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| 1 | Liver iron transport显示文摘肝在铁新陈代谢起一个中央作用。它是为铁的主要存储地点并且也表示涉及铁运输和铁动态平衡的规定的分子的一个复杂范围。与肝的铁运输或规定联系的越来越多的基因被识别了。这些包括转铁蛋白受体(TFR1 并且 2 ) , ferrireductase (STEAP3 ) ,运输 ers 二价的金属 transporter-1 (DMT1 ) 和象 haemochromatosis 蛋白质, HFE 和 haemojuvelin (HJV ) 一样的 ferroportin (FPN ) ,它正在表明分子。许多也这些基因参予铁集中于肝的肽 hepcidin 的规章的小径。然而,我们开始仍然仅仅正在理解在肝之间的复杂相互作用熨运输和铁动态平衡。这评论在铁运输和铁动态平衡的规定构画出我们铁新陈代谢和他们的角色的分子的当前的知识。 | Ross M Graham Anita CG Chua Carly E Herbison John K Olynyk Debbie Trinder | 2007 | World Journal of Gastroenterology2007，13，35： | 12 |
| 2 | Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs显示文摘AIM To investigate the long-term effect of dietary education on a low fermentable oligosaccharide, disaccharide and polyol(FODMAP) diet on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS Participants with IBS(Rome III) were randomized to two groups. Group I commenced a low FODMAP diet at baseline. At three months, group II, so far a comparator group, crossed over to a low FODMAP diet while group I started re-challenging foods. All patients completed the IBS SSS(IBS symptom severity scoring system, 0-500 points increasing with severity), IBS Qo L questionnaire(0-100 increasing with Qo L), a FODMAP specific food frequency questionnaire and provided a stool sample at baseline, three and six months for microbiome analysis.RESULTS Fifty participants were enrolled into group I(n = 23) or group II(n = 27). Participants in both groups were similar in baseline values but with more men in group I. There was a significantly lower IBS SSS(275.6 ± 63.6 to 128.8 ± 82.5 vs 246.8 ± 71.1 to 203.6 ± 70.1)(P < 0.0002) and increased Qo L(68.5 ± 18.0 to 83 ± 13.4 vs 72.9 ± 12.8 to 73.3 ± 14.4)(P < 0.0001) in group I vs group II at 3 mo. The reduced IBS SSS was sustained at 6 mo in group I(160 ± 102) and replicated in group II(124 ± 76). Fiber intake decreased on the low FODMAP diet(33 ± 17 g/d to 21 ± 8 g/d)(P < 0.01) and after re-introducing FODMAP containing foods increased again to 27 ± 9 g/d. There was no change seen in the intestinal microbiome when participants adopted a low FODMAP diet.CONCLUSION This study demonstrated that a reduction in FODMAPs improves symptoms in IBS and this improvement can be maintained while reintroducing FODMAPs. | Ruth M Harvie Alexandra W Chisholm Jordan E Bisanz Jeremy P Burton Peter Herbison Kim Schultz Michael Schultz | 2017 | World Journal of Gastroenterology2017，23，25： | 5 |
| 3 | Prevalence and knowledge of hepatitis C in a middle-aged population,Dunedin,New Zealand显示文摘AIM:To determine the prevalence of infection with hepatitis C virus(HCV) in those most at risk of advanced liver disease and to identify gaps in knowledge of HCV.METHODS: Questionnaires were mailed to randomly selected residents aged 40-59 to assess the extent of their general knowledge about HCV. The questionnaire assessed demographics, the extent of general knowledge about viral hepatitis, potential risks for infection and the prevalence of risk factors associated with increased progression of liver fibrosis. Anonymised residual laboratory blood samples from 40-59 years old people from Dunedin taken in hospital or in the community, were tested for HCV antibodies and alanine transaminase(ALT), aspartate transaminase(AST), gamma-glutamyl transpeptidase(GGT). Linear regression was performed to examine whether the demographics sex, age, socio-economic status, qualification level and occupation sector(categorical variables) were predictors of level of general knowledge about hepatitis. For the demographics that werefound to be significant predictors of score outcome, multiple regression analysis was used to determine independent effects. χ2 tests were used to compare our selected sample and our responder population demographics, to the demographics of the entire 40-59 years old population in Dunedin using the 2006 NZ census data. Exact confidence intervals for the proportion positive for HCV and HBV were calculated using the binomial distribution.RESULTS: The response rate to the mailed questionnaire was 431/1400(30.8%). On average 59.4% questions were answered correctly. Predictors for higher scores, indicating greater knowledge about symptoms and transmission included sex(female, P < 0.01), higher level of qualification(P < 0.000) and occupation sector(P < 0.000). Sharing intravenous drug utensils was a known risk factor for disease transmission(94.4%), but the sharing of common household items such as a toothbrush was not. 93% of the population were unaware that HCV infection can be asymptomatic. 25% did not know that treatment was available in New Zealand and of those who did know, only 40% assumed it was funded. Six hundred and eighty-two residual anonymised blood samples were tested for HCV antibodies, ALT, AST and GGT. The prevalence for HCV was 4.01%, 95%CI: 2.6%-5.8%. Liver function tests were not useful for identifying likelyhood of HCV infection.CONCLUSION: Prevalence of HCV in our population is high, and the majority have limited knowledge of HCV and its treatment. | Jane Vermunt Margaret Fraser Peter Herbison Anna Wiles Martin Schlup Michael Schultz | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 4 | The role of remote ischemic preconditioning in organ protection after cardiac surgery: a meta-analysis显示文摘 | Nur A.B. Haji Mohd Yasin Peter Herbison Pankaj Saxena Slavica Praporski Igor E. Konstantinov | 2014 | Journal of Surgical Research2014，，1： | 2 |
| 5 | Nasogastric intubation after intestinal resection 显示文摘 | Reasbeck PG Rice ML Herbison GP | 1984 | Surg Gynecol Obstet1984，158，： | 1 |
| 6 | Effectiveness of anticholinergic drugs compared with placebo in the treatment of overactive bladder: systematic review显示文摘 | Herbison P Hay-Smith J Ellis G | 2003 | BMJ2003，326，7394： | 1 |
| 7 | Major sex differences in non-genomic estrogen actions on intracellular signaling in mouse brain in vivo显示文摘 | Abraham IM Herbison AE | 2005 | Neuroscience2005，131，4： | 1 |
| 8 | The effect of leaving dentures in place on bag-mask ventilation at induction of general anesthesia显示文摘 | Conlon NP Sullivan RP Herbison PG | 2007 | Anesthesia and Analgesia2007，，02： | 1 |
| 9 | Effectiveness of anticho- linergic drugs compared with placebo in the treatment of overactive bladder: systematic review 显示文摘 | Herbison P Hay-Smith J Ellis G | 2003 | BMJ2003，326，7394： | 1 |
| 10 | Obstetric practice and the prevalence of urinauy incontinence three months after delivery 显示文摘 | Wilson PD Herbison R Herbison GP | 1996 | Br J Obstet Gynaeeol1996，103，2： | 1 |
| 11 | Obstetric prac- tice and the prevalence of urinary incontinence three months after delivery 显示文摘 | Wihun P D Herbison R M Herbimn G P | 1996 | Br J Obstet Gyunecol1996，103，2： | 1 |
| 12 | Functional applianee treatment assessed using the PAR index 显示文摘 | Wijayaratne D Harkness M Herbison P | 2000 | Aust Orthod J2000，16，3： | 1 |
| 13 | Postnatal development of Kisspeptin neurons in mouse hypothalamus,sexual dimorphism and projections to gonadotrop in-releasing hormone neurons显示文摘 | Clarkson J Herbison AE | 2006 | Endocrinology2006，147，12： | 1 |
| 14 | Psychotropic drugs and fatal pulmonary embolism显示文摘 | Parkin L Skegg DC Herbison GP | 2003 | Phannacoepidemiol Drug Saf2003，12，8： | 1 |
| 15 | Incidence of thrombotic cardiovascular events in patients taking celecoxib compared with those taking rofecoxib:interim results from the New Zealand Intensive Medicines Monitoring Pregrammed显示文摘 | Harrison-Woolrych M Herbison P McLean R | 2005 | Drug Safety2005，28，5： | 1 |
| 16 | Stress urinary incontinence following childbirth:Primigr avida's obstetric and other dangerous factors显示文摘 | Glazener C M A Herbison G P | 2006 | BJOG2006，113，： | 1 |
| 17 | Interventions for relieving the pain and discomfort of screening mammography显示文摘 | Miller D Livingstone V Herbison P | 2008 | Cochrane Database Syst Rev2008，，00： | 1 |
| 18 | Obstetric practice and the prevalence of urinary incontinence three months after delivery显示文摘 | Wilson PD Herbison R Herbison GP | 1996 | British Journal of Obstetrics and Gynaecology1996，103，2： | 1 |
| 19 | The im- pact of body mass index on semen parameters and repro- ductive hormones in human males: a systematic review with meta-analysis 显示文摘 | MacDonald A A Herbison G P Showell M | 2010 | Hum Reprod Update2010，16，3： | 1 |
| 20 | A randomized controlled trial toinvestigate the effects of water-based exercise to improve fallsrisk and physical function in older adults with lower-extremityosteoarthritis显示文摘 | Hale LA Waters D Herbison P | | 0，，01： | 1 |
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