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| 1 | GRADE指南:Ⅵ.证据质量评价--不精确性(随机误差)显示文摘GRADE建议通过检查95%可信区间(CI)为决定不精确性的最佳方法。在指南实际运用中,如果CI的上、下限值代表了真实效应,而临床实际情况与之不符时,必须降低证据质量级别(即对效应估计值的把握度)。除外当效应值很大且可信区间提示效应稳健,而总样本量不大且事件数很少的情况,其他应考虑因不精确性而降低证据质量级别。作此决定时,可计算有足够检验效能的单个试验所需的病例数(定义为'最优信息样本量',即optimal information size,OIS)。对连续型变量,我们建议用类似方法,首先考虑可信区间上、下限值,再计算OIS。系统评价(SR)所需方法略有不同。如果95%CI不包括相对危险度(RR)为1,且总事件发生数或病例数超过OIS标准,则精确性良好。如果95%CI包括了明显获益或危害(我们建议以RR值<0.75或>1.25作粗标准),即使达到OIS要求,因不精确性而降低证据质量级别较恰当。 | Gordon Guyatt Andrew D.Oxman Regina Kunz Jan Brozek Pablo Alonso-Coello David Rind PJ Devereaux Victor M.Montori Bo Freyschuss Gunn Vist Roman Jaeschke John W.Williams Jr. Mohammad Hassan Murad David Sinclairk Yngve Falck-Ytter Joerg Meerpohl Craig Whittington Kristian orlund Je Andrews Holger J.Schünemann 代表GRADE工作组 李幼平 王莉 陈尹 高霑 | 2011 | 中国循证医学杂志2011，11，12： | 43 |
| 2 | Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells显示文摘 | Wang JW David DJ Monckton JE | 2008 | J Neurosci2008，28，6： | 1 |
| 3 | Polymeric im- munoglobulin receptor in intestinal immune defense against the lumen-dwelling protozoan parasite Giardia显示文摘 | DAVIDS B J PALM JE HOUSLEY MP | 2006 | J Immunal2006，177，9： | 1 |
| 4 | Polymeric immunoglobulin receptor in intestinal immune defense against the lumen-dwelling protozoan parasite Giardia 显示文摘 | Davids B J Palm JE Housley MP | 2006 | J Immunol2006，177，9： | 1 |
| 5 | The NIH human microbiome project显示文摘 | NIH HMP Working Group Peterson J Garges S Giovanni M McInnes P Wang L Schloss JA Bonazzi V McEwen JE Wetterstrand KA Deal C Baker CC Di Francesco V Howcroft TK Karp RW Lunsford RD Wellington CR Belachew T Wright M Giblin C David H Mills M Salomon R Mullins C Akolkar B Begg L Davis C Grandison L Humble M Khalsa J Little AR Peavy H Pontzer C Portnoy M Sayre MH Starke-Reed P Zakhari S Read J Watson B Guyer M | 2009 | Genome Res2009，19，12： | 1 |
| 6 | Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells显示文摘 | Wang JW David DJ Monckton JE | 2008 | J Neurosci2008，28，： | 1 |
| 7 | Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells 显示文摘 | Wang JW David D J Monckton JE | 2008 | Journal of Neuroscience2008，28，6： | 1 |
| 8 | Small airways:a time to revisit?显示文摘 | David JE Malcolm G | 1998 | Thorax1998，53，8： | 1 |
| 9 | Gas chromatographic determination of chloramphenicol residues in shrimp: interlaboretory study显示文摘 | Robert K David C Holland JE | 1994 | J AOAC International1994，77，3： | 1 |
| 10 | Polymeric immunoglobulin receptor in intestinal immune defense against the lumen-dwelling protozoan parasite Giardia显示文摘 | DAVIDS B J PALM JE HOUSLEY MP | 2006 | J Immunol2006，177，9： | 1 |
| 11 | Urology:scrotal pain显示文摘 | David JE Yale SH Goldman IL | | 0，，02： | 1 |
| 12 | Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases 显示文摘 | David C Gloria G Stephent JE | 2004 | PNAS2004，101，10： | 1 |
| 13 | Determination of Chromium in Serum and Urine 显示文摘 | David EN John B Stephen JE | 2002 | Perkin Emer Inc ApplNote2002，4，1： | 1 |
| 14 | Clinical outcome of magnetic-resonance-guided focused ultrasound surgery (MRgFUS) in the treatment of symptomatic u- terine fibroids显示文摘 | Kamp JE David M Scheurig-Muenkler C | 2013 | RoFo2013，185，2： | 1 |
| 15 | Estimated risks of radiation in duced fatal cancer from pediatric CT显示文摘 | David JE Carl DE Eric J H | 2001 | AJR2001，176，： | 1 |
| 16 | Multiplex PCR for rapid detection of genes encoding acquired metallo-β-lactamases显示文摘 | Matthew JE James K David ML | 2007 | Journal of Antimicrobial Chemoth-Erapy2007，59，： | 1 |
| 17 | Polymeric immunoglobulin receptor in intestinal immune defense against the lumen-dwelling protozoan parasite Giardia显示文摘 | Davids BJ Palm JE Housley MP | 2006 | J Immunol2006，177，9： | 1 |
| 18 | Chronic fluoxetine stimu- lates maturation and synaptic plasticity of adultbom hippocampal granule cells 显示文摘 | Wang JW David D J Monckton JE | 2008 | J Neurosci2008，28，6： | 1 |
| 19 | Surgical treatment of intertrochanterie hip fractures using a sliding hip screw显示文摘 | Richard FK Thomas JE David CT | 2005 | Journal of orthopaedic trauma2005，19，： | 1 |
| 20 | The Human ZIP1 Transporter Mediates Zinc Uptake in Human K562 Erythroleukemia Cells 显示文摘 | Alex GL David JE | 2001 | J Biol Chem2001，276，22： | 1 |
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