|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Increased Quality of Life Among Hepatocellular Carcinoma Patients Treated with Radioembolization, Compared with Chemoembolization显示文摘 | Riad Salem Margaret Gilbertsen Zeeshan Butt Khairuddin Memon Michael Vouche Ryan Hickey Talia Baker Michael M. Abecassis Rohi Atassi Ahsun Riaz David Cella James L. Burns Daniel Ganger Al B. Benson Mary F. Mulcahy Laura Kulik Robert Lewandowski | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 2 |
| 3 | 低剂量白细胞介素-2在11种自身免疫疾病中的免疫学和临床疗效:单中心开放临床试验显示文摘背景调节性T(Tregs)细胞可以预防自身免疫并控制炎症,在各种自身免疫性或自身炎症性疾病中的研究都表明Treg细胞不足。由于低剂量白细胞介素-2(low-dose interleukin-2,ld-IL2)能够扩增并激活Tregs细胞,因此ld-IL2具有广泛的治疗潜力。目的我们通过一项临床试验观察ld-IL2治疗11种自身免疫性疾病中1种的效果,旨在评估ld-IL2的治疗潜力并选择疾病,以用于进一步的临床开发。方法本研究为前瞻开放性Ⅰ~Ⅱa期临床观察,入选了46例轻中度患者,诊断分别为类风湿关节炎、强直性脊柱炎、系统性红斑狼疮、牛皮癣、白塞病、肉芽肿性多血管炎、大动脉炎、克罗恩病、溃疡性结肠炎、自身免疫性肝炎或硬化性胆管炎。所有患者都接受了ld-IL2(100万IU/天)5天,然后每两周注射一次,维持6个月。所有患者均接受了深入的免疫监测和临床评估。结果在任何疾病类型以及任何合并药物治疗的患者中,ld-IL2都显示出了良好的耐受性。通过经典的免疫表型分析和广泛的免疫表型分析发现所有患者的Tregs细胞均被特异性地扩增激活,而效应T细胞没有被活化,提示ld-IL2具有临床疗效的前景。结论本研究中所采用的IL-2剂量和治疗方案可以选择性地激活和扩增Tregs细胞,并且对于不同的疾病种类以及不同的合并用药都是安全的。这一临床疗效以及初步结果可以为ld-IL2在各种自身免疫和自身炎症性疾病中开展Ⅱ期临床试验观察疗效提供了依据。试验注册号NCT01988506. | Michelle Rosenzwajg Roberta Lorenzon Patrice Cacoub Hang Phuong Pham Fabien Pitoiset Karim El Soufi Claire RIbet Claude Bernard Selim Aractingi Beatrice Banneville Laurent Beaugerie Francis Berenbaum Julien Champey Olivier Chazouilleres Christophe Corpechot Bruno Fautrel Arsfene Mekinian Elodie Regnier David Saadoun Joe-Elie Salem Jeremie Sellam Philippe Seksik Anne Daguenel-Nguyen Valene Doppler Jeremie Mariau Eric Vicaut David Klatzmann 杨新蕾(译) 张卓莉(校) | 2019 | 英国医学杂志中文版2019，22，2： | 2 |
| 4 | Treatment of Unresectable Primary and Metastatic Liver Cancer with Yttrium-90 Microspheres (TheraSphere?): Assessment of Hepatic Arterial Embolization显示文摘 | Kent Sato Robert J. Lewandowski James T. Bui Reed Omary Russell D. Hunter Laura Kulik Mary Mulcahy David Liu Howard Chrisman Scott Resnick Albert A. Nemcek Robert Vogelzang Riad Salem | 2006 | CardioVascular and Interventional Radiology2006，，4： | 2 |
| 5 | High-Dose Split-Course Radiation Therapy for Anal Cancer: Outcome Analysis Regarding the Boost Strategy (CORS-03 Study)显示文摘 | Jean-Michel Hannoun-Levi Cécile Ortholan Michel Resbeut Eric Teissier Philippe Ronchin Didier Cowen Audrey Zaccariotto Karen Bénézery Eric Fran?ois Naji Salem Steve Ellis David Azria Jean-Pierre Gerard | 2011 | International Journal of Radiation Oncology Biology Physics2011，，3： | 1 |
| 6 | Impact of Surgical Clipping on Survival in Unruptured and Ruptured Cerebral Aneurysms: A Population-Based Study显示文摘 | Gavin W. Britz Leon Salem David W. Newell Joseph Eskridge David R. Flum | 2004 | Stroke: Journal of the American Heart Association2004，，6： | 1 |
| 7 | 90Y Radioembolization for Metastatic Neuroendocrine Liver Tumors: Preliminary Results From a Multi-institutional Experience显示文摘 | Thomas K. Rhee Robert J. Lewandowski David M. Liu Mary F. Mulcahy Gary Takahashi Paul D. Hansen Al B. Benson Andrew S. Kennedy Reed A. Omary Riad Salem | 2008 | Annals of Surgery2008，，6： | 1 |
| 8 | Intra-arterial Therapy for Advanced Intrahepatic Cholangiocarcinoma: A Multi-institutional Analysis显示文摘 | Omar Hyder J. Wallis Marsh Riad Salem Elena N. Petre Sanjeeva Kalva Eleni Liapi David Cosgrove Donielle Neal Ihab Kamel Andrew X. Zhu Constantinos T. Sofocleous Jean-Francois H. Geschwind Timothy M. Pawlik | 2013 | Annals of Surgical Oncology2013，，12： | 1 |
| 9 | Gastrointestinal Complications Associated with Hepatic Arterial Yttrium-90 Microsphere Therapy显示文摘 | Ravi Murthy Daniel B. Brown Riad Salem Steven G. Meranze Douglas M. Coldwell Sunil Krishnan Rodolfo Nunez Amit Habbu David Liu William Ross Alan M. Cohen Michael Censullo | 2007 | Journal of Vascular and Interventional Radiology2007，，4： | 1 |
| 10 | Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy显示文摘 | C. Marcela Diaz-Montero Mohamed Labib Salem Michael I. Nishimura Elizabeth Garrett-Mayer David J. Cole Alberto J. Montero | 2009 | Cancer Immunology Immunotherapy2009，，1： | 1 |
| 11 | Mapping of liver fat with triple-echo gradient echo imaging: validation against 3.0-T proton MR spectroscopy显示文摘 | Boris Guiu Romaric Loffroy Jean-Michel Petit Serge Aho Douraied Ben Salem David Masson Patrick Hillon Jean-Pierre Cercueil Denis Krause | 2009 | European Radiology2009，，7： | 1 |
| 12 | Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy显示文摘 | C. Marcela Diaz-Montero Mohamed Labib Salem Michael I. Nishimura Elizabeth Garrett-Mayer David J. Cole Alberto J. Montero | 2009 | Cancer Immunology, Immunotherapy2009，，1： | 1 |
| 13 | Treatment of Unresectable Primary and Metastatic Liver Cancer with Yttrium-90 Microspheres (TheraSphere?): Assessment of Hepatic Arterial Embolization显示文摘 | Kent Sato Robert J. Lewandowski James T. Bui Reed Omary Russell D. Hunter Laura Kulik Mary Mulcahy David Liu Howard Chrisman Scott Resnick Albert A. Nemcek Robert Vogelzang Riad Salem | 2006 | CardioVascular and Interventional Radiology2006，，4： | 1 |
| 14 | Primary Anastomosis or Hartmann’s Procedure for Patients With Diverticular Peritonitis? A Systematic Review显示文摘 | Leon Salem M.D. David R. Flum M.D. M.P.H | 2004 | Diseases of the Colon & Rectum2004，，11： | 1 |
| 15 | T cells from induced and spontaneous models of SLE recognize a common T cell epitope on β2-glycoprotein Ⅰ显示文摘Systemic lupus erythematosus is a prototypic model for B-cell epitope spread in autoimmunity.Autoantibodies to numerous molecularly distinct self-antigens emerge in a sequential manner over several years,leading to disease manifestations.Among the earliest autoantibodies to appear are those targeting phospholipid-binding proteins,particularlyβ2-glycoprotein Ⅰ.Notably,mice immunized with β2-glycoprotein Ⅰ and lipopolysaccharide develop a strong T cell response to β2-glycoprotein Ⅰ that is associated with autoantibody production and renal disease,similar to that seen in human SLE.Here we hypothesized that mice with murine systemic lupus erythematosus,whether induced or spontaneous,should have T cells that recognizeβ2-glycoprotein I.We evaluated the response of splenic T cells from mice with induced(C57BL/6 and C3H/HeN)and spontaneous(MRL/lpr)systemic lupus erythematosus to peptides spanning the entire sequence of humanβ2GPI.We found that mice with induced and spontaneous systemic lupus erythematosus recognize a common T cell epitope(peptide 31;LYRDTAVFECLPQHAMFG)in domain Ⅲ ofβ2-glycoprotein I.β2GPI-reactive CD4^(+)T cells from the two models differed primarily in cytokine production:T cells from mice with induced SLE expressed IFN-γ,while T cells from MRL/lpr mice expressed both IL-17 and IFN-γ,indicating that IL-17-expressing T cells are not necessary for generating aβ2GPI-reactive T cell response.These data suggest that the generation of aβ2-glycoprotein Ireactive T cell response is shared by both induced and spontaneous models of systemic lupus erythematosus and that this T cell response may mediate epitope spread to autoantibodies in both models. | David Salem Rebecca Subang Masataka Kuwana Jerrold S.Levine Joyce Rauch | 2019 | Cellular & Molecular Immunology2019，16，8： | 1 |
| 16 | Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy显示文摘 | C. Marcela Diaz-Montero Mohamed Labib Salem Michael I. Nishimura Elizabeth Garrett-Mayer David J. Cole Alberto J. Montero | 2009 | Cancer Immunology Immunotherapy2009，，1： | 1 |
| 17 | Effect of mixed solvents on PCDTBT:PC 70 BM based solar cells显示文摘 | Salima Alem Ta-Ya Chu Shing C. Tse Salem Wakim Jianping Lu Raluca Movileanu Ye Tao Francis Bélanger Denis Désilets Serge Beaupré Mario Leclerc Sheila Rodman David Waller Russell Gaudiana | 2011 | Organic Electronics2011，，11： | 1 |
| 18 | computed tomography diagnosis of ischemia and complete obstruction in small bowel obstruction: A systematic review显示文摘 | Rebecca D. Mallo B.S. Leon Salem M.D. Tasneem Lalani M.D. David R. Flum M.D. M.P.H | 2005 | Journal of Gastrointestinal Surgery2005，，5： | 1 |
| 19 | Functional magnetic resonance imaging in an animal model of pancreatic cancer显示文摘AIM: To test the hypotheses that diffusion weighed (DW)and transcatheter intraarterial perfusion (TRIP)magnetic resonance imaging (MRI) can each be used to assess regional differences in tumor function in an animal pancreatic cancer model.METHODS: VX2 tumors were implanted in pancreata of 6 rabbits. MRI and digital subtraction angiography (DSA) were performed 3 wk following implantation. With a 2-French catheter secured in the rabbit's gastroduodenal artery, each rabbit was transferred to an adjacent 1.5T MRI scanner. DWand TRIP-MRI were performed to determine if necrotic tumor core could be differentiated from viable tumor periphery. For each, we compared mean differences between tumor core/ periphery using a 2-tailed paired t-test (α = 0.05). Imaging was correlated with histopathology. RESULTS: Tumors were successfully grown in all rabbits, confirmed by necropsy. On DW-MRI, mean apparent diffusion coeffi cient (ADC) value was higher in necrotic tumor core (2.1 ± 0.3 mm2/s) than in viable tumor periphery (1.4 ± 0.5 mm2/s) (P < 0.05). On TRIP-MRI, mean perfusion values was higher in tumor periphery (110 ± 47 relative units) than in tumor core (66 ± 31 relative units) (P < 0.001). CONCLUSION: Functional MRI can be used to differentiate necrotic from viable tumor cells in an animal pancreatic cancer model using ADC (DW-MRI) and perfusion (TRIP-MRI) values. | Robert J Lewandowski Aaron C Eifler David J Bentrem Johnathan C Chung Gayle E Woloschak Robert Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，26： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员