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| 1 | Mitochondrial neuronal uncoupling proteins:a target for potential disease-modification in Parkinson’s disease Philip显示文摘This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson’s disease(PD).Mitochondria provide cellular energy in the form of ATP via oxidative phosphorylation,but as an integral part of this process,superoxides and other reactive oxygen species are also produced.Excessive free radical production contributes to oxidative stress.Cells have evolved to handle such stress via various endogenous anti-oxidant proteins.One such family of proteins is the mitochondrial uncoupling proteins(UCPs),which are anion carriers located in the mitochondrial inner membrane.There are five known homologues(UCP1 to 5),of which UCP4 and 5 are predominantly expressed in neural cells.In a series of previous publications,we have shown how these neuronal UCPs respond to 1-methyl-4-phenylpyridinium(MPP+;toxic metabolite of MPTP)and dopamine-induced toxicity to alleviate neuronal cell death by preserving ATP levels and mitochondrial membrane potential,and reducing oxidative stress.We also showed how their expression can be influenced by nuclear factor kappa-B(NF-B)signaling pathway specifically in UCP4.Furthermore,we previously reported an interesting link between PD and metabolic processes through the protective effects of leptin(hormone produced by adipocytes)acting via UCP2 against MPP+-induced toxicity.There is increasing evidence that these endogenous neuronal UCPs can play a vital role to protect neurons against various pathogenic stresses including those associated with PD.Their expression,which can be induced,may well be a potential therapeutic target for various drugs to alleviate the harmful effects of pathogenic processes in PD and hence modify the progression of this disease. | WL Ho Jessica WM Ho Hui-Fang Liu Danny HF So Zero HM Tse Koon-Ho Chan David B Ramsden Shu-Leong Ho | 2012 | Translational Neurodegeneration2012，1，1： | 3 |
| 2 | HBsAg Seroclearance in Chronic Hepatitis B in Asian Patients: Replicative Level and Risk of Hepatocellular Carcinoma显示文摘 | Man–Fung Yuen Danny Ka–Ho Wong James Fung Philip Ip David But Ivan Hung Kevin Lau John Chi–Hang Yuen Ching–Lung Lai | 2008 | Gastroenterology2008，，4： | 2 |
| 3 | A review of transfer of training studies in the past deeade显示文摘 | Eddie W I Cheng Danny C K Ho | 2001 | Personnel Review2001，30，1： | 1 |
| 4 | Helicobacter pylori induces promoter methylation of E‐cadherin via interleukin‐1β activation of nitric oxide production in gastric cancer cells显示文摘 | Fung‐Yu Huang Annie On‐On Chan Asif Rashid Danny Ka‐Ho Wong Chi‐Hin Cho Man‐Fung Yuen | 2012 | Cancer2012，，20： | 1 |
| 5 | Improving the COCOMO model using a neuro-fuzzy approach 显示文摘 | Xishi Huang Danny Ho Jing Ren | 2007 | Applied Soft Computing (S1568-4946)2007，7，： | 1 |
| 6 | Improving the COCOMOModel Using a Neuro-fuzzy Approach显示文摘 | Huang Xishi Ho Danny Ren Jing | 2007 | Applied Soft Computing2007，，7： | 1 |
| 7 | Efficient Message Passing Interface (MPI) for Parallel Computing on Clusters of Workstations显示文摘 | Jehoshua Bruck Danny Dolev Ching-Tien Ho | 1997 | Journal of Parallel and Distributed Computing1997，40，： | 1 |
| 8 | Occult hepatitis B infection and HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma显示文摘 | Danny Ka Ho Wong Fung Yu Huang Ching Lung Lai Ronnie Tung Ping Poon Wai Kay Seto James Fung Ivan Fan Ngai Hung Man Fung Yuen | 2011 | Hepatology2011，，3： | 1 |
| 9 | Design and Build Project Success Factors: Multivariate Analysis显示文摘 | Albert P. C. Chan Danny C. K. Ho C. M. Tam | 2001 | Journal of Construction Engineering and Management2001，，2： | 1 |
| 10 | An empirical validation of object-oriented design metrics for fault prediction显示文摘 | Jie Xu Danny Ho Luiz Fernando Capretz | 2008 | Journal of Computer Science2008，4，7： | 1 |
| 11 | Imroving the CocomoModel using a neuro-fuzzy approach显示文摘 | Huang Xishi Ho Danny Ren Jing | 2007 | Applied Soft Computing2007，7，1： | 1 |
| 12 | Helicobacter pylori induces promoter methylation of E‐cadherin via interleukin‐1β activation of nitric oxide production in gastric cancer cells显示文摘 | Fung‐Yu Huang Annie On‐On Chan Asif Rashid Danny Ka‐Ho Wong Chi‐Hin Cho Man‐Fung Yuen | 2012 | Cancer2012，，20： | 1 |
| 13 | Design and Build Project Success Factors: Multivariate Analysis显示文摘 | Albert P. C. Chan Danny C. K. Ho C. M. Tam | 2001 | Journal of Construction Engineering and Management2001，，2： | 1 |
| 14 | Fluctuating temperature modifies heat-mortality association around the globe显示文摘Studies have investigated the effects of heat and temperature variability(TV)on mortality.However,few assessed whether TV modifies the heat-mortality association.Data on daily temperature and mortality in the warm season were collected from 717 locations across 36 countries.TV was calculated as the standard deviation of the average of the same and previous days’minimum and maximum temperatures. | Yao Wu Bo Wen Shanshan Li Antonio Gasparrini Shilu Tong Ala Overcenco Ales Urban Alexandra Schneider Alireza Entezari Ana Maria Vicedo-Cabrera Antonella Zanobetti Antonis Analitis Ariana Zeka Aurelio Tobias Barrak Alahmad Ben Armstrong Bertil Forsberg CarmenÍñiguez Caroline Ameling César De la Cruz Valencia ChristoferÅström Danny Houthuijs Do Van Dung Dominic Royé Ene Indermitte Eric Lavigne Fatemeh Mayvaneh Fiorella Acquaotta Francesca de’Donato Francesco Sera Gabriel Carrasco-Escobar Haidong Kan Hans Orru Ho Kim Iulian-Horia Holobaca Jan Kyselý Joana Madureira Joel Schwartz Klea Katsouyanni Magali Hurtado-Diaz Martina SRagettli Masahiro Hashizume Mathilde Pascal Micheline de Sousa Zanotti Stagliorio Coélho Noah Scovronick Paola Michelozzi Patrick Goodman Paulo Hilario Nascimento Saldiva Rosana Abrutzky Samuel Osorio Tran Ngoc Dang Valentina Colistro Veronika Huber Whanhee Lee Xerxes Seposo Yasushi Honda Michelle L.Bell Yuming Guo | 2022 | The Innovation2022，3，2： | 0 |
| 15 | Octadecylamine and glucose-coderived hydrophobic carbon dots-modified porous silica for chromatographic separation显示文摘A hydrophobic carbon dots(Glc-OCDs)derived from octadecylamine and glucose were successfully synthesized for the first time and then grafted onto the porous silica surface by the“Nano-on-Micro”strategy,which was served as a new stationary phase(Sil-Glc-OCDs)for reversed-phase liquid chromatography.The structure of this stationary phase was carefully verified by laser scanning confocal microscope,Fourier transform infrared spectrometry,elemental analysis,contact angle measurement,etc.Several analytes including seven polycyclic aromatic hydrocarbons,eight alkylbenzenes,eight phenols and seven sulfonamides can be well separated on this stationary phase.Better separation performance for certain analytes over commercial C_(18) column was obtained.Interestingly,this stationary phase exhibited excellent chromatographic selectivity in the separation of the isomers of tert‑butylbenzene,sec‑butylbenzene,isobutylbenzene and n-butylbenzene.In addition,this new Sil-Glc-OCDs column was also applied for detection of calycosin-7-glucoside,ononin,calycosin,formononetin,genistein and isorhamnetin in the extract of Radix Astragali,which were found that the concentration was 0.15 g/L,0.088 g/L,0.14 g/L,0.086 g/L,0.18 g/L and 0.29 g/L,respectively.We believe that this CDs-grafted silica materials are promising for chromatographic separation. | Jia Chen Ning Yuan Danni Jiang Qian Lei Bei Liu Weiyang Tang Kyung Ho Row Hongdeng Qiu | 2021 | Chinese Chemical Letters2021，32，11： | 0 |
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