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| 1 | 肛裂临床诊治指南(第三次修订)显示文摘“美国结直肠外科医师协会(American Societyof ColonandRectal Surgeons.ASCRS)”(协会)致力于推进结直肠和肛门疾病的相关理论以及预防和诊疗水平的提高,给患者提供优质的医疗服务。“标准委员会”由协会中在结直肠外科方面有显著专长的成员组成。该委员会的建立是为了引领国际结直肠和肛门疾病诊治的发展,以建立具有循证医学证据的临床诊疗指南。指南是涵盖性的,非指令性的,目的是为临床决策提供信息,而非具体的治疗方法。指南适用于所有相关的医护人员以及希望得到相应指南中疾病的相关诊治信息的患者。 | Farshid Araghizadeh ~ Robin Boushey Sridhar Chalasani George Chang Robert Cima Gary Dunn Daniel Feingold Philip Fleshner Daniel Geisler Jill Genua Sharon Gregorcyk Daniel Herzig Andreas Kaiser Ravin Kumar David Larson Steven Mills John Monson P. Terry Phang Feza Remzi David Rivadeneira Howard Ross Peter Senatore Elin Sigurdson Thomas Stahl Scott Steele Scott Strong Charles Tement Judith Trudel Madhulika Varnna Martin Weiser 丁义江(译) 皇甫少华(译) 丁曙晴(译) | 2013 | 中华胃肠外科杂志2013，16，7： | 70 |
| 2 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 3 | Petawatt and exawatt class lasers worldwide显示文摘In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has developed.We are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under construction.In addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR facilities.So apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development. | Colin N.Danson Constantin Haefner Jake Bromage Thomas Butcher Jean-Christophe FChanteloup Enam A.Chowdhury Almantas Galvanauskas Leonida A.Gizzi Joachim Hein David I.Hillier Nicholas W.Hopps Yoshiaki Kato Efim A.Khazanov Ryosuke Kodama Georg Korn Ruxin Li Yutong Li Jens Limpert Jingui Ma Chang Hee Nam David Neely Dimitrios Papadopoulos Rory R.Penman Liejia Qian Jorge J.Rocca andrey A.Shaykin Craig W.Siders Christopher Spindloe Sándor Szatmári Raoul M.G.M.Trines Jianqiang Zhu Ping Zhu Jonathan D.Zuegel | 2019 | High Power Laser Science and Engineering2019，7，3： | 33 |
| 4 | Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study显示文摘Background and purpose COVID-19 is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2).Apart from respiratory complications,acute cerebrovascular disease(CVD)has been observed in some patients with COVID-19.Therefore,we described the clinical characteristics,laboratory features,treatment and outcomes of CVD complicating SARS-CoV-2 infection.Materials and methods Demographic and clinical characteristics,laboratory findings,treatments and clinical outcomes were collected and analysed.Clinical characteristics and laboratory findings of patients with COVID-19 with or without new-onset CVD were compared.Results Of 219 patients with COVID-19,10(4.6%)developed acute ischaemic stroke and 1(0.5%)had intracerebral haemorrhage.COVID-19 with new onset of CVD were significantly older(75.7±10.8 years vs 52.1±15.3 years,p<0.001),more likely to present with severe COVID-19(81.8%vs 39.9%,p<0.01)and were more likely to have cardiovascular risk factors,including hypertension,diabetes and medical history of CVD(all p<0.05).In addition,they were more likely to have increased inflammatory response and hypercoagulable state as reflected in C reactive protein(51.1(1.3-127.9)vs 12.1(0.1-212.0)mg/L,p<0.05)and D-dimer(6.9(0.3-20.0)vs 0.5(0.1-20.0)mg/L,p<0.001).Of 10 patients with ischemic stroke;6 received antiplatelet treatment with aspirin or clopidogrel;and 3 of them died.The other four patients received anticoagulant treatment with enoxaparin and 2 of them died.As of 24 March 2020,six patients with CVD died(54.5%).Conclusion Acute CVD is not uncommon in COVID-19.Our findings suggest that older patients with risk factors are more likely to develop CVD.The development of CVD is an important negative prognostic factor which requires further study to identify optimal management strategy to combat the COVID-19 outbreak. | Yanan Li Man Li Mengdie Wang Yifan Zhou Jiang Chang Ying Xian David Wang Ling Mao Huijuan Jin Bo Hu | 2020 | Stroke & Vascular Neurology2020，5，3： | 22 |
| 5 | 西藏恰功铁矿岩浆演化序列及斑岩出溶流体特征显示文摘冈底斯成矿带是碰撞造山过程形成的最重要的成矿带,恰功矽卡岩铁(铜)矿床即位于冈底斯成矿带中部。本文在详细的野外地质填图和室内研究基础上确定了恰功铁矿与成矿有关的斑岩体为二长花岗斑岩,锆石的U-Pb定年结果为68.8±2.2Ma,明显早于冈底斯东部与后碰撞伸展有关的斑岩型矿床和主碰撞期形成的矽卡岩型矿床,其应代表了冈底斯一次尚未被充分认识到的成矿事件。通过对成矿斑岩的岩石学、岩石化学、岩浆出溶流体的包裹体岩相学、显微测温分析及包裹体成分的LRM、LA-ICP-MS和PIXE分析,本文探讨了与该矽卡岩矿床有关的斑岩的岩浆起源、斑岩侵位机制及出溶流体特征。结果表明,成矿斑岩为矿区最早的侵入岩单元,具有壳幔源混源特征,其常量元素组成与冈底斯东部斑岩铜矿带的埃达克质岩相近,但稀土和微量元素组成与东部斑岩明显不同,为地幔物质上涌并诱发角闪岩相下地壳熔融的产物,岩体侵位深度大(>7km)、剥蚀程度高。早期岩浆出溶的流体为高温、高压、高盐度流体,其中富含Fe、Pb、Zn、Cu等成矿金属,与世界其他斑岩铜矿床相比,相对富铁、铅而贫铜。流体的沸腾作用发生于钾硅化阶段,形成了一套富气、高盐、高固相和气液包裹体组合,不同于早期出溶流体的包裹体组合。从岩浆起源和出溶流体性质可以看出,该斑岩具有形成与斑岩有关的铁铅多金属矿床的成矿潜力,但从该矿区地表出露的蚀变和包裹体测压结果可以看出,该斑岩体目前剥蚀深度较大,对斑岩型矿床保存不利,对该斑岩体及与成矿关系的认识对理解该区内的矿床成因和指导区域找矿具有重要的指示意义。 | 谢玉玲 李应栩 Zhaoshan CHANG David R. COOKE Chris G. RYAN Jamie LAIRD 白劲松 刘云飞 李光明 张丽 | 2009 | 地质学报2009，83，12： | 19 |
| 6 | Selective serotonin reuptake inhibitors in the treatment of premature ejaculation显示文摘在早泄( PE )的处理关于 se lective 血清素举起禁止者( SSRI )考察并且估计然后在减轻 PE.Data 为 SSRI 的使用有关现状知识提供实际建议和可能的机制更改研究的目的用 Medline 采购原料,在减轻 PE 有关 SSRI 和他们的可能的机制的使用从1996年1月1日出版到2006年8月1日的 48 篇文章被发现并且 reviewed.Study selectio 然而,他们的效果是中等的,关于类型,剂量,协议和持续时间没有一个通用协议。作为 PE 的第一药方治疗, Dapoxetine 可以改变这种瓶颈状况。SSRI 被建议与终生的 PE 在年轻人被过去常,并且当 etiological 因素被移开,但是 PE 仍然存在时,获得了 PE。Phosphodiesterase 5 禁止者(PDE5 ) 被建议独自被采用或当 SSRI 没能对待与 SSRI 联系的 PE 或性机能障碍时,与 SSRI 结合了发生。基于每天把他们当作一个合适的时期在需求上服药的协议被建议第一被选。可能的机制包括增加的 serotonergic neurotransmission 和激活的 5-hydroxytryptamine 2C ( 5-HT2C )受体,然后交换射精的阀值到高水平,减少阴茎敏感和他们的自己 antidepression.Conclusion 完成当前的 SSRI 的功效在 PE 的处理是中等的,他们没被 FDA 同意了,进一步要评估的因此新的 SSRI 相似 dapoxetine 需要。 | WANG Wei-fu CHANG Le Suks Minhas David J Ralph | 2007 | Chinese Medical Journal2007，，11： | 14 |
| 7 | Use of blood-based biomarkers for early diagnosis and surveillance of colorectal cancer显示文摘Early screening for colorectal cancer(CRC) holds the key to combat and control the increasing global burden of CRC morbidity and mortality. However, the current available screening modalities are severely inadequate because of their high cost and cumbersome preparatory procedures that ultimately lead to a low participation rate. People simply do not like to have colonoscopies. It would be ideal, therefore, to develop an alternative modality based on blood biomarkers as the first line screening test. This will allow for the differentiation of the general population from high risk individuals. Colonoscopy would then become the secondary test, to further screen the high risk segment of the population. This will encourage participation and therefore help to reach the goal of early detection and thereby reduce the anticipated increasing global CRC incidence rate. A blood-based screening test is anappealing alternative as it is non-invasive and poses minimal risk to patients. It is easy to perform, can be repeated at shorter intervals, and therefore would likely lead to a much higher participation rate. This review surveys various blood-based test strategies currently under investigation, discusses the potency of what is available, and assesses how new technology may contribute to future test design. | Ganepola AP Ganepola Joel Nizin John R Rutledge David H Chang | 2014 | World Journal of Gastrointestinal Oncology2014，6，4： | 11 |
| 8 | Novel blood-based microRNA biomarker panel for early diagnosis of pancreatic cancer显示文摘AIM:To develop a panel of blood-based diagnostic biomarkers consisting of circulating microRNAs for the detection of pancreatic cancer at an early stage.METHODS:Blood-based circulating microRNAs were profiled by high throughput screening using microarray analysis,comparing differential expression between early stage pancreatic cancer patients(n = 8) and healthy controls(n = 11).A panel of candidate microRNAs was generated based on the microarray signature profiling,including unsupervised clustering and statistical analysis of differential expression levels,and findings from the published literature.The selected candidate microRNAs were then confirmed using TaqMan real-time quantitative reverse transcription polymerase chain reaction(RT-qPCR) to further narrow down to a three-microRNA diagnostic panel.The three-microRNA diagnostic panel was validated with independent experimental proce-dures and instrumentation of RT-qPCR at an independent venue with a new cohort of cancer patients(n = 11),healthy controls(n = 11),and a group of high risk controls(n = 11).Receiver operating characteristic curve analysis was performed to assess the diagnostic capability of the three-microRNA panel.RESULTS:In the initial high throughput screening,1220 known human microRNAs were screened for differential expression in pancreatic cancer patients versus controls.A subset of 42 microRNAs was then generated based on this data analysis and current published literature.Eight microRNAs were selected from the list of 42 targets for confirmation study,and three-microRNAs,miR-642b,miR-885-5p,and miR-22,were confirmed to show consistent expression between microarray and RT-qPCR.These three microRNAs were then validated and evaluated as a diagnostic panel with a new cohort of patients and controls and found to yield high sensitivity(91%) and specificity(91%) with an area under the curve of 0.97(P < 0.001).Compared to the CA19-9 marker at 73%,the three-microRNA panel has higher sensitivity although CA19-9 has higher specificity of 100%.CONCLUSION:The identified panel of three microRNA biomarkers can potentially be used as a diagnostic tool for early stage pancreatic cancer. | Ganepola AP Ganepola John R Rutledge Paritosh Suman Anusak Yiengpruksawan David H Chang | 2014 | World Journal of Gastrointestinal Oncology2014，6，1： | 9 |
| 9 | Disease monitoring in inflammatory bowel disease显示文摘The optimal method for monitoring quiescent disease in patients with Crohn's disease(CD) and ulcerative colitis is yet to be determined. Endoscopic evaluation with ileocolonoscopy is the gold standard but is invasive,costly,and time-consuming. There are many commercially available biomarkers that may be used in clinical practice to evaluate disease status in patients with inflammatory bowel disease(IBD),but the most widely adopted biomarkers are C-reactive protein(CRP) and fecal calprotectin(FC). This review summarizes the evidence for utilizing CRP and FC for monitoring IBD during clinical remission and after surgical resection. Endoscopic correlation with CRP and FC is evaluated in each disease state. Advantages and drawbacks of each biomarker are discussed with special consideration of isolated ileal CD. Fecal immunochemical testing,traditionally used for colorectal cancer screening,is mentioned as a potential new alternative assay in the evaluation of IBD. Based on a mixture of information gleaned from biomarkers,clinical status,and endoscopic evaluation,the best treatment decisions can be made for the patient with IBD. | Shannon Chang Lisa Malter David Hudesman | 2015 | World Journal of Gastroenterology2015，21，40： | 8 |
| 10 | Bionic Optimization Design of Electronic Nose Chamber for Oil and Gas Detection显示文摘 | Zhiyong Chang Youhong Sun Yuchen Zhang Yanli Gao Xiaohui Weng Donghui Chen Liewe David Jun Xie | 2018 | Journal of Bionic Engineering2018，15，3： | 6 |
| 11 | The Future of Psychology: Evolutionary Approach to Scientific Psychology显示文摘 | Lei Chang David C. Geary | 2007 | 心理学报2007，39，3： | 6 |
| 12 | The strigolactone receptor D14 targets SMAX1 for degradation in response to GR24 treatment and osmotic stress显示文摘The effects of the phytohormone strigolactone(SL)and smoke-derived karrikins(KARs)on plants are generally distinct,despite the fact that they are perceived through very similar mechanisms.The homologous receptors DWARF14(D14)and KARRIKIN-INSENSITIVE2(KAI2),together with the F-box protein MORE AXILLARY GROWTH2(MAX2),mediate SL and KAR responses,respectively,by targeting different SMAX1-LIKE(SMXL)family proteins for degradation.These mechanisms are putatively well-insulated,with D14-MAX2 targeting SMXL6,SMXL7,and SMXL8 and KAI2-MAX2 targeting SMAX1 and SMXL2 in Arabidopsis thaliana.Recent evidence challenges this model.We investigated whether D14 can target SMAX1 and whether this occurs naturally.Genetic analysis indicates that the SL analog GR24 promotes D14-SMAX1 crosstalk.Although D14 shows weaker interactions with SMAX1 than with SMXL2 or SMXL7,D14 mediates GR24-induced degradation of SMAX1 in plants.Osmotic stress triggers SMAX1 degradation,which is protective,through SL biosynthesis and signaling genes.Thus,D14-SMAX1 crosstalk may be beneficial and not simply a vestige of the evolution of the SL pathway. | Qingtian Li Elena Sánchez Martín-Fontecha Aashima Khosla Alexandra R.F.White Sunhyun Chang Pilar Cubas David C.Nelson | 2022 | Plant Communications2022，3，2： | 5 |
| 13 | The interplay of aging,genetics and environmental factors in the pathogenesis of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta and intracellular inclusions called Lewy bodies(LB).During the course of disease,misfoldedα-synuclein,the major constituent of LB,spreads to different regions of the brain in a prion-like fashion,giving rise to successive non-motor and motor symptoms.Etiology is likely multifactorial,and involves interplay among aging,genetic susceptibility and environmental factors.Main body:The prevalence of PD rises exponentially with age,and aging is associated with impairment of cellular pathways which increases susceptibility of dopaminergic neurons to cell death.However,the majority of those over the age of 80 do not have PD,thus other factors in addition to aging are needed to cause disease.Discovery of neurotoxins which can result in parkinsonism led to efforts in identifying environmental factors which may influence PD risk.Nevertheless,the causality of most environmental factors is not conclusively established,and alternative explanations such as reverse causality and recall bias cannot be excluded.The lack of geographic clusters and conjugal cases also go against environmental toxins as a major cause of PD.Rare mutations as well as common variants in genes such as SNCA,LRRK2 and GBA are associated with risk of PD,but Mendelian causes collectively only account for 5%of PD and common polymorphisms are associated with small increase in PD risk.Heritability of PD has been estimated to be around 30%.Thus,aging,genetics and environmental factors each alone is rarely sufficient to cause PD for most patients.Conclusion:PD is a multifactorial disorder involving interplay of aging,genetics and environmental factors.This has implications on the development of appropriate animal models of PD which take all these factors into account.Common converging pathways likely include mitochondrial dysfunction,impaired autophagy,oxidative stress and neuroinflammation,which are associated with the accumulation and spread of misfoldedα-synuclein and neurodegeneration.Understanding the mechanisms involved in the initiation and progression of PD may lead to potential therapeutic targets to prevent PD or modify its course. | Shirley Yin-Yu Pang Philip Wing-Lok Ho Hui-Fang Liu Chi-Ting Leung Lingfei Li Eunice Eun Seo Chang David Boyer Ramsden Shu-Leong Ho | 2019 | Translational Neurodegeneration2019，8，1： | 5 |
| 14 | Effects of water-based binders on electrochemical performance of manganese dioxide cathode in mild aqueous zinc batteries显示文摘In the majority of rechargeable batteries including lithium-ion batteries,polyvinylidene fluoride(PVdF)binders are the most commonly used binder for both anode and cathode.However,using PVdF binder requires the organic solvent of N-methyl-2-pyrrolidone which is expensive,volatile,combustible,toxic,and has poor recyclability.Therefore,switching to aqueous electrode processing routes with non-toxic binders would provide a great leap forward towards the realization of ideally fully sustainable and environmentally friendly electrochemical energy storage devices.Various water-soluble binders(aqueous binders)were characterized and compared to the performance of conventional PVdF.Our study demonstrates that the electrochemical performance of Zn/MnO_(2) aqueous batteries is significantly improved by using sodium carboxymethyl cellulose(CMC)binder.In addition,CMC binders offer desirable adhesion,good wettability,homogeneous material distribution,and strong chemical stability at certain pH levels(3.5-5)without any decomposition for long-cycle life. | Hee Jung Chang Ismael A.Rodriguez-Pere Matthew Fayette Nathan L.Canfield Huilin Pan Daiwon Choi Xiaolin Li David Reed | 2021 | Carbon Energy2021，3，3： | 5 |
| 15 | Morbidity and Mortality Analysis of 200 Treatments With Cytoreductive Surgery and Hyperthermic Intraoperative Intraperitoneal Chemotherapy Using the Coliseum Technique显示文摘 | Arvil D. Stephens MD Robert Alderman PA-C David Chang MD Gary D. Edwards PA-C Jesus Esquivel MD Gilbert Sebbag MD Mark A. Steves MD Paul H. Sugarbaker MD | 1999 | Annals of Surgical Oncology1999，，8： | 5 |
| 16 | 1423 Pancreaticoduodenectomies for Pancreatic Cancer: A Single-Institution Experience显示文摘 | Jordan M. Winter John L. Cameron Kurtis A. Campbell Meghan A. Arnold David C. Chang JoAnn Coleman Mary B. Hodgin Patricia K. Sauter Ralph H. Hruban Taylor S. Riall Richard D. Schulick Michael A. Choti Keith D. Lillemoe Charles J. Yeo | 2006 | Journal of Gastrointestinal Surgery2006，，9： | 5 |
| 17 | Bioreduction of nitrate in groundwater using a pilot-scale hydrogen-based membrane biofilm reactor显示文摘A long-term pilot-scale H_(2)-based membrane biofilm reactor(MBfR)was tested for removal of nitrate from actual groundwater.A key feature of this secondgeneration pilot MBfR is that it employed lower cost polyester hollow fibers and still achieved high loading rate.The steady-state maximum nitrate surface loading at which the effluent nitrate and nitrite concentrations were below the Maximum Contaminant Level(MCL)was at least 5.9 g·N·(m^(2)·d)^(–1),which corresponds to a maximum volumetric loading of at least 7.7 kg·N·(m^(3)·d)^(–1).The steady-state maximum nitrate surface area loading was higher than the highest nitrate surface loading reported in the firstgeneration MBfRs using composite fibers(2.6 g·N·(m^(2)·d)^(–1)).This work also evaluated the H_(2)-utilization efficiency in MBfR.The measured H_(2)supply rate was only slightly higher than the stoichiometric H_(2)-utilization rate.Thus,H_(2)utilization was controlled by diffusion and was close to 100%efficiency,as long as biofilm accumulated on the polyester-fiber surface and the fibers had no leaks. | Youneng TANG Michal ZIV-EL Chen ZHOU Jung Hun SHIN Chang Hoon AHN Kerry MEYER Daniel CANDELARIA David FRIESE Ryan OVERSTREET Rick SCOTT Bruce ERITTMANN | 2010 | Frontiers of Environmental Science & Engineering2010，4，3： | 4 |
| 18 | p53 isoform △113p53/△133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage显示文摘在 DNA 双海滨的 p53 的禁止的角色裂缝(DSB ) 修理对它的压制肿瘤的性质似乎矛盾。p53 isoform Δ 113p53/Δ 133p53 是反对 p53 apoptotic 的 p53 目标基因活动。然而,它在 DNA 损坏修理的功能的信息正在缺乏。这里,我们报导那 Δ 113p53 表示被 γ 强烈导致; -irradiation, 然而并非由紫外照耀或热电震疗法。惊人地, Δ 113p53 支持 DNA DSB 修理小径包括相应再结合,非相应的结束加入并且单个海滨的退火。学习 Δ 的生物意义;在支持 DNA DSB 修理的 113p53,我们产生了 zebrafish Δ 113p53 经由抄写的 M/M 异种像使活跃之物的受动器核酸酶技术并且发现异种对 γ 更敏感;照耀。人的 ortholog, Δ 133p53,被 γ 仅仅也导致;照耀和功能修理支持 DNA DSB。Δ 133p53-knockdown 房间响应 γ 在以后的阶段在 G2 阶段被逮捕;照耀由于 unrepaired DNA DSB 的高水平,它最后导致了房间老朽。而且, Δ 113p53/Δ 133p53 经由 upregulating 支持 DNA DSB 修理由到在他们的倡导者的 p53 应答的元素的一种新奇类型的绑定的修理基因 rad51, lig4 和 rad52 的抄写。我们的结果表明那 Δ 113p53/Δ 133p53 是为由阻止 apoptosis 并且支持 DNA DSB 修理禁止房间老朽的 DNA 损坏应力的一个进化地保存的支持幸存的因素。我们的数据也建议 Δ 的正式就职;在正常房间或纸巾的 133p53 表示为癌症病人提供一个重要忍耐标记给放射疗法。 | Lu Gong Hongjian Gong Xiao Pan Changqing Chang Zhao Ou Shengfan Ye Le Yin Lina Yang Ting Tao Zhenhai Zhang Cong Liu David P Lane Jinrong Peng Jun Chen | 2015 | Cell Research2015，25，3： | 4 |
| 19 | Hyperthermic intraperitoneal doxorubicin: pharmacokinetics, metabolism, and tissue distribution in a rat model显示文摘 | Pierre Jacquet Andrew Averbach O. Anthony Stuart David Chang Paul H. Sugarbaker | 1997 | Cancer Chemotherapy and Pharmacology1997，，2： | 4 |
| 20 | The Cost-Effectiveness of Neoadjuvant Chemoradiation is Superior to a Surgery-First Approach in the Treatment of Pancreatic Head Adenocarcinoma显示文摘 | Daniel E. Abbott Ching-Wei David Tzeng Ryan P. Merkow Scott B. Cantor George J. Chang Matthew Harold Katz David J. Bentrem Karl Y. Bilimoria Christopher H. Crane Gauri R. Varadhachary James L. Abbruzzese Robert A. Wolff Jeffrey E. Lee Douglas B. Evans Jas | 2013 | Annals of Surgical Oncology2013，，3： | 3 |
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