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14篇 您的检索式:作者名="Daeyoung"
    题名 作者 年代 出处 被引量
1Effects of consumer preferences on the convergence of mobile telecommunications devices显示文摘Yeonbae Kim Jeong-Dong Lee Daeyoung Koh 2005Applied Economics2005,,7:1
2关于韩国保障措施的现状及其问题的考察显示文摘Kim Daeyoung Lee Donghac 2006贸易救济2006,,1:1
3Atherogenic lipoproteins stimulate mesangial cell p42 mitogen-activated protein kinase显示文摘Bassa BV Daeyoung DR Michael A 1998J Am Soc Nephrol1998,9,3:1
4UPnP based intelliget multimedia service archi- tecture for digital home network显示文摘Sung Jongwoo Kim Daeyoung Song Hyungjoo 2006Software Tech- nologies for Future Embedded and Ubiquitous Sys- tems2006,3,4:1
5Multiple tandem jets in cross-flow显示文摘Daeyoung Yu All M S Joseph H W Lee 2006Journal of Hydraulic Engineering2006,132,9:1
6Production of nuclear transfer-derived piglets using porcine fetal fibroblasts transfected with the enhanced green fluorescent protein显示文摘Sanghwan H Gabsang L Daeyoung K 2003Biol Reprod2003,69,:1
7Wireless packet scheduling based on the cumulative distribution function of user transmission rates显示文摘Daeyoung P S Kwon H H Lee B G 2005IEEE Transactions on Communications2005,53,11:1
8Corticotropin-releasing factor induces immune escape of cervical cancercells by downregulation of NKG2D显示文摘Hyunkeun Song Hyunjin Park Gabin Park Yeong Kim Hyun-Kyung Lee Dong-Hoon Jin Hyung-Sik Kang Dae-Ho Cho Daeyoung Hur 2014Oncology Reports2014,,1:1
9Software architecture supporting integratcd real-time systems显示文摘Kim Daeyoung Lee Yannhang Younis Mohanmed 2003The Journal of Systems and Software2003,65,1:1
10Product ion of nuclear transfer derived piglets using porcinef et al fibroblast stransfect ed with the enhanced green fluorescent prot ein显示文摘Sanghwan H Y Gabsang L Daeyoung K 2003Biol Reprod2003,69,:1
11Enhancements to FPMIPv6for improved seamless vertical handover between LTE and heterogeneous access networks显示文摘Jongmoon Chung Daeyoung Lee Song W J 2013IEEE Wireless Communications2013,20,3:1
12Dietary resveratrol alters lipid metabolism-related gene expression of mice on an atherogenic diet显示文摘Jiyun Ahn Iljin Cho Suna Kim Daeyoung Kwon Taeyoul Ha 2008Journal of Hepatology2008,,6:1
13A new approach to job shop scheduling problems with due date constraints considering operation subcontracts显示文摘Daeyoung Chung Kichang Lee Kitae Shin Jinwoo Park 2005International Journal of Production Economics2005,,2:1
14A novel IRAK4/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR/MYD88-mediated NF-κB pathway显示文摘Interleukin-1 receptor-associated kinase 4(IRAK4)is a pivotal enzyme in the Toll-like receptor(TLR)/MYD88 dependent signaling pathway,which is highly activated in rheumatoid arthritis tissues and activated B cell-like diffuse large B-cell lymphoma(ABC-DLBCL).Inflammatory responses followed by IRAK4 activation promote B-cell proliferation and aggressiveness of lymphoma.Moreover,proviral integration site for Moloney murine leukemia virus 1(PIM1)functions as an anti-apoptotic kinase in propagation of ABC-DLBCL with ibrutinib resistance.We developed a dual IRAK4/PIM1 inhibitor KIC-0101 that potently suppresses the NF-κB pathway and proinflammatory cytokine induction in vitro and in vivo.In rheumatoid arthritis mouse models,treatment with KIC-0101 significantly ameliorated cartilage damage and inflammation.KIC-0101 inhibited the nuclear translocation of NF-κB and activation of JAK/STAT pathway in ABC-DLBCLs.In addition,KIC-0101 exhibited an anti-tumor effect on ibrutinib-resistant cells by synergistic dual suppression of TLR/MYD88-mediated NF-κB pathway and PIM1 kinase.Our results suggest that KIC-0101 is a promising drug candidate for autoimmune diseases and ibrutinib-resistant B-cell lymphomas.Sae-Bom Yoon Hyowon Hong Hee-Jong Lim Ji Hye Choi Yoon Pyo Choi Seong Wook Seo Hyuk Woo Lee Chong Hak Chae Woo-Kyu Park Hyun Young Kim Daeyoung Jeong Tran Quang De Chang-Seon Myung Heeyeong Cho 2023Acta Pharmaceutica Sinica B2023,13,3:0
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