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| 1 | Test Data Generation for Stateful Network Protocol Fuzzing Using a Rule-Based State Machine显示文摘To improve the efficiency and coverage of stateful network protocol fuzzing, this paper proposes a new method, using a rule-based state machine and a stateful rule tree to guide the generation of fuzz testing data. The method first builds a rule-based state machine model as a formal description of the states of a network protocol.This removes safety paths, to cut down the scale of the state space. Then it uses a stateful rule tree to describe the relationship between states and messages, and then remove useless items from it. According to the message sequence obtained by the analysis of paths using the stateful rule tree and the protocol specification, an abstract data model of test case generation is defined. The fuzz testing data is produced by various generation algorithms through filling data in the fields of the data model. Using the rule-based state machine and the stateful rule tree,the quantity of test data can be reduced. Experimental results indicate that our method can discover the same vulnerabilities as traditional approaches, using less test data, while optimizing test data generation and improving test efficiency. | Rui Ma Daguang Wang Changzhen Hu Wendong Ji Jingfeng Xue | 2016 | Tsinghua Science and Technology2016，21，3： | 13 |
| 2 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 3 | PUBLIC SCIENTIFIC LITERACY IN CHINA显示文摘In 1992, a research group under China Association for Science and Technology, conducted the first national survey of the public attitudes towards science and technology. This paper shows the data stemmed from the processed results of the survey. | Li Daguang(Institute for S&T Popularization, China Association for Science and Technology) | 1995 | Bulletin of the Chinese Academy of Sciences1995，9，4： | 2 |
| 4 | Ancient DNA sequences of rice from the low Yangtze reveal significant genotypic divergence显示文摘Rice (Oryza sativa) was first domesticated in the lower and middle Yangtze regions of China, and rice remains have been found in many Chinese archaeological sites. Until now, only phenotypic archeobotanical evidence, such as the spikelet bases of ancient grains, has been used to speculate on the domestication process and domestication rate of rice. In this study, we sequenced 4 genomic segments from rice remains in Tianluoshan, a site of the local Hemudu Neolithic culture in the low Yangtze and two other archaeological sites (~2400 and 1200 BC, respectively). We compared our sequences with those of the current domesticated and wild rice (O. rufipogon) populations. At least two genotypes were found in the remains from each site, suggesting a heterozygotic state of the rice seeds. One ancient genotype was not found in the current domesticated population and might have been lost. The rice remains belonged to the japonica group, and most if not all were japonica-type, suggesting that the remains might be at an early stage of indica-japonica divergence or an indica-japonica mixture. We also identified sequences with significant similarity to those from species of Sapindales, Zygophyllales, and Brassicales, which is consistent with the identification of other plant remains in the Tianluoshan site and the common rice field weeds such as mustards in southern China. | FAN LongJiang GUI YiJie ZHENG YunFei WANG Yu CAI DaGuang YOU XiuLing | 2011 | Chinese Science Bulletin2011，56，28： | 2 |
| 5 | Progress in reaserch and application of perovskite composite oxide 显示文摘 | Li Daguang Zhang Hongyi Zhang Hefeng | 2006 | Mater Rev2006，，： | 1 |
| 6 | Sporamin-mediated resistance to beet cyst nematodes (Heterodera schachtii Schm.) is dependent on trypsin inhibitory activity in sugar beet (Beta vulgaris L.) hairy roots显示文摘 | Daguang Cai Tim Thurau Yanyan Tian Tina Lange Kai-Wun Yeh Christian Jung | 2003 | Plant Molecular Biology2003，，6： | 1 |
| 7 | Engineering nematode resistance in crop species显示文摘 | Christian Jung Daguang Cai Michael Kleine | 1998 | Trends in Plant Science1998，，7： | 1 |
| 8 | 显示文摘 | Zhang Daguang Zhou Youhe | 2008 | Computational Mate- rials Science2008，44，： | 1 |
| 9 | The promoter of the nematode resistance gene Hs1 pro?1 activates a nematode-responsive and feeding site-specific gene expression in sugar beet ( Beta vulgaris L.) and Arabidopsis thaliana显示文摘 | Tim Thurau Sirak Kifle Christian Jung Daguang Cai | 2003 | Plant Molecular Biology2003，，3： | 1 |
| 10 | An Study of Smelting Reduction between V-Ti Slag System and Carbon Saturated Molten Iron显示文摘 | Tu Shiwei Wang Daguang Xuan Demao | 1989 | Iron Steel Vanadium Titanium1989，10，2： | 1 |
| 11 | The Physical Chemistry Action of Vanadium between Slag and Iron Photographs in the Condition of Slag contenting Vanadium Oxide Returning to Blast Furnace显示文摘 | Wang Daguang Xia Anwu | 1980 | Engineering Chemistry & Metallurgy1980，1，2： | 1 |
| 12 | Molecular markers for genic male sterility in Chinese cabbage显示文摘 | Miao Ying Felix Dreyer Daguang Cai | 2003 | Euphytica2003，132，： | 1 |
| 13 | High-resolution mapping of YACs and the single-copy gene Hs1pro?1 on Beta vulgaris chromosomes by multi-colour fluorescence in situ hybridization显示文摘 | Christine Desel Christian Jung Daguang Cai Michael Kleine Thomas Schmidt | 2001 | Plant Molecular Biology2001，，1： | 1 |
| 14 | Effects of brain-derived neurotrophic factor on synapsin expression in rat spinal cord anterior horn neurons cultured in vitro显示文摘Brain-derived neurotrophic factor (BDNF) promotes synaptic formation and functional maturation by upregulating synapsin expression in cortical and hippocampal neurons. However, it remains controversial whether BDNF affects synapsin expression in spinal cord anterior horn neurons. Wistar rat spinal cord anterior horn neurons were cultured in serum-supplemented medium containing BDNF, BDNF antibody, and Hank's solution for 3 days, and then synapsin I and synaptophysin protein and mRNA expression was detected. Under serum-supplemented conditions, the number of surviving neurons in the spinal cord anterior horn was similar among BDNF, anti-BDNF, and control groups (P > 0.05). Synapsin I and synaptophysin protein and mRNA expressions were increased in BDNF-treated neurons, but decreased in BDNF antibody-treated neurons (P < 0.01). These results indicated that BDNF significantly promotes synapsin I and synaptophysin expression in in vitro-cultured rat spinal cord anterior horn neurons. | Zhifei Wang Daguang Liao Changqi Li | 2010 | Neural Regeneration Research2010，5，16： | 1 |
| 15 | Cloning and characterization of novel PDE4D isoforms PDE4D6 and PDE4D7 显示文摘 | Daguang Wang Chengjun Deng Bozena Bugaj-Gaweda | 2003 | Cellular Signalling2003，15，： | 1 |
| 16 | Survey and Study on Combustion Performance of W-Flame Double Arch Boiler显示文摘By the end of 1997, totally ten 300 MW grade W-flame double arch boilers, firing anthracite or meager coal, were operating in China. These W-flame boilers were designed and supplied separately by four different manufacturers in the world, using either their own technology or foreign patent. It is shown by a recent survey that all these boilers are having a normal operation. However, there is still some room to be improved, such as boiler furnace configuration. Also, for raising the burnout rate and avoiding local slagging, furnace volume and burner layout need to be deliberated. And the tineness of pulverized coal and the air / coal ratio need to be improved. Some suggestions are made in this paper for optimizing the boiler design, Test data for the minimum stable combustion load and NOx emission are given too. | Yuan Ying Xiang Daguang (Thermal Power Research Institute State Power Corporation of China) | 2000 | Electricity2000，，1： | 1 |
| 17 | Identification and molecular cloning of putative odorant-binding proteins and Chemosensory protein from the hethylid wasp,Scleroderma guani Xiao et Wu显示文摘 | Lu Daguang Li Xiangrui Liu Xiaoxia | 2007 | Journal of Chemical Ecology2007，33，： | 1 |
| 18 | Influence of activation temperature on the properties of polyacrylonitrile-based activated carbon hollow fiber 显示文摘 | Yang Mingehien Yu Daguang | 1998 | Journal of Applied Polymer Science1998，68，8： | 1 |
| 19 | Novel multifunctional theranostic nanoagents based on Ho^(3+) for CT/MRI dual-modality imaging-guided photothermal therapy显示文摘Because of the intrinsic defects of traditional treatment of cancer,it is quite needed to construct novel theranostic nanoagents that can not only improve the accuracy of imaging diagnosis but also achieve highly efficient therapy of cancer.Herein,we fabricated polydopamine-functionalized ammonium holmium fluoride nanocomposites(AHF@PDA)for dual-modality bioimaging(magnetic resonance imaging(MRI)and computed tomography(CT))owing to the high X-ray attenuation feature and magnetic property of Ho^(3+).Moreover,PDA shell endows AHF@PDA with excellent photothermal conversion performances and robust biocompatibility,leading to good treatment effect in vitro and in vivo.All above positive results certify that AHF@PDA have good potential as theranostic agents for clinical application in the future. | Dongzhi Xue Yang Liu Longhai Jin Yinghui Wang Fengzhi Cui Jianhua Liu Xiaoqing Li Songtao Zhang Ying Zhao Na Yin Rui Niu Daguang Wang Hongjie Zhang | 2021 | Science China Chemistry2021，64，4： | 1 |
| 20 | Engineering CeO_(2)/CuO heterostructure anchored on upconversion nanoparticles with boosting ROS generation-primed apoptosisferroptosis for cancer dynamic therapy显示文摘Highly toxic reactive oxygen species(ROS)induced apoptosis and ferroptosis have been considered as significant cell death pathways for cancer therapy.However,insufficient amount of intracellular ROS extremely restricts the therapeutic effect.Toward this,we report a rationally designed nanocomposite(mUCC)with enhanced ROS generation ability,inducing the combination of apoptosis and ferroptosis through synergistic photodynamic therapy(PDT)and chemodynamic therapy(CDT).Under 808 nm near-infrared(NIR)light irradiation,photocatalytic reaction is triggered starting from the separation of electron-hole pairs on the surface of heterojunction(CeO_(2)/CuO),realizing improved ROS production.Simultaneously,mUCC served as Fenton-like agent exhibits considerable ability to generate highly toxic·OH under tumor microenvironment(TME).The boosted accumulation of ROS disrupts the redox balance within tumor cells and results in the integration of apoptosis and ferroptosis.In addition,mUCC shows satisfactory tumor targeting property benefiting from the cancer cell membrane functionalization under the guidance of magnetic resonance imaging(MRI)and NIR fluorescence imaging.The intelligent mUCC with good biocompatibility and excellent antitumor response achieves efficient tumor elimination under synergistic PDT and CDT.This work offers an elective approach for further development of ROS-based therapeutic nanoplatform in cancer therapy. | Xuan Gao Jing Feng Kehong Lv Yifei Zhou Ruohao Zhang Shuyan Song Hongjie Zhang Daguang Wang | 2023 | Nano Research2023，16，4： | 1 |
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