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| 1 | Recent progress in tumor photodynamic immunotherapy显示文摘Photodynamic therapy(PDT)is a promising alternative approach for effective cancer treatment,which can directly destroy local tumor cells due to the generation of cytotoxic singlet oxygen and reactive oxygen species(ROS)in the tumor cells.Intriguingly,PDT-mediated cell death is also associated with anti-tumor immune response.Howeve r,immunosuppre s sion of tumor microe nvironment is able to limit the immune response induced by PDT,it is therefore necessary to combine with immunocheckpoint inhibitor and immunoadjuvant for synergistic treatment of tumors.Herein,the recent advances of PDT,immunotherapy,and photodynamic immunotherapy are reviewed. | Lijun Shen Tianjiao Zhou Yatong Fan Xin Chang Yi Wang Jianguo Sun Lei Xing Hulin Jiang | 2020 | Chinese Chemical Letters2020，31，7： | 2 |
| 2 | Progress in drug delivery system for fibrosis therapy显示文摘Fibrosis is a necessary process in the progression of chronic disease to cirrhosis or even cancer,which is a serious disease threatening human health.Recent studies have shown that the early treatment of fibrosis is turning point and particularly important.Therefore,how to reverse fibrosis has become the focus and research hotspot in recent years.So far,the considerable progress has been made in the development of effective anti-fibrosis drugs and targeted drug delivery.Moreover,the existing research results will lay the foundation for more breakthrough delivery systems to achieve better anti-fibrosis effects.Herein,this review summaries anti-fibrosis delivery systems focused on three major organ fibrotic diseases such as liver,pulmonary,and renal fibrosis accompanied by the elaboration of relevant pathological mechanisms,which will provide inspiration and guidance for the design of fibrosis drugs and therapeutic systems in the future. | Lei Xing Xin Chang Lijun Shen Chenglu Zhang Yatong Fan Chongsu Cho Zhiqi Zhang Hulin Jiang | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，1： | 2 |
| 3 | A networked swellable dextrin nanogels loading Bcl2 siRNA for melanoma tumor therapy显示文摘在这研究,联网的可胀大的糊精 nanogel (DNG ) 被开发完成刺激应答的小介入为黑瘤肿瘤的 RNA (siRNA ) 版本治疗。siRNA 被费用冷凝作用装进多维的糊精 nanogels,积极精氨酸残余在糊精脊梁修改了。而且,联网的 nanogel 被破坏并且基于它的 bioreducible 松开了应答的性质在 bioreducible 控制加速的 siRNA 版本细胞内部的环境,当它在正常生理的条件下面仍然保持稳定时。我们由传播电子显微镜学评估在减少的缓冲区状况下面表明了可胀大的有的那 DNG 和拆卸性质。DNG 完成了被触发谷胱甘肽的拆卸货物的选择版本根据共焦的显微镜学观察跟随进 cytosol 的 endosomal 逃跑。因此,这聪明的 nanogel 完成了突出的酶基因 silencing 效率并且减少在 vitro 并且在 vivo 的 Bcl2 蛋白质表示基于西方的污点分析。而且,这 nanogel 在 C57BL/6 老鼠为 B16F10 异种皮移植肿瘤展出了优异反肿瘤活动。这些结果证明联网的 DNG 为基因冷凝作用是有效的并且为肿瘤治疗控制细胞内部的版本。总的来说,这些调查结果建议这多维的可胀大的刺激应答的糊精 nanogel 是有为基因和药交货的大诺言的创新策略。 | Huipeng Li Zhanwei Zhou Feiran Zhang Yuxin Guo Xue Yang Hulin Jiang Fei Tan David Oupicky Minjie Sun | 2018 | Nano Research2018，11，9： | 1 |
| 4 | Folate-conjugated polyspermine for lung cancer–targeted gene therapy显示文摘Biodegradable polyamines have long been studied as potential recombinant viral gene vectors.Spermine(SPE) is an endogenous tetra-amine with excellent biocompatibility yet poor gene condensation capacity. We have previously synthesized a polyspermine based on SPE and poly(ethylene glycol)(PEG)diacrylate(SPE-alt-PEG) for enhanced transfection performance, but the synthesized SPE-alt-PEG still lacked specificity towards cancer cells. In this study, folic acid(FA) was incorporated into SPE-alt-PEG to fabricate a targeted gene delivery vector(FA-SPE-PEG) via an acylation reaction. FA-SPE-PEG exhibited mild cytotoxicity in both cancer cells and normal cells. FA-SPE-PEG possessed higher transfection efficiency than PEI 25 K and Lipofectamines2000 in two tested cancer cell lines at functional weight ratios, and its superiority over untargeted SPE-alt-PEG was prominent in cells with overexpressed folate receptors(FRs). Moreover, in vivo delivery of green fluorescent protein(GFP) with FA-SPE-PEG resulted in highest fluorescent signal intensity of all investigated groups. FA-SPE-PEG showed remarkably enhanced specificity towards cancer cells both in vivo and in vitro due to the interaction between FA and FRs. Taken together, FA-SPE-PEG was demonstrated to be a prospective targeted gene delivery vector with high transfection capacity and excellent biocompatibility. | Mei Zhang You-Kyoung Kim Pengfei Cui Jialiang Zhang Jianbin Qiao Yujing He Jinyuan Lyu Chengqiong Luo Lei Xing Hulin Jiang | 2016 | Acta Pharmaceutica Sinica B2016，6，4： | 0 |
| 5 | Breaking-then-curing strategy for efficient cystic echinococcosis therapy显示文摘Cystic echinococcosis(CE)is one of the most harmful and life-threatening helminths.As the essential therapeutics,chemotherapy is always difficult to achieve desired anti-echinococcal effect due to the problems that the echinococcus granulosus cyst laminated layer makes the drug difficult to infiltrate and the poor solubility of drugs.In this study,we established a“breaking-then-curing”anti-echinococcal treatment strategy for efficient CE therapy.The photodynamic therapy(PDT)was used as a breaker to produce toxic reactive oxygen species(ROS)and damage the laminated layer of protoscolices(PSCs),leading to enhanced infiltration of albendazole sulfoxide nanoparticles(ABZSO NPs).Then,ABZSO NP was worked as curer for efficient anti-echinococcal treatment.As a result,the breaking-then-curing treatment strategy could generate more intracellular ROS in PSCs induced by plenty of ABZSO NPs,greatly increasing the mortality rate of PSCs in a shorter time than using ABZSO NPs alone,leading to the attenuation of laminated layer and finally disintegrating PSCs.We believe the“breaking-then-curing”strategy will suggest great potential in the treatment of CE and provide a new sight for anti-echinococcal treatment. | Tianjiao Zhou Yuan Xu Yuehong Gong Mingtao Yu Enzhen Xu Wusimanjiang Aimaiti Ruijia Ma Lei Xing Hao Wen Jianhua Wang Hulin Jiang | 2022 | Chinese Chemical Letters2022，33，6： | 0 |
| 6 | Dual inhibition of glucose uptake and energy supply synergistically restrains the growth and metastasis of breast cancer显示文摘Metastatic breast cancer(MBC) is one of the most common and knotty diseases in female population which could place them in a life-threatening condition. For malignant proliferation and migration, cancer cells require a large amount of glucose and energy to meet the demand of rapid metabolism. Hence,efficiently diminishing the utilization of energy substances by cancer cells is emerging as validated therapeutic strategies for cancer therapy. Herein, a nanoplatform with dual-inhibition of glucose uptake and oxidative phosphorylation(OXPHOS) was designed, which consisted of albendazole(ABZ) and atovaquone(ATO) by simple carrier-free self-assembling. The introduction of ABZ could evidently decrease glucose uptake to reduce the main “energy fuel” of cancer cells. Meanwhile, as a blocker of OXPHOS, ATO would reduce adenosine triphosphate(ATP) production and ameliorate hypoxia microenvironment by suppressing mitochondrial respiratory chain. Under such dual inhibition of energy metabolism, AA NPs exerted synergistic energy exhaustion effect and outstanding hypoxia improvement function, efficiently inhibiting tumor growth and metastasis. This research not only illustrates the feasibility of energy metabolism therapy by co-inhibiting glucose uptake and OXPHOS, but also provides an ingenious tactic to diminish metastasis during MBC treatment. | Yuan Xu Liling Huang Yuyang Bi Qi Song Mengmeng Zhang Lingfeng Zhang Tianjiao Zhou Lei Xing Hulin Jiang | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
| 7 | A GSH-depleted platinum(Ⅳ) prodrug triggers ferroptotic cell death in breast cancer显示文摘Cisplatin is the first-line drug for treatment of various solid tumors including breast cancer due to the broad anti-tumor spectrum and strong anti-tumor effect.However,serious side effects and long-term medication of reduced sensitivity by high GSH in tumor cells have severely restricted its further clinical application.Herein,a GSH-depleted Pt(Ⅳ)prodrug(Platin B)based on cisplatin and 4-carboxylphenylboronic acid pinacol ester was prepared to solve the problems.As an excellent GSH scavenger,4-carboxylphenylboronic acid pinacol ester could be activated by intracellular redox reactions to release quinone methide,thereby amplifying oxidative stress and leading to breast cancer ferroptosis therapy.Interestingly,the consumption of GSH can also reduce cisplatin inactivation,enhance the sensitivity of tumor cells to cisplatin and efficiently induce apoptosis/ferroptosis.This work highlights the use of GSH scavenger for triggering ferroptotic cell death in breast cancer. | Dachuan Qi Lei Xing Lijun Shen Wenshuang Sun Cheng Cai Chunhua Xue Xuwei Song Hua Yu Hulin Jiang Chengjun Li Qingri Jin Zhiqi Zhang | 2022 | Chinese Chemical Letters2022，33，10： | 0 |
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