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| 1 | pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus显示文摘AIM: To investigate the pRb expression in a large group of patients with history of chronic exposure to the main risk factors for development of squamous cell carcinoma of the esophagus. METHODS: One hundred and seventy asymptomatic individuals at high risk for esophageal squamous cell carcinoma (consumption of more than 80 g of ethanol and 10 cigarettes/d for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa. As a control group, specimens of esophageal mucosa obtained from 20 healthy subjects were also studied. Immunohistochemical assessment of the tissues was performed using a monoclonal antibody anti-pRB protein. RESULTS: Absence of the pRB staining, indicating loss of RB function, was observed in 33 (19.4%) of the individuals at risk for esophageal cancer, but in none of the healthy controls (P < 0.02). Loss of pRb expression increased in a stepwise fashion according to the severity of the histological findings (P < 0.005): normal mucosa (11/97 or 11.3%), chronic esophagitis (17/60 or 28.3%), low-grade dysplasia (3/10 or 30%), high-grade dysplasia 1/2 or 50%) and squamous cell carcinoma (1/1 or 100%). CONCLUSION: Our findings suggest that abnormal expression of the pRB protein may be implicated in the process of esophageal carcinogenesis. Additional studies are warranted to define the role of the pRBprotein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy. | Simone S Contu Paulo C Contu Daniel C Damin Renato B Fagundes Fabiano Bevilacqua Aline S Rosa Joo C Prolla Luis F Moreira | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 2 | Effect of relative impeller-to-volute position on hydraulic efficiency and static radial force distribution in a circular volute cen- trifugal pump 显示文摘 | Daniel O B Lutz K Ronald D F | 2000 | Transactions of the ASME2000，122，3： | 1 |
| 3 | Treatment of acute exacerbations of chronic bronchitis: comparison of trovafloxacin and amoxicillin in a multicentre,double- blind,double- dummy study显示文摘 | O'Doherty B Daniel R | 1998 | Eur J Clin Microbiol Infect Dis1998，17，6： | 1 |
| 4 | The effects of logistics capabilities and strategy on firm performance 显示文摘 | DANIEL F L SCOTF B K JOHN O | 2000 | Journal of Business Logistics2000，21，2： | 1 |
| 5 | Stroke and cardiac arrhythmias显示文摘 | Daniele O Caravaglios G Fierro B | 2002 | J Stroke Cerebrovasc Dis2002，11，1： | 1 |
| 6 | Long-term safety of rituximab in rheumatoid arthritis: 9.5-year follow-up of the global clinical trial programme with a focus on adverse events of interest in RA patients显示文摘 | Ronald F van Vollenhoven Paul Emery Clifton O Bingham Edward C Keystone Roy M Fleischmann Daniel E Furst Nicola Tyson Neil Collinson Patricia B Lehane | 2013 | Annals of the Rheumatic Diseases2013，，9： | 1 |
| 7 | The effects of logistics capabilities and strategy on firm performance显示文摘 | Daniel F L Scott B K John O | 2000 | Journal of Business Logistics2000，21，2： | 1 |
| 8 | Effects of left ventricular pacing on cardiac performance and on quality of life in patients with drug refractory heart failure显示文摘 | Gabriele L Michele B Daniele O | 2000 | Am J Cardiol2000，，： | 1 |
| 9 | Full-scale testing of draped nets for rock fall protection 显示文摘 | Paola B Claudio O Daniele P | 2009 | Canadian Geotechnical Journal2009，46，3： | 1 |
| 10 | Simultaneous monitoring of oil film thickness and temperature in fluid film bearings 显示文摘 | Sergei B Glavatskih a O sten Uusitalo a Daniel J Spohn b | 2001 | Tribology International2001，34，： | 1 |
| 11 | Protective effect of HMG-CoA reductase inhibitor on experiment renal ischemia-reperfusion injury显示文摘 | O'Donnell M Daniels F Burne-Taney M Keane W Kasiske B | 2003 | Am J Nephrol2003，23，1： | 1 |
| 12 | Pyrethroids, pyrrethrin, and piperonyl butoxide in sediments by high-resolution gas chromatography/highresolution mass spectrometry显示文摘 | MILLION B W DANIEL R O | 2006 | Journal of Chromatography A2006，1135，1： | 1 |
| 13 | Wavelet Based denoising for traffic volume time series forecasting with self-Organizing neural networks显示文摘 | Daniel B G Francisco J D David G O | 2010 | Computer-Aided Civil and Infrastructure Engineering2010，25，7： | 1 |
| 14 | Heterogeneous cross linking of waterborne two component polyurethanes (WB2K-PUR): stratification processes and the and the role of water显示文摘 | Daniel B O Marek W U | 2005 | Polymer2005，46，8： | 1 |
| 15 | Success-ful English Channel Swimming:The Peak Experience显示文摘 | DANIEL B HOLLANDER EDMUND O ACEVEDO | 2000 | SportPsychol2000，14，： | 1 |
| 16 | Hierarchical decision tree induction in distributed genomic databases显示文摘 | AMIR B O DANIEL K ASSAF S | 2005 | IEEE Transactions on Knowledge and Data Engineering2005，17，8： | 1 |
| 17 | Psoriasis显示文摘 | Frank O N Daniel H K Jonathan B | 2009 | N Engl J Med2009，361，： | 1 |
| 18 | Micromechanics-based determination of effective elastic properties of polymer bonded explosives显示文摘 | Biswajit B Daniel O A | 2003 | Physica B2003，338，： | 1 |
| 19 | On predicting the effective elastic properties of polymer bonded explosives using the recursive cell methods显示文摘 | Biswajit B Daniel O A | 2004 | Solid and Structure2004，41，： | 1 |
| 20 | Protective effect of HMG-CoA reductase inhibitor on experimental renal ischemia-reperfusion injury显示文摘 | Yokota N O' Donnell M Daniels F Burne-Taney M Keane W Kasiske B | 2003 | Am J Nephrol2003，23，1： | 1 |
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