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| 1 | Chinese Stroke Center Alliance:a national effort to improve healthcare quality for acute stroke and transient ischaemic attack:rationale,design and preliminary findings显示文摘Background In June 2015,the Chinese Stroke Association(CSA)initiated the Chinese Stroke Center Alliance(CSCA)to establish the national hospital-based stroke care quality assessment and improvement platform.This article outlines its objectives,operational structure,patient population,quality improvement(QI)intervention tools,data elements,data collection methodology and current patient and hospital data.Methods The CSCA is a national,hospital-based,multicentre,voluntary,multifaceted intervention and continuous QI initiative.This multifaceted intervention includes stroke centre development,written care protocols,workshops and a monitoring/feedback system of evidencebased performance measures.The data coordinating centre of the CSCA resides at the China National Clinical Research Center for Neurological Diseases,Beijing Tiantan Hospital.results As of July 2017,1576 hospitals in China have contributed detailed clinical information to serve as a benchmark for the stroke care quality of 433264 patients with acute stroke/transient ischaemic attacks(TIA),including 352572(81.38%)acute ischaemic stroke,30362(7.01%)TIA,42080(9.71%)spontaneous intracranial haemorrhage,5505(1.27%)subarachnoid haemorrhage and 2745(0.63%)not specified stroke.Conclusion The CSCA programme is designed to establish a continuous national stroke registry and help healthcare providers develop stroke centres and treat patients in a consistent manner in accordance with accepted national guidelines and,ultimately,improve patient outcomes.It supports the CSA mission to reduce stroke burden in China. | Yongjun Wang Zixiao Li Yilong Wang Xingquan Zhao Liping Liu Xin Yang Caiyun Wang Hongqiu Gu Fuying Zhang Chunjuan Wang Ying Xian David Z Wang Qiang Dong Anding Xu Jizong Zhao Chinese Stroke Center Alliance investigators | 2018 | Stroke & Vascular Neurology2018，3，4： | 38 |
| 2 | Association of elevated hs-CRP and multiple infarctions with outcomes of minor stroke or TIA: subgroup analysis of CHANCE randomised clinical trial显示文摘Background and purpose The relationship of high-sensitive C-reactive protein(hs-CRP)levels and infarction numbers with the prognosis of stroke is uncertain.This study evaluated the association of different hs-CRP levels and infarction numbers with the prognosis of acute minor ischaemic stroke or transient ischaemic attack(TIA).Methods A subset of 807 patients with both hs-CRP measurement and baseline MRI was included from the Clopidogrel in High-risk Patients with Acute Non-disabling Cerebrovascular Events trial.The primary efficacy outcome was the occurrence of an ischaemic stroke at the 1-year follow-up.Infarction numbers were classified as multiple acute infarctions(MAIs),single acute infarction and no acute infarction(NAI).The association between different hs-CRP levels with different infarction numbers and the risk of any outcome was analysed using multivariable Cox regression models.Results Among the 807 patients,84(10.4%)patients had a recurrent ischaemic stroke within 1 year.After adjustment for conventional confounding factors,patients with both elevated hs-CRP levels and MAIs were associated with approximately 4.7-fold of risk of ischaemic stroke within 1 year(16.7% vs 3.5%,HR 4.68,95% CI 1.54 to 14.23,p=0.007),compared with those with non-elevated hs-CRP levels and NAI.Similar results were observed for the composite events.Conclusions Combined elevated hs-CRP levels and MAIs may increase 1-year stroke risk stratification efficiency in patients with minor ischaemic stroke or TIA compared with using those markers alone,which indicated that the combination of inflammatory and imaging markers might improve the effectiveness of risk stratification concerning minor ischaemic stroke or TIA. | Guangyao Wang Jing Jing Jiejie Li Yuesong Pan Hongyi Yan Xia Meng Xingquan Zhao Liping Liu Hao Li David Z Wang Yongjun Wang Yilong Wang | 2021 | Stroke & Vascular Neurology2021，6，1： | 11 |
| 3 | MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines显示文摘AIM:To investigate expression of microRNA(miRNA)and potential targets in chemotherapy resistant esoph-ageal cancer cell lines.METHODS:An in-vitro model of acquired chemotherapy resistance in esophageal adeno-(EAC)and squamous cell carcinoma(ESCC)cells was used,and microRNA expression profiles for cisplatin or 5-fluorouracil(5-FU)resistant variants vs chemotherapy sensitive controls were compared using microarray and quantitative real-time polymerase chain reaction(PCR).The expression of chemotherapy-relevant genes potentially targeted by the dysregulated microRNAs in the chemotherapy resistant variants was also evaluated.RESULTS:Chemotherapy resistant sublines were found to have specific miRNA signatures,and these miRNA signatures were different for the cisplatin vs 5-FU resistant cells from the same tumor cell line,and also for EAC vs ESCC cells with resistance to the same specific chemotherapy agent.Amongst others,miR-27b-3p,miR-193b-3p,miR-192-5p,miR-378 a-3p,miR-125a-5p and miR-18a-3p were dysregulated,consistent with negative posttranscriptional control of KRAS,TYMS,ABCC3,CBL-B and ERBB2 expression via these miRNAs.CONCLUSION:The current study supports the hypothesis that microRNA expression has an impact on chemotherapy resistance in esophageal cancer. | Richard Hummel Corina Sie David I Watson Tingting Wang Alfiya Ansar Michael Z Michael Mark Van der Hoek Joerg Haier Damian J Hussey | 2014 | World Journal of Gastroenterology2014，20，40： | 8 |
| 4 | Is tenecteplase ready to replace alteplase to treat acute ischaemic stroke? The knowns and unknowns显示文摘Tenecteplase(TNKase,TNK-tPA or TNK)is a thrombolytic agent derived from the tissue plasminogen activator(tPA).It is a 527-amino acid glycoprotein developed by replacing three amino acids at the T,N and K positions of the glycoprotein structure of tPA under genetic recombinant technology.After replacing threonine 103 with asparagine,asparagine 117 with glutamine and a tetra-alanine at amino acids 296–299,TNK is about eightfold more potent in dissolving clot,80-fold higher resistance to plasminogen activator inhibitor-1 and 14-fold enhanced relative fibrin specificity,and with a longer half-life(20 min).1 Hence,TNK is administered as a single intravenous bolus. | Yi Dong Yi Sui Xin Cheng David Z Wang | 2022 | Stroke & Vascular Neurology2022，7，1： | 3 |
| 5 | Design optimization of short stroke single phase tubular permanent magnet motor for refrigeration applications 显示文摘 | WANG J B DAVID H LIN Z Y | 2010 | IEEE Transactions on In- dustry Electronic2010，57，1： | 1 |
| 6 | Bi-directional PCA with assembled matrix distance metric for image recognition 显示文摘 | ZUO W M DAVID Z WANG K Q | 2006 | IEEE Transaction Systems Man and Cybernetics2006，36，4： | 1 |
| 7 | A parameterized direct LDA and its application to face recognition 显示文摘 | SONG F X ZHANG DAVID WANG J Z | 2007 | Neurocomputing2007，71，12： | 1 |
| 8 | Oxidation of aqueous sulfite ion by nitrogen dioxide 显示文摘 | David L Wang Y Z Chang S G | 1993 | EnvironmentalScience&Technology1993，27，： | 1 |
| 9 | Palmprint recognition using eigenpalms features显示文摘 | Lu Guangming David Z Wang Kuanquan | 2003 | Pattern Recognition Letters2003，24，910： | 1 |
| 10 | Influences of the Atlantic warm pool on western hemisphere summer rainfall and Atlantic hurricanes显示文摘 | Wang C Z David B E Lee S K | 2006 | Journal of Climate2006，19，： | 1 |
| 11 | A cartesian grid method for modeling multiple moving objects in 2D incompressible viscous flow显示文摘 | David Russell Jane Wang Z | 2003 | Journal of Computational Physics2003，191，： | 1 |
| 12 | Refinement and generation of decision rules through training and augmentation of neural networks显示文摘 | WANG F Y HUANG Z Y DAVID D Q | 1998 | International Journal of Intelligent Control and Systems1998，12，3： | 1 |
| 13 | Simple synthesis of yolk-shelled Zn Co2O4microspheres towards enhancing the electrochemical performance of lithium-ion batteries in conjunction with a sodium carboxymethyl cellulose binder显示文摘 | Li J F Wang J Z David W | 2013 | J Mater Chem A2013，1，15： | 1 |
| 14 | Oil spill identification显示文摘 | Wang Z D Fingas M David S | 1999 | Journal of Chromatography A1999，843，12： | 1 |
| 15 | Page oil spill identification显示文摘 | WANG Z D MERV F DAVID S | 1999 | Journal of Chromatography A1999，843，： | 1 |
| 16 | Oil spill identification显示文摘 | Wang Z D Fingas M Page David S | 1999 | Journal of Chromatography A1999，843，： | 1 |
| 17 | Stem cell treatment improves post stroke neurological outcomes:a comparative study in male and female rats显示文摘Background and purpose The therapeutic potential of different stem cells for ischaemic stroke treatment is intriguing and somewhat controversial.Recent results from our laboratory have demonstrated the potential benefits of human umbilical cord blood-derived mesenchymal stem cells(MSC)in a rodent stroke model.We hypothesised that MSC treatment would effectively promote the recovery of sensory and motor function in both males and females,despite any apparent sex differences in post stroke brain injury.Methods Transient focal cerebral ischaemia was induced in adult Sprague-Dawley rats by occlusion of the middle cerebral artery.Following the procedure,male and female rats of the untreated group were euthanised 1 day after reperfusion and their brains were used to estimate the resulting infarct volume and tissue swelling.Additional groups of stroke-induced male and female rats were treated with MSC or vehicle and were subsequently subjected to a battery of standard neurological/neurobehavioral tests(Modified Neurological Severity Score assessment,adhesive tape removal,beam walk and rotarod).The tests were administered at regular intervals(at days 1,3,5,7 and 14)after reperfusion to determine the time course of neurological and functional recovery after stroke.Results The infarct volume and extent of swelling of the ischaemic brain were similar in males and females.Despite similar pathological stroke lesions,the clinical manifestations of stroke were more pronounced in males than females,as indicated by the neurological scores and other tests.MSC treatment significantly improved the recovery of sensory and motor function in both sexes,and it demonstrated efficacy in both moderate stroke(females)and severe stroke(males).Conclusions Despite sex differences in the severity of post stroke outcomes,MSC treatment promoted the recovery of sensory and motor function in male and female rats,suggesting that it may be a promising treatment for stroke. | Koteswara Rao Nalamolu Bharath Chelluboina Casimir A Fornal Siva Reddy Challa David M Pinson David Z Wang Jeffrey D Klopfenstein Krishna Kumar Veeravalli | 2021 | Stroke & Vascular Neurology2021，6，4： | 1 |
| 18 | Hypobaric storage removes scald-related volatiles during the low temperature induction of superficial scald of apples 显示文摘 | Wang Z Y David R Dilley | 2000 | Postharvest Bio Tech2000，18，： | 1 |
| 19 | Oil spill identification显示文摘 | Wang Z D Fingas M F David S P | 1999 | Journal of Chromatography A1999，843，36： | 1 |
| 20 | Silver-coated TiO2 nano- structured anode materials for lithium ion batteries 显示文摘 | Rahman M M Wang J Z David W | 2010 | J Solid State Electrochem2010，14，5： | 1 |
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