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| 1 | Small intestinal bacterial overgrowth syndrome显示文摘Human intestinal microbiota create a complex polymi-crobial ecology. This is characterised by its high population density, wide diversity and complexity of interaction. Any dysbalance of this complex intestinal microbiome, both qualitative and quantitative, might have serious health consequence for a macro-organism, including small intestinal bacterial overgrowth syndrome (SIBO).SIBO is defined as an increase in the number and/or alteration in the type of bacteria in the upper gastro-intestinal tract. There are several endogenous defence mechanisms for preventing bacterial overgrowth: gastric acid secretion, intestinal motility, intact ileo-caecal valve, immunoglobulins within intestinal secretion and bacte-riostatic properties of pancreatic and biliary secretion. Aetiology of SIBO is usually complex, associated with disorders of protective antibacterial mechanisms (e.g. achlorhydria, pancreatic exocrine insuff iciency, immuno-deficiency syndromes), anatomical abnormalities (e.g. small intestinal obstruction, diverticula, f istulae, surgical blind loop, previous ileo-caecal resections) and/or motility disorders (e.g. scleroderma, autonomic neuropathy in diabetes mellitus, post-radiation enteropathy, small intestinal pseudo-obstruction). In some patients more than one factor may be involved. Symptoms related to SIBO are bloating, diarrhoea, malabsorption, weight loss and malnutrition. The gold standard for diagnosing SIBO is still microbial investigation of jejunal aspirates. Noninvasive hydrogen and methane breath tests are most commonly used for the diagnosis of SIBO using glucose or lactulose. Therapy for SIBO must be com-plex, addressing all causes, symptoms and complica-tions, and fully individualised. It should include treatment of the underlying disease, nutritional support and cyclical gastro-intestinal selective antibiotics. Prognosis is usually serious, determined mostly by the underlying disease that led to SIBO. | Jan Bures Jiri Cyrany Darina Kohoutova Miroslav Frstl Stanislav Rejchrt Jaroslav Kvetina Viktor Vorisek Marcela Kopacova | 2010 | World Journal of Gastroenterology2010，16，24： | 52 |
| 2 | Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention显示文摘Many epidemiological and experimental studies have suggested that dietary fiber plays an important role in colon cancer prevention. These findings may relate to the ability of fiber to reduce the contact time of carcinogens within the intestinal lumen and to promote healthy gut microbiota, which modifies the host's metabolism in various ways. Elucidation of the mechanisms by which dietary fiber-dependent changes in gut microbiota enhance bile acid deconjugation, produce short chain fatty acids, and modulate inflammatory bioactive substances can lead to a better understanding of the beneficial role of dietary fiber. This article reviews the current knowledge concerning the mechanisms via which dietary fiber protects against colon cancer. | Huawei Zeng Darina L Lazarova Michael Bordonaro | 2014 | World Journal of Gastrointestinal Oncology2014，6，2： | 19 |
| 3 | CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer显示文摘This paper reviews the distinctive roles played by the transcriptional coactivators CREB-binding protein(CBP) and p300 in Wnt/β-catenin signaling and cell physiology in colorectal cancer(CRC). Specifically, we focus on the effects of CBP- and p300-mediated Wnt activity on(1) neoplastic progression;(2) the activities of butyrate, a breakdown product of dietary fiber, on cell signaling and colonic cell physiology;(3) the development of resistance to histone deacetylase inhibitors(HDACis), including butyrate and synthetic HDACis, in colonic cells; and(4) the physiology and number of cancer stem cells. Mutations of the Wnt/β-catenin signaling pathway initiate the majority of CRC cases, and we have shown that hyperactivation of this pathway by butyrate and other HDACis promotes CRC cell apoptosis. This activity by butyrate may in part explain the preventive action of fiber against CRC. However, individuals with a high-fiber diet may still develop neoplasia; therefore, resistance to the chemopreventive action of butyrate likely contributes to CRC. CBP or p300 may modify the ability of butyrate to influence colonic cell physiology since the two transcriptional coactivators affect Wnt signaling, and likely, its hyperactivation by butyrate. Also, CBP and p300 likely affect colonic tumorigenesis, as well as stem cell pluripotency. Improvement of CRC prevention and therapy requires a better understanding of the alterations in Wnt signaling and gene expression that underlie neoplastic progression, stem cell fate, and the development of resistance to butyrate and clinically relevant HDACis. Detailed knowledge of how CBP- and p300 modulate colonic cell physiology may lead to new approaches for anti-CRC prevention and therapeutics, particularly with respect to combinatorial therapy of CBP/p300 inhibitors with HDACis. | Michael Bordonaro Darina L Lazarova | 2015 | World Journal of Gastroenterology2015，21，27： | 6 |
| 4 | Same-day 2-L PEG-citrate-simethicone plus bisacodyl vs split 4-L PEG: Bowel cleansing for late-morning colonoscopy显示文摘AIM: To evaluate the efficacy, tolerability, acceptability and feasibility of bisacodyl plus low volume polyethyleneglycol-citrate-simeticone(2-L PEG-CS) taken the same day as compared with conventional split-dose 4-L PEG for late morning colonoscopy. METHODS: Randomised, observer-blind, parallel group, comparative trial carried out in 2 centres. Out patients of both sexes, aged between 18 and 85 years, undergoing colonoscopy for diagnostic investigation, colorectal cancer screening or follow-up were eligible. The PEG-CS group received 3 bisacodyl tablets(4 tablets for patients with constipation) at bedtime and 2-L PEG-CS in the morning starting 5 h before colonoscopy. The control group received a conventional 4-L PEG formulation given as split regimen; the morning dose was taken with the same schedule of the low volume preparation. The Ottawa Bowel Preparation Scale(OBPS) score was used as the main outcome measure.RESULTS: A total of 164 subjects were enrolled and 154 completed the study; 78 in the PEG-CS group and 76 in the split 4-L PEG group. The two groups were comparable at baseline. The OBPS score in the PEG-CS group(3.09 ± 2.40) and in the PEG group(2.39 ± 2.55) were equivalent(difference +0.70; 95%CI:-0.09-1.48). This was confirmed by the rate of successful bowel cleansing in the PEG-CS group(89.7%) and in the PEG group(92.1%)(difference-2.4%; 95%CI:-11.406.70). PEG-CS was superior in terms of mucosa visibility compared to PEG(85.7% vs 72.4%, P = 0.042). There were no significant differences in caecum intubation rate, time to reach the caecum and withdrawal time between the two groups. The adenoma detection rate was similar(PEG-CS 43.6% vs PEG 44.7%). No serious adverse events occurred. No difference was found in tolerability of the bowel preparations. Compliance was equal in both groups: more than 90% of subjects drunk the whole solution. Willingness to repeat the same bowel preparations was about 90% for both regimes. CONCLUSION: Same-day PEG-CS is feasible, effective as split-dose 4-L PEG for late morning colonoscopy and does not interfere with work and daily activities the day before colonoscopy. | Annalisa de Leone Darina Tamayo Giancarla Fiori Davide Ravizza Cristina Trovato Giuseppe De Roberto Linda Fazzini Marco Dal Fante Cristiano Crosta | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，9： | 5 |
| 5 | The activation of beta-catenin by Wnt signaling mediates the effects of histone deacetylase inhibitors显示文摘 | Michael Bordonaro Darina L. Lazarova Alan C. Sartorelli | 2007 | Experimental Cell Research2007，，8： | 1 |
| 6 | Celiac disease: in vivo diagnosis by confocal endomicroscopy显示文摘 | Cristina Trovato Angelica Sonzogni Davide Ravizza Giancarla Fiori Marzia Rossi Darina Tamayo Mara Jo Miller Maria Teresa Bardella Cristiano Crosta | 2007 | Gastrointestinal Endoscopy2007，，7： | 1 |
| 7 | Poly (vinyl alcohol) stabilisation in thermoplastic processing显示文摘 | Pavol Alexy Darina Kachova Miroslav Krgiak | 2002 | Polymer Degradation and Stability2002，78，： | 1 |
| 8 | Determination of apigenin in rat plasma by high-performance liquid chromatography显示文摘 | Darina Romanová Daniel Grancai Beáta Jóēová | 2000 | Journal of Chromatography A2000，870，： | 1 |
| 9 | Ontological support for learning content management 显示文摘 | DARINA DICHEVA CHRISTO DICHEV | 2008 | Interdisciplinary Studies in Computer Science2008，，1： | 1 |
| 10 | Poly (vinyl alcohol) Stabilisation in Thermoplastic Processing 显示文摘 | ALEXY Pavol DARINA Kachovd MIROSLAV Kriak | 2002 | Polymer Degradation and Stability2002，，78： | 1 |
| 11 | Spoil heaps from brown coal minings:Technical re-clamation versus spontaneous revegetation显示文摘 | Darina Hodacova Karel Prach | 2003 | Restoration Ecology2003，8，2： | 1 |
| 12 | State-Space Model of a Me- chanical System in MATLAB/Simulink 显示文摘 | Peter Sivdk Darina Hroncovd | 2012 | Procedia Engi- neering2012，48，： | 1 |
| 13 | Rapid and simple method for determination of hexabromocyclododecanes and other LC–MS–MS-amenable brominated flame retardants in fish显示文摘 | Darina Lankova Michala Kockovska Ondrej Lacina Kamila Kalachova Jana Pulkrabova Jana Hajslova | 2013 | Analytical and Bioanalytical Chemistry2013，，24： | 1 |
| 14 | Poly(vinyl alcohol) stabilization in thermoplastic processing显示文摘 | Pavol Alexy Darina Kachova Miroslav Krsiak | 2002 | Polymer Degradation and Stability2002，78，3： | 1 |
| 15 | Re- duction of carcinogenesis by bio-based lignin derivatives 显示文摘 | Bozena Kosikova Darina SlamenovO MOria MikulOsovta | 2002 | Biomass and Bioenergy2002，23，： | 1 |
| 16 | Poly (vinyl alcohol)stabilization in thermo plastic processing 显示文摘 | Pavol Alexy Darina Kachova Miroslav Kriaketal | 2002 | Polymer Degradation and Stability2002，78，： | 1 |
| 17 | Cleanup of water surface from oil spills using natural sorbent materials 显示文摘 | Olga V R Darina V I Alexandr A I | 2014 | Proce- dia Chemistry2014，，10： | 1 |
| 18 | An Approach to Interoperability of Ontology-basedEducational Repositories显示文摘 | Darina Aroyo L | 2006 | Engineering Education and Life-longLearning2006，16，12： | 1 |
| 19 | -State-Space model of a mechanical system in MATLAB/Simulink显示文摘 | Peter Sivfik Darina Hroncovfi | 2012 | Procedia Engineering2012，48，： | 1 |
| 20 | Poly(vinyl alcohol) stabilization in thermoplastic processing显示文摘 | Pavol Alexy Darina Kachova Miroslav Krsiak Dusan Bakos Barbora Simkova | 2002 | Polymer Degradation and Stability2002，78，： | 1 |
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