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| 1 | Lapatinib plus capecitabine in treating HER2-positive advanced breast cancer:efficacy,safety,and biomarker results from Chinese patients显示文摘Overexpression of human epidermal growth factor receptor-2(HER2) in metastatic breast cancer(MBC) is associated with poor prognosis.This single-arm open-label trial(EGF109491;NCT00508274) was designed to confirm the efficacy and safety of lapatinib in combination with capecitabine in 52 heavily pretreated Chinese patients with HER2-positive MBC.The primary endpoint was clinical benefit rate(CBR).Secondary endpoints included progression-free survival(PFS),time to response(TTR),duration of response(DoR),central nervous system(CNS) as first site of relapse,and safety.The results showed that there were 23 patients with partial responses and 7 patients with stable disease,resulting in a CBR of 57.7%.The median PFS was 6.34 months(95% confidence interval,4.93-9.82 months).The median TTR and DoR were 4.07 months(range,0.03-14.78 months) and 6.93 months(range,1.45-9.72 months),respectively.Thirteen(25.0%) patients had new lesions as disease progression.Among them,2(3.8%) patients had CNS disease reported as the first relapse.The most common toxicities were palmar-plantar erythrodysesthesia(59.6%),diarrhea(48.1%),rash(48.1%),hyperbilirubinemia(34.6%),and fatigue(30.8%).Exploratory analyses of oncogenic mutations of PIK3CA suggested that of 38 patients providing a tumor sample,baseline PIK3CA mutation status was not associated with CBR(P = 0.639) or PFS(P = 0.989).These data confirm that the lapatinib plus capecitabine combination is an effective and well-tolerated treatment option for Chinese women with heavily pretreated MBC,irrespective of PIK3CA status. | Bing-He Xu Ze-Fei Jiang Daniel Chua Zhi-Min Shao Rong-Cheng Luo Xiao-Jia Wang Dong-Geng Liu Winnie Yeo Shi-Ying Yu Beth Newstat Alka Preston Anne-Marie Martin Hai-Dong Chi Li wang | 2011 | Chinese Journal of Cancer2011，30，5： | 17 |
| 2 | Detection of Stage I nasopharyngeal carcinoma by serologicscreening and clinical examination显示文摘In a prospective study, 42 048 adults residing in Zhongshan City, Guangdong, China, were followed for 16 years, and 171 of them developed nasopharyngeal carcinoma (NPC). Although Epstein-Barr virus (EBV) antibody levels of the cohort fluctuated, the antibody levels of 93% of the patients with NPC were raised and maintained at high levels for up to 10 years prior to diagnosis. This suggests that the serologic window affords an opportunity to monitor tumor progression during the preclinical stage of NPC development, facilitating early NPC detection. We reviewed the clinical records of the 171 patients with NPC in the prospective study to assess the efficacy of early NPC detection by serologic screening and clinical examination. Of the 171 patients, 51 had Stage I tumor (44 were among the 73 patients detected by clinical examination and 7 were among the 98 patients presented to outpatient department). Initial serologic screening predicted 58 (95.1%) of the 61 patients detected within 2 years. The risk of the screened population (58/3093) raised 13 times relative to cohort (61/42 048) during this period. Clinical examination detected all the 58 predicted cases, and 35 (60.3%) of which were diagnosed with Stage I tumor. The serologic prediction rate fell to 33.6% (37/110) 2 to 16 years after screening. The proportion of cases detected by clinical examination fell to 40.5% (15/37). The proportion of Stage I tumors among the cases detected by clinical examination during both periods remained at about 60%. We concluded that early detection of NPC can be accomplished by repeated serologic screening to maintain high prediction rates and by promptly examining screened subjects to detect tumors before the symptoms develop. | Ming-Fang Ji Yuan-Long Yu Wei-Ming Cheng Yong-Sheng Zong Park Sze-Park Ng Daniel Tsin-Tien Chua Mun-Hon Ng | 2011 | Chinese Journal of Cancer2011，30，2： | 3 |
| 3 | Chemotherapy in locally advanced nasopharyngeal carcinoma: An individual patient data meta-analysis of eight randomized trials and 1753 patients显示文摘 | Bertrand Baujat Hélène Audry Jean Bourhis Anthony T.C. Chan Haluk Onat Daniel T.T. Chua Dora L.W. Kwong Muhyi al-Sarraf Kwan-Hwa Chi Masato Hareyama Sing F. Leung Kullathorn Thephamongkhol Jean-Pierre Pignon | 2006 | International Journal of Radiation Oncology, Biology, Physics2006，，1： | 2 |
| 4 | Porous carbon spheres via microwave-assisted synthesis for capacitive deionization显示文摘 | Yong Liu Likun Pan Taiqiang Chen Xingtao Xu Ting Lu Zhuo Sun Daniel H.C. Chua | 2015 | Electrochimica Acta2015，，： | 2 |
| 5 | Emerging viral diseases of Southeast Asia and the Western Pacific显示文摘 | Mackenzie JS Chua KB Daniels PW | 2001 | Emerg Infect Dis2001，7，3： | 1 |
| 6 | Vibratory response of diamond-like amorphous car bon cantilevers under different temperatures显示文摘 | CHUA DANIEL H C TAY B K ZHANG P | 2004 | Diamond Relat Mater2004，13，： | 1 |
| 7 | Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis显示文摘 | Pierre Blanchard Anne Lee Sophie Marguet Julie Leclercq Wai Tong Ng Jun Ma Anthony T C Chan Pei-Yu Huang Ellen Benhamou Guopei Zhu Daniel T T Chua Yong Chen Hai-Qiang Mai Dora L W Kwong Shie Lee Cheah James Moon Yuk Tung Kwan-Hwa Chi George Fountzilas Li | 2015 | The Lancet Oncology2015，，： | 1 |
| 8 | Factors contributing to the efficacy of concurrent–adjuvant chemotherapy for locoregionally advanced nasopharyngeal carcinoma: Combined analyses of NPC-9901 and NPC-9902 Trials显示文摘 | Anne W.M. Lee Stewart Y. Tung Roger K.C. Ngan Rick Chappell Daniel T.T. Chua T.X. Lu Lillian Siu Terence Tan L.K. Chan W.T. Ng T.W. Leung Y.T. Fu Gordon K.H. Au C. Zhao Brian O’Sullivan E.H. Tan W.H. Lau | 2010 | European Journal of Cancer2010，，5： | 1 |
| 9 | Emerging viral diseases of Southeast Asia and the Western Pacific 显示文摘 | Mackenzie JS Chua KB Daniels PW | 2001 | EmergInfect Dis2001，7，3： | 1 |
| 10 | Reirradiation of nasopharyngeal carcinoma with intensity-modulated radiotherapy显示文摘 | Daniel TT Chua Jonathan ST Sham Lucullus HT Leung | 2005 | Radiotherapy and Oncology2005，77，3： | 1 |
| 11 | Randomized Trial of Radiotherapy Plus Concurrent-Adjuvant Chemotherapy vs Radiotherapy Alone for Regionally Advanced Nasopharyngeal Carci- noma 显示文摘 | Anne WM Lee Stewart Y Tung Daniel TT Chua | 2010 | YNCI Journal of the National Cancer Institute2010，102，15： | 1 |
| 12 | Chemotherapy in locally advanced nasopharyngeal carcinoma: An individual patient data meta-analysis of eight randomized trials and 1753 patients显示文摘 | Bertrand Baujat Hélène Audry Jean Bourhis Anthony T.C. Chan Haluk Onat Daniel T.T. Chua Dora L.W. Kwong Muhyi al-Sarraf Kwan-Hwa Chi Masato Hareyama Sing F. Leung Kullathorn Thephamongkhol Jean-Pierre Pignon | 2006 | International Journal of Radiation Oncology Biology Physics2006，，1： | 1 |
| 13 | Hepatic iron loading in mice increases cholesterol biosynthesis显示文摘 | Ross M. Graham Anita C. G. Chua Kim W. Carter Roheeth D. Delima Daniel Johnstone Carly E. Herbison Martin J. Firth Rebecca O’Leary Elizabeth A. Milward John K. Olynyk Debbie Trinder | 2010 | Hepatology2010，，2： | 1 |
| 14 | Structural characterization of dual-metal containing diamond-like carbon nanocomposite films by pulsed laser deposition显示文摘 | Koh A T T Hsieh J Chua Daniel H C | | 0，，5： | 1 |
| 15 | Emerging viral diseases of Southeast Asia and the Western Pacific显示文摘 | Mackenzie J S Chua K B Daniels P W | 2001 | Emerg Infect Dis2001，7，3： | 1 |
| 16 | Emerging viral dis- eases of Southeast Asia and the western Pacific 显示文摘 | Mackenzie JS Chua KB Daniels PW | 2001 | Emerg Infect Dis2001，7，3： | 1 |
| 17 | Nipah virus: a recently emergent deadly paramyxovirus 显示文摘 | Chua KB Bellini WJ Rota PA Harcourt BH Tamin A Lam SK Ksiazek TG RoUin PE Zaki SR Shieh W Goldsmith CS Gubler DJ Roehrig JT Eaton B Gould AR Olson J Field H Daniels P Ling AE Peters CA Anderson IJ Mahy BW | 2000 | Science2000，288，5470： | 1 |
| 18 | Outcome of Fractionated Stereotactic Radiotherapy for 90 Patients With Locally Persistent and Recurrent Nasopharyngeal Carcinoma显示文摘 | Shao-Xiong Wu Daniel T.T. Chua Mei-Ling Deng Chong Zhao Feng-Yan Li Jonathan S.T. Sham Han-Yu Wang Yong Bao Yuan-Hong Gao Zhi-Fan Zeng | 2007 | International Journal of Radiation Oncology, Biology, Physics2007，，3： | 1 |
| 19 | The effect of interruptions and prolonged treatment time in radiotherapy for nasopharyngeal carcinoma显示文摘 | Dora L.W. Kwong Jonathan S.T. Sham Daniel T.T. Chua Damon T.K. Choy Gordon K.H. Au P.M. Wu | 1997 | International Journal of Radiation Oncology Biology Physics1997，，3： | 1 |
| 20 | Emerging viral disease of Southeast Asia and the Western Pacific 显示文摘 | Mackenzie JS Chua KB Daniels PW Eaton BT Field HE Hall RA Halpin K Johansen CA Kirkland PD Lam SK McMinn P Nisbet DJ Paru R Pyke AT Ritchie SA Siba P Smith DW Smith GA van den Hurk AF Wang LF Williams DT | 2001 | Emerg Infect Dis2001，7，3： | 1 |
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