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| 1 | Rotary-scaling fine-tuning (RSFT) method for optimizing railway wheel profiles and its application to a locomotive显示文摘The existing multi-objective wheel profile optimization methods mainly consist of three sub-modules:(1)wheel profile generation,(2)multi-body dynamics simulation,and(3)an optimization algorithm.For the first module,a comparably conservative rotary-scaling finetuning(RSFT)method,which introduces two design variables and an empirical formula,is proposed to fine-tune the traditional wheel profiles for improving their engineering applicability.For the second module,for the TRAXX locomotives serving on the Blankenburg–Rubeland line,an optimization function representing the relationship between the wheel profile and the wheel–rail wear number is established based on Kriging surrogate model(KSM).For the third module,a method combining the regression capability of KSM with the iterative computing power of particle swarm optimization(PSO)is proposed to quickly and reliably implement the task of optimizing wheel profiles.Finally,with the RSFT–KSM–PSO method,we propose two wear-resistant wheel profiles for the TRAXX locomotives serving on the Blankenburg–Rubeland line,namely S1002-S and S1002-M.The S1002-S profile minimizes the total wear number by 30%,while the S1002-M profile makes the wear distribution more uniform through a proper sacrifice of the tread wear number,and the total wear number is reduced by 21%.The quasi-static and hunting stability tests further demonstrate that the profile designed by the RSFT–KSM–PSO method is promising for practical engineering applications. | Yunguang Ye Yayun Qi Dachuan Shi Yu Sun Yichang Zhou Markus Hecht | 2020 | Railway Engineering Science2020，28，2： | 6 |
| 2 | COPII mitigates ER stress by promoting formation of ER whorls显示文摘Cells mitigate ER stress through the unfolded protein response(UPR).Here,we report formation of ER whorls as an effector mechanism of the ER stress response.We found that strong ER stress induces formation of ER whorls,which contain ER-resident proteins such as the Sec61 complex and PKR-like ER kinase(PERK).ER whorl formation is dependent on PERK kinase activity and is mediated by COPII machinery,which facilitates ER membrane budding to form tubular-vesicular ER whorl precursors.ER whorl precursors then go through Sec22b-mediated fusion to form ER whorls.We further show that ER whorls contribute to ER stressinduced translational inhibition by possibly modulating PERK activity and by sequestering translocons in a ribosome-free environment.We propose that formation of ER whorls reflects a new type of ER stress response that controls inhibition of protein translation. | Fang Xu Wanqing Du Qin Zou Yuting Wang Xin Zhang Xudong Xing Ying Li Dachuan Zhang Huimin Wang Wenhao Zhang Xinyao Hu Xin Liu Xiaoling Liu Shaojin Zhang Jinqiang Yu Jianhuo Fang Fajin Li Ying Zhou Tieqiang Yue Na Mi Haiteng Deng Peng Zou Xiaowei Chen Xuerui Yang Li Yu | 2021 | Cell Research2021，31，2： | 4 |
| 3 | TGF-β1-supplemented decellularized annulus fibrosus matrix hydrogels promote annulus fibrosus repair显示文摘Annulus fibrosus(AF)repair remains a challenge because of its limited self-healing ability.Endogenous repair strategies combining scaffolds and growth factors show great promise in AF repair.Although the unique and beneficial characteristics of decellularized extracellular matrix(ECM)in tissue repair have been demonstrated,the poor mechanical property of ECM hydrogels largely hinders their applications in tissue regeneration.In the present study,we combined polyethylene glycol diacrylate(PEGDA)and decellularized annulus fibrosus matrix(DAFM)to develop an injectable,photocurable hydrogel for AF repair.We found that the addition of PEGDA markedly improved the mechanical strength of DAFM hydrogels while maintaining their porous structure.Transforming growth factor-β1(TGF-β1)was further incorporated into PEGDA/DAFM hydrogels,and it could be continuously released from the hydrogel.The in vitro experiments showed that TGF-β1 facilitated the migration of AF cells.Furthermore,PEGDA/DAFM/TGF-β1 hydrogels supported the adhesion,proliferation,and increased ECM production of AF cells.In vivo repair performance of the hydrogels was assessed using a rat AF defect model.The results showed that the implantation of PEGDA/DAFM/TGF-β1 hydrogels effectively sealed the AF defect,prevented nucleus pulposus atrophy,retained disc height,and partially restored the biomechanical properties of disc.In addition,the implanted hydrogel was infiltrated by cells resembling AF cells and well integrated with adjacent AF tissue.In summary,findings from this study indicate that TGF-β1-supplemented DAFM hydrogels hold promise for AF repair. | Qiang Wei Dachuan Liu Genglei Chu Qifan Yu Zhao Liu Jiaying Li Qingchen Meng Weishan Wang Fengxuan Han Bin Li | 2023 | Bioactive Materials2023，，1： | 3 |
| 4 | Electronic circuit model for proton exchange membrane fuel cells 显示文摘 | Dachuan Yu S Yuvarajan | 2005 | Power Sources (S0378-7753)2005，142，1： | 1 |
| 5 | A unified dual-fitting approximation algorithm for the facility location problems with linear/submodular penalties显示文摘 | Yu Li Donglei Du Naihua Xiu Dachuan Xu | 2014 | Journal of Combinatorial Optimization2014，，3： | 1 |
| 6 | Approximation Algorithms for Integrated Distribution Network Design Problems显示文摘 | Yu Li Jia Shu Xi Wang Naihua Xiu Dachuan Xu Jiawei Zhang | 2013 | INFORMS Journal on Computing2013，，3： | 1 |
| 7 | Improved approximation algorithms for the robust fault-tolerant facility location problem显示文摘 | Yu Li Dachuan Xu Donglei Du Naihua Xiu | 2012 | Information Processing Letters2012，，10： | 1 |
| 8 | A novel power converter for photovohaic applications 显示文摘 | YUVARAJAN S YU Dachuan XU Shanguang | 2004 | Journal of Power Sources2004，135，12： | 1 |
| 9 | A combinatorial 2.375-approximation algorithm for the facility location problem with submodular penalties显示文摘 | Yu Li Donglei Du Naihua Xiu Dachuan Xu | 2012 | Theoretical Computer Science2012，，： | 1 |
| 10 | A novel power converter for photovoltaic applications显示文摘 | S. Yuvarajan Dachuan Yu Shanguang Xu | 2004 | Journal of Power Sources2004，，1： | 1 |
| 11 | A novel power converter for photovoltaic applications 显示文摘 | YUVARAJAN S YU Dachuan XU Shanguang | 2004 | Journal of Power Sources2004，135，12： | 1 |
| 12 | A Novel Power Converter for Photovoltaic Applications显示文摘 | S Yuvarajan Dachuan Yu Shanguang Xu | 2004 | Journal of Power Sources2004，135，： | 1 |
| 13 | Javascript instrumentation for browser security显示文摘 | Yu Dachuan Chander A Islam N | 2007 | ACM SIGPLAN Notices2007，42，1： | 1 |
| 14 | Interfacial Reinitiation of Free Radicals Enables the Regeneration of Broken Polymeric Hydrogel Actuators显示文摘Living organisms,from plants to animals,have inspired and guided the design and fabrication of polymeric hydrogels with biomimetic morphology,shape deformation,and actuation behavior.However,the existing polymeric hydrogels are fragile and vulnerable,which seriously hinders further application.Therefore,endowing hydrogels with a biomimetic self-growth property and regenerating the macroscopic shape of hydrogels after they suffer significant damage are highly desirable for the next generation of adaptive biomimetic hydrogels.Inspired by the tail regeneration of geckos,we herein report an efficient and universal strategy of interfacial diffusion polymerization(IDP),which can regenerate the polymeric layer at a solid–liquid interface,thereby growing new hydrogels on the existing hydrogel layers.Through changing the solvent viscosity and/or monomer type of the hydrogel precursor,diverse new hydrogels have been regenerated to endow the initial hydrogels with additional fluorescent functions and/or actuating properties.Due to the high efficiency and universality of IDP,an injured hydrogel actuator can be repaired,regenerated,and recovered to its initial condition,even after suffering severe damage such as cutting or piercing.We believe that the regeneration strategy of polymeric hydrogels will inspire the design of biomimetic materials and motivate the fabrication of the next generation of soft robots with adaptive and multifunctional properties. | Baoyi Wu Huanhuan Lu Yukun Jian Dachuan Zhang Yu Peng Jie Zhuo Xiaoxia Le Jiawei Zhang Patrick Théato Tao Chen | 2023 | CCS Chemistry2023，5，3： | 0 |
| 15 | An approximation algorithm for the k-median warehouse-retailer network design problem显示文摘We study the generalizedk-median version of the warehouse-retailer network design problem(kWRND).We formulate the k-WRND as a binary integer program and propose a 6-approximation randomized algorithm based on Lagrangian relaxation. | LI Yu XIU NaiHua XU DaChuan | 2013 | Science China Mathematics2013，56，11： | 0 |
| 16 | Thermal degradation of BaAl_2Si_2O_8:Eu^(2+) phosphor excited by near ultraviolet light显示文摘Eu2+ doped BaAl2Si2O8 phosphor was synthesized by one-step calcination of precursors that were prepared by chemical co-precipitation.The thermal degradation properties of BaAl2Si2O8:Eu2+ were investigated by photoluminescence,lifetime and chromaticity coordinate measurements.BaAl2Si2O8:Eu2+ is efficiently excited by incident light of 250-400 nm,which matches the emission of near ultraviolet LED chips well.BaAl2Si2O8:Eu2+ exhibits broad blue emission at 470 nm because of the 4f65d1-4f7(8S7/2) transition of Eu2+ ions,and the emission band shows an unusual blue shift with bandwidth broadening and emission intensity decreasing as the annealing temperature is increased.The luminescence decay and CIE chromaticity coordinates of BaAl2Si2O8:Eu2+ were determined to investigate its application in white LEDs. | MA MingXing ZHU DaChuan ZHAO Cong HAN Tao CAO ShiXiu LEI Yu TU MingJing | 2012 | Chinese Science Bulletin2012，57，14： | 0 |
| 17 | A GSH-depleted platinum(Ⅳ) prodrug triggers ferroptotic cell death in breast cancer显示文摘Cisplatin is the first-line drug for treatment of various solid tumors including breast cancer due to the broad anti-tumor spectrum and strong anti-tumor effect.However,serious side effects and long-term medication of reduced sensitivity by high GSH in tumor cells have severely restricted its further clinical application.Herein,a GSH-depleted Pt(Ⅳ)prodrug(Platin B)based on cisplatin and 4-carboxylphenylboronic acid pinacol ester was prepared to solve the problems.As an excellent GSH scavenger,4-carboxylphenylboronic acid pinacol ester could be activated by intracellular redox reactions to release quinone methide,thereby amplifying oxidative stress and leading to breast cancer ferroptosis therapy.Interestingly,the consumption of GSH can also reduce cisplatin inactivation,enhance the sensitivity of tumor cells to cisplatin and efficiently induce apoptosis/ferroptosis.This work highlights the use of GSH scavenger for triggering ferroptotic cell death in breast cancer. | Dachuan Qi Lei Xing Lijun Shen Wenshuang Sun Cheng Cai Chunhua Xue Xuwei Song Hua Yu Hulin Jiang Chengjun Li Qingri Jin Zhiqi Zhang | 2022 | Chinese Chemical Letters2022，33，10： | 0 |
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