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| 1 | Atrophic gastritis: Risk factor for esophageal squamous cell carcinoma in a Latin-American population显示文摘AIM: To study the association between atrophic gastritis (AG) and esophageal squamous cell carcinoma (ESCC) in a Latin-America population. METHODS: A case-control study was performed at two reference Brazilian hospitals including patients diagnosed with advanced ESCC and dyspeptic patients who had been subjected to upper gastrointestinal endoscopy, with biopsies of the gastric antrum and body.All cases with ESCC were reviewed by a single pathologist, who applied standard criteria for the diagnosis of mucosal atrophy, intestinal metaplasia, and dysplasia, all classified as AG. The data on the patients' age, sex, smoking status, and alcohol consumption were collected from clinical records, and any missing information was completed by telephone interview. The association between AG and ESCC was assessed by means of univariate and multiple conditional logistic regressions. RESULTS: Most patients were male, and the median age was 59 years (range: 37-79 years) in both the ESCC and control groups. Univariate analysis showed that an intake of ethanol greater than 32 g/d was an independent risk factor that increased the odds of ESCC 7.57 times (P = 0.014); upon multiple analysis, alcohol intake of ethanol greater than 32 g/d exhibited a risk of 4.54 (P = 0.081), as adjusted for AG and smoking. Smoking was shown to be an independent risk factor that increased the odds of ESCC 14.55 times (P = 0.011) for individuals who smoked 0 to 51 packs/year and 21.40 times (P = 0.006) for those who smoked more than 51 packs/year. Upon multiple analyses, those who smoked up to 51 packs/year exhibited a risk of 7.85 (P = 0.058), and those who smoked more than 51 packs/ year had a risk 11.57 times higher (P = 0.04), as adjusted for AG and alcohol consumption. AG proved to be a risk factor that increased the odds of ESCC 5.33 times (95%CI: 1.55-18.30, P = 0.008) according to the results of univariate conditional logistic regression. CONCLUSION: There was an association by univariate conditional logistic regression between AG and ECSS in this sample of Latin-American population. | Emiliano de Carvalho Almodova Walmar Kerche de Oliveira Lucas Faria Abraho Machado Juliana Rigotto Grejo Thiago Rabelo da Cunha Wagner Colaiacovo Erika Veruska Paiva Ortolan | 2013 | World Journal of Gastroenterology2013，19，13： | 5 |
| 2 | Potential role of Limosilactobacillus fermentum as a probiotic with anti-diabetic properties: A review显示文摘Oxidative stress,inflammation,and gut microbiota impairments have been implicated in the development and maintenance of diabetes mellitus.Strategies capable of recovering the community of commensal gut microbiota and controlling diabetes mellitus have increased in recent years.Some lactobacilli strains have an antioxidant and anti-inflammatory system capable of protecting against oxidative stress,inflammation,and diabetes mellitus.Experimental studies and some clinical trials have demonstrated that Limosilactobacillus fermentum strains can beneficially modulate the host antioxidant and anti-inflammatory system,resulting in the amelioration of glucose homeostasis in diabetic conditions.This review presents and discusses the currently available studies on the identification of Limosilactobacillus fermentum strains with anti-diabetic properties,their sources,range of dosage,and the intervention time in experiments with animals and clinical trials.This review strives to serve as a relevant and well-cataloged reference of Limosilactobacillus fermentum strains capable of inducing anti-diabetic effects and promoting health benefits. | Diego Cabral Lacerda Paulo César Trindade da Costa Paula Brielle Pontes Lucas Alves Carneiro dos Santos JoséPatrocínio Ribeiro Cruz Neto Cristiane Cosmo Silva Luis Vanessa Polyana de Sousa Brito JoséLuiz de Brito Alves | 2022 | World Journal of Diabetes2022，13，9： | 3 |
| 3 | Streptococcus agalactiae:Identification methods,antimicrobial susceptibility, and resistance genes in pregnant women显示文摘BACKGROUND Group B Streptococcus(GBS)is a normal component of the gastrointestinal and genital microbiota in humans and can lead to important infections in newborns.AIM To compare GBS isolation and identification methods as well as to assess the antibiotic susceptibility and to identify resistance genes in GBS strains from pregnant women attended in healthcare services from the city of Vitória da Conquista,in Bahia State,Brazil.METHODS From January 2017 to February 2018,vaginorectal swabs were obtained from 186 participants and the samples were seeded onto chromogenic agar for GBS before and after inoculation in selective broth.Confirmatory identification using 3 CAMP and latex tests was performed in samples with GBS-suggestive colonies.Then,disk diffusion antibiograms were performed in GBS-positive samples,and the detection of the resistance genes ermB,ermTR,mefA,and linB in the clindamycin and/or erythromycin-resistant samples was carried out.RESULTS Thirty-two samples(17.2%)were GBS-positive.The culture in chromogenic agar after sample incubation in selective broth was the most sensitive method(96.9%)for GBS detection.All isolates were susceptible to penicillin,ampicillin,cefotaxime,and vancomycin.Clindamycin resistance was observed in 6 samples(18.8%),while 8 samples(25%)were erythromycin-resistant.All erythromycin and/or clindamycin-resistant GBS strains had negative D-tests.Two strains(25%)presented an M phenotype and 6 isolates(75%)presented a cMLSB phenotype.The ermB gene was identified in 4 samples(44.4%),the mefA gene was also found in 4 samples(44.4%),the ermTR gene was identified in 1 isolate(11.1%),and the linB gene was not found in any isolate.CONCLUSION This study evidenced that the screening for SGB can be performed by means of various methods,including chromogenic media,and that the chemoprophylaxis for pregnant women who cannot use penicillin must be susceptibility-guided. | Fabrícia Almeida Fernandes Santana Tais Viana Ledo de Oliveira Marcelo Barreto de Souza Filho Lucas Santana Coelho da Silva Breno Bittencourt de Brito Fabrício Freire de Melo Cláudio Lima Souza Lucas Miranda Marques Márcio Vasconcelos Oliveira | 2020 | World Journal of Clinical Cases2020，8，18： | 2 |
| 4 | Unplanned extubation in pediat-ric critically ill patients : a systematic review and best practive recom-medations 显示文摘 | Lucas da Silva PS de Carvalho WB | 2010 | Pediatric Critical Care Med2010，11，2： | 1 |
| 5 | Electrocardiographic criteria for vagotonia—validation with pharmacological parasympathetic blockade in healthy subjects显示文摘 | José Kawazoe Lazzoli Pedro Paulo da Silva Soares Antonio Claudio Lucas da Nóbrega Claudio Gil Soares de Araújo | 2002 | International Journal of Cardiology2002，，2： | 1 |
| 6 | Preoperative rectal tumor embolization as an adjunctive tool for bloodless abdominoperineal excision:A case report显示文摘BACKGROUND Abdominoperineal excision(APE)-related hemorrhage can be challenging due to difficult access to pelvic organs and the risk of massive blood loss.The objective of the present study was to demonstrate the use of preoperative embolization(PE)as a strategy for blood preservation in a patient with a large low rectal tumor with a high risk of bleeding,scheduled for APE.CASE SUMMARY A 56-year-old man presented to our institution with a one-year history of anal bleeding and rectal tenesmus.The patient was diagnosed with bulky adenocarcinoma limited to the rectum.As the patient refused any clinical treatment,surgery without previous neoadjuvant chemoradiation was indicated.The patient underwent a tumor embolization procedure,two days before surgery performed via the right common femoral artery.The tumor was successfully devascularized and no major bleeding was noted during APE.Postoperative recovery was uneventful and a one-year follow-up showed no signs of recurrence.CONCLUSION Therapeutic tumor embolization may play a role in bloodless surgeries and increase surgical and oncologic prognoses.We describe a patient with a bulky low rectal tumor who successfully underwent preoperative embolization and bloodless abdominoperineal resection. | Marley Ribeiro Feitosa Lucas Fernandes de Freitas Antonio Balestrim Filho Guilherme Seizem Nakiri Daniel Giansante Abud Ligia Magnani Landell Mariângela Ottoboni Brunaldi Jose Joaquim Ribeiro da Rocha Omar Feres Rogério Serafim Parra | 2020 | World Journal of Clinical Oncology2020，11，12： | 1 |
| 7 | Unplanned extubation in pediat pediatric critically ill patients:a systematic review and best practive recommedations显示文摘 | Lucas da Silva PS de Carvalho WB | 2010 | Pediatric Critical Care Med2010，11，2： | 1 |
| 8 | Structure and function of the von Willebrand factor A1 domain:analysis with monoclonal antibodies reveals distinct binding sites involved in recognition of the platelet membrane glycoprotein Ib-IX-V complex and ristocetin-dependent activation显示文摘 | De Luca M Facey DA Favaloro EJ | | 0，，01： | 1 |
| 9 | Creatine supplementation prevents fatty liver in rats fed choline-deficient diet: a burden of one-carbon and fatty acid metabolism显示文摘 | Rafael Deminice Gabriela Salim Ferreira de Castro Lucas Vieira Francisco Lilian Eslaine Costa Mendes da Silva Jo?o Felipe Rito Cardoso Fernando Tadeu Trevisan Frajacomo Bruno Gonzaga Teodoro Leonardo dos Reis Silveira Alceu Afonso Jordao | 2015 | The Journal of Nutritional Biochemistry2015，，4： | 1 |
| 10 | Susceptibility of Mycobacterium tuberculosis to first- line antimycobacterial agents in a Brazilian hospital : assessing the u- tility of the tetrazolium ( MTT ) microplate assay 显示文摘 | Michela De Luca Ferraril Maria Alice da Silva Telles Lucilaine Ferrazoli | 2010 | Mem Inst Os- waldo Cruz2010，105，5： | 1 |
| 11 | Value of Clinical Pulmonary Infection Score in Critically Ill Children as a Surrogate for Diagnosis of Ventilator-Associated Pneumonia显示文摘 | Paulo Sérgio Lucas da Silva Vania Euzébio de Aguiar Werther Brunow de Carvalho Marcelo Cunio Machado Fonseca | 2014 | Journal of Critical Care2014，，： | 1 |
| 12 | Platelet-rich plasma vs bone marrow aspirate concentrate:An overview of mechanisms of action and orthobiologic synergistic effects显示文摘The use of orthobiologics as a novel therapy for the treatment of numerous musculoskeletal disorders has increased considerably over the past decade.Currently,there are multiple alternatives available as suitable treatments;however,the use of autologous blood-derived products such as platelet-rich plasma(PRP),bone marrow aspirate(BMA)and BMA concentrate(BMAC),specifically,is expanding.Although many investigations attempted to demonstrate the effectiveness of these therapies,even with positive results,the literature lacks standardized protocols and overall accuracy in study designs,which leads to variance and difficulty in reproducibility of protocols.The efficacy of PRP for the treatment of cartilage,bone and muscle tissues is well known.Although BMAC has generated optimistic results for the same purposes,its applicability in clinical trials is still relatively recent when compared to PRP.Both products demonstrate the potential to set forth reparative processes,each in their own distinct mechanism.The combination of these biological products has been previously proposed,yet little is known about their synergism.Evidence indicates that growth factor,cytokine,and chemokine profiles seen in both PRP and BMAC vary but are likely to work synergistically to enhance musculoskeletal healing.BMAC products seem to work well without PRP;however,the addition of PRP to BMAC has been shown to act as a rich and natural source of culture medium for stem cells located either peripherally or in the bone marrow itself.Nevertheless,additional variables associated with the use of BMAC and PRP in orthopedics must be further evaluated in order to consolidate the efficacy of this therapeutic strategy. | JoséFábio Santos Duarte Lana Lucas Furtado da Fonseca Rafael da Rocha Macedo Tomas Mosaner William Murrell Ashok Kumar Joseph Purita Marco Antonio Percope de Andrade | 2021 | World Journal of Stem Cells2021，13，2： | 1 |
| 13 | Characterization of Blood Oxidative Stress in Type 2 Diabetes Mellitus Patients: Increase in Lipid Peroxidation and SOD Activity显示文摘 | Suziy de M. Bandeira Glaucevane da S. Guedes Lucas José S. da Fonseca André S. Pires Daniel P. Gelain José Claudio F. Moreira Luíza A. Rabelo Sandra Mary L. Vasconcelos Marília Oliveira F. Goulart Felipe Dal-Pizzol | 2012 | Oxidative Medicine and Cellular Longevity2012，，： | 1 |
| 14 | Unplanned extubation in pediatric critically ill patients: a systematic review and best practice recommendations显示文摘 | Lucas da Silva PS de Carvalho WB | 2010 | Pediatr Crit Care Med2010，11，2： | 1 |
| 15 | Downstaging Without Complete Pathologic Response After Neoadjuvant Treatment Improves Cancer Outcomes for cIII but not cII Rectal Cancers显示文摘 | Luiz Felipe de Campos-Lobato MD Luca Stocchi MD Andre da Luz Moreira MD Matthew F. Kalady MD Daniel Geisler MD David Dietz MD Ian C. Lavery MD Feza H. Remzi MD Victor W. Fazio MD | 2010 | Annals of Surgical Oncology2010，，7： | 1 |
| 16 | Immunotherapy in glioblastoma treatment:Current state and future prospects显示文摘Glioblastoma remains as the most common and aggressive malignant brain tumor,standing with a poor prognosis and treatment prospective.Despite the aggressive standard care,such as surgical resection and chemoradiation,median survival rates are low.In this regard,immunotherapeutic strategies aim to become more attractive for glioblastoma,considering its recent advances and approaches.In this review,we provide an overview of the current status and progress in immunotherapy for glioblastoma,going through the fundamental knowledge on immune targeting to promising strategies,such as Chimeric antigen receptor T-Cell therapy,immune checkpoint inhibitors,cytokine-based treatment,oncolytic virus and vaccine-based techniques.At last,it is discussed innovative methods to overcome diverse challenges,and future perspectives in this area. | Samuel Luca Rocha Pinheiro Fabian Fellipe Bueno Lemos Hanna Santos Marques Marcel Silva Luz Luís Guilherme de Oliveira Silva Clara Faria Souza Mendes dos Santos Karolaine da Costa Evangelista Mariana Santos Calmon Matheus Sande Loureiro Fabrício Freire de Melo | 2023 | World Journal of Clinical Oncology2023，14，4： | 1 |
| 17 | Correlation between nitrate concentration in groundwater and parameters affecting aquifer intrinsic vulnerability显示文摘 | Debernardi L De Luca DA Lasagna M | 2008 | Environmental Geology2008，55，： | 1 |
| 18 | Compositional and structural alterations of chondroitin and dermatan sulfates during the progression of atherosclerosis and aneurysmal dilatation of the human abdominal aorta显示文摘 | Theocharis AD Theocharis DA De Luca G | 2002 | Biochimie2002，84，7： | 1 |
| 19 | Unplanned extubation in pediatric critically ill patients:a systematic review and best practice recommendations 显示文摘 | Lucas da Silva PS de Carvalho WB | 2010 | Pediatr Crit Care Med2010，11，2： | 1 |
| 20 | Unplanned extubation in ped- iatric critically ill patients: A systematic review and best practice recommendations显示文摘 | Lucas da Silva PS de Carvalho WB | 2010 | Pediatric Crit Care Med2010，11，2： | 1 |
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