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| 1 | Berbamine suppresses cell proliferation and promotes apoptosis in ovarian cancer partially via the inhibition of Wnt/β-catenin signaling显示文摘 | Heng Zhang Yunping Jiao Chunyang Shi Xiao Song Ying Chang Yong Ren Xiaolin Shi | 2018 | Acta Biochimica et Biophysica Sinica2018，50，6： | 9 |
| 2 | TGIF2 promotes the progression of lung adenocarcinoma by bridging EGFR/RAS/ERK signaling to cancer cell stemness显示文摘TGF-β-induced factor homeobox 2(TGIF2)is a transcription regulator that plays essential roles in the regulation of development and cell fate decisions.Aberrant expression of TGIF family proteins has been observed in several cancers,including ovarian,esophageal,and colorectal cancers.Here,we report that TGIF2 mediates the EGFR–RAS–ERK signaling pathway to enhance the stemness of lung adenocarcinoma(LUAD)cells and,therefore,promote the progression and metastasis of LUAD.We found that high TGIF2 expression was closely correlated with tumor growth,lymph node metastasis,and survival of patients with LUAD.Mice bearing TGIF2-silenced H1299 xenografts developed smaller tumors and fewer lung metastases.Importantly,silencing TGIF2 decreased the cancer stem cell(CSC)-like properties in A549 and H1299 cells.Furthermore,we identified that TGIF2 binding to the OCT4 promoter promotes its expression.In both LUAD cells and in vivo LUAD mouse models,we revealed that EGFR–RAS–ERK signaling phosphorylated TGIF2 and increased its stability,which was important for TGIF2-promoted LUAD stemness since phosphorylation-deficient TGIF2 mutants lost these functions.Thus,our study revealed that an important factor,TGIF2,bridges EGFR signaling to the CSC characteristics of LUAD cells,which can be utilized as an effective target for LUAD therapy. | Renle Du Wenzhi Shen Yi Liu Wenjuan Gao Wei Zhou Jun Li Shuangtao Zhao Chong Chen Yanan Chen Yanhua Liu Peiqing Sun Rong Xiang Yi Shi Yunping Luo | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 7 |
| 3 | Prevalence of Metabolic Syndrome and Risk Factors Among Chinese Adults:Results from a Population-Based Study—Beijing,China,2017–2018显示文摘Summary What is already known about this topic?Metabolic syndrome(MetS)is one of the most easily available health indicative markers for cardiovascular diseases,and it has become a major public health problem worldwide due to increasing urbanization and aging populations.The prevalence of MetS increased dramatically in China,however,there are no records of MetS defined by the 2017 Chinese Diabetes Society for Beijing by far.What is added by this report?In this study,the data of 24,412 participants aged 18–74 years from a large population-based study in Beijing was collected.The overall prevalence of MetS among Beijing residents was 24.5%.The prevalence was 35.2%in males and 15.4%in females.What are the implications for public health practice?Effective public health strategies should target males,people with older age,lower education,higher body mass index,smokers,those who drink alcohol,those who are unemployed or retired,and those who live in rural areas on MetS prevention and control. | Jufen Liu Qingping Liu Zhiwen Li Jing Du Chao Wang Yanlin Gao Zaihua Wei Jing Wang Yunping Shi Jianting Su Yang Liu Ping Wang Chunyan Xie Gang Li Bing Shao Le Zhang | 2022 | China CDC weekly2022，4，29： | 4 |
| 4 | DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway显示文摘Wnt signaling pathways,including the canonical Wnt/β-catenin pathway,planar cell polarity pathway,and Wnt/Ca2+signaling pathway,play important roles in neural development during embryonic stages.The DVL genes encode the hub proteins for Wnt signaling pathways.The mutations in DVL2 and DVL3 were identified from patients with neural tube defects(NTDs),but their functions in the pathogenesis of human neural diseases remain elusive.Here,we sequenced the coding regions of three DVL genes in 176 stillborn or miscarried fetuses with NTDs or Dandy-Walker malformation(DWM)and 480 adult controls from a Han Chinese population.Four rare mutations were identified:DVL1 p.R558 H,DVL1 p.R606 C,DVL2 p.R633 W,and DVL3 p.R222 Q.To assess the effect of these mutations on NTDs and DWM,various functional analyses such as luciferase reporter assay,stress fiber formation,and in vivo teratogenic assay were performed.The results showed that the DVL2 p.R633 W mutation destabilized DVL2 protein and upregulated activities for all three Wnt signalings(Wnt/β-catenin signaling,Wnt/planar cell polarity signaling,and Wnt/Ca2+signaling)in mammalian cells.In contrast,DVL1 mutants(DVL1 p.R558 H and DVL1 p.R606 C)decreased canonical Wnt/β-catenin signaling but increased the activity of Wnt/Ca2+signaling,and DVL3 p.R222 Q only decreased the activity of Wnt/Ca2+signaling.We also found that only the DVL2 p.R633 W mutant displayed more severe teratogenicity in zebrafish embryos than wild-type DVL2.Our study demonstrates that these four rare DVL mutations,especially DVL2 p.R633 W,may contribute to human neural diseases such as NTDs and DWM by obstructing Wnt signaling pathways. | Lingling Liu Weiqi Liu Yan Shi Ling Li Yunqian Gao Yunping Lei Richard Finnell Ting Zhang Feng Zhang Li Jin Huili Li Wufan Tao Hongyan Wang | 2020 | Journal of Genetics and Genomics2020，47，6： | 2 |
| 5 | Quasi-in-situ study on{10-12}twinning-detwinning behavior of rolled Mg-Li alloy in two-step compression(RD)-compression(ND)process显示文摘Twinning-detwinning(TDT)behavior in a strongly basal-textured Mg-Li alloy during two-step compression(RD)-compression(ND)process was investigated using quasi-in-situ EBSD.TDT behavior and TDT variants selection were statistically discussed with the loading path for the first time.Non-Schmid twinning behavior was observed in the first step compression,owing to the local stress fluctuations by neighboring twins;in contrast,Schmid’s law well predicted the detwinning variants selection.This asymmetrical TDT behavior was first investigated to date related with the strong basal texture and loading path.Besides,with the progress of compression,Schmid factors for twinning demonstrated a decreasing tendency;however,those for detwinning during the second step displayed an abnormally increasing trend,fundamentally stemming from prior twinning behavior. | Biaobiao Yang Chenying Shi Siyu Zhang Jingjing Hu Jianwei Teng Yujie Cui Yunping Li Akihiko Chiba | 2022 | Journal of Magnesium and Alloys2022，10，10： | 2 |
| 6 | Study of the Coding in the Progressive Image Transmission显示文摘 | Sun YunLian Shi Gang Chen YunPing | 1996 | Proceedings of ICSP1996，2，： | 1 |
| 7 | P2P worm detection based on application identification显示文摘 | Chunhe Xia Yunping Shi Xiaojian Li Wei Gao | 2007 | Frontiers of Computer Science in China2007，，1： | 1 |
| 8 | Characteristics of Lung Function and Prevalence of Airflow Obstruction Among Individuals Aged 18–74 Years-Beijing,China,2017–2018显示文摘What is already known about this topic?Airflow obstruction is the hallmark of many chronic respiratory diseases and may indicate the potential for the development of other progressive diseases.There are currently no representative studies of lung function in Beijing.An up-to-date estimation of the characteristics of lung function and airflow obstruction is thus needed.What is added by this report?The estimated prevalence of airflow obstruction was 14.68%in Beijing,2017–2018.The values of vital capacity,forced vital capacity,and forced expiratory volume in the first second were 3.09 L,2.66 L,2.22 L,respectively.What are the implications for public health practice?Effective public health strategy for lung in Beijing should target older people,current or former smokers,and individuals who live in urban environments,have a low education level,exhibit a high smoking index,and/or have an abnormal body mass index. | Jiamin Wang Jing Du Yanlin Gao Yunping Shi Jianting Su Qingping Liu Yang Liu Ping Wang Chao Wang Bing Shao Gang Li | 2022 | China CDC weekly2022，4，51： | 0 |
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