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| 1 | The Global Boundary Stratotype Section and Point for the base of the Danian Stage (Paleocene, Paleogene,"Tertiary", Cenozoic) at El Kef, Tunisia—Original definition and revision显示文摘 | Eustoquio Molina Laia Alegret Ignacio Arenillas José A. Arz Njoud Gallala Jan Hardenbol Katharina von Salis Etienne Steurbau Noeel Vandenberghe Dalila Zaghbib-Turki | 2006 | Episodes2006，29，4： | 9 |
| 2 | Insulin like growth factor-1 increases fatty liver preservation in IGL-1 solution显示文摘AIM: To investigate the benefits of insulin like growth factor-1 (IGF-1) supplementation to serum-free institut georges lopez-1 (IGL-1) solution to protect fatty liver against cold ischemia reperfusion injury. METHODS: Steatotic livers were preserved for 24 h in IGL-1 solution supplemented with or without IGF-1 and then perfused 'ex vivo ' for 2 h at 37℃. We examined the effects of IGF-1 on hepatic damage and function (transaminases, percentage of sulfobromophthalein clearance in bile and vascular resistance). We also studied other factors associated with the poor tolerance of fatty livers to cold ischemia reperfusion injury such as mitochondrial damage, oxidative stress, nitric oxide, tumor necrosis factor-α (TNF-α) and mitogen-activated protein kinases.RESULTS: Steatotic livers preserved in IGL-1 solutionsupplemented with IGF-1 showed lower transaminase levels, increased bile clearance and a reduction in vascular resistance when compared to those preserved in IGL-1solution alone. These benefits are mediated by activation of AKT and constitutive endothelial nitric oxide synthase (eNOS), as well as the inhibition of inflammatory cytokines such as TNF-α. Mitochondrial damage and oxidative stress were also prevented.CONCLUSION: IGL-1 enrichment with IGF-1 increasedfatty liver graft preservation through AKT and eNOS activation, and prevented TNF-α release during normothermic reperfusion. | Mohamed Amine Zaouali Susagna Padrissa-Altés Ismail Ben Mosbah Hassen Ben Abdennebi Olivier Boillot Antoni Rimola Dalila Saidane-Mosbahi Joan Roselló-Catafau | 2010 | World Journal of Gastroenterology2010，16，45： | 6 |
| 3 | Antihydatic and immunomodulatory effects of Punica granatum peel aqueous extract in a murine model of echinococcosis显示文摘Objective:To investigate the effect of pomegranate peel aqueous extract(PGE) on the development of secondary experimental echinococcosis and on the viability of Echinococcux granulosus protoscoleces,and the immunomodulatory properties of PGE.Methods:Swiss mice were inoculated intraperitoneally with viable protoscoleces.Then,PGE was orally administered daily during cystic echinococcosis development.Cyst development and hepatic damage were macroscopically and histologically analyzed.The production of nitric oxide and TNF-α was assessed in plasma and the hepatic expression of iNOS.TNF-α,NF-κB and CD68 was examined.Moreover,protoscoleces were cultured and treated with different concentrations of PGE.Results:It was observed that in vitro treatment of protoscoleces caused a significant decrease in viability in a PGE-dose-dependent manner.In vivo,after treatment of cystic echinococcosis infected mice with PGE,a significant decrease in nitric oxide levels(P<0.000 1)and TNF-α levels(P<0.001) was observed.This decline was strongly related to the inhibition of cyst development(rate of hydatid cyst growth inhibition=63.08%) and a decrease in CD68 expression in both the pericystic layer of hepatic hydatid cysts and liver tissue(P<0.000 1).A significant diminution of iNOS,TNF-α and NF-κB expression was also observed in liver tissue of treated mice(P<0.000 1).Conclusions:Our results indicate an antihydatic scolicidal effect and immunomodulatory properties of PGE,suggesting its potential therapeutic role against Echinococcuss granulosus infection. | Moussa Labsi Lila Khelifi Dalila Mezioug Imene Soufli Chafia Touil-Boukoffa | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，3： | 5 |
| 4 | Sudden hearing loss associated with peginterferon and ribavirin combination therapy during hepatitis C treatment显示文摘在丙肝处理期间与木钉干扰素和 ribavirin 联系的不利效果是众所周知的。突然的听觉损失很少被报导了。包含的可能的机制包括干扰素,汽车免疫,和 hematological 变化的直接 ototoxicity。听觉损失充分经常在抗病毒的治疗的中止以后被解决。我们与长期的丙肝报导一个 47 岁的人,遗传型 2 交流在以木钉干扰素高山开始治疗以后开发了突然的听觉损失 22 wk 哈在 180 mug/wk 和 ribavirin 的剂量的 2a 800 mg 每天。因为症状没变得更坏,抗病毒的治疗为 2 wk 被继续,根据病人的愿望。听见损失在治疗的结束以后在 2 wk 以内解决了。浆液肝丙氨酸 aminotransferase 仍然保持正常在期间并且在抗病毒的治疗的结束以后。HCV RNA 在治疗的结束是无法发现的并且仍然保持否定 24 wk 以后。因此,病人们应该知道听觉损失可以与木钉干扰素治疗,而是决定发生是否继续或到站,治疗基于医生的临床的判断和病人的愿望。 | Héla Elloumi Fatma Houissa Najet Bel Hadj Dalila Gargouri Malika Romani Jamel Kharrat AbdelJabbar Ghorbel | 2007 | World Journal of Gastroenterology2007，13，40： | 4 |
| 5 | Anal squamous intraepithelial lesions and condyloma in HIV-infected heterosexual men,homosexual men and women:prevalence and associated factors显示文摘 | Laurent A Dalila B Philippe R | 2007 | AIDS2007，21，11： | 1 |
| 6 | Effects of 2,4-D and kinetin on callus induction of Barringtonia racemosa leaf and endosperm explant in different types of basal media显示文摘 | Dalila Z D Jaafar H ManafA A | 2013 | Asian Journal of Plant Sciences2013，12，1： | 1 |
| 7 | Essential Oils for Complementary Treatment of Surgical Patients: State of the Art显示文摘 | Susanna Stea Alina Beraudi Dalila De Pasquale Luigi Gori | 2014 | Evidence-Based Complementary and Alternative Medicine2014，，： | 1 |
| 8 | Water pH and surfaetant addition effects on the stability of an algerian crude oil emulsion 显示文摘 | Mortada Daaou Dalila Bendedoueh | 2012 | Journal of Saudi Chemical Society2012，16，3： | 1 |
| 9 | In Vitro Study of Nitric Oxide Metabolites Effects on Human Hydatid of Echinococcus granulosus显示文摘 | Razika Zeghir-Bouteldja Manel Amri Saliha Aitaissa Samia Bouaziz Dalila Mezioug Chafia Touil-Boukoffa Claudio Genchi | 2009 | Journal of Parasitology Research2009，，： | 1 |
| 10 | Natural killer cell dynamic profile is associated with treatment outcome in patients with chronic HCV infection<!-- Doctopic: VH -->显示文摘 | Barbara Oliviero Dalila Mele Elisabetta Degasperi Alessio Aghemo Eleonora Cremonesi Maria Grazia Rumi Carmine Tinelli Stefania Varchetta Stefania Mantovani Massimo Colombo Mario U. Mondelli | 2013 | Journal of Hepatology2013，，1： | 1 |
| 11 | Unique immunological profile in patients with COVID-19显示文摘The relationship between severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)and host immunity is poorly understood.We performed an extensive analysis of immune responses in 32 patients with severe COVID-19,some of whom succumbed A control population of healthy subjects was included.Patients with COVID-19 had an altered distribution of peripheral blood lymphocytes,with an increased proportion of mature natural killer(NK)cells and low T-cell numbers.NK cells and CD8^(+)T cells overexpressed T-cellimmunoglobulin and mucin domain-3(TIM-3)and CD69.NK cell exhaustion was attested by increased frequencies of programmed cell death protein 1(PD-1)positive cells and reduced frequencies of natural killer group 2 member D(NKG2D)-,DNAX accessory molecule-1(DNAM-1)-and sialic acid-binding Ig-like lectin 7(Siglec-7)-expressing NK cells,associated with a reduced ability to secrete interferon(IFN)γ.Patients with poor outcome showed a contraction of immature CD56^(bright) and an expansion of mature CD57^(+)F_(CEI)Rlγ^(eng) adaptive NK cells compared to survivors.Increased serum levels of IL-6 were also more frequently identified in deceased patients compared to survivors.Of note,monocytes secreted abundant quantities of IL-6,IL-8,and IL-1β which persisted at lower levels several weeks after recovery with concomitant normalization of CD69,PD-1 and TIM-3 expression and restoration of CD8^(+)T cell numbers.A hyperactivated/exhausted immune response dominate in severe SARS-CoV-2 infection,probably driven by an uncontrolled secretion of inflammatory cytokines by monocytes.These findings unveil a unique immunological profile in COVID-19 patients that will help to design effective stage-specific treatments for this potentially deadly disease. | Stefania Varchetta Dalila Mele Barbara Olivier Stefania Mantovani Serena Ludovisi Antonella Cerino Raffaele Bruno Alberto Castelli Mario Mosconi Marco Vecchia Silvia Roda Michele Sachs Catherine Klersy Mario U.Mondelli | 2021 | Cellular & Molecular Immunology2021，18，3： | 1 |
| 12 | Antihydatic and immunomodulatory effects of Algerian propolis ethanolic extract:In vitro and in vivo study显示文摘Objective: To evaluate the in vitro and in vivo effect of the Algerian propolis ethanolic extract(EEP) against Echinococcus granulosus(E. granulosus) infection. Methods: In vitro scolicidal activity of EEP was investigated on the protoscolices of hydatid cyst. This in vitro study was conducted by using an in vivo assay. BALB/c mice were inoculated with E. granulosus and treated with propolis for three months. Hydatid cysts development was assessed. Nitric oxide(NO), tumor necrosis factor alpha(TNF-α) production and inducible NO synthase, NF-κB, and TNF-α spleen expression were estimated by Griess method and immunofluorescence respectively.Results: Our study revealed that EEP has a high scolicidal activity against E. granulosus. Oral administration of EEP decreased TNF-α, NF-κB and inducible NO synthase expression in the spleen tissues in the CE+EEP group, in comparison with the CE group. Concomitantly, EEP treatment caused an important systemic decrease in NO and TNF-α levels. These findings are associated with the reduction of CE development. Conclusions: This is the first report demonstrating with interest the antihydatic and immunomodulatory effects of the Algerian EEP, suggesting its therapeutic potential for the hydatid disease treatment. | Nahla Deghbar Dalila Mezioug Touri Kahina Yacine-Miloud Medjdoub Chafia Touil-Boukoffa | 2019 | Asian Pacific Journal of Tropical Medicine2019，12，3： | 1 |
| 13 | Kallikrein-Related Peptidase 14 Acts on Proteinase-Activated Receptor 2 to Induce Signaling Pathway in Colon Cancer Cells显示文摘 | Valérie Gratio Céline Loriot G. Duke Virca Katerina Oikonomopoulou Francine Walker Eleftherios P. Diamandis Morley D. Hollenberg Dalila Darmoul | 2011 | The American Journal of Pathology2011，，5： | 1 |
| 14 | Tissue antioxidant statusdiffers in sponteneously hypertensive rats fed fish protein or casein显示文摘 | Dalila A Y Sihem M Emmanuelle P | 2003 | The Journal of Nutrition2003，133，2： | 1 |
| 15 | Kallikrein-Related Peptidase 4显示文摘 | Valérie Gratio Nathalie Beaufort Lina Seiz Josefine Maier G. Duke Virca Mekdes Debela Nicolai Grebenchtchikov Viktor Magdolen Dalila Darmoul | 2010 | The American Journal of Pathology2010，，3： | 1 |
| 16 | Preservation of steatotic livers in IGL‐1 solution显示文摘 | Ismail Ben Mosbah Joan Roselló‐Catafau Rosa Franco‐Gou Hassen Ben Abdennebi Dalila Saidane Silvina Ramella‐Virieux Olivier Boillot Carmen Peralta | 2006 | Liver Transpl2006，，8： | 1 |
| 17 | Synthesis and Characterization of a Neodymium Zirconate Pyrochlore Doped with Ytterbium: (YbxNdl-x)2Zr2O7 (x = 0.1, 0.25 and 0.4)显示文摘 | Nour-el-hayet Kamel Dalila Moudir Ziane Kamel Hamid Ait-Amar | 2013 | 材料科学与工程(中英文B版)2013，3，1： | 1 |
| 18 | Aberrant expression and activation of the thrombin receptor protease-activated receptor-1 induced cell proliferation and motility in human colon cancer cells显示文摘 | Dalila Darmoul Valérie Gratio Hélène Devud | 2003 | Am J Pathol2003，162，5： | 1 |
| 19 | Air pressure fluctuations in a prairie soil显示文摘 | Pierre R Dalila M Jean-claude G | 1998 | Soil Sci Soc Am1998，62，： | 1 |
| 20 | Effect of photoperiod and feeding schedule on growth and survival of larvae of the fighting conch Strombus pugilis Linné, 1758 (Mollusca, Gastropoda)显示文摘 | Nancy Brito-Manzano Dalila Aldana-Aranda | 2013 | Aquaculture2013，，： | 1 |
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