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| 1 | Association of serum concentration of organochlorine pesticides with dietary intake and other lifestyle factors among urban Chinese women显示文摘 | Dai Q Zheng W | 2007 | Environment International2007，33，2： | 1 |
| 2 | MicroRNA, immunoregulation, a new paradigm for inflammation, and autoimmune diseases显示文摘 | Dai R Ahmed understanding SA | 2011 | Translat Res2011，157，4： | 1 |
| 3 | Stromal Antiapoptotic Paracrine Loop in Perineural Invasion of Prostatic Carcinoma 显示文摘 | Ayala GE Dai H Tahir SA | 2006 | Cancer Res2006，66，10： | 1 |
| 4 | microRNA, a new paradigm for understanding immunoregnlation, inflammation, and autoimmune diseases 显示文摘 | Dai R Ahmed SA | 2011 | Transl Res2011，157，4： | 1 |
| 5 | MicroRNA,a new paradigm for understanding immunoregulation,inflammation and autoimmune diseases显示文摘 | Dai R Ahmed SA | 2011 | Transl Res2011，157，4： | 1 |
| 6 | MicroRNA,a new paradigm for understanding immunoregulation,inflammation,and autoimmune diseases显示文摘 | Dai R Ahmed SA | | 0，，： | 1 |
| 7 | Suppression of LPS-induced interferon-gamma and nitric oxide in splenic lymphocytes by select estrogen-regulated microRNAs: A novel mechanism of immune modulation 显示文摘 | Dai R Phillips RA Zhang Y Khan D Crasta O Ahmed SA | 2008 | Blood2008，112，12： | 1 |
| 8 | New Gene Variants Associated with the Risk of Chronic HBV Infection显示文摘Some patients with chronic hepatitis B virus(HBV)infection failed to clear HBV,even persistently continue to produce antibodies to HBV.Here we performed a two stage genome wide association study in a cohort of Chinese patients designed to discover single nucleotide variants that associate with HBV infection and clearance of HBV.The first stage involved genome wide exome sequencing of 101 cases(HBsAg plus anti-HBs positive)compared with 102 control patients(antiHBs positive,HBsAg negative).Over 80%of individual sequences displayed 209 sequence coverage.Adapters,uncertain bases[10%or low-quality base calls([50%)were filtered and compared to the human reference genome hg19.In the second stage,579 chronic HBV infected cases and 439 HBV clearance controls were sequenced with selected genes from the first stage.Although there were no significant associated gene variants in the first stage,two significant gene associations were discovered when the two stages were assessed in a combined analysis.One association showed rs506121-“T”allele[within the dedicator of cytokinesis 8(DOCK8)gene]was higher in chronic HBV infection group than that in clearance group(P=0.002,OR=0.77,95%CI[0.65,0.91]).The second association involved rs2071676—A allele within the Carbonic anhydrase(CA9)gene that was significantly elevated in chronic HBV infection group compared to the clearance group(P=0.0003,OR=1.35,95%CI[1.15,1.58]).Upon replication these gene associations would suggest the influence of DOCK8 and CA9 as potential risk genetic factors in the persistence of HBV infection. | Mengjie Fan Jing Wang Sa Wang Tengyan Li Hong Pan Hankui Liu Huifang Xu Daria V.Zhernakova Stephen J.O’Brien Zhenru Feng Le Chang Erhei Dai Jianhua Lu Hongli Xi Yanyan Yu Jianguo Zhang Binbin Wang Zheng Zeng | 2020 | Virologica Sinica2020，35，4： | 1 |
| 9 | Summary of the 7th international workshop on spallation materials technology 显示文摘 | Dai Y Mansur LK Maloy SA | 2006 | Journal of Nuclear Materials [ISSN 0022-3115]2006，356，13： | 1 |
| 10 | Polyurethane elasto-mers through multi-hydrogen-bonded association of den- dritic structures 显示文摘 | Chen CP Dai SA Chang HL | 2005 | Polymer2005，46，11： | 1 |
| 11 | MicroRNA,a new paradigm for understandingimmunoregulation,inflammation,and autoimmune diseases 显示文摘 | Dai K Ahmed SA | 2011 | Transl Res2011，157，4： | 1 |
| 12 | MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases 显示文摘 | Dai R Ahmed SA | 2011 | Transl Res2011，157，4： | 1 |
| 13 | MicroRNA, a new para- digm for understanding immunoregulation, inflammation, and autoimmune diseases 显示文摘 | Dai R Ahmed SA | 2011 | Transl Res2011，157，4： | 1 |
| 14 | Stromal antiapoptotic paracrine loop in perineural invasion of prostatic carcinoma显示文摘 | Ayala GE Dai H Tahir SA | 2006 | Cancer Res2006，66，10： | 1 |
| 15 | MieroRNA, a new paradigm for understanding immunoregulatian, inflammation, and autoimmune diseases 显示文摘 | Dai R Ahmed SA | 2011 | Transl Res2011，157，4： | 1 |
| 16 | IL-15 as memory T-cell adjuvant for topical HIV-1 DermaVir vaccine 显示文摘 | Calarota SA Dai AL Trocio JN | 2008 | Vaccine2008，3，67： | 1 |
| 17 | MicroRNA,a new paradigm for understanding immunoregulation,inflammation,and autoimmune diseases显示文摘 | Dai R Ahmed SA | 2011 | Transl Res2011，157，4： | 1 |
| 18 | MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases显示文摘 | Dai R Ahmed SA | 2011 | Transl Res2011，157，4： | 1 |
| 19 | Evaluation of an ischemic model in ischemia prone and general Mongolian gerbils by neurological symptom, injury,and sex difference显示文摘Background: In the previous study, we established an ischemia-prone gerbil population(IG), which was selectively bred to increase the incidence of unilateral carotid arterial occlusion(UCO)-induced ischemia in Mongolian gerbils. However, if the characteristics of ischemia model in IG are the same as those in general gerbils(GG), and if the neurological symptoms are associated with the neurological insults in IG is still unclear.Methods: In the present study, we evaluated the UCO model in IG by analyzing neurological symptoms, neurological injury in the hippocampal CA1 region and compared with GG.Results: The data showed that the ratios of neurological symptom scores ≥ 2 in the IG and GG groups were 65.0% vs 30.0%, respectively, and were significantly different(P <.01).The neuronal damage following a UCO ischemic insult in the IG group was more severe compared to the GG group. There was a high correlation between the neurological insults' scale and the neurological symptom score in the IG and GG groups(r =.979 and.943 in the IG and GG groups, respectively). In animals with mild neurological symptom scores(2 and 3), the neuronal insults were significantly different between female and male gerbils in both IG and GG.Conclusion: Our findings suggest that IG population would likely be more advantageous to establish an ischemic model. | Xiao-yan Du Chang-long Li Meng Guo Ying Wang Hong-gang Guo Fang-wei Dai Xiao-ying Sa Zhen-wen Chen | 2018 | Animal Models and Experimental Medicine2018，1，1： | 0 |
| 20 | One hundred and ninety-two weeks treatment of entecavir maleate for Chinese chronic hepatitis B predominantly genotyped B or C显示文摘BACKGROUND Entecavir(ETV)is a potent and selective nucleotide analog with significant activity against hepatitis B virus(HBV).ETV maleate is a derivative compound of ETV and was reported to have an efficacy and safety profile that is comparable to ETV(Baraclude)when used in Chinese patients with chronic hepatitis B(CHB)in phase III clinical trials(Clinical Trials.gov number,NCT-01926288)at weeks 48,96,and 144.AIM To investigate the antiviral potency and safety of ETV maleate at week 192 in Chinese CHB patients predominantly genotyped B or C.METHODS In this double-blind study,we randomly assigned patients to receive 0.5 mg/d ETV(Group A)or ETV maleate(Group B)(ratio,1:1),each with a placebo tablet for 48 wk.Then,all patients received open-label treatment with 0.5 mg/d ETV maleate starting at week 49.The primary efficacy endpoint was the reduction in HBV DNA levels from baseline.Secondary endpoints included the proportion of patients with undetectable HBV DNA(<20 IU/m L),serologic response,serum alanine aminotransferase(ALT)normalization and development of resistance mutations.RESULTS Two hundred eighteen patients who were hepatitis B e antigen(HBe Ag)positive and 57 who were HBe Ag negative were analyzed and predominantly presented with genotype B(49.82%)or C(48.73%).For the HBe Ag-positive CHB patients,the mean HBV DNA level decrease(6.61 Log10 IU/m L vs 6.69 Log10 IU/m L,P>0.05),viral suppression with HBV DNA<20 IU/m L(83.33%vs 79.17%,P>0.05)and HBe Ag seroconversion(28.77%vs 20.00%,P>0.05)occurred similarly between Groups A and B at week 192.However,there was a significant difference in the proportion of patients with normal ALT levels(91.14%vs 78.38%,P<0.05).For the HBe Ag-negative CHB patients,no significant difference was found between Groups A and B at week 192 in terms of reductions in HBV DNA levels from baseline(6.05 Log10 IU/m L vs 6.03 Log10 IU/m L,P>0.05),percentages of patients who achieved undetectable HBV DNA(100%vs 100%,P>0.05)and rates of ALT normalization(95.65%vs 100.00%,P>0.05).Safety and adverse event profiles were similar between Groups A and B.Two HBe Ag-positive patients in Group A and 5 in Group B developed genotypic resistance to ETV.CONCLUSION Long-term ETV maleate treatment for up to 192 wk is effective and safe in Chinese CHB patients predominantly genotyped as B or C. | Jing-Hang Xu Sa Wang Da-Zhi Zhang Yan-Yan Yu Chong-Wen Si Zheng Zeng Zhong-Nan Xu Jun Li Qing Mao Hong Tang Ji-Fang Sheng Xin-Yue Chen Qin Ning Guang-Feng Shi Qing Xie Xi-Quan Zhang Jun Dai | 2022 | World Journal of Clinical Cases2022，10，28： | 0 |
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