|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical and histopathological correlations of fecal calprotectin release in colorectal carcinoma显示文摘AIM:To determine calprotectin release before and after colorectal cancer operation and compare it to tumor and histopathological parameters.METHODS:The study was performed on patients with diagnosed colorectal cancer admitted for operation.Calprotectin was measured in a single stool sample before and three months after the operation using an enzymelinked immunosorbent assay(ELISA).Calprotectin levels greater than or equal to 50μg/g were considered positive.The compliance for collecting stool samples was assessed and the value of calprotectin was correlated to tumor and histopathological parameters of intra-and peri-tumoral inflammation.Surgical specimens were fixed in neutral buffered formalin and stained with hematoxylin and eosin.Staging was performed according to the Dukes classification system and the 7th edition tumor node metastasis classification system.Intra-and peri-tumoral inflammation was graded according to the Klintrup criteria.Immunohistochemical quantification was performed for MPO,CD45R0,TIA-1,CD3,CD4,CD8,CD57,and granzyme B.Statistical significance was measured using Wilcoxon signed rank test,Kruskal Wallis test and Spearman’s rank correlation coefficient as appropriate.RESULTS:Between March 2009 and May 2011,80 patients with colorectal cancer(46 men and 34 women,with mean age of 71±11.7 years old)were enrolled in the study.Twenty-six patients had rectal carcinoma,29 had left-side tumors,23 had right-side tumors,and2 had bilateral carcinoma.In total,71.2%of the patients had increased levels of calprotectin before the operation(median 205μg/g,range 50-2405μg/g)and experienced a significant decrease three months after the operation(46μg/g,range 10-384μg/g,P<0001).The compliance for collecting stool samples was 89.5%.Patients with T3 and T4 tumors had significantly higher values than those with T1 and T2 cancers(P=0.022).For all other tumor parameters(N,M,G,L,V,Pn)and location,no significant difference in calprotectin concentration was found.Furthermore,the calprotectin levels and histological grading of both peri-and intra-tumoral inflammation was not correlated.Additional testing with specific markers for lymphocytes and neutrophils also revealed no statistically significant correlation.CONCLUSION:Fecal calprotectin decreases significantly after colorectal cancer operation.Its value depends exclusively on the individual T-stage,but not on other tumor or histopathological parameters. | Frank Serge Lehmann Francesca Trapani Ida Fueglistaler Luigi Maria Terracciano Markus von Flüe Gieri Cathomas Andreas Zettl Pascal Benkert Daniel Oertli Christoph Beglinger | 2014 | World Journal of Gastroenterology2014，20，17： | 6 |
| 2 | Biliary phosphatidylcholine and lysophosphatidylcholine profiles in sclerosing cholangitis显示文摘AIM:To analyze phospholipid profiles in intrahepatic bile from patients with primary sclerosing cholangitis(PSC)and secondary sclerosing cholangitis(SSC).METHODS:Intrahepatic bile specimens collected via endoscopic retrograde cholangiography from 41 patients were analyzed.Fourteen of these patients were diagnosed with PSC,10 with SSC,11 with choledocholithiasis or no identifiable biliary disease,and 6 with cholangiocellular carcinoma(CCC).Bile acid,cholesterol,protein,and bilirubin contents as well as pancreas lipase activity in bile were determined by biochemical methods.Phosphatidylcholine(PC)and lysophosphatidylcholine(LPC)species were quantified using nanoelectrospray ionization tandem mass spectrometry.RESULTS:Bile from all the examined patient groups showed a remarkably similar PC and LPC species composition,with only minor statistical differences.Total biliary PC concentrations were highest in controls(8030±1843 mol/L)and lowest in patients with CCC(1969±981 mol/L)(P=0.005,controls vs SSC and CCC,respectively,P<0.05).LPC contents in bile were overall low(4.2%±1.8%).Biliary LPC/PC ratios and ratios of biliary PC to bilirubin,PC to cholesterol,PC to protein,and PC to bile acids showed no intergroup differences.CONCLUSION:PC and LPC profiles being similar in patients with or without sclerosing cholangitis,these phospholipids are likely not of major pathogenetic importance in this disease group. | Annika Gauss Robert Ehehalt Wolf-Dieter Lehmann Gerhard Erben Karl-Heinz Weiss Yvonne Schaefer Petra Kloeters-Plachky Adolf Stiehl Wolfgang Stremmel Peter Sauer Daniel Nils Gotthardt | 2013 | World Journal of Gastroenterology2013，19，33： | 3 |
| 3 | Mycorrhizal responses to biochar in soil – concepts and mechanisms显示文摘 | Daniel D. Warnock Johannes Lehmann Thomas W. Kuyper Matthias C. Rillig | 2007 | Plant and Soil (-)2007，，1： | 2 |
| 4 | GEOEssential–mainstreaming workflows from data sources to environment policy indicators with essential variables显示文摘When defining indicators on the environment,the use of existing initiatives should be a priority rather than redefining indicators each time.From an Information,Communication and Technology perspective,data interoperability and standardization are critical to improve data access and exchange as promoted by the Group on Earth Observations.GEOEssential is following an end-user driven approach by defining Essential Variables(EVs),as an intermediate value between environmental policy indicators and their appropriate data sources.From international to local scales,environmental policies and indicators are increasingly percolating down from the global to the local agendas.The scientific business processes for the generation of EVs and related indicators can be formalized in workflows specifying the necessary logical steps.To this aim,GEOEssential is developing a Virtual Laboratory the main objective of which is to instantiate conceptual workflows,which are stored in a dedicated knowledge base,generating executable workflows.To interpret and present the relevant outputs/results carried out by the different thematic workflows considered in GEOEssential(i.e.biodiversity,ecosystems,extractives,night light,and food-water-energy nexus),a Dashboard is built as a visual front-end.This is a valuable instrument to track progresses towards environmental policies. | Anthony Lehmann Stefano Nativi Paolo Mazzetti Joan Maso Ivette Serral Daniel Spengler Aidin Niamir Ian McCallum Pierre Lacroix Petros Patias Denisa Rodila Nicolas Ray Grégory Giuliani | 2020 | International Journal of Digital Earth2020，13，2： | 1 |
| 5 | Mycorrhizal responses to biochar in soil – concepts and mechanisms显示文摘 | Daniel D. Warnock Johannes Lehmann Thomas W. Kuyper Matthias C. Rillig | 2007 | Plant and Soil (-)2007，，1： | 1 |
| 6 | Combinatorial auctions with decreasing marginal utilities显示文摘 | Benny Lehmann Daniel Lehmann Noam Nisan | 2006 | Games and Economic Behavior2006，55，2： | 1 |
| 7 | Mycorrhizal responses to biochar in soil – concepts and mechanisms显示文摘 | Daniel D. Warnock Johannes Lehmann Thomas W. Kuyper Matthias C. Rillig | 2007 | Plant and Soil2007，，1： | 1 |
| 8 | Vitamin E isomers in grain amaranths (Amaranthus spp.)显示文摘 | James W. Lehmann Daniel H. Putnam Asaf A. Qureshi | 1994 | Lipids1994，，3： | 1 |
| 9 | A Phase‐Contrast MRI Study of Acute and Chronic Hydrodynamic Alterations after Hydrocephalus Induced by Subarachnoid Hemorrhage显示文摘 | Guillaume Saliou Gaelle Paradot Catherine Gondry Roger Bouzerar Pierre Lehmann Marc Etienne Meyers Daniel Le Gars Hervé Deramond Olivier Balédent | 2011 | Journal of Neuroimaging2011，，4： | 1 |
| 10 | Mycorrhizal responses to biochar in soil – concepts and mechanisms显示文摘 | Daniel D. Warnock Johannes Lehmann Thomas W. Kuyper Matthias C. Rillig | 2007 | Plant and Soil (-)2007，，1： | 1 |
| 11 | Image Guided Radiation Therapy (IGRT) Technologies for Radiation Therapy Localization and Delivery显示文摘 | Jennifer De Los Santos Richard Popple Nzhde Agazaryan John E. Bayouth Jean-Pierre Bissonnette Mary Kara Bucci Sonja Dieterich Lei Dong Kenneth M. Forster Daniel Indelicato Katja Langen Joerg Lehmann Nina Mayr Ishmael Parsai William Salter Michael Tomblyn | 2013 | International Journal of Radiation Oncology, Biology, Physics2013，，： | 1 |
| 12 | Reversibility of Soil Productivity Decline with Organic Matter of Differing Quality Along a Degradation Gradient显示文摘 | Joseph M. Kimetu Johannes Lehmann Solomon O. Ngoze Daniel N. Mugendi James M. Kinyangi Susan Riha Lou Verchot John W. Recha Alice N. Pell | 2008 | Ecosystems2008，，5： | 1 |
| 13 | 拉伯斯维尔—约尔市政博物馆扩建显示文摘mzld建筑师团队,1977年成立于瑞士比尔市。事务所的工作领域广阔,覆盖了从城市规划到细节问题、从工业项目到博物馆项目的诸多领域。事务所刻意选择多元化的公司员工,20多名员工中,每人都有着不同的文化、年龄和经历背景,这使多元化的公司文化得以提升。激烈的内部讨论催发出很多不同种类的项目方案,但这些项目方案都有一个共同点:同项目和场地相统一。mzld已经赢得了超过50个竞赛奖项,其中20多个被付诸实践。它们负责的重要项目包括伯尔尼的历史博物馆扩建(2001—2009年)和位于纽约的与联合国总部大楼相邻的空间,本项目于2004年对外开放,瑞士总统约瑟夫·戴斯和时任联合国总秘书长科菲·安南出席了项目启动仪式。 | Pat Tanner Andreas Frank Monica Udrea Daniele Di Giacinto Carol Hutmacher Claude Marbach Roman Lehmann Regina Tadorian Réne Robeck Julia Wurst Beat Junker Frederike Kluth | 2012 | 城市环境设计2012，，10： | 0 |
| 14 | Developing food,water and energy nexus workflows显示文摘There is a growing recognition of the interdependencies among the supply systems that rely upon food,water and energy.Billions of people lack safe and sufficient access to these systems,coupled with a rapidly growing global demand and increasing resource constraints.Modeling frameworks are considered one of the few means available to understand the complex interrelationships among the sectors,however development of nexus related frameworks has been limited.We describe three opensource models well known in their respective domains(i.e.TerrSysMP,WOFOST and SWAT)where components of each if combined could help decision-makers address the nexus issue.We propose as a first step the development of simple workflows utilizing essential variables and addressing components of the above-mentioned models which can act as building-blocks to be used ultimately in a comprehensive nexus model framework.The outputs of the workflows and the model framework are designed to address the SDGs. | Ian McCallum Carsten Montzka Bagher Bayat Stefan Kollet Andrii Kolotii Nataliia Kussul Mykola Lavreniuk Anthony Lehmann Joan Maso Paolo Mazzetti Aline Mosnier Emma Perracchione Mario Putti Mattia Santoro Ivette Serral Leonid Shumilo Daniel Spengler Steffen Fritza | 2020 | International Journal of Digital Earth2020，13，2： | 0 |
| 15 | Acute Effect of High-Intensity Climbing on Performance and Muscle Oxygenation in Elite Climbers显示文摘High-intensity training(HIT)is known to have deteriorating effects on performance which manifest in various physiological changes such as lowered force production and oxidative capacity.However,the effect of HIT in climbing on finger flexor performance has not been investigated yet.Twenty-one climbers partook in an intervention study with three assessment time points:pre-HIT,post-HIT,and 24-h post-HIT.The HIT involved four five-minute exhaustive climbing tasks.Eight climbers were assigned to a control group.Assessments consisted of three finger flexor tests:maximum voluntary contraction(MVC),sustained contraction(SCT),and intermittent contraction tests(ICT).During the SCT muscle oxygenation(SmO_(2))metrics were collected via NIRS sensors on the forearm.The HIT had significant deteriorating effects on all force production metrics(MVC−18%,SCT−55%,ICT−59%).Post-24 h showed significant recovery,which was less pronounced for the endurance tests(MVC−3%,SCT−16%,ICT−22%).SmO_(2)metrics provided similar results for the SCT with medium to large effect sizes.Minimally attainable SmO_(2)and resting SmO_(2)both showed moderate negative correlations with pre-HIT force production respectively;r=−0.41,P=0.102;r=−0.361,P=0.154.A strong association was found between a loss of force production and change in minimally attainable SmO_(2)(r=−0.734,P=0.016).This study presents novel findings on the deteriorating effects of HIT on finger flexor performance and their oxidative capacity.Specifically,the divergent results between strength and endurance tests should be of interest to coaches and athletes when assessing athlete readiness. | Andri Feldmann Remo Lehmann Frieder Wittmann Peter Wolf Jiří Baláš Daniel Erlacher | 2022 | Journal of Science in Sport and Exercise2022，4，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员