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| 1 | Carbohydrates mediate sperm-ovum adhesion and triggering of the acrosome reaction显示文摘The fertilization process is the net result of a complex sequence of events that collectively result in the fusion of the opposite gametes. The male gamete undergoes continuous morphological and biochemical modifications during sperm development in the testis (spermatogenesis), maturation in the epididymis, and capacitation in the female reproductive tract. Only the capacitated spermatozoa are able to recognize and bind to the bioactive glycan residue(s) on the ovum's extracellular coat, the zona pellucida (ZP). Sperm-zona binding in the mouse and several other species is believed to take place in two stages. First, capacitated (acrosome-intact) spermatozoa loosely and reversibly adhere to the zona-intact ovum. In the second stage tight irreversible binding occurs. Both types of bindings are attributed to the presence of glycan- binding proteins (receptors) on the sperm plasma membrane and their complementary bioactive glycan units (ligands) on the surface of the ZP. The carbohydrate-mediated adhesion event initiates a signal transduction cascade resulting in the exocytosis of acrosomal contents. This step is believed to be prerequisite which allows the hypemctivated acrosome-reacted spermatozoa to penetrate the ZP and fertilize the ovum. This review focuses on the role of carbohydrate residues in sperm-ovum interaction, and triggering of the acrosome reaction. I have attempted to discuss extensive progress that has been made to enhance our understanding of the well programmed multiple molecular events necessary for successful fertilization. This review will identify these events, and discuss the functional significance of carbohydrates in these events. | Daulat R.P | 2000 | Asian Journal of Andrology2000，2，2： | 2 |
| 2 | Chemical wellbore plug for zone isolation in horizontal wells 显示文摘 | Saaverdra N F Ecopetrol M Daulat D | 1998 | SPE 39647- MS1998，，： | 1 |
| 3 | Topoisomerase inhibitors as anticancer agents: a patent update显示文摘 | Daulat B Khadka Won-Jea Cho | 2013 | Expert Opinion on Therapeutic Patents2013，，8： | 1 |
| 4 | Safety of cephal- osporin administration to patients with histories of penicillin allergy显示文摘 | DAULAT S SOLENSKY R EARL HS | 2004 | Allergy Clin Immunol2004，113，6： | 1 |
| 5 | Signal transduction path ways that regulate sperm capacitation and the acro some reaction显示文摘 | AIDA A H DAULAT T | 2009 | Arch Biochem Biophys2009，485，： | 1 |
| 6 | Molecular organiza- tion and dynamics of the melatonin MT1 receptor/RGS20/G (1) protein complex reveal asymmetry of receptor dimers for RGSand G(1) coupling显示文摘 | Maurice P Daulat A M Turecek R | 2010 | EMBO J2010，29，21： | 1 |
| 7 | Gene expression analy- sis in early embryos through reverse transcription quantitative PCR ( RT- qPCR ) 显示文摘 | Peynot N V6ronique D Daulat R K | 2015 | Nuclear Reprogramming Springer New York2015，，： | 1 |
| 8 | Safety of cephalosporin administration to patients with histories of penicillin allergy显示文摘 | Daulat S Solensky R Earl H S | 2004 | J Allergy Clin Immunol2004，113，6： | 1 |
| 9 | Long-term complete re- sponses to combination therapies and allogeneic stem cell trans- plants in patients with SOzaxy syndrome 显示文摘 | Polansky M Talpur R Daulat S | 2015 | Clin Lymphoma Myeloma Lenk2015，15，5： | 1 |
| 10 | Evidence for the presence of highmannose/hybrid oligosaccharide chain (s) on the mouse ZP2 and ZP3显示文摘 | Daulat Ram P Tulsiani | 1992 | Biol Reprod1992，46，： | 1 |
| 11 | Beta blockers for congestive heart failure显示文摘 | Daulat Manurung Hanafi B Trisnohadi | | 0，，01： | 1 |
| 12 | Targetoid hemosiderotic hemangioma-a dynamic vascular tumor:report of 3 cases with episodic and cyclic changes and comparison with solitary angiokeratomas显示文摘 | Carlson JA Daulat S Goodheart HP | 1999 | J Am Acad Dermatol1999，41，21： | 1 |
| 13 | Development of pemphigus vulgaris in a patient with psoriasis treated with etanercept显示文摘 | Daulat S Detweiler JG Pandya AG | 2009 | J Eur Acad Dermatol Venereol2009，23，4： | 1 |
| 14 | Calcium-sensing receptor modulates cell adhesion and migration via integrins显示文摘 | Tharmalingam S Daulat AM Antflick JE | 2011 | J Biol Chem2011，286，40： | 1 |
| 15 | Caving performance through the integration of microseismic activity and numerical modeling at DOZ-PT Freeport,Indonesia显示文摘This article describes an undergoing research at PT Freeport,Indonesia,in which the main goal is to use the microseismic information recorded as a result of mining to analyze cave propagation and stress performance on the actual production and fixed infrastructure. At the moment,several numerical experiments have been conducted to correlate the mining activity with the microseismic events using the data collected during year 2005 and 2006. As a result of the preliminary analysis a microand a macrocracking envelop were proposed on the basis of computation of stress behavior at the location of the events. Stresses have been computed using standard elastic continuous boundary element models. The correlation between the average source radius and the stress performance has provided a method to propose a macrocracking criterion. Several techniques have been tested to nucleate the microseismic activity around different geological features. This last attempt was aimed to look at potential overstresses induced over the undercut and extraction level drifts. A method was devised to integrate the microseismicity into a 3-dimensional ride distribution model. This model has shown to be very effective to quantify the overstress induced as a result of computing volumetric microseismicity density. The volumetric microseismic model showed to induce overstress up to 10 MPa over a period of two months. The future work will concentrate on the calibration of the integrated model with actual damage observations made at the current mining infrastructure. | Rubio Enrique Napitupulu Daulat | 2009 | International Journal of Minerals,Metallurgy and Materials2009，16，1： | 0 |
| 16 | 异亮氨酸可降低肉鸡日粮中粗蛋白的添加水平显示文摘鉴于生产中减少粗蛋白使用的需求,营养师在日粮中添加异亮氨酸以降低粗蛋白使用量,研究显示当各年龄段肉鸡的可消化异亮氨酸与可消化赖氨酸的比值为0.69时,可以在控制经济效益的情况下实现最佳生产性能。 | Daulat Khan 王丽萍(译) 林子怡(校) 唐彩琰(审) 张涛(制表) | 2021 | 国外畜牧学(猪与禽)2021，41，6： | 0 |
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