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| 1 | Nonalcoholic fatty liver disease and the heart in children and adolescents显示文摘Over the last two decades, the rise in the prevalence rates of overweight and obesity explains the emergence of nonalcoholic fatty liver disease(NAFLD) as the leading cause of chronic liver disease worldwide. As described in adults, children and adolescents with fatty liver display insulin resistance, glucose intolerance, and dyslipidemia. Thus NAFLD has emerged as the hepatic component of the metabolic syndrome(MetS) and a strong cardiovascular risk factor even at a very early age. Several studies, including pediatric populations, have reported independent associations between NAFLD and markers of subclinical atherosclerosis including impaired flow-mediated vasodilation, increased carotid artery intima-media thickness, and arterial stiffness, after adjusting for cardiovascular risk factors and MetS. Also, it has been shown that NAFLD is associated with cardiac alterations, including abnormal left ventricular structure and impaired diastolic function. The duration of these subclinical abnormalities may be important, because treatment to reverse the process is most likely to be effective earlier in the disease. In the present review, we examine the current evidence on the association between NAFLD and atherosclerosis as well as between NAFLD and cardiac dysfunction in the pediatric population, and discuss briefly the possible biological mechanisms linking NAFLD and cardiovascular changes. We also address the approach to treatment for this increasingly prevalent disease, which is likely to have an important future global impact on the burden of ill health, to prevent not only end-stage liver disease but also cardiovascular disease. | Lucia Pacifico Claudio Chiesa Caterina Anania Antonio De Merulis John Frederick Osborn Sara Romaggioli Eugenio Gaudio | 2014 | World Journal of Gastroenterology2014，20，27： | 3 |
| 2 | Pre-emptive analgesia for postoperative pain control: a review 显示文摘 | Campiglia L Consales G De Gaudio A R | 2010 | Clin Drug Investig2010，302，： | 1 |
| 3 | Videolaparoscopic chule- cystectomy induces a hemostasis activation of lower grade than does open surgery显示文摘 | Prisco D De Gaudio AR Carla R | 2000 | Surg Endosc2000，14，2： | 1 |
| 4 | Device related infections in cirlicaliy ill patients Part lI ; Prevention of venlilator assoeialed pneumonia and urinary tract infections 显示文摘 | Difilippo A De Gaudio AR | 2003 | J Che me!hes2003，15，6： | 1 |
| 5 | Microalbuminuria as an early index of impairment of glomerular permeability in postoperative septic patients显示文摘 | De Gaudio AR Adembri C Grechi S | 2000 | Intensive Care Med2000，26，： | 1 |
| 6 | Videolaparoscopic cholecystectomy induces a hemostasis activation of lower grade than does open surgery显示文摘 | Prisco O De Gaudio AR Carla R | | 0，，04： | 1 |
| 7 | Isolation and characterization of four type-1 ribosome-inactivating proteins, with polynucleotide:adenosine glycosidase activity, from leaves of Phytolacca dioica L.显示文摘 | Antimo Di Maro Paola Valbonesi Andrea Bolognesi Fiorenzo Stirpe Paolo De Luca Gesualdo Siniscalco Gigliano Luciano Gaudio Pasquale Delli Bovi Pasquale Ferranti Antonio Malorni Augusto Parente | 1999 | Planta1999，，1： | 1 |
| 8 | Pre-emptive analgesia for postoperative pain control:a review显示文摘 | Campiglia L Consales G De Gaudio AR | 2010 | Clin Drug Investig2010，30，2： | 1 |
| 9 | Percutaneous injection of ethanol to treat autonomous thyroid nodules显示文摘 | Mazzeo S Toni M G De Gaudio C | 1993 | A JR1993，161，8： | 1 |
| 10 | Percutaneous injection of ethanol to treat autonomous thyroid nodules显示文摘 | Mazzeo S Toni MG De Gaudio C | 1993 | AJR Am J Roentgenol1993，161，4： | 1 |
| 11 | State entropy and bispectral index correlation with end tidal sevoflurane concen- trations显示文摘 | Rinaldi S Consales G De Gaudio A R | 2007 | Minerva Anestesiol2007，73，12： | 1 |
| 12 | Sepsis associated encephalopathy显示文摘 | Chelazzi C Consales G De Gaudio AR | 2008 | Current Anaesthesia &Critical Care2008，19，1： | 1 |
| 13 | The effect of glutathione and N-acetylcysteine on lipoperoxidative damage in patients with early septic shock 显示文摘 | Ortolani O Conti A De Gaudio S | 2000 | Am J Respir Crit Care Med2000，161，6： | 1 |
| 14 | Pre-emptive analgesia for postoperative pain control: a reviewJ显示文摘 | Campiglia L Consales G De Gaudio AR | 2010 | Clin Drug Investig2010，30，2： | 1 |
| 15 | Antioxidant therapy in critically septic patients显示文摘 | Rinaldi S Landueci F De Gaudio AR | 2009 | Curt Drug Targets2009，10，1： | 1 |
| 16 | Therapeutic use of albumin 显示文摘 | DE GAUDIO A R | 1995 | Int J Artif Organs1995，18，4： | 1 |
| 17 | Sepsis associated encephalopathy显示文摘 | Chelazzi C Consales G De Gaudio AR | 2008 | Current Anaesthesia & Critical Care2008，19，1： | 1 |
| 18 | Hypertonic saline solution: a safe ahemative to mannitol 18% in neurosurgery 显示文摘 | De Vivo P Del Gaudio A Ciritella P | 2001 | Minerva Anesthesiol2001，67，： | 1 |
| 19 | Sepsis associatedencephalopathy 显示文摘 | Chelazzi C Consales G De Gaudio | 2008 | Curr Anaesth Crit Care2008，19，1： | 1 |
| 20 | Sedation in PACU :indications ,monitoring, complications显示文摘 | De Gaudio AR Rinaldi S | 2005 | Current Drug Targets2005，6，7： | 1 |
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