minimum or non-visible scarring at both the double eyelid surgical scar(85.6%) and the inner canthus(80.3%). Issues concerning function and appearance were minimal as 80.3% reported satisfaction with both domains. Notably, the majority of patients reported either a high or very high satisfaction rate to yield a mean score of 104 out of 120(P<0.05).CONCLUSION: Integration of our modified Z-epicanthoplasty with blepharoplasty produces good outcomes based on PROM results, which shows a positive linear relationship with patient satisfaction scores. | Jing-Yi Zhao Xiao-Shuang Guo Guo-Dong Song Xian-Lei Zong Xiao-Nan Yang Le Du Chen-Zhi Lai Zuo-Liang Qi Xiao-Lei Jin | 2018 | International Journal of Ophthalmology(English edition)2018，11，12： | 7 |
| 13 | Effects of potassium deficiency on photosynthesis,chloroplast ultrastructure,ROS,and antioxidant activities in maize(Zea mays L.)显示文摘Potassium(K)deficiency significantly decreases photosynthesis due to leaf chlorosis induced by accumulation of reactive oxygen species(ROS).But,the physiological mechanism for adjusting antioxidative defense system to protect leaf function in maize(Zea mays L.)is unknown.In the present study,four maize inbred lines(K-tolerant,90-21-3 and 099;K-sensitive,D937 and 835)were used to analyze leaf photosynthesis,anatomical structure,chloroplast ultrastructure,ROS,and antioxidant activities.The results showed that the chlorophyll content,net photosynthetic rate(P_n),stomatal conductance(G_s),photochemical quenching(q_P),and electron transport rate of PSII(ETR)in 90-21-3 and 099 were higher than those in D937 and 835 under K deficiency treatment.Parameters of leaf anatomical structure in D937 that were significantly changed under K deficiency treatment include smaller thickness of leaf,lower epidermis cells,and vascular bundle area,whereas the vascular bundle area,xylem vessel number,and area in 90-21-3 were significantly larger or higher.D937 also had seriously damaged chloroplasts and PSII reaction centers along with increased superoxide anion(O_2^-·)and hydrogen peroxide(H_2O_2).Activities of antioxidants,like superoxide dismutase(SOD),catalase(CAT),and ascorbate peroxidase(APX),were significantly stimulated in 90-21-3 resulting in lower levels of O_2^-·and H_2O_2.These results indicated that the K-tolerant maize promoted antioxidant enzyme activities to maintain ROS homeostasis and suffered less oxidative damage on the photosynthetic apparatus,thereby maintaining regular photosynthesis under K deficiency stress. | DU Qi ZHAO Xin-hua XIA Le JIANG Chun-ji WANG Xiao-guang HAN Yi WANG Jing YU Hai-qiu | 2019 | Journal of Integrative Agriculture2019，18，2： | 6 |
| 14 | A novel approach for one-step forming ε-caprolactam from cyclohexane nitrozation catalyzed by transition metal salt显示文摘The nitrozation reaction of cyclohexane in one-step reaction to form ε-caprolactam has been studied using transition metal salt as catalysts in this work. The results indicated that the catalysts play an especially important role. This method is expected to be a novel way to synthesize other lactam by similar reaction. The possible mechanism was suggested. | Li Qiu Mao Bo Hua Wu Du Lin Yin Kui Yi You Ping Le Liu He An Luo | 2007 | Chinese Chemical Letters2007，18，3： | 6 |
| 15 | Moxibustion upregulates hippocampal progranulin expression显示文摘In China,moxibustion is reported to be useful and has few side effects for chronic fatigue syndrome,but its mechanisms are largely unknown.More recently,the focus has been on the wealth of information supporting stress as a factor in chronic fatigue syndrome,and largely concerns dysregulation in the stress-related hypothalamic-pituitary-adrenal axis.In the present study,we aimed to determine the effect of moxibustion on behavioral symptoms in chronic fatigue syndrome rats and examine possible mechanisms.Rats were subjected to a combination of chronic restraint stress and forced swimming to induce chronic fatigue syndrome.The acupoints Guanyuan(CV4) and Zusanli(ST36,bilateral) were simultaneously administered moxibustion.Untreated chronic fatigue syndrome rats and normal rats were used as controls.Results from the forced swimming test,open field test,tail suspension test,real-time PCR,enzyme-linked immunosorbent assay,and western blot assay showed that moxibustion treatment decreased m RNA expression of corticotropin-releasing hormone in the hypothalamus,and adrenocorticotropic hormone and corticosterone levels in plasma,and markedly increased progranulin m RNA and protein expression in the hippocampus.These findings suggest that moxibustion may relieve the behavioral symptoms of chronic fatigue syndrome,at least in part,by modulating the hypothalamic-pituitary-adrenal axis and upregulating hippocampal progranulin. | Tao Yi Li Qi Ji Li Jing-jing Le Lei Shao Xin Du Jing-cheng Dong | 2016 | Neural Regeneration Research2016，11，4： | 6 |
| 16 | Gravitational wave astrophysics, data analysis and multimessenger astronomy显示文摘This paper reviews gravitational wave sources and their detection. One of the most exciting potential sources of gravitational waves are coalescing binary black hole systems. They can occur on all mass scales and be formed in numerous ways, many of which are not understood. They are generally invisible in electromagnetic waves, and they provide opportunities for deep investigation of Einstein's general theory of relativity. Sect. 1 of this paper considers ways that binary black holes can be created in the universe, and includes the prediction that binary black hole coalescence events are likely to be the first gravitational wave sources to be detected. The next parts of this paper address the detection of chirp waveforms from coalescence events in noisy data.Such analysis is computationally intensive. Sect. 2 reviews a new and powerful method of signal detection based on the GPUimplemented summed parallel infinite impulse response filters. Such filters are intrinsically real time alorithms, that can be used to rapidly detect and localise signals. Sect. 3 of the paper reviews the use of GPU processors for rapid searching for gravitational wave bursts that can arise from black hole births and coalescences. In sect. 4 the use of GPU processors to enable fast efficient statistical significance testing of gravitational wave event candidates is reviewed. Sect. 5 of this paper addresses the method of multimessenger astronomy where the discovery of electromagnetic counterparts of gravitational wave events can be used to identify sources, understand their nature and obtain much greater science outcomes from each identified event. | LEE Hyung Mok LE BIGOT Eric-Olivier DU ZhiHui LIN ZhangXi GUO XiangYu WEN LinQing PHUKON Khun Sang PANDEY Vihan BOSE Sukanta FAN Xi-Long HENDRY Martin | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，12： | 5 |
| 17 | Recent developments in microfluidic device-based preparation, functionalization, and manipulation of nano- and micro-materials显示文摘Microfluidic systems provide a powerful platform for preparing,functionalizing,and manipulating nano-/micro-materials.In this review,we summarize the characteristics of state-of-the-art microfluidic techniques and their application to processing novel nano-/micro-materials with tunable size,shape,morphology,composition,and properties.A variety of synthesis strategies based on novel microfiuidic devices are presented and compared,including their integration with real-time monitoring,external fields,and automatic feedback control.Novel functional nano-/micro-materials with complex structures have been controllably prepared and post-processed to obtain high-quality products.Strategies for controlling and tuning physical and chemical properties are also examined in terms of the design and function of microfluidic platforms.We provide an outlook on future developments in the processing of nano-/micro-materials by microfluidic technologies. | Guangsheng Luo Le Du Yujun Wang Kai Wang | 2019 | Particuology2019，17，4： | 5 |
| 18 | Prevalence of Metabolic Syndrome and Risk Factors Among Chinese Adults:Results from a Population-Based Study—Beijing,China,2017–2018显示文摘Summary What is already known about this topic?Metabolic syndrome(MetS)is one of the most easily available health indicative markers for cardiovascular diseases,and it has become a major public health problem worldwide due to increasing urbanization and aging populations.The prevalence of MetS increased dramatically in China,however,there are no records of MetS defined by the 2017 Chinese Diabetes Society for Beijing by far.What is added by this report?In this study,the data of 24,412 participants aged 18–74 years from a large population-based study in Beijing was collected.The overall prevalence of MetS among Beijing residents was 24.5%.The prevalence was 35.2%in males and 15.4%in females.What are the implications for public health practice?Effective public health strategies should target males,people with older age,lower education,higher body mass index,smokers,those who drink alcohol,those who are unemployed or retired,and those who live in rural areas on MetS prevention and control. | Jufen Liu Qingping Liu Zhiwen Li Jing Du Chao Wang Yanlin Gao Zaihua Wei Jing Wang Yunping Shi Jianting Su Yang Liu Ping Wang Chunyan Xie Gang Li Bing Shao Le Zhang | 2022 | China CDC weekly2022，4，29： | 4 |
| 19 | Ni nanoparticles supported on carbon as efficient catalysts for steam reforming of toluene(model tar)显示文摘This paper investigated the influences of surface properties of carbon support and nickel precursors(nickel nitrate, nickel chloride and nickel acetate) on Ni nanoparticle sizes and catalytic performances for steam reforming of toluene. Treatment with nitric acid helped to increase the amount of functional groups on the surface and hydrophilic nature of carbon support, leading to a homogeneous distribution of Ni nanoparticles. The thermal decomposition products of nickel precursor also played an important role, Ni nanoparticles supported on carbon treated with acid using nickel nitrate as the precursor exhibited the smallest mean diameter of 4.5 nm. With the loading amount increased from 6 wt% to 18 wt%, the mean particle size of Ni nanoparticles varied from4.5 nm to 9.1 nm. The as-prepared catalyst showed a high catalytic activity and a good stability for toluene steam reforming: 98.1% conversion of toluene was obtained with the Ni content of 12 wt% and the S/C ratio of3, and the conversion only decreased to 92.0% after 700 min. Because of the high activity, good stability, and low cost, the as-prepared catalyst opens up new opportunities for tar removing. | Chun Shen Wuqing Zhou Hao Yu Le Du | 2018 | Chinese Journal of Chemical Engineering2018，26，2： | 4 |
| 20 | Leptin activates the JAK/STAT pathway to promote angiogenesis in RF/6A cells in vitro显示文摘AIM: To investigate the effect of leptin on the angiogenesis of RF/6 A cells(monkey retinal choroidal endothelial cells) in vitro and test the cellular signaling in the mechanism.METHODS: RF/6 A cells were cultured in vitro and randomly divided into four groups: normal control, with leptin at 50, 100, 200 ng/m L for cell counting kit-8(CCK8). RF/6 A cell proliferation and migration were examined by Transwell assays, while RF/6 A cell tube formation by Matrigel assay. JAK2, p-JAK2, STAT3, and p-STAT3 protein expression was measured by Western blotting. Cells were then divided into the following treatment groups: control, 100 ng/m L leptin and AG-490(100 ng/m L leptin+10 μmol/L AG-490) for examinations of RF/6 A cellular behaviour again. Analysis of differences was carried out using one-way ANOVA and least significant difference(LSD).RESULTS: RF/6 A cell proliferation, migration and cell tube formation were promoted significantly by leptin in a dose-dependent manner(P<0.05). Western blotting showed that leptin up-regulated p-JAK2 and p-STAT3 expression levels. Treatment with the JAK/STAT pathway inhibitor, AG-490, decreased leptin-induced p-JAK2 and p-STAT3 expression, and inhibited cell proliferation, migration and cell tube formation induced by leptin(P<0.05). CONCLUSION: Leptin can promote RF/6 A cell angiogenesis in vitro via activation of the JAK2/STAT3 signaling pathway. | Le Zhang Rong Li Bing-Hui Wu Ting-Ting Liang Zhe Liu Wei Ju Yi Wang Yu-Ting Wen Ming-Cui Liu Jun-Hui Du | 2022 | International Journal of Ophthalmology(English edition)2022，15，4： | 4 |
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