|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies显示文摘Normal cells are hijacked by cancer cells forming together heterogeneous tumor masses immersed in aberrant communication circuits that facilitate tumor growth and dissemination.Besides the well characterized angiogenic effect of some tumor-derived factors;others,such as BDNF,recruit peripheral nerves and leukocytes.The neurogenic switch,activated by tumor-derived neurotrophins and extracellular vesicles,attracts adjacent peripheral fibers(autonomic/sensorial)and neural progenitor cells.Strikingly,tumor-associated nerve fibers can guide cancer cell dissemination.Moreover,IL-1β,CCL2,PGE2,among other chemotactic factors,attract natural immunosuppressive cells,including T regulatory(Tregs),myeloid-derived suppressor cells(MDSCs),and M2 macrophages,to the tumor microenvironment.These leukocytes further exacerbate the aberrant communication circuit releasing factors with neurogenic effect.Furthermore,cancer cells directly evade immune surveillance and the antitumoral actions of natural killer cells by activating immunosuppressive mechanisms elicited by heterophilic complexes,joining cancer and immune cells,formed by PD-L1/PD1 and CD80/CTLA-4 plasma membrane proteins.Altogether,nervous and immune cells,together with fibroblasts,endothelial,and bone-marrow-derived cells,promote tumor growth and enhance the metastatic properties of cancer cells.Inspired by the demonstrated,but restricted,power of anti-angiogenic and immune cell-based therapies,preclinical studies are focusing on strategies aimed to inhibit tumor-induced neurogenesis.Here we discuss the potential of anti-neurogenesis and,considering the interplay between nervous and immune systems,we also focus on anti-immunosuppression-based therapies.Small molecules,antibodies and immune cells are being considered as therapeutic agents,aimed to prevent cancer cell communication with neurons and leukocytes,targeting chemotactic and neurotransmitter signaling pathways linked to perineural invasion and metastasis. | Rodolfo Daniel Cervantes-Villagrana Damaris Albores-García Alberto Rafael Cervantes-Villagrana Sara Judit García-Acevez | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 2 | Can chemical analysis confirm a wine's authenticity 显示文摘 | Damaris Christensen | 2000 | Science News2000，157，1： | 1 |
| 3 | Regulation of flavonoid biosynthesis involves an unexpected complex transcriptional regulation of TT 8 expression, in A rabidopsis显示文摘 | Wenjia Xu Damaris Grain José Gourrierec Erwana Harsco?t Adeline Berger Vincent Jauvion Aurélie Scagnelli Nathalie Berger Przemyslaw Bidzinski Zsolt Kelemen Fabien Salsac Antoine Baudry Jean‐Marc Routaboul Lo?c Lepiniec Christian Dubos | 2013 | New Phytol2013，，1： | 1 |
| 4 | Multi-site evaluation of IKONOS data for classification of tropical coral reef environments显示文摘 | Serge Andréfou?t Philip Kramer Damaris Torres-Pulliza Karen E Joyce Eric J Hochberg Rodrigo Garza-Pérez Peter J Mumby Bernhard Riegl Hiroya Yamano William H White Mayalen Zubia John C Brock Stuart R Phinn Abdulla Naseer Bruce G Hatcher Frank E Muller-Karg | 2003 | Remote Sensing of Environment2003，，1： | 1 |
| 5 | Progress in Mapping and Cloning Qualitative and Quantitative Resistance Against Phytophthora infestans in Potato and Its Wild Relatives显示文摘 | Ingo Hein Paul R. J. Birch Sarah Danan Véronique Lefebvre Damaris Achieng Odeny Christiane Gebhardt Friederike Trognitz Glenn J. Bryan | 2009 | Potato Research2009，，3： | 1 |
| 6 | Vaccine-related adverse events in Cuban children, 1999-2008 显示文摘 | Belkys M Galindo Damarys Concepci6n Miguel A Galindo | 2012 | MEDICC review2012，14，1： | 1 |
| 7 | The changing risk of Plasmodium falciparum malaria infection in Africa: 2000–10: a spatial and temporal analysis of transmission intensity显示文摘 | Abdisalan M Noor Damaris K Kinyoki Clara W Mundia Caroline W Kabaria Jonesmus W Mutua Victor A Alegana Ibrahima Socé Fall Robert W Snow | 2014 | The Lancet2014，，： | 1 |
| 8 | Identifying RNA Modifications by Direct RNA Sequencing Reveals Complexity of Epitranscriptomic Dynamics in Rice显示文摘Transcriptome analysis based on high-throughput sequencing of a cDNA library has been widely applied to functional genomic studies.However,the cDNA dependence of most RNA sequencing techniques constrains their ability to detect base modifications on RNA,which is an important element for the post-transcriptional regulation of gene expression.To comprehensively profile the N^(6)-methyladenosine(m^(6)A)and N^(5)-methylcytosine(m5 C)modifications on RNA,direct RNA sequencing(DRS)using the latest Oxford Nanopore Technology was applied to analyze the transcriptome of six tissues in rice.Approximately 94 million reads were generated,with an average length ranging from 619 nt to 1013 nt,and a total of 45,707 transcripts across 34,763 genes were detected.Expression profiles of transcripts at the isoform level were quantified among tissues.Transcriptome-wide mapping of m^(6)A and m5 C demonstrated that both modifications exhibited tissue-specific characteristics.The transcripts with m^(6)A modifications tended to be modified by m5 C,and the transcripts with modifications presented higher expression levels along with shorter poly(A)tails than transcripts without modifications,suggesting the complexity of gene expression regulation.Gene Ontology analysis demonstrated that m^(6)A-and m5 C-modified transcripts were involved in central metabolic pathways related to the life cycle,with modifications on the target genes selected in a tissue-specific manner.Furthermore,most modified sites were located within quantitative trait loci that control important agronomic traits,highlighting the value of cloning functional loci.The results provide new insights into the expression regulation complexity and data resource of the transcriptome and epitranscriptome,improving our understanding of the rice genome. | Feng Yu Huanhuan Qi Li Gao Sen Luo Rebecca Njeri Damaris Yinggen Ke Wenhua Wu Pingfang Yang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 1 |
| 9 | Four methods of phoria tesiting evaluated in aclinical setting显示文摘 | Gurbal N Damari D | 2005 | Optometry2005，76，6： | 1 |
| 10 | Vesicle associated membrane protein of arabidopsis suppresses Bax - induced apoptosis in yeast downstream of oxidative burst 显示文摘 | Levine A Belbengi B Damari - Weisler H | 2001 | J Biol Chem2001，276，46： | 1 |
| 11 | Treatment of trigeminal ganglion neurons in vitro with NGF,GDNF or BDNF:effects on neuronal survival,neurochemical properties and TRPV1-mediated neuropeptide secretion显示文摘 | Theodore J Price Michael D Louria Damaries Candelario-Soto | 2005 | BMC Neuroscience2005，10，： | 1 |
| 12 | Multi-site evaluation of IKONOS data for classification of tropical coral reef environments显示文摘 | Serge Andréfou?t Philip Kramer Damaris Torres-Pulliza Karen E Joyce Eric J Hochberg Rodrigo Garza-Pérez Peter J Mumby Bernhard Riegl Hiroya Yamano William H White Mayalen Zubia John C Brock Stuart R Phinn Abdulla Naseer Bruce G Hatcher Frank E Muller-Karg | 2003 | Remote Sensing of Environment2003，，1： | 1 |
| 13 | Multi-site evaluation of IKONOS data for classification of tropical coral reef environments显示文摘 | Andréfouet S Kramer P Damaris T P | 2003 | Remote Sensing of Environment2003，88，： | 1 |
| 14 | Multisite evaluation of IKONOS data for classification of tropical coral reef environments显示文摘 | ANDREFOUET SERGE PHILIP KRAMER DAMARIS TORRES-PULLIZA | 2003 | Remote Sensing of Environment2003，88，12： | 1 |
| 15 | Treatment of trigeminal ganglion neurons in vitro with NGF, GDNF or BDNF: effects on neuronal survival, neurochemical properties and TRPV1-mediated neuropeptide secretion显示文摘 | Theodore J Price Michael D Louria Damaries Candelario-Soto | 2005 | BMC Neuroscience2005，10，： | 1 |
| 16 | Constructing gender, constructing the urban: a review of Anglo-American feminist urban geography 显示文摘 | Bondi L Damaris Rose | 2003 | Gender Place & Culture2003，10，3： | 1 |
| 17 | PATTERNS OF ENGRAFTMENT IN DIFFERENT STRAINS OF IMMUNODEFICIENT MICE RECONSTITUTED WITH HUMAN PERIPHERAL BLOOD LYMPHOCYTES1显示文摘 | Thierry Berney R. Damaris Molano Antonello Pileggi Pierre Cattan Hua Li Camillo Ricordi Luca Inverardi | 2001 | Transplantation2001，，1： | 1 |
| 18 | Treatment of Chronic Endometritis in Dairy Cows with an Intrauterine Application of Enzymes 显示文摘 | Marc Drillich Damaris Raab Miriam Wittke | 2005 | Theriogenology2005，63，7： | 1 |
| 19 | Treatment of chronic hepatitis C virus infection in the United States: some remaining obstacles显示文摘 | Gloria Searson Ellen S. Engelson Damaris Carriero Donald P. Kotler | 2014 | Liver Int2014，，5： | 1 |
| 20 | Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after trausplantation显示文摘 | Antonello P Damaris MR Thierry B | 2001 | Diabetes2001，50，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员