|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Long-Term Effects of Manure and Inorganic Fertilizers on Yield and Soil Fertility for a Winter Wheat-Maize System in Jiangsu, China显示文摘Winter wheat-maize rotations are dominant cropping systems on the North China Plain, where recently the use of organic manure with grain crops has almost disappeared. This could reduce soil fertility and crop productivity in the long run. A 20-year field experiment was conducted to 1) assess the effect of inorganic and organic nutrient sources on yield and yield trends of both winter wheat and maize, 2) monitor the changes in soil organic matter content under continuous wheat-maize cropping with different soil fertility management schemes, and 3) identify reasons for yield trends observed in Xuzhou City, Jiangsu Province, over a 20-year period. There were eight treatments applied to both wheat and maize seasons: a control treatment (C); three inorganic fertilizers, that is, nitrogen (N), nitrogen and phosphorus (NP), and nitrogen, phosphorus and potassium (NPK); and addition of farmyard manure (FYM) to these four treatments, that is, M, MN, MNP, and MNPK. At the end of the experiment the MN, MNP, and MNPK treatments had the highest yields, about 7 t wheat ha-1 and 7.5 t maize ha-1, with each about 1 t ha-1 more than the NPK treatments. Over 20 years with FYM soil organic matter increased by 80% compared to only 10% with NPK, which explained yield increases. However, from an environmental and agronomic perspective, manure application was not a superior strategy to NPK fertilizers. If manure was to be applied, though, it would be best applied to the wheat crop, which showed a better response than maize. | JIANG Dong H. HENGSDIJK DAI Ting-Bo W. de BOER JING Qi CAO Wei-Xing | 2006 | Pedosphere2006，16，1： | 40 |
| 2 | 25-羟维生素D和甲状旁腺激素与高血压的相关性显示文摘有研究证实,维生素D缺乏和甲状旁腺激素(PTH)过高与高血压的发生密切相关。维生素D缺乏不仅可以影响肾素血管紧张素系统及PTH水平,而且可以直接参与血管炎性反应,影响高血压的发生发展。PTH可以通过促进血管炎性反应及血管钙化等参与高血压的进展。目前还没有前瞻性研究同时评估维生素D和PTH水平与高血压发病的关系。该研究分析多民族动脉粥样硬化研究的前瞻性数据,发现低水平25羟维生素D[25(OH)D]和高水平PTH与高血压发病相关,特别是在肥胖人群中。但在校正混杂因素后,25(OH)D水平与高血压发病的相关性无统计学意义,而PTH水平与高血压发病仍然相关。鉴于维生素D缺乏和PTH过量在人群中是普遍现象,该研究对于更好地了解高血压发病机制,在人群中开展高血压预防工作有重要意义。 | van Ballegooijen AJ Kestenbaum B Sachs MC de Boer IH Siscovick DS Hoofnagle AN Ix JH Visser M Brouwer IA 练桂丽 叶鹏 | 2014 | 中华高血压杂志2014，22，6： | 10 |
| 3 | Efficacy of thioguanine treatment in inflammatory bowel disease: A systematic review显示文摘AIM To critically assess the available literature regarding the efficacy of thioguanine treatment in inflammatory bowel disease(IBD) patients, irrespective of the(hepato-) toxicity profile.METHODS A systematic literature search of the MEDLINE database using Pub Med was performed using the keywords 'thioguanine', '6-TG', 'thioguanine', 'inflammatory bowel disease', 'IBD', 'Crohn's disease', 'Ulcerative colitis' and 'effectiveness' in order to identify relevant articles published in English starting from 2000. Reference lists of the included articles were crosschecked for missing articles. Reviewed manuscripts concerning the effectiveness of thioguanine treatment in IBD were reviewed by the authors and the data were extracted. Data were subsequently analyzed with descriptive statistics. Due to the lack of standardized outcomes, a formal meta-analysis was not performed.RESULTS A total of 11 applicable studies were found that involved the effectiveness of thioguanine therapy in IBD. Eight studies were conducted in a prospectivemanner, in the remaining three studies, data was collected retrospectively. In total, 353 IBD-patients(225 patients with Crohn's disease, 119 with ulcerative colitis and nine with unclassified IBD) with prior azathioprine/mercaptopurine resistance and/or intolerance(n = 321) or de novo thioguanine administration(n = 32) were included for analysis, of which 228(65%) had clinical improvement on thioguanine therapy, based on standard IBD questionnaires, biochemical parameters or global physician assessments. Short-term results were based on 268 treatment years(median follow-up 9 mo, range 3-22 mo) with a median daily dose of 20 mg(range 10-80 mg). Discontinuation, mostly due to adverse events, was reported in 72 patients(20%). CONCLUSION The efficacy of thioguanine therapy in IBD patients intolerant to conventional thiopurine therapy is observed in 65%, with short term adverse events in 20% of patients. | Berrie Meijer Chris JJ Mulder Godefridus J Peters Adriaan A van Bodegraven Nanne KH de Boer | 2016 | World Journal of Gastroenterology2016，22，40： | 5 |
| 4 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 5 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 6 | Coeliac disease in Dutch patients with Hashimoto’s thyroiditis and vice versa显示文摘AIM: To define the association between Hashimoto’s thyroiditis and coeliac disease in Dutch patients. METHODS: A total of 104 consecutive patients with Hashimoto’s thyroiditis underwent coeliac serological tests (antigliadins, transglutaminase and endomysium antibodies) and HLA-DQ typing. Small intestinal biopsy was performed when any of coeliac serological tests was positive. On the other hand, 184 patients with coeliac disease were subjected to thyroid biochemical (thyroid stimulating hormone and free thyroxine) and thyroid serological tests (thyroglobulin and thyroid peroxidase antibodies). RESULTS: Of 104 patients with Hashimoto’s thyroiditis, sixteen (15%) were positive for coeliac serology and five patients with documented villous atrophy were diagnosed with coeliac disease (4.8%; 95% CI 0.7-8.9). HLA-DQ2 (and/or -DQ8) was present in all the five and 53 patients with Hashimoto’s thyroiditis (50%; 95% CI 43-62). Of 184 patients with coeliac disease, 39 (21%) were positive for thyroid serology. Based on thyroid biochemistry, the 39 patients were subclassified into euthyroidism in ten (5%; 95% CI 2-9), subclinicalhypothyroidism in seven (3.8%; 95% CI 1.8-7.6), and overt hypothyroidism (Hashimoto’s thyroiditis) in 22 (12%; 95% CI 8-16). Moreover, four patients with coeliac disease had Graves’ disease (2%; 95% CI 0.8-5) and one patient had post-partum thyroiditis. CONCLUSION: The data from a Dutch population confirm the association between Hashimoto’s thyroiditis and coeliac disease. Screening patients with Hashimoto’s thyroiditis for coeliac disease and vice versa is recom- mended. | Muhammed Hadithi Hans de Boer Jos WR Meijer Frans Willekens Jo A Kerckhaert Roel Heijmans Amado Salvador Pea Coen DA Stehouwer Chris JJ Mulder | 2007 | World Journal of Gastroenterology2007，13，11： | 4 |
| 7 | Auto immune hepatitis显示文摘To provide an update of the latest trends in epidemiology, clinical course, diagnostics, complications and treatment of auto immune hepatitis(AIH). A search ofthe MEDLINE database was performed using the search terms: 'auto immune hepatitis', 'clinical presentation', 'symptoms', 'signs', 'diagnosis', 'auto antibodies', 'laboratory values', 'serology', 'histopathology', ' h i s t o l o g y ', ' g e n e t i c s ', 'HLA g e n e s ', 'non-HLA genes', 'environment', 'epidemiology', 'prevalence', 'incidence', 'demographics', 'complications', 'HCC', 'PBC', 'PSC', 'corticosteroid', 'therapy', 'treatment', 'alternative treatment'. English-language full-text articles and abstracts were considered. Articles included reviews, meta-analysis, prospective retrospective studies. No publication date restrictions were applied. AIH is an immune meditated progressive inflammatory liver disease that predominantly affects middle-aged females but may affect people of all ages. The clinical spectrum of AIH is wide, ranging from absent or mild symptoms to fulminant hepatic failure. The aetiology of AIH is still unknown, but is believed to occur as the consequence of an aberrant immune response towards an un-known trigger in a genetically susceptible host. In the absence of a gold standard, diagnosis is based on the combination of clinical, biochemical and histopathological criteria. Immunosuppressive treatment has been the cornerstone of treatment since the earliest description of the disease in 1950 by Waldenstr?m. Such treatment is often successful at inducing remission and generally leads to normal life expectancy. Nevertheless, there remain significant areas of unmet aetiological a clinical needs including fundamental insight in disease pathogenesis, optimal therapy, duration of treatment and treatment alternatives in those patients unresponsive to standard treatment regimens. | nicole mf van gerven ynto s de boer chris jj mulder carin mj van nieuwkerk gerd bouma | 2016 | World Journal of Gastroenterology2016，22，19： | 3 |
| 8 | Sex-specific effects of inbreeding and early ife conditions on the adult oxidative balance显示文摘 | Raissa Anna DE BOER David COSTANTINI Giulia CASASOLE Hamada ABDELGAWAD Han ASARD Marcel EENS Wendt MIJLLER | 2018 | Current Zoology2018，64，5： | 2 |
| 9 | Newly Designed CRRT Membranes for Sepsis and SIRS—A Pragmatic Approach for Bedside Intensivists Summarizing the More Recent Advances: A Systematic Structured Review显示文摘 | Patrick M. Honore Rita Jacobs Olivier Joannes-Boyau Jouke De Regt Elisabeth De Waele Viola van Gorp Willem Boer Lies Verfaillie Herbert D. Spapen | 2013 | ASAIO Journal2013，，2： | 2 |
| 10 | Limitation of myocardial infarct size after primary angioplasty:Is a higher patency the only mechanism?显示文摘 | OTTERVANGER J P LIEM A De BOER M J | 1999 | Am Heart J1999，137，3： | 2 |
| 11 | Galectin-3 Mediates Aldosterone-Induced Vascular Fibrosis显示文摘 | Laurent Calvier Maria Miana Pascal Reboul Victoria Cachofeiro Ernesto Martinez-Martinez Rudolf A. de Boer Fran?oise Poirier Patrick Lacolley Faiez Zannad Patrick Rossignol Natalia López-Andrés | 2013 | Arteriosclerosis, Thrombosis, and Vascular Biology2013，，1： | 2 |
| 12 | The fibrosis marker galectin‐3 and outcome in the general population显示文摘 | R. A. de Boer D. J. van Veldhuisen R. T. Gansevoort A. C. Muller Kobold W. H. van Gilst H. L. Hillege S. J. L. Bakker P. van der Harst | 2011 | Journal of Internal Medicine2011，，1： | 2 |
| 13 | Angiographic Assessment of Myocardial Reperfusion in Patients Treated With Primary Angioplasty for Acute Myocardial Infarction: Myocardial Blush Grade显示文摘 | Arnoud W.J. van ’t Hof Aylee Liem Harry Suryapranata Jan C.A. Hoorntje Menko-Jan de Boer Felix Zijlstra | 1998 | Circulation1998，，23： | 2 |
| 14 | Long-term benefi t of primary angioplasty as compared with thrombolytic therapy for acute myocardial infarction显示文摘 | Zijlstra F Hoorntje JC de Boer MJ | | the New England Journal of Medicine0，，： | 2 |
| 15 | Inclusion of geometrical uncertainties in radiotherapy treatment planning by means of coverage probability显示文摘 | Joep C. Stroom Hans C.J. de Boer Henk Huizenga Andries G. Visser | 1999 | International Journal of Radiation Oncology Biology Physics1999，，4： | 2 |
| 16 | ACE inhibition attenuates radiation-induced cardiopulmonary damage显示文摘 | Sonja J. van der Veen Ghazaleh Ghobadi Rudolf A. de Boer Hette Faber Megan V. Cannon Peter W. Nagle Sytze Brandenburg Johannes A. Langendijk Peter van Luijk Robert P. Coppes | 2014 | Radiotherapy and Oncology2014，，： | 2 |
| 17 | 热轧宽带钢正火轧制的经验显示文摘1 正火轧制的目的诸如液压系统用精密钢管、石油管、远程输送管道、交通工具的框架结构、压力容器以及机器构件均广泛使用热轧宽带钢。此类焊接结构中,有些构件必须用正火状态下使用性能优良的结构钢来制造。就热轧宽带钢的生产和加工而言,如果不通过炉内补充正火,而是在轧制过程中直接达到这种状态,会具有更多的优越性。这种方法可节约能源和时间,改善环境,而且有利于用户直接进行带材的深加工。 | Harald de Boer 刘治平 | 1992 | 武钢技术1992，30，12： | 2 |
| 18 | Variation of Adenoma Prevalence by Age, Sex, Race, and Colon Location in a Large Population: Implications for Screening and Quality Programs显示文摘 | Douglas A. Corley Christopher D. Jensen Amy R. Marks Wei K. Zhao Jolanda de Boer Theodore R. Levin Chyke Doubeni Bruce H. Fireman Charles P. Quesenberry | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 2 |
| 19 | 给河流空间——欧洲莱茵河洪水管理经验显示文摘过去数百年间,荷兰的河流空间持续萎缩。河流两岸堤防不断加高,居住人民越来越多,两岸地面发生沉降,同时降水更多、更频繁,河流需要下泄越来越多的水量。按照最不乐观的情况估计,堤防决口可能会给400万荷兰人民带来危险。基于这些原因,荷兰政府采取措施,通过实施河流的防洪规划来增进安全。河流在39处被给予更多的空间,措施包括'给河流空间'项目。除安全因素外,'给河流空间'项目同时考虑了环境因素:河流周边地区变得更具吸引力,为自然和娱乐提供了更多空间。包括省政府、市政府、水董会和荷兰交通水利部等在内的17个单位在实施此项目的过程中密切合作,确保了所有利益相关者的积极参与。荷兰基础设施和环境部负责该项目的管理工作,并作为主要投资方,共为该项目投资23亿欧元。 | Ingwer de Boer | 2012 | 人民黄河2012，34，10： | 2 |
| 20 | 跟骨关节内移位骨折的功能疗效和患者满意度——切开复位、经皮手术和非手术治疗对比研究显示文摘对于跟骨关节内移位骨折,约60%的工薪阶层患者会选择切开复位内固定术(openreductionandinternalfixation,ORIF)治疗,术后恢复工作通常需要5~10个月,相当一部分患者1年内无法恢复工作;而对于保守治疗患者,骨折症状通常会持续1~2年,高达16%的患者需行关节内固定手术。本研究的主要目的是比较3种跟骨关节内移位骨折治疗方案——ORIF、经皮手术和非手术治疗的疗效差异。 | De Boer AS Van Lieshout EM Den Hartog D 叶翔凌 夏远军 | 2016 | 中国骨科临床与基础研究杂志2016，8，6： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员