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| 1 | Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis显示文摘AIM:To evaluate the clinical significance of cystatin C and renal resistive index for the determination of renal function in patients with liver cirrhosis.METHODS:We conducted a study of 63 patients with liver cirrhosis.A control group comprised of 30 age and gender-matched healthy persons.Serum cystatin C was determined in all study subjects and renal Doppler ultrasonography was made.Estimated glomerular filtration rate from serum creatinine(GFRCr)and cystatin C(GFRCys)was calculated.RESULTS:We confirmed significant differences in val-ues of cystatin C between patients with different stages of liver cirrhosis according to Child-Pugh(P=0.01),and a significant correlation with model of end stage liver disease(MELD)score(rs=0.527,P<0.001).More patients with decreased glomerular filtration rate were identified based on GFRCys than on GFRCr(P<0.001).Significantly higher renal resistive index was noted in Child-Pugh C than in A(P<0.001)and B stage(P=0.001).Also,a significant correlation between renal resistive index and MELD score was observed(rs=0.607,P<0.001).Renal resistive index correlated significantly with cystatin C(rs=0.283,P=0.028)and showed a negative correlation with GFRCys(rs=-0.31,P=0.016).CONCLUSION:Cystatin C may be a more reliable marker for assessment of liver insufficiency.Additionally,cystatin C and renal resistive index represent sensitive indicators of renal dysfunction in patients with liver cirrhosis. | Dorde Culafi Milos tuli Radmila Obrenovi Danijela Mileti Dragana Mija Milica Stojkovi Marija Jovanovi Milica Culafi | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 2 | Effect of water matrices on removal of veterinary pharmaceuticals by nanofiltration and reverse osmosis membranes显示文摘This study explored the removal of five veterinary pharmaceuticals (VPs) (sulfamethoxazole (SMETOX), trimethoprim (TMP), ciprofloxacin (CIPRO), dexamethasone (DEXA) and febantel (FEBA)) from different water matrices (Milli-Q water, model water, tap water and real pharmaceutical wastewater using four types of nanofiltration (NF) membranes (NF90, NF270, NF and HL) and two reverse osmosis (RO) membranes (LFC-1 and XLE). All VPs were added to different water matrices at a concentration of 10 mg/L. Rejections of VPs and water flux were measured. The rejection increased with increase of molecular weight. The highest rejections were obtained with RO membranes (LFC-1, XLE) and tight NF (NF90) membrane. In general, the rejection of VPs was higher in model water and tap water than in Milli-Q water, but the water flux was lower. This was mainly explained by ion adsorption inside the membranes pores. Narrower pore size counteracted the effect of presence of low concentration of natural organic matter (NOM) in tap water. The NOM was assumed to enhance the adsorption of VPs onto membrane surface, increased the size exclusion and electrostatic repulsion also appeared during the transport. Investigated water matrices had influence on water flux decline due to their complexity. | Davor Dolar Ana Vukovi Danijela Aperger Kreimir Kouti | 2011 | Journal of Environmental Sciences2011，23，8： | 4 |
| 3 | Esophagogastric anastomosis in rats: Improved healing by BPC 157 and L-arginine, aggravated by L-NAME显示文摘AIM To cure typically life-threatening esophagogastric anastomosis in rats, lacking anastomosis healing and sphincter function rescue, in particular. METHODS Because we assume esophagogastric fistulas represent a particular NO-system disability, we attempt to identify the benefits of anti-ulcer stable gastric pentadecapeptide BPC 157, which was in trials for ulcerative colitis and currently for multiple sclerosis, in rats with esophagocutaneous fistulas. Previously, BPC 157 therapies have promoted the healing of intestinal anastomosis and fistulas, and esophagitis and gastric lesions, along with rescued sphincter function. Additionally, BPC 157 particularly interacts with the NOsystem. In the 4 d after esophagogastric anastomosis creation, rats received medication(/kg intraperitoneallyonce daily: BPC 157(10 μg, 10 ng), L-NAME(5 mg), or L-arginine(100 mg) alone and/or combined or BPC 157(10 μg, 10 ng) in drinking water). For rats underwent esophagogastric anastomosis, daily assessment included progressive stomach damage(sum of the longest diameters, mm), esophagitis(scored 0-5), weak anastomosis(m L H2 O before leak), low pressure in esophagus at anastomosis and in the pyloric sphincter(cm H2O), progressive weight loss(g) and mortality. Immediate effect assessed blood vessels disappearance(scored 0-5) at the stomach surface immediately after anastomosis creation. RESULTS BPC 157(all regimens) fully counteracted the perilous disease course from the very beginning(i.e., with the BPC 157 bath, blood vessels remained present at the gastric surface after anastomosis creation) and eliminated mortality. Additionally, BPC 157 treatment in combination with L-NAME nullified any effect of L-NAME that otherwise intensified the regular course. Consistently, with worsening(with L-NAME administration) and amelioration(with L-arginine), either L-arginine amelioration prevails(attenuated esophageal and gastric lesions) or they counteract each other(L-NAME + L-arginine); with the addition of BPC 157(L-NAME + L-arginine + BPC 157), there was a marked beneficial effect. BPC 157 treatment for esophagogastric anastomosis, along with NOS-blocker L-NAME and/or NOS substrate L-arginine, demonstrated an innate NO-system disability(as observed with L-arginine effectiveness). BPC 157 distinctively affected corresponding events: worsening(obtained with L-NAME administration that was counteracted); or amelioration(L-arginine + BPC 157-rats correspond to BPC 157-rats).CONCLUSION Innate NO-system disability for esophagogastric anastomoses, including L-NAME-worsening, suggests that these effects could be corrected by L-arginine and almost completely eliminated by BPC 157 therapy. | Zeljko Djakovic Ivka Djakovic Vedran Cesarec Goran Madzarac Tomislav Becejac Goran Zukanovic Domagoj Drmic Lovorka Batelja Anita Zenko Sever Danijela Kolenc Alen Pajtak Nikica Knez Mladen Japjec Kresimir Luetic Dinko Stancic-Rokotov Sven Seiwerth Predrag Sikiric | 2016 | World Journal of Gastroenterology2016，22，41： | 3 |
| 4 | Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME显示文摘AIM To counteract/reveal celecoxib-induced toxicity and NO system involvement. METHODS Celecoxib(1 g/kg b.w. ip) was combined with therapy with stable gastric pentadecapeptide BPC 157(known to inhibit these lesions, 10 μg/kg, 10 ng/kg, or 1 ng/kg ip) and L-arginine(100 mg/kg ip), as well as NOS blockade [N(G)-nitro-L-arginine methyl ester(L-NAME)](5 mg/kg ip) given alone and/or combined immediately after celecoxib. Gastrointestinal, liver, and brain lesions and liver enzyme serum values in rats were assessed at 24 h and 48 h thereafter. RESULTS This high-dose celecoxib administration, as a result of NO system dysfunction, led to gastric, liver, and brain lesions and increased liver enzyme serum values. The L-NAME-induced aggravation of the lesions was notable for gastric lesions, while in liver and brain lesions the beneficial effect of L-arginine was blunted. L-arginine counteracted gastric, liver and brain lesions. These findings support the NO system mechanism(s), both NO system agonization(L-arginine) and NO system antagonization(L-NAME), that on the whole are behind all of these COX phenomena. An even more complete antagonization was identified with BPC 157(at both 24 h and 48 h). A beneficial effect was evident on all the increasingly negative effects of celecoxib and L-NAME application and in all the BPC 157 groups(L-arginine + BPC 157; L-NAME + BPC 157; L-NAME + L-arginine + BPC 157). Thus, these findings demonstrated that BPC 157 may equally counteract both COX-2 inhibition(counteracting the noxious effects of celecoxib on all lesions) and additional NOS blockade(equally counteracting the noxious effects of celecoxib + L-NAME). CONCLUSION BPC 157 and L-arginine alleviate gastrointestinal, liver and brain lesions, redressing NSAIDs' post-surgery application and NO system involvement. | Domagoj Drmic Danijela Kolenc Spomenko Ilic Lara Bauk Marko Sever Anita Zenko Sever Kresimir Luetic Jelena Suran Sven Seiwerth Predrag Sikiric | 2017 | World Journal of Gastroenterology2017，23，29： | 2 |
| 5 | Interplay of SOX transcription factors and microRNAs in the brain under physiological and pathological conditions显示文摘Precise tuning of gene expression,accomplished by regulato ry networks of transcription factors,epigenetic modifiers,and microRNAs,is crucial for the proper neural development and function of the brain cells.The SOX transcription factors are involved in regulating diverse cellular processes during embryonic and adult neurogenesis,such as maintaining the cell stemness,cell prolife ration,cell fate decisions,and terminal diffe rentiation into neurons and glial cells.MicroRNAs represent a class of small non-coding RNAs that play important roles in the regulation of gene expression.Together with other gene regulatory factors,microRNAs regulate different processes during neurogenesis and orchestrate the spatial and temporal expression important for neurodevelopment.The emerging data point to a complex regulatory network between SOX transcription factors and microRNAs that govern distinct cellular activities in the developing and adult brain.Deregulated SOX/mic roRNA interplay in signaling pathways that influence the homeostasis and plasticity in the brain has been revealed in various brain pathologies,including neurodegenerative disorders,traumatic brain injury,and cancer.Therapeutic strategies that target SOX/microRNA interplay have emerged in recent years as a promising tool to target neural tissue regeneration and enhance neuro restoration.N umerous studies have confirmed complex intera ctions between microRNAs and SOX-specific mRNAs regulating key features of glioblastoma.Keeping in mind the crucial roles of SOX genes and microRNAs in neural development,we focus this review on SOX/microRNAs interplay in the brain during development and adulthood in physiological and pathological conditions.Special focus was made on their interplay in brain pathologies to summarize current knowledge and highlight potential future development of molecular therapies. | Milena Stevanovic Danijela Stanisavljevic Ninkovic Marija Mojsin Danijela Drakulic Marija Schwirtlich | 2022 | Neural Regeneration Research2022，17，11： | 2 |
| 6 | Crosstalk between dietary patterns,obesity and nonalcoholic fatty liver disease显示文摘The prevalence of nonalcoholic fatty liver disease(NAFLD)is rising worldwide,paralleling the epidemic of obesity.The liver is a key organ for the metabolism of proteins,fats and carbohydrates.Various types of fats and carbohydrates in isocaloric diets differently influence fat accumulation in the liver parenchyma.Therefore,nutrition can manage hepatic and cardiometabolic complications of NAFLD.Even moderately reduced caloric intake,which leads to a weight loss of 5%-10%of initial body weight,is effective in improving liver steatosis and surrogate markers of liver disease status.Among dietary patterns,the Mediterranean diet mostly prevents the onset of NAFLD.Furthermore,this diet is also the most recommended for the treatment of NAFLD patients.However,clinical trials based on the dietary interventions in NAFLD patients are sparse.Since there are only a few studies examining dietary interventions in clinically advanced stages of NAFLD,such as active and fibrotic steatohepatitis,the optimal diet for patients in these stages of the disease must still be determined.In this narrative review,we aimed to critically summarize the associations between different dietary patterns,obesity and prevention/risk for NAFLD,to describe specific dietary interventions’impacts on liver steatosis in adults with NAFLD and to provide an updated overview of dietary recommendations that clinicians potentially need to apply in their daily practice. | Danijela Ristic-Medic Joanna Bajerska Vesna Vucic | 2022 | World Journal of Gastroenterology2022，28，27： | 2 |
| 7 | The influence of single and combined IL28B polymorphisms on response to treatment of chronic hepatitis C显示文摘 | Ivana Lazarevic Jelena Djordjevic Maja Cupic Danijela Karalic Dragan Delic Neda Svirtlih Jasmina Simonovic Petar Svorcan Natasa Milic Tanja Jovanovic | 2013 | Journal of Clinical Virology2013，，： | 2 |
| 8 | Structural and functional studies on the stalk of the transferrinreceptor显示文摘 | DANIJELA D ZONG L DEBORAH FK | 2009 | Biochem Biophys Res Commun2009，381，4： | 1 |
| 9 | Effect of Specific Packaging Conditions on Myoglobin and Meat Color 显示文摘 | -UPUT Z DANIJELA LAZIC L | 2012 | Food and Feed Reareh2012，33，2： | 1 |
| 10 | Cramer-Rao Bounds for Joint RSS/DoA-Based Primary-User Localiza- tion in Cognitive Radio Networks 显示文摘 | WANG Jun CHEN Jianshu DANIJELA C | 2013 | IEEE Transactions on Wireless Communications2013，12，3： | 1 |
| 11 | Solid phase extraction and HPLC determination of veterinary pharma- ceuticals in wastewater显示文摘 | Babic Sandra Asperger Danijela Mutavdzic Dragana | 2006 | Talanta2006，，： | 1 |
| 12 | Detection of Tumor PIK3 CA Status in Metastatic Breast Cancer Using Peripheral Blood 显示文摘 | Michaela JH Danijela J Evan B | 2012 | Clin Cancer Res2012，18，12： | 1 |
| 13 | C-reactive protein Level in Severe Stenosis of Cerebral Arteries 显示文摘 | Zlata FM Danijela VH Vlatka PK | 2007 | Cerebrovasc Dis2007，23，56： | 1 |
| 14 | Removal of wastewaters by spontaneous flow conditions显示文摘 | Bojic Aleksandar Bojic Danijela Cu^2+ and Zn^2+ from model reduction-coagulation process in Hazardous Materials 2009 168 Andjelkovic Tatjana | 2009 | Journal of2009，，23： | 1 |
| 15 | Pediatric Reference Intervals for 34 Biochemical Analytes in Urban School Children and Adolescents显示文摘 | Nada Jagarinec Zlata Flegar-Me?tri? Branka ?urina Danijela Vrhovski-Hebrang Vladimira Preden-Kerekovi? | 1998 | Clinical Chemistry and Laboratory Medicine1998，，5： | 1 |
| 16 | Milk yield and composition, body condition, rumen characteristics, and blood metabolites of dairy cows fed diet supplemented with palm oil 显示文摘 | Danijela K Bojan B Marko K | 2015 | Chem Biol Technol Agric2015，2，1： | 1 |
| 17 | Aloe emodin inhibits the cytotoxic action of tumor necrosis factor 显示文摘 | Ljubica Harhaji Sanja Mijato Danijela Maksimovic-Ivanic | 2007 | European Journal of Pharmacology2007，568，： | 1 |
| 18 | Targeting the Cancer Initiating Cell: The Ultimate Target for Cancer Therapy显示文摘 | James A. McCubrey Linda S. Steelman Stephen L. Abrams Negin Misaghian William H. Chappell Jorg Basecke Ferdinando Nicoletti Massimo Libra Giovanni Ligresti Francac Stivala Danijela Maksimovic-Ivanic Sanja Mijatovic Giuseppeo Montalto Melchiorre Cervello P | 2012 | Current Pharmaceutical Design2012，，13： | 1 |
| 19 | Phenolic Profile, Antioxidant Capacity, and Antimicrobial Activity of Leaf Extracts from Six Vitis vinifera L. Varieties显示文摘 | Vi?nja Katalinic SonjaSmole Mozina Ivana Generalic Danijela Skroza Ivica Ljubenkov Anja Klancnik | 2013 | International Journal of Food Properties2013，，1： | 1 |
| 20 | The determination of steel cleanliness in the as-cast steel ingot 26NiCrMoV14显示文摘 | Danijela Anica Skobir Matjaz Godec Martin Balcar | 2010 | Vacuum2010，84，： | 1 |
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