| 1 | Parthenolide increases the sensitivity of gastric cancer cells to chemotherapy显示文摘OBJECTIVE:To investigate the effect of parthenolide(PTL),a sesquiterpene lactone medicinal compound,on the sensitivity of the gastric cancer cell line SGC7901 and the DPP-and ADR-resistant sublines SGC7901/DDP and SGC7901/ADR to cisplatin[diamminedichloroplatinum(Ⅱ),DDP]and adriamycin(ADR)in vitro.METHODS:SGC7901,SGC7901/DDP,and SGC7901/ADR were treated with various concentrations of PTL alone or in combination with DDP or ADR.The effects on cell proliferation,apoptosis,and expression/activity of several proliferation/apoptosis-related proteins[B-cell lymphoma-2(Bcl-2),cyclin D1,nuclear factor-kappa B(NF-κB),and Caspase-8]and drug transporters(P-glycoprotein and multidrug resistance protein-1)were measured using flow cytometry,Western blotting,and in vitro activity assays.RESULTS:Treatment of SGC7901 cells with PTL inhibited cell growth,increased apoptosis,and sensitized the cells to DPP.Mechanistically,PTL treatment resulted in downregulation of NF-κB activity and Bcl-2 expression,and upregulation of Caspase-8 activity.Similarly,PTL co-treatment of SGC7901/DDP and SGC7901/ADR overcame their resistance to DDP and ADR,respectively,with concomitant inhibition of NF-κB,Bcl-2,Cyclin D1,P-glycoprotein,and multidrug resistance protein-1 expression and/or activity.CONCLUSION:PTL treatment decreases drug resistance in SGC7901,SGC7901/DDP,and SGC7901/ADR cells,as reflected by induction of apoptosis,inhibition of proliferation,downregulation of pro-survival and drug resistance pathways,and upregulation of pro-apoptotic pathways.Our results suggest that co-treatment with PTL may thus complement existing therapies for gastric cancer. | Liu Minghua Yang Ying Liu Dajun Cao Ye Li Yan | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 5 |
| 4 | Shipborne oceanic high-spectral-resolution lidar for accurate estimation of seawater depth-resolved optical properties显示文摘Lidar techniques present a distinctive ability to resolve vertical structure of optical properties within the upper water column at both day-and night-time.However,accuracy challenges remain for existing lidar instruments due to the ill-posed nature of elastic backscatter lidar retrievals and multiple scattering.Here we demonstrate the high performance of,to the best of our knowledge,the first shipborne oceanic high-spectral-resolution lidar(HSRL)and illustrate a multiple scattering correction algorithm to rigorously address the above challenges in estimating the depth-resolved diffuse attenuation coefficient Kd and the particulate backscattering coefficient bbp at 532 nm.HSRL data were collected during day-and night-time within the coastal areas of East China Sea and South China Sea,which are connected by the Taiwan Strait.Results include vertical profiles from open ocean waters to moderate turbid waters and first lidar continuous observation of diel vertical distribution of thin layers at a fixed station.The root-mean-square relative differences between the HSRL and coincident in situ measurements are 5.6%and 9.1%for Kd and bbp,respectively,corresponding to an improvement of 2.7-13.5 and 4.9-44.1 times,respectively,with respect to elastic backscatter lidar methods.Shipborne oceanic HSRLs with high performance are expected to be of paramount importance for the construction of 3D map of ocean ecosystem. | Yudi Zhou Yang Chen Hongkai Zhao Cedric Jamet Davide Dionisi Malik Chami Paolo Di Grolamo James H.Churnside Aleksey Malinka Huade Zhao Dajun Qiu Tingwei Cui Qun Liu Yatong Chen Sornsiri Phongphattarawat Nanchao Wang Sijie Chen Peng Chen Ziwei Yao Chengfeng Le Yuting Tao Peituo Xu Xiaobin Wang Binyu Wang Feitong Chen Chuang Ye Kai Zhang Chong Liu Dong Liu | 2022 | Light(Science & Applications)2022，11，10： | 0 |
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