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| 1 | Buyang Huanwu Decoction fraction protects against cerebral ischemia/reperfusion injury by attenuating the inflammatory response and cellular apoptosis显示文摘Buyang Huanwu Decoction fraction extracted from Buyang Huanwu Decoction contains saponins of Astragalus, total paeony glycoside and safflower flavones. The aim of this study was to demonstrate the neuroprotective effect and mechanism of Buyang Huanwu Decoction fraction on ischemic injury both in vivo and in vitro. In vivo experiments showed that 50-200 mg/kg Buyang Huanwu Decoction fraction reduced infarct volume and pathological injury in ischemia/reperfusion rats, markedly inhibited expression of nuclear factor-κB and tumor necrosis factor-α and promoted nestin protein expression in brain tissue. Buyang Huanwu Decoction fraction (200 mg/kg) exhibited significant effects, which were similar to those of 100 mg/kg Ginkgo biloba extract. In vitro experimental results demonstrated that 10-100 mg/L Buyang Huanwu Decoction fraction significantly improved cell viability, decreased the release of lactate dehydrogenase and malondialdehyde levels, and inhibited the rate of apoptosis in HT22 cells following oxygen-glucose deprivation. Buyang Huanwu Decoction fraction (100 mg/L) exhibited significant effects, which were similar to those of 100 mg/L Ginkgo biloba extract. These findings suggest that Buyang Huanwu Decoction fraction may represent a novel, protective strategy against cerebral ischemia/reperfusion injury in rats and oxygen-glucose deprivation-induced damage in HT22 cells in vitro by attenuating the inflammatory response and cellular apoptosis. | Yulian Jin Liuyi Dong Changqing Wu Jiang Qin Sheng Li Chunyan Wang Xu Shao Dake Huang | 2013 | Neural Regeneration Research2013，8，3： | 11 |
| 2 | Enhanced antibacterial behavior of a novel Cu-bearing high-entropy alloy显示文摘Contact infection of bacteria and viruses has been a critical threat to human health. The worldwideoutbreak of COVID-19 put forward urgent requirements for the research and development of the selfantibacterial materials, especially the antibacterial alloys. Based on the concept of high-entropy alloys, thepresent work designed and prepared a novel Co_(0.4)FeCr_(0.9)Cu_(0.3) antibacterial high-entropy alloy with superior antibacterial properties without intricate or rigorous annealing processes, which outperform the antibacterial stainless steels. The antibacterial tests presented a 99.97% antibacterial rate against Escherichiacoli and a 99.96% antibacterial rate against Staphylococcus aureus after 24 h. In contrast, the classic antibacterial copper-bearing stainless steel only performed the 71.50% and 80.84% antibacterial rate, respectively. The results of the reactive oxygen species analysis indicated that the copper ion release and theimmediate contact with copper-rich phase had a synergistic effect in enhancing antibacterial properties.Moreover, this alloy exhibited excellent corrosion resistance when compared with the classic antibacterialstainless steels, and the compression test indicated the yield strength of the alloy was 1015 MPa. Thesefindings generate fresh insights into guiding the designs of structure-function-integrated antibacterial alloys. | Guangyu Ren Lili Huang Kunling Hu Tianxin Li Yiping Lu Dongxu Qiao Haitao Zhang Dake Xu Tongmin Wang Tingju Li Peter K.Liaw | 2022 | Journal of Materials Science & Technology2022，，22： | 6 |
| 3 | Novel vertical channel double gate structures for high density and low power flash memory applications显示文摘The flash memory technology meets physical and technical obstacles in further scaling. New structures and new materials are implemented as possible solutions. This paper focuses on two kinds of new flash cells for high density and low power memory applications based on the vertical channel double gate structure. The proposed VD-NROM with dual-nitride-trapping-layer and vertical structure can achieve four-bit-per-cell storage capability. And the proposed VSAS-FG cell benefits the high programming efficiency, low power and high density capability, which can be realized without any additional mask and can achieve the self-alignment of the split-gate channel and the floating-gate. The two novel flash cell structures can be considered as potential candidates for different flash memory applications. | HUANG Ru ZHOU FaLong CAI YiMao WU DaKe ZHANG Xing | 2008 | Science in China(Series F)2008，51，6： | 2 |
| 4 | Effects of flavonoids derived from Taxus yunnanensis on p-glycoprotein and cytochrome P450 3A4显示文摘The intestinal uptake of paclitaxel is hampered by trans-membrane efflux transporters such as P-glycoprotein(P-gp),and paclitaxel is mainly metabolized by cytochrome P4503A4(CYP3A4)presented in the liver.Our previous results demonstrated that flavonoids extracted from Taxus yunnanensis could improve the oral absorption of paclitaxel.The current study was purposed to investigate the effects of the flavonoid extracts on P-gp and CYP3A4 in vitro.The expression and activity of P-gp were detected by western blotting and intracellular rhodamine 123 accumulation assay in Caco-2 cells treated with the flavonoids extract.The expression of CYP3A4 was investigated by western blotting in mouse primary hepatocytes and the activity of CYP3A4 was detected by LC-MS/MS method using rat liver microsomes.Our results showed that the flavonoid extracts from T.yunnanensis could inhibit P-gp activity and concurrently decrease the expression and activity of CYP3A4.In conclusion,activity of P-gp and CYP3A4 could be inhibited by flavonoids extracted from T.yunnanensis which might be potential candidates for development of oral formulation of paclitaxel. | Jifu Li Dake Cai Huichang Bi Jing Jin Min Huang | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，3： | 2 |
| 5 | Investigation of melt-growth alumina/aluminum titanate composite ceramics prepared by directed energy deposition显示文摘Al_(2)O_(3)/Al_(6)Ti_(2)O_(13) composite ceramics with low thermal expansion properties are promising for the rapid preparation of large-scale and complex components by directed energy deposition-laser based(DED-LB)technology.However,the wider application of DED-LB technology is limited due to the inadequate understanding of process conditions.The shaping quality,microstructure,and mechanical properties of Al_(2)O_(3)/Al_(6)Ti_(2)O_(13)(6 mol%TiO_(2))composite ceramics were systematically investigated as a function of energy input in an extensive process window.On this basis,the formation mechanism of solidification defects and the evolution process of microstructure were revealed,and the optimized process parameters were determined.Results show that high energy input improves the fluidity of the molten pool and promotes the uniform distribution and full growth of constituent phases,thus,facilitating the elimination of solidification defects,such as pores and strip gaps.In addition,the microstructure size is strongly dependent on the energy input,increasing when the energy input increases.Moreover,the morphology of theα-Al_(2)O_(3) phase gradually transforms from cellular into cellular dendrite with increasing energy input due to changing solidification conditions.Under the comprehensive influence of solidification defects and microstructure size,the fracture toughness and flexural strength of Al_(2)O_(3)/Al_(6)Ti_(2)O_(13) composite ceramics present a parabolic law behavior as the energy input increases.Optimal shaping quality and excellent mechanical properties are achieved at an energy input range of 0.36-0.54 W*min^(2) g^(-1) mm^(-1).Within this process window,the average microhardness,fracture toughness,and flexural strength of Al_(2)O_(3)/Al_(6)Ti_(2)O_(13) composite ceramics are up to 1640 Hv,3.87 MPa m^(1/2),and 227 MPa,respectively.This study provides practical guidance for determining the process parameters of DED-LB of melt growth Al_(2)O_(3)/Al_(6)Ti_(2)O_(13) composite ceramics. | Yunfei Huang Dongjiang Wu Dake Zhao Fangyong Niu Guangyi Ma | 2021 | International Journal of Extreme Manufacturing2021，3，3： | 2 |
| 6 | mTOR regulate EMT through RhoA and Rac1 pathway in prostate cancer显示文摘 | XianGuo Chen HaiYan Cheng TengFei Pan Yi Liu Yang Su CuiPing Ren DaKe Huang XiaoJun Zha ChaoZhao Liang | 2015 | Mol. Carcinog2015，，10： | 1 |
| 7 | The expression of vascular endothelial growth factor in mast cells promotes the neovascularisation of human pterygia显示文摘 | Kun Liang Zhengxuan Jiang Bingying Zhao Jijia Shen Dake Huang Liming Tao | 2012 | British Journal of Ophthalmology2012，，9： | 1 |
| 8 | The expression of vascular endothelial growth factor in mast cells promotes the neovascularisation of human pterygia显示文摘 | Kun Liang Zhengxuan Jiang Bingying Zhao Jijia Shen Dake Huang Liming Tao | 2012 | British Journal of Ophthalmology2012，，9： | 1 |
| 9 | Tropical Pacific trends under global warming: El Nio-like or La Nia-like?显示文摘Many state-of-the-art climate models project that the tropical Pacific sea surface temperature (SST) response to the greenhouse gas (GHG) forcing would be an ‘El Nino-like’ pattern. | Tao Lian Dake Chen Jun Ying Ping Huang Youmin Tang | 2018 | National Science Review2018，5，6： | 1 |
| 10 | Correlation between 18F-FDG uptake and the expression of glucose transporter-1 and hypoxia-inducible factor-1α in transplanted VX2 tumors显示文摘 | Huiqin Xu Biao Li Wenjing Yu Hui Wang Xuefeng Zhao Yuanchun Yao Dake Huang | 2013 | Nuclear Medicine Communications2013，，10： | 1 |
| 11 | Protective effects of astragalosides on dexamethasone and Aβ25-35induced learning and memory impairments due to decrease amyloid precursor protein expression in 12-month male rats显示文摘 | Li Weizu Wu Wangyang Huang Dake | 2012 | Food and Chemical Toxicology2012，50，6： | 1 |
| 12 | Biofilm inhibition and corrosion resistance of 2205-Cu duplex stainless steel against acid producing bacterium Acetobacter aceti显示文摘Acid producing bacterium Acetobacter aceti causes pitting corrosion of stainless steel(SS).This work investigated the enhanced resistance of 2205-Cu duplex stainless steel(DSS)against biocorrosion by A.aceti in comparison with 2205 DSS using electrochemical and surface analysis techniques.With the addition of Cu to 2205 DSS,biofilms on the 2205-Cu DSS surface were inhibited effectively.The largest pit depth on 2205-Cu DSS surface in the presence of A aceti was 2.6μm,smaller than 5.5μm for 2205 DSS surface.The i(corr)was 0.42±0.03μA cm^-2 for 2205-Cu DSS in the biotic medium,which was much lower than that for 2205 DSS(3.69±0.65μA cm^-2).All the results indicated that the A aceti biofilm was considerably inhibited by the release of Cu^2+ions from the 2205-Cu DSS matrix,resulting in the mitigation of biocorrosion by A aceti. | Dan Liu Ru Jia Dake Xu Hongying Yang Ying Zhao Msaleem Khan Songtao Huang Jiankang Wen Ke Yang Tingyue Gug | 2019 | Journal of Materials Science & Technology2019，35，11： | 0 |
| 13 | Multi-omics analysis reveals the evolutionary origin of diterpenoid alkaloid biosynthesis pathways in Aconitum显示文摘Diterpenoid alkaloids(DAs) have been often utilized in clinical practice due to their analgesic and anti-infammatory properties. Natural DAs are prevalent in the family Ranunculaceae, notably in the Aconitum genus. Nevertheless, the evolutionary origin of the biosynthesis pathway responsible for DA production remains unknown.In this study, we successfully assembled a highquality, pseudochromosome-level genome of the DA-rich species Aconitum vilmorinianum(A.vilmorinianum)(5.76 Gb). An A. vilmorinianumspecific whole-genome duplication event was discovered using comparative genomic analysis,which may aid in the evolution of the DA biosynthesis pathway. We identified several genes involved in DA biosynthesis via integrated genomic, transcriptomic, and metabolomic analyses. These genes included enzymes encoding target ent-kaurene oxidases and aminotransferases, which facilitated the activation of diterpenes and insertion of nitrogen atoms into diterpene skeletons, thereby mediating the transformation of diterpenes into DAs. The divergence periods of these genes in A. vilmorinianum were further assessed, and it was shown that two major types of genes were involved in the establishment of the DA biosynthesis pathway. Our integrated analysis offers fresh insights into the evolutionary origin of DAs in A.vilmorinianum as well as suggestions for engineering the biosynthetic pathways to obtain desired DAs. | Dake Zhao Ya Zhang Huanxing Ren Yana Shi Ding Dong Zonghang Li Guanghong Cui Yong Shen Zongmin Mou Edward JKennelly Luqi Huang Jue Ruan Suiyun Chen Diqiu Yu Yupeng Cun | 2023 | Journal of Integrative Plant Biology2023，65，10： | 0 |
| 14 | Single-cell technologies:From research to application显示文摘In recent years,more and more single-cell technologies have been developed.A vast amount of single-cell omics data has been generated by large projects,such as the Human Cell Atlas,the Mouse Cell Atlas,the Mouse RNA Atlas,the Mouse ATAC Atlas,and the Plant Cell Atlas.Based on these single-cell big data,thousands of bioinformatics algorithms for quality control,clustering,cell-type annotation,developmental inference,cell-cell transition,cell-cell interaction,and spatial analysis are developed.With powerful experimental single-cell technology and state-of-the-art big data analysis methods based on artificial intelligence,the molecular landscape at the single-cell level can be revealed. | Lu Wen Guoqiang Li Tao Huang Wei Geng Hao Pei Jialiang Yang Miao Zhu Pengfei Zhang Rui Hou Geng Tian Wentao Su Jian Chen Dake Zhang Pingan Zhu Wei Zhang Xiuxin Zhang Ning Zhang Yunlong Zhao Xin Cao Guangdun Peng Xianwen Ren Nan Jiang Caihuan Tian Zi-Jiang Chen | 2022 | The Innovation2022，3，6： | 0 |
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