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| 1 | Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability显示文摘Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug compounds that limits in vivo bioavailability owing to their low dissolution rate in the gastrointestinal fluids following oral administration.The particle technology involves several approaches from the conventional size reduction processes to the newer,novel particle technologies that modify the solubility properties of the drugs and produce solid,powdered form of the drugs that are readily soluble in water and can be easily formulated into various dosage forms.This review highlights the solid particle technologies available for improving solubility,dissolution and bioavailability of drugs with poor aqueous solubility. | Prakash Khadka Jieun Ro Hyeongmin Kim Iksoo Kim Jeong Tae Kim Hyunil Kim Jae Min Cho Gyiae Yun Jaehwi Lee | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，6： | 15 |
| 2 | Assessment of Hydrocarbon Prospectivity in Terai and Siwaliks, Exploration Block 2, Western Nepal显示文摘 | Dharma Raj Khadka | 2017 | Journal of Geological Resource and Engineering2017，5，3： | 3 |
| 3 | Is laser photocoagulation still effective in diabetic macular edema? Assessment with optical coherence tomography in Nepal显示文摘AIM: To find out the outcome of laser photocoagulation in clinically significant macular edema (CSME) by optical coherence tomography (OCT). · METHODS: It was a prospective, non-controlled, case series study enrolling 81 eyes of 64 patients with CSME between August 2008 and January 2010. All patients received modified grid photocoagulation with frequency doubled Nd: YAG laser. Each patient was evaluated in terms of best-corrected visual acuity (BCVA) and regression or progression of maculopathy after laser therapy at 1, 3 and 6 months. Spearman's correlation test was used to show the correlation between BCVA and total macular volume (TMV). Analysis of variance (ANOVA) was used to compare among groups and independent t-test was used to compare in each group. · RESULTS: There is high correlation between BCVA and TMV (P ≤0.001). BCVA improved in 50.6%, remained static in 39.5 % and deteriorated in 9.9% patients after 6 month of treatment. The Baseline TMV (mean and SD) were 9.26±1.83, 10.4±2.38, 11.5±3.05, 8.89±0.75 and 9.47±1.98 mm3 for different OCT patterns, ST (sponge like thickening), CMO (cystoid macular edema), SFD (subfoveal detachment), VMIA (Vitreo macular interface abnormality) and average TMV respectively (P =0.04). After 6 months of laser treatment, the mean TMV decreased from 9.47±1.98mm3 to 8.77±1.31mm3(P =0.01). In ST there was significant decrease in TMV, P =0.01, Further within these groups at 6 months, they were significantly different, P =0.01. · CONCLUSION: OCT showed the different morphological variant of CSME while the response of treatment is different. TMV decreased the most and hence showed the improvement in vision after 6 months of laser treatment. In the era of Anti vascular endothelial growth factors (VEGFs), efficacy of laser seems to be in shadow but it is still first line of treatment in developing nation like Nepal where antiVEGFs may not be easily available and affordable. | Arjun Shrestha Deepak Khadka Angira Karmacharya Nhukesh Maharjan Anand Shrestha Raba Thapa Govinda Poudyal | 2012 | International Journal of Ophthalmology(English edition)2012，5，2： | 3 |
| 4 | Enhanced intestinal lymphatic absorption of saquinavir through supersaturated self-microemulsifying drug delivery systems显示文摘The therapeutic potential of saquinavir, a specific inhibitor of human immunodeficiency virus(HIV)-1 and HIV-2 protease enzymes, has been largely limited because of a low solubility and consequnt low bioavailability. Thus, we aimed to design a supersaturated selfmicroemulsifying drug delivery system(S-SMEDDS) that can maintain a high concentration of saquinavir in gastro-intestinal fluid thorugh inhibiting the drug precipitation to enhance the lymphatic transport of saquinavir and to increase the bioavailability of saquinavir considerably. Solubilizing capacity of different oils, surfactants, and cosurfactants for saquinavir was evaluated to select optimal ingredients for preparation of SMEDDS.Through the construction of pseudo-ternary phase diagram, SMEDDS formulations were established. A polymer as a precipitation inhibitor was selected based on its viscosity and drug precipitation inhibiting capacity. The S-SMEDDS and SMEDDS designed were administered at an equal dose to rats. At predetermined time points, levels of saquinavir in lymph collected from the rats were assessed. SMEDDS prepared presented a proper selfmicroemulsification efficiency and dispersion stability. The S-SMEDDS fabricated using the SMEDDS and hydroxypropyl methyl cellulose 2910 as a precipitation inhibitor exhibited a signficantly enhanced solubilizing capacity for saquinavir. The drug concentration in a simulated intestinal fluid evaluated with the S-SMEDDS was also maintained at higher levels for prolonged time than that examined with the SMEDDS. The S-SMEDDS showed a considerably enhanced lymphatic absoprtion of saquinavir in rats compared to the SMEDDS.Therefore, the S-SMEDDS would be usefully exploited to enhance the lymphatic absorption of hydrophobic drugs that need to be targeted to the lymphatic system. | Kanghee Jo Hyeongmin Kim Prakash Khadka Taejun Jang Soo Jin Kim Seong-Ha Hwang Jaehwi Lee | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，3： | 2 |
| 5 | Single burr hole for chronic subdural hematoma显示文摘 | Khadka NK Sharme GKR Roka YB | 2008 | Nepal Med Coll J2008，10，： | 1 |
| 6 | Human RECQL1participates in telomere maintenance显示文摘 | Popuri V Hsu J Khadka P | 2014 | Nucleic Acids Res2014，42，9： | 1 |
| 7 | Topoisomerase inhibitors as anticancer agents: a patent update显示文摘 | Daulat B Khadka Won-Jea Cho | 2013 | Expert Opinion on Therapeutic Patents2013，，8： | 1 |
| 8 | CAD/CAM and rapid prototyped ti- tanium for reconstruction of ramus defect and condylar fracture caused by mandibular reduction 显示文摘 | WangG Li J Khadka A | 2012 | Oral Surg Oral Med Oral Pathol Oral Radi2012，113，3： | 1 |
| 9 | Cardiovascular autonomic function and vibration perception threshold in type 2 diabetes mellitus 显示文摘 | Goit RK Khadka R Sharma SK | 2012 | J Diabetes Complications2012，26，4： | 1 |
| 10 | Effectiveness of the community- based Low Vision Service Wales: a long-term outcome study显示文摘 | Ryan B Khadka J Bunce C | 2013 | Br J Ophthalmo12013，97，4： | 1 |
| 11 | Control of multitransparency windows via dark-state phase manipulation显示文摘 | U Khadka Y P Zhang M Xiao | 2010 | Phys Rev A2010，81，02： | 1 |
| 12 | Denosumab: A bone antiresorptive drug显示文摘 | Navdeep Dahiya Anjan Khadka A.K. Sharma A.K. Gupta Nishith Singh D.B.S. Brashier | 2014 | Medical Journal Armed Forces India2014，，： | 1 |
| 13 | Etiology of urinary tract infection and drug resistance cases of uropathogenes显示文摘 | Bhatt CP Shrestha B Khadka S | 2013 | J Kathmandu Med Coll2013，1，2： | 1 |
| 14 | Cognitive trajectories after postoperative delirium显示文摘 | KHADKA J MCALINDEN C PESUDOVS K | 2012 | N Engl J Med2012，367，12： | 1 |
| 15 | DNA markers for sex: Molecular evidence for gender dimorphism in dioecious Mercurialis annua L.显示文摘 | D.K. Khadka A. Nejidat M. Tal A. Golan-Goldhirsh | 2002 | Molecular Breeding2002，，4： | 1 |
| 16 | Low-cost struviteproduction using source - separated urine in Nepal 显示文摘 | Etter B Tilley E Khadka R | | Water R es0，45，2： | 1 |
| 17 | Virtual screening and synthesis of quinazolines as novel JAK2 inhibitors 显示文摘 | YANG S H KHADKA D B CHO S H | 2011 | Bioorg Med Chem2011，19，12： | 1 |
| 18 | CAD/CAM and rapid prototyped titanium for reconstruction of ramus defect and condylar fracture-caused by mandibular reduction 显示文摘 | Wang G Li J Khadka A | 2012 | Oral Surg Oral Med Oral Pathol Oral Radiol2012，113，3： | 1 |
| 19 | A comprehensive evalua- tion of the precision(repeatability and reproducibility)of the Oc- ulus Pentacam HR显示文摘 | McAlinden C Khadka J Pesudovs K | 2011 | Invest Ophthalmol Vis Sci2011，52，： | 1 |
| 20 | Oxidative DNA damage and inflammatory responses in cultured human cells and in humans exposed to traffic-related particles 显示文摘 | Vattanasit U Navasumrit P Khadka MB | 2014 | Int J Hyg Environ Health2014，217，1： | 1 |
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