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| 1 | Non-alcoholic fatty liver disease and obesity: Biochemical, metabolic and clinical presentations显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common liver disease in the world.Presentation of the disease ranges from simple steatosis to non-alcoholic steatohepatitis(NASH).NAFLD is a hepatic manifestation of metabolic syndrome that includes central abdominal obesity along with other components.Up to80%of patients with NAFLD are obese,defined as a body mass index(BMI)>30 kg/m2.However,the distribution of fat tissue plays a greater role in insulin resistance than the BMI.The large amount of visceral adipose tissue(VAT)in morbidly obese(BMI>40 kg/m2)individuals contributes to a high prevalence of NAFLD.Free fatty acids derived from VAT tissue,as well as from dietary sources and de novo lipogenesis,are released to the portal venous system.Excess free fatty acids and chronic low-grade inflammation from VAT are considered to be two of the most important factors contributing to liver injury progression in NAFLD.In addition,secretion of adipokines from VAT as well as lipid accumulation in the liver further promotes inflammation through nuclear factor kappa B signaling pathways,which are also activated by free fatty acids,and contribute to insulin resistance.Most NAFLD patients are asymptomatic on clinical presentation,even though some may present with fatigue,dyspepsia,dull pain in the liver and hepatosplenomegaly.Treatment for NAFLD and NASH involves weight reduction through lifestyle modifications,anti-obesity medication and bariatric surgery.This article reviews the available information on the biochemical and metabolic phenotypes associated with obesity and fatty liver disease.The relative contribution of visceral and liver fat to insulin resistance is discussed,and recommendations for clinical evaluation of affected individuals is provided. | Sandra Milic Davorka Lulic Davor Stimac | 2014 | World Journal of Gastroenterology2014，20，28： | 52 |
| 2 | Glucagon-like-1 receptor agonists and sodium/glucose cotransporter-2 inhibitors combination—are we exploiting their full potential in a real life setting?显示文摘BACKGROUND The sodium/glucose cotransporter-2 inhibitors(SGLT-2i)and glucagon-like-1 receptor agonists(GLP-1RA)are antidiabetic agents effective both in hemoglobin A1c(HbA1c)reduction(with a low risk of hypoglycemia)and cardiovascular event prevention.In patients with type 2 diabetes,the add-on value of combination therapy of GLP-1RA and an SGLT-2i seems promising.AIM To investigate whether the efficacy of GLP-1RA and SGLT-2i combination observed in randomized controlled trials translates into therapeutic benefits in the Croatian population during routine clinical practice and follow-up.METHODS We included 200 type 2 diabetes patients with poor glycemic control and analyzed the effects of treatment intensification with(1)GLP-1RA on top of SGLT-2i,(2)SGLT-2i on top of GLP-1RA compared to(3)simultaneous addition of both agents.The primary study endpoint was the proportion of participants with HbA1c<7.0%and/or 5%bodyweight reduction.Secondary outcomes included changes in fasting plasma glucose(FPG),prandial plasma glucose,lowdensity lipoprotein cholesterol,estimated glomerular filtration rate(eGFR),and cardiovascular(CV)incidents assessment over a follow-up period of 12 mo.RESULTS The majority of patients were over 65-years-old,had diabetes duration for more than 10 years.The initial body mass index was 39.41±5.49 kg/m2 and HbA1c 8.32±1.26%.Around half of the patients in all three groups achieved target HbA1c below 7%.A more pronounced decrease in the HbA1c seen with simultaneous SGLT-2i and GLP-1RA therapy was a result of higher baseline HbA1c and not the effect of initiating combination therapy.The number of patients achieving FPG below 7.0 mmol/L was significantly higher in the SGLT-2i group(P=0.021),and 5%weight loss was dominantly achieved in the simultaneous therapy group(P=0.044).A composite outcome(reduction of HbA1c below 7%(53 mmol/mol)with 5%weight loss)was achieved in 32.3%of total patients included in the study.Only 18.2%of patients attained composite outcome defined as HbA1c below 7%(53 mmol/mol)with 5%weight loss and low-density lipoprotein cholesterol<2.5 mmol/L.There were no significant differences between treatment groups.No differences were observed regarding CV incidents or eGFR according to treatment group over a follow-up period.CONCLUSION Combination therapy with GLP-1RA and SGLT-2i is effective in terms of metabolic control,although it remains to be determined whether simultaneous or sequential intensification is better. | Maja Cigrovski Berkovic Ines Bilic-Curcic Tomislav Bozek Davorka Herman Mahecic Sanja KlobucarMajanovic Silvija Canecki-Varzic Jelena Andric Srecko Marusic Anna Mrzljak | 2020 | World Journal of Diabetes2020，11，11： | 1 |
| 3 | On the investigation of the neurophysiological correlates of knowledge mental fatigue using the EEG signal 显示文摘 | Okogbaa G Richard L Davorka F | 1994 | Applied Ergonomics1994，25，6： | 1 |
| 4 | High-mobility group box 1 (HMGB1) protein: Friend and foe显示文摘 | Luis Ulloa Davorka Messmer | 2006 | Cytokine and Growth Factor Reviews2006，，3： | 1 |
| 5 | Comparison of acute effects of red wine, beer and vodka against hyperoxia-induced oxidative stress and increase in arterial stiffness in healthy humans显示文摘 | Mladen Krnic Darko Modun Danijela Budimir Grgo Gunjaca Ivan Jajic Jonatan Vukovic Ilza Salamunic Davorka Sutlovic Bernard Kozina Mladen Boban | 2011 | Atherosclerosis2011，，2： | 1 |
| 6 | On the investigation of the neurophysiological correlates of knowledge mental fatigue using the EEG signal显示文摘 | Okogbaa G Richard L Davorka Filipusic | 1994 | Applied Ergonomics1994，25，6： | 1 |
| 7 | Teaching evidence based medicine in family medicine显示文摘 | Vrdoljak Davorka | 2012 | Acta Med Acad2012，41，： | 1 |
| 8 | On the investigation of the neurophysiological correlates of knowledge mental fatigue using the EEG signal显示文摘 | OKOGBAA G RICHARD L DAVORKA FILIPUSIC | 1994 | Appl Ergonomics1994，25，6： | 1 |
| 9 | 克罗地亚测震学的发展和地震层析成像研究(英文)显示文摘克罗地亚地球物理学家莫霍洛维奇在研究 1909 年 10 月 8 日克罗地亚地震的地震波走时特征时,首次发现了该地区的地壳与地幔的分界面,后被命名'莫霍界面',简称 Moho 界面。1927 年,莫霍洛维奇又在地震记录中识别出了 S*震相,证实了在地壳内部还会存在另一个康拉德(Conrad)间断面。地震层析成像是研究地球内部结构的重要方法之一。为纪念莫霍洛维奇诞生 150 周年,莫霍界面发现 100 周年,特发此文,以兹纪念。 | Marijan Herak Davorka Herak | 2008 | CT理论与应用研究(中英文)2008，17，3： | 0 |
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