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| 1 | The reversal of antineoplastic drug resistance in cancer cells by B-elemene显示文摘Multidrug resistance(MDR), deined as the resistance of cancer cells to compounds with diverse structures and mechanisms of actions, signiicantly limits the eicacy of antitumor drugs. A major mechanism that mediates MDR in cancer is the overexpression of adenosine triphosphate(ATP)?binding cassette transporters. These transporters bind to their respective substrates and catalyze their elux from cancer cells, thereby lowering the intracellular concentra?tions of the substrates and thus attenuating or even abolishing their eicacy. In addition, cancer cells can become resistant to drugs via mechanisms that attenuate apoptosis and cell cycle arrest such as alterations in the p53, check point kinase, nuclear factor kappa B, and the p38 mitogen?activated protein kinase pathway. In this review, we discuss the mechanisms by which β?elemene, a compound extracted from Rhizoma zedoariae that has clinical antitumor eicacy, overcomes drug resistance in cancer. | Guan-Nan Zhang Charles R.Ashby Jr. Yun-Kai Zhang Zhe-Sheng Chen Huiqin Guo | 2015 | Chinese Journal of Cancer2015，34，11： | 9 |
| 2 | Spatial correlation analysis of sea-bottom backscattering显示文摘The principle of the spatial correlation characteristics of sea-bottom backscattering was expounded.The Kirchhoff model is introduced to simulate sea-bottom backscattering and the spatial correlation is calculated.Some sediment characteristic parameters,such as the ratio of sediment mass density to water mass density,the ratio of sediment sound speed to water sound speed,the attenuation coefficient of sound waves,the strength and exponent of seabottom interface roughness spectrum,are considered while simulating and their influences on spatial correlation are analyzed.By establishing the expressions of the sediment characteristic parameters with the logarithmic sediment grain size,the variation tendency of the spatial correlation versus the logarithmic sediment grain size is obtained.The width of the major lobe of the spatial correlation function narrows as the logarithmic sediment grain size increases.The comparisons between simulated data and in-situ data collected in October 2007 have proven that their spatial correlation function waveforms agree well under the same sediment characteristics. | KUAI Duojie WANG Changhong FENG Lei WANG Yuling QIU Wei YI Huiqin CHEN Long | 2012 | Chinese Journal of Acoustics2012，31，3： | 9 |
| 3 | MIMO free space optical communication based on orthogonal space time block code显示文摘An appropriate coding method that can reduce the error rate of communication system is especially important to the free space optical communication. STBC (space-time block code) is an orthogonal encoding method integrating space domain and time domain. The technology can combat fading effectively and improve error rate performance. In this paper, first, an STBC fit for optical communication with intensity modulation and direct detection (IM/DD) is proposed by combining the orthogonality of the Alamouti space-time code and the QPPM modulation. Then, the error rate performance of the system is analyzed under four cases: with or without channel fading, with or without background radiation. At last, this scheme is confirmed by Monte Carlo approach. It is shown that this method not only realizes the full speed rate transmission, and can improve the error rate performance of the system effectively, but also overcomes the scintillation effect exerted by atmosphere turbulence. When the symbol error probability (SEP) is 2×10-3, according to the 1× 1 system, the sending power of the 2×1 system is nearly reduced by 3.5 dBJ, and the 2×2 system is nearly reduced by 9 dBJ. | WANG HuiQin KE XiZheng ZHAO Li | 2009 | Science in China(Series F)2009，52，8： | 7 |
| 4 | Rice OsFLS2-Mediated Perception of Bacterial Flagellins Is Evaded by Xanthomonas oryzae pvs. oryzae and oryzicola显示文摘细菌的 flagellins 被受体 kinase FLAGELLIN SENSITIVE2 (FLS2 ) 经常认出并且在双子叶的植物激活被触发 MAMP 的免疫。然而,单子叶植物的米饭的能力理解糟糕认出关键米饭病原体和它的生物关联遗体的 flagellins。我们证明在 Arabidopsis 的宫外地表示的 OsFLS2 察觉到得到的 flg22 肽和 invitro 净化了 Acidovorax avenae (Aa ) 以一种表示水平依赖者方式的 flagellin,但是不认出净化的 flagellins 或衍生物 flg22 Xanthomonas oryzae pvs 的 Xo 肽。oryzae (Xoo ) 和 oryzicola (Xoc ) 。一致地, flg22 肽和净化的 Aa flagellin,然而并非 Xoo/Xoc flagellins,在米饭导致象防卫基因正式就职和 MAPK 激活那样的各种各样的有免疫力的回答。由米饭的 flagellin 的感觉确实导致强壮的抵抗到 Xoo 感染,在米饭的预告的处理与 Aa flagellin 离开以后,出现。OsFLS2 被发现在它的感觉特性或敏感不同于 AtFLS2 到不同 flg22 序列。另外, Xoc flagellin 的 translational 以后修正被编码 glycosyltransferase rbfC,而是这有的小效果的删除在 Xoc 活动性上改变, rpfC 变化 detectably 没在米饭上减少 Xoc 毒力。从 Xoo/Xoc 的编码 flagellin 警察的删除堵住了游泳活动性而且显著地没改变 Xoo/Xoc 毒力。当在米饭躲避古老的 flagellin 察觉系统时,这些结果建议 Xoo/Xoc 带允许活动性的 flg22 区域氨基酸变化,它为另外的细菌的病原体保留识别能力。 | Shanzhi Wang Zhe Sun Huiqin Wang Lijuan Liu Fen Lu Jun Yang Min Zhang Shiyong Zhang Zejian Guo Andrew F. Bent Wenxian Sun | 2015 | Molecular Plant2015，8，7： | 7 |
| 5 | Delay-dependent Robust Stability Analysis of Power Systems with PID Controller显示文摘This study examines the robust stability of a power system,which is based on proportional-integral-derivative load frequency control and involves uncertain parameters and time delays.The model of the system is firstly established,following which the system is transformed into a closed-loop system with feedback control.On this basis,a new augmented Lyapunov-Krasovskii(LK)functional is established for using the new Bessel-Legendre inequality to estimate the derivative of the functional,which can provide a maximum lower bound.A stability criterion is then derived by employing the LK functional and Bessel-Legendre inequality.Finally,numerical examples are used to demonstrate the validity and superiority of the proposed method. | Li Shen Huiqin Xiao | 2019 | Chinese Journal of Electrical Engineering2019，5，2： | 6 |
| 6 | Intranasal and oral vaccination with protein-based antigens: advantages, challenges and formulation strategies显示文摘大多数病原体在人的 mucosal 表面开始他们的感染。因此, mucosal 种痘,通过特别口头或 intranasal 管理线路,高度为传染疾病被需要。同时,基于蛋白质的抗原提供一种更安全的选择给基于的整个病原体或 DNA 在疫苗的开发的。然而,在他们到达指向,相对低的 immunogenicity ,以及蛋白质抗原的低稳定性的地点以前, intranasally 或口头上地交付了蛋白质疫苗的唯一的 biopharmaceutical 障碍需要克服,要求有头脑、调整的 mucosal 疫苗明确的表达包括 immunostimulants 的选择,合适的疫苗的交货系统的鉴定,和准确作文和生产条件的决心。这评论试图提供蛋白质的新调查基于抗原的疫苗的明确的表达开发,包括 immunostimulants 和为 intranasal 和口头的政府的疫苗的交货系统的优化的用法。 | Shujing Wang Huiqin Liu Xinyi Zhang Feng Qian | 2015 | Protein & Cell2015，6，7： | 6 |
| 7 | Enhancement of innate immune system in monocot rice by transferring the dicotyledonous elongation factor Tu receptor EFR显示文摘The elongation factor Tu(EF-Tu) receptor(EFR) in cruciferous plants specifically recognizes the N-terminal acetylated elf18 region of bacterial EF-Tu and thereby activates plant immunity.It has been demonstrated that Arabidopsis EFR confers broad-spectrum bacterial resistance in the EFR transgenic solanaceous plants.Here,the transgenic rice plants(Oryza sativa L.ssp.japonica cv.Zhonghua 17) and cell cultures with constitutive expression of AtEFR were developed to investigate whether AtEFR senses EF-Tu and thus enhances bacterial resistance in the monocot plants.We demonstrated that the Xanthomonas oryzae-derived elf18 peptide induced oxidative burst and mitogen-activated protein kinase activation in the AtEFR transgenic rice cells and plants,respectively.Pathogenesis-related genes,such as OsPBZ1,were upregulated dramatically in transgenic rice plant and cell lines in response to elf18 stimulation.Importantly,pretreatment with elf18 triggered strong resistance to X.oryzae pv.oryzae in the transgenic plants,which was largely dependent on the AtEFR expression level.These plants also exhibited enhanced resistance to rice bacterial brown stripe,but not to rice fungal blast.Collectively,the results indicate that the rice plants with heterologous expression of AtEFR recognize bacterial EF-Tu and exhibit enhanced broad-spectrum bacterial disease resistance and that pattern recognition receptor-mediated immunity may be manipulated across the two plant classes,dicots and monocots. | Fen Lu Huiqin Wang Shanzhi Wang Wendi Jiang Changlin Shan Bin Li Jun Yang Shiyong Zhang Wenxian Sun | 2015 | Journal of Integrative Plant Biology2015，57，7： | 6 |
| 8 | Hypothesis review:The direct interaction of food nanoparticles with the lymphatic system显示文摘Besides digestion and assimilation,there are other modes of direct interaction between food and human body.As it is known,the mucosal layer of the digestive tract interfaces with food after the digestion process.It has been demonstrated to uptake the micro-and nanoparticles via mucosa-associated lymphatic tissues(MALT).On the other hand,food is a typical polydisperse system and contains micro-and nanoparticles with different sizes and properties.Accordingly,it is hypothesized that food nanoparticles can directly interact with MALT and more specifically with the support of the preliminary experimental data from our research,that antioxidant nanoparticles can interact with the lymphatic vessels.This kind of interaction would be of great physiological importance.The confirmation of the hypothesis will establish a significant and novel approach to understand food system and provide answers to currently incomprehensible phenomena such as the biological functions of phytochemicals with low bioavailability.©2012 Production and hosting by Elsevier B.V.on behalf of Beijing Academy of Food Sciences. | Wei Lu Jingke Guo Jianwu Zhou Lijing Ke Shutao Liu Guanzhen Gao Huiqin Wang Wei Ding Pingfan Rao | 2012 | Food Science and Human Wellness2012，1，1： | 5 |
| 9 | Artificial intelligence and big data facilitated targeted drug discovery显示文摘Different kinds of biological databases publicly available nowadays provide us a goldmine of multidiscipline big data.The Cancer Genome Atlas is a cancer database including detailed information of many patients with cancer.DrugBank is a database including detailed information of approved,investigational and withdrawn drugs,as well as other nutraceutical and metabolite structures.PubChem is a chemical compound database including all commercially available compounds as well as other synthesisable compounds.Protein Data Bank is a crystal structure database including X-ray,cryo-EM and nuclear magnetic resonance protein three-dimensional structures as well as their ligands.On the other hand,artificial intelligence(AI)is playing an important role in the drug discovery progress.The integration of such big data and AI is making a great difference in the discovery of novel targeted drug.In this review,we focus on the currently available advanced methods for the discovery of highly effective lead compounds with great absorption,distribution,metabolism,excretion and toxicity properties. | Benquan Liu Huiqin He Hongyi Luo Tingting Zhang Jingwei Jiang | 2019 | Stroke & Vascular Neurology2019，4，4： | 5 |
| 10 | Effects of volumetric allocation on heave response of semisubmersible in deep sea显示文摘The configuration of semisubmersibles consisting of pontoons and columns and their corresponding heave motion response in incident progressive waves are examined. The purpose of the present study is to provide a theoretical approach to estimating the effects of volumetric allocation on natural period and response amplitude operator (RAO) in heave motion. We conclude that the amplitude of heave motion response can be considerably suppressed by appropriately adjusting volumetric allocation so that the natural heave period keeps away from the range of wave energy. The theoretical formulae are found in good agreement with the corresponding computational results by WAMIT. | ZHANG HuiQin LI JiaChun | 2009 | Science China(Technological Sciences)2009，52，3： | 5 |
| 11 | The role of cupric in maintaining the structure of CopC显示文摘The CopC protein from pseudomonas syringae pathovar tomato is expressed as one of four proteins encoded by the operon CopABCD that is responsible for copper resistance. And there are one trypto-phan (83), one tyrosine (79), and three phenylalanines (35, 43, 99) in apoCopC. The fluorescence peak of apoCopC is located near 320 nm, and the peak shifts toward 353 nm in the presence of 10 mmol·L^(-1) urea with excitation at 280 nm. Using urea as a chemical agent, the conformational stabilities of apoCopC and Cu_N^(2+) -CopC were monitored by fluorescence spectrum in 20 mmol·L^(-1) phosphate buffer and 100 mmol·L^(-1) sodium chloride at pH 6.0. The free energy of stabilization for apoCopC and Cu_N^(2+)-CopC is 16.29±0.65 kJ·mol^(-1) and 26.26±0.35 kJ·mol^(-1), respectively. The distance between the tryptophan residue and the Cu^(2+) in Cu_N^(2+) -CopC has been studied by observing Frster type nonradia-tive energy transfer. And it is calculated to be 11.6 . | ZHENG XiaoYan PANG ErGuo LI HuiQin ZHAO YaQin YANG BinShengt | 2007 | Chinese Science Bulletin2007，52，6： | 4 |
| 12 | Variation and heritability of morphological and physiological traits among Leymus chinensis genotypes under different environmental conditions显示文摘Intraspecific trait variation and heritability in different environmental conditions not only suggest a potential for an evolutionary response but also have important ecological consequences at the population, community, and ecosystem levels. However, the contribution of quantitative trait variation within a grassland species to evolutionary responses or ecological consequences is seldom documented. Leymus chinensis is an important dominant species in semi-arid grasslands of China, which has seriously suffered from drought and high temperature stresses in recent decades. In the present study, we measured variation and heritability of 10 quantitative traits, namely the number of tillers, maximum shoot height, number of rhizomes, maximum rhizome length, rhizome mass, aboveground mass, root mass, maximum net photosynthetic rate(Pmax), specific leaf area(SLA), and leaf length to leaf width ratio(LL/LW), for 10 genotypes of L. chinensis under one non-stress(Ck) condition and three environmental stress conditions(i.e., drought(Dr), high temperature(Ht), and both drought and high temperature(DrHt)). Result indicated that(1) the interaction of genotype and environmental condition(G×E) was significant for 6 traits but not significant for the other 4 traits as shown by two-way analysis of variance(ANOVA), suggesting that different selection forces were placed for different traits on the factors dominating phenotypic responses to different environmental conditions. Moreover, these significant G×E effects on traits indicated significantly different phenotypic adaptive responses among L. chinensis genotypes to different environmental conditions. Additionally, individuals could be grouped according to environmental condition rather than genotype as shown by canonical discriminant analysis, indicating that environmental condition played a more important role in affecting phenotypic variation than genotype;(2) by one-way ANOVA, significant differences among L. chinensis genotypes were found in all 10 traits under Ck and Dr conditions, in 8 traits under Dr Ht condition and only in 4 traits under Ht condition; and(3) all 10 traits showed relatively low or non-measurable broad-sense heritability(H_2) under stress conditions. However, the lowest H_2 value for most traits did not occur under DrHt condition, which supported the hypothesis of 'unfavorable conditions have unpredictable effects' rather than 'unfavorable conditions decrease heritability'. Results from our experiment might aid to improve predictions on the potential impacts of climate changes on L. chinensis and eventually species conservation and ecosystem restoration. | YANG Xue LI Junpeng ZHAO Tingting MO Lidong ZHANG Jianli REN Huiqin ZHAO Nianxi GAO Yubao | 2019 | Journal of Arid Land2019，11，1： | 4 |
| 13 | Visualization of aging-associated chromatin alterations with an engineered TALE system显示文摘在实时房间的特定的 genomic loci 的可视化在多样的生物过程期间是为在染色质建筑学的动态变化的调查的一个前提,例如细胞的老化。然而,当前的精确 genomic 成像方法被缺乏妨碍荧光灯有高特性和 signal-to-noise 的探针形成对照。我们发现那常规抄写像使活跃之物的受动器(故事) 趋于形成蛋白质总数,从而在成像应用程序损害他们的性能。通过屏蔽,我们发现有故事的那熔化 thioredoxin 阻止了总数形成,开基于故事的 genomic 成像的完整的力量。用熔化 thioredoxin 的故事(TTALE ) ,我们在各种各样的 genomic loci 完成了高质量的成像并且观察联系老化(epi ) 在在人和老鼠早衰模型的 telomeres 和着丝点的 genomic 改变。重要地,我们鉴别 ribosomal DNA 的摩擦为人的老化作为一个分子的标记重复。我们的学习为精确在 vitro 并且在 vivo 监视染色质动力学建立一个简单、柔韧的成像方法。 | Ruotong Ren Liping Deng Yanhong Xue Keiichiro Suzuki Weiqi Zhang Yang Yu Jun Wu Liang Sun Xiaojun Gong Huiqin Luan Fan Yang Zhenyu Ju Xiaoqing Ren Si Wang Hong Tang Lingling Geng Weizhou Zhang Jian Li Jie Qiao Tao Xu Jing Qu Guang-Hui Liu | 2017 | Cell Research2017，27，4： | 4 |
| 14 | Toxoplasma gondii GRA15II effector-induced M1 cells ameliorate liver fibrosis in mice infected with Schistosomiasis japonica显示文摘Recent studies indicated that type II Toxoplasma gondii(Tg)GRA15II favored the generation of classically activated macrophages(M1),whereas type I/III TgROP16I/III promoted the polarization of alternatively activated macrophages(M2).A number of studies have demonstrated that M2 cells are involved in the pathogenesis of the liver fibrogenesis caused by Schistosoma japonicum.The purpose of the present study was to explore the inhibitory effect of Toxoplasma-derived TgGRA15II on mouse hepatic fibrosis with schistosomiasis.The gra15II and rop16I/III genes were amplified from strains T.gondii PRU and Chinese 1 Wh3,respectively.Lentiviral vectors containing the gra15II or rop16I/III plasmid were constructed and used to infect the RAW264.7 cell line.The polarization of the transfected cells was evaluated,followed by co-culture of the biased macrophages with mouse hepatic stellate JS1 cells.Then,mice were injected with GRA15II-driven macrophages via the tail vein and infected with S.japonicum cercariae.TgGRA15II induced a M1-biased response,whereas TgROP16I/III drove the macrophages to a M2-like phenotype.The in vitro experiments indicated that JS1 cell proliferation and collagen synthesis were decreased following co-culture with TgGRA15II-activated macrophages.Furthermore,mice inoculated with TgGRA15II-biased macrophages displayed a notable alleviation of collagen deposition and granuloma formation in their liver tissues.Our results suggest that TgGRA15II-induced M1 cells may dampen the M2 dominant pathogenesis of hepatic fibrosis and granulomatosis.These results provide insights into the use of parasite-derived immunomodulators as potential anti-fibrosis agents and to re-balance the schistosomiasis-induced immune response. | Yuanyuan Xie Huiqin Wen Ke Yan Shushu Wang Xuesong Wang Jian Chen Yuanling Li Yuanhong Xu Zhengrong Zhong Jilong Shen Deyong Chu | 2018 | Cellular & Molecular Immunology2018，15，2： | 4 |
| 15 | Identification and characterization of two human immunodeficiency virus type 1 unique recombinant forms from Yunnan, China显示文摘Dear Editor,Recombination contributes greatly to the diversity of human immunodeficiency virus type 1(HIV-1).A large number of recombinant strains have been found in China,particularly in Yunnan,which is considered the HIV-1 epicenter of China.Surveillance of unique recombinant forms is helpful for prediction of new circulating recombinant forms.In this study,we identified two | Jianjian Li Lin Li Shaomin Yang Jingyun Li Mi Zhang Cuixian Yang Jiafa Liu Huiqin Li | 2016 | Virologica Sinica2016，31，2： | 4 |
| 16 | A novel quality evaluation method for magnolia bark using electronic nose and colorimeter data with multiple statistical algorithms显示文摘Background:Magnolia bark(Magnolia Officinalis REHD.&WILS.and Magnolia officinalis REHD.&WILS.VAR.biloba REHD.&WILS,Hou Po in Chinese),is widely applied in clinical prescriptions and Chinese patent medicines.Origin place is a crucial factor affecting the quality of Hou Po,and chemical composition is an important index for evaluating its quality,which is closely related to its clinical efficacy.This study aims to develop a novel method for rapidly,accurately and comprehensively identifying the origin places of Hou Po and predicting the contents of its important chemical components.Methods:High performance liquid chromatography was used to analyze the contents of magnolol and honokiol and ultra-performance liquid chromatography the contents of magnocurarine and magnoflorine.The cold soak method was used to determine the contents of water-soluble extracts.The E-nose and colorimeter were used to determine the odor and color characteristics,respectively,of the collected Hou Po samples.Results:Using several statistical algorithms,different discriminant models based on the E-nose and colorimeter data were established to distinguish the origin place of Hou-Po and predict the chemical components of honokiol,magnolol,magnocurarine,magnoflorine and water-soluble extracts.The results showed that the Random Forest classifier combined with the ten-fold cross-validation method provided the highest classification accuracy for origin place,accounting for 99.53%among these models.The correlation coefficients between predicted and experimental values of the five chemical components were all higher than 0.96.Conclusion:This study has indicated that the electronic nose and colorimeter are promising methods for evaluating the quality of Chinese herbal medicines both qualitatively and quantitatively. | Jiahui Li Yuanyang Shao Yuebao Yao Yuetong Yu Guangzhao Cao Huiqin Zou Yonghong Yan | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，2： | 4 |
| 17 | An Examination of the Predictability of Tropical Cyclone Genesis in High-Resolution Coupled Models with Dynamically Downscaled Coupled Data Assimilation Initialization显示文摘Predicting tropical cyclone(TC)genesis is of great societal importance but scientifically challenging.It requires fineresolution coupled models that properly represent air−sea interactions in the atmospheric responses to local warm sea surface temperatures and feedbacks,with aid from coherent coupled initialization.This study uses three sets of highresolution regional coupled models(RCMs)covering the Asia−Pacific(AP)region initialized with local observations and dynamically downscaled coupled data assimilation to evaluate the predictability of TC genesis in the West Pacific.The APRCMs consist of three sets of high-resolution configurations of the Weather Research and Forecasting−Regional Ocean Model System(WRF-ROMS):27-km WRF with 9-km ROMS,and 9-km WRF with 3-km ROMS.In this study,a 9-km WRF with 9-km ROMS coupled model system is also used in a case test for the predictability of TC genesis.Since the local sea surface temperatures and wind shear conditions that favor TC formation are better resolved,the enhanced-resolution coupled model tends to improve the predictability of TC genesis,which could be further improved by improving planetary boundary layer physics,thus resolving better air−sea and air−land interactions. | Mingkui LI Shaoqing ZHANG Lixin WU Xiaopei LIN Ping CHANG Gohkan DANABASOGLU Zhiqiang WEI Xiaolin YU Huiqin HU Xiaohui MA Weiwei MA Haoran ZHAO Dongning JIA Xin LIU Kai MAO Youwei MA Yingjing JIANG Xue WANG Guangliang LIU Yuhu CHEN | 2020 | Advances in Atmospheric Sciences2020，37，9： | 4 |
| 18 | Perceived resource support for chronic illnesses among diabetics in north-western China显示文摘社会支持的高水平能改进长期的糖尿病自我管理。从单身的来源的支持被评估了。这研究试图分析支持从多重并且为由使用长期的病资源的糖尿病的病人的 multilevel 来源调查(CIRS ) 。影响 CIRS 的利用的因素也被评估。有糖尿病的 297 个病人的一个总数用 CIRS 被调查并且在 Shihezi 城市里察觉了糖尿病自我管理规模,中国。描述的统计被用来解释规模的人口统计的变量和分数。影响长期的病资源的利用的因素通过 univariate 分析被决定然后由 multivariate 检验了逻辑回归分析。调查的 297 个糖尿病的病人, 67% 没能到达利用长期的病资源的标准(超过 3 个点) 。而且,长期的病资源的利用中等断然与糖尿病的自我管理被相关(r = 0.75, P < 0.05 ) 。根据 multivariate 逻辑回归分析,变老(或, 3.42;95%CI, 1.19-9.84 ) 并且每月的收入(或, 5.27;95%CI, 1.86-14.90 ) 断然显著地与 CIRS 分数被联系。有高中的个人(或, 2.61;95%CI, 1.13-6.05 ) 并且学院(或, 3.02;95%CI, 1.13-8.04 ) 度与小学教育比那些在调查获得了更高的分数。结果显示了为长期的病自我管理,特别地个人的调整和组织的资源和支持的那利用,不在在西北的中国的社区的糖尿病患者之中是理想的。长期的病资源的改进利用为合适的糖尿病自我管理是导致的。而且,长期的病资源的利用的水平与年龄,有文化水平,和每月的收入增加了。 | Huiqin Zhong Ya Shao Ling Fan Tangshen Zhong Lu Ren Yan Wang | 2016 | Frontiers of Medicine2016，10，2： | 3 |
| 19 | Photoelectrochemical performance of birnessite films and photoelectrocatalytic activity toward oxidation of phenol显示文摘Birnessite films on fluorine-doped tin oxide(FTO) coated glass were prepared by cathodic reduction of aqueous KMnO_4. The deposited birnessite films were characterized with X-ray diffraction, Raman spectroscopy, scanning electron microscopy and atomic force microscopy.The photoelectrochemical activity of birnessite films was investigated and a remarkable photocurrent in response to visible light was observed in the presence of phenol, resulting from localized manganese d–d transitions. Based on this result, the photoelectrocatalytic oxidation of phenol was investigated. Compared with phenol degradation by the electrochemical oxidation process or photocatalysis separately, a synergetic photoelectrocatalytic degradation effect was observed in the presence of the birnessite film coated FTO electrode.Photoelectrocatalytic degradation ratios were influenced by film thickness and initial phenol concentrations. Phenol degradation with the thinnest birnessite film and initial phenol concentration of 10 mg/L showed the highest efficiency of 91.4% after 8 hr. Meanwhile, the kinetics of phenol removal was fit well by the pseudofirst-order kinetic model. | Huiqin Zhang Hongrui Ding Xin Wang Cuiping Zeng Anhuai Lu Yan Li Changqiu Wang | 2017 | Journal of Environmental Sciences2017，29，2： | 3 |
| 20 | Detailed resume of RNA m^(6)A demethylases显示文摘N6-Methyladenosine(m^(6)A) is the most abundant internal modification in eukaryotic mRNA,playing critical role in various bioprocesses. Like other epigenetic modifications, m^(6)A modification can be catalyzed by the methyltransferase complex and erased dynamically to maintain cells homeostasis. Up to now, only two m^(6)A demethylases have been reported, fat mass and obesity-associated protein(FTO)and alkylation protein AlkB homolog 5(ALKBH5), involving in a wide range of mRNA biological progress, including mRNA shearing, export, metabolism and stability. Furthermore, they participate in many significantly biological signaling pathway, and contribute to the progress and development of cancer along with other diseases. In this review, we focus on the studies about structure, inhibitors development and biological function of FTO and ALKBH5. | Dandan Shen Bo Wang Ya Gao Lijuan Zhao Yaping Bi Jinge Zhang Ning Wang Huiqin Kang Jingru Pang Ying Liu Luping Pang Zhe-Sheng Chen Yi-Chao Zheng Hong-Min Liu | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 3 |
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