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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 3 | Homoclinic Bifurcation of Orbit Flip with Resonant Principal Eigenvalues显示文摘Codimension-3 bifurcations of an orbit-flip homoclinic orbit with resonant principal eigen-values are studied for a four-dimensional system.The existence,number,co-existence and non-coexistence of 1-homoclinic orbit,1-periodic orbit,2n-homoclinic orbit and 2n-periodic orbit are ob-tained.The bifurcation surfaces and existence regions are also given. | Tian Si ZHANG De Ming ZHU | 2006 | Acta Mathematica Sinica,English Series2006，22，3： | 6 |
| 4 | Quantum phase transition and entanglement in Li atom system显示文摘By use of the exact diagonalization method, the quantum phase transition and en- tanglement in a 6-Li atom system are studied. It is found that entanglement appears before the quantum phase transition and disappears after it in this exactly solvable quantum system. The present results show that the von Neumann entropy, as a measure of entanglement, may reveal the quantum phase transition in this model. | SI LiMing1 & HOU JiXuan2 1 Department of Electronic Engineering, School of Information Science and Technology, Beijing Institute of Technology, Beijing 100081, China 2 Laboratoire de Chimie, UMR 5182 CNRS, Ecole Normale Supérieure de Lyon, 46, Allée d’Italie, F-69364 Lyon Cedex 07, France | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，11： | 6 |
| 5 | Ketoconazole Associated Hepatotoxicity: A Systematic Review and Metaanalysis显示文摘Objective To evaluate the incidence of Ketoconazole associated hepatotoxicity and related factors. Methods Literature retrieval was conducted by using multi-databases for meta-analysis on Ketoconazole associated hepatotoxicity. The data were collected with a standardized form. Overall estimation of incidence of hepatotoxicity for specific study type was calculated by using a DerSimonian-Laird random-effects model owing to the substantial differences among the studies. Results Totally 204 eligible studies were included in the analysis. The incidence of Ketoconazole associated hepatotoxicity was 3.6%-4.2%. The dosage and duration specific subgroup analyses did not show any significant difference among groups, while the age specific subgroup analysis showed the incidence in children and people aged >60 years was 1.4% (95% CI: 0.5%-4.2%) and 3.2% (95% CI: 1.1%-8.7%) respectively. Additionally, the incidence of the hepatotoxicity was higher in people who had oral administration of ketoconazole beyond the provisions of the usage instructions, and the incidence was 5.7% (95% CI: 4.5%-7.2%). Conclusion Ketoconazole associated hepatotoxicity was common. Off-label use might increase the risk of liver damage. Well-designed large sample studies are needed to identify the risk factors in future. | YAN Jiang Ying NIE Xiao Lu TAO Qing Mei ZHAN Si Yan ZHANG Yan De | 2013 | Biomedical and Environmental Sciences2013，26，7： | 6 |
| 6 | A New Isoprenylated flavonol from the Leaves of Broussonetia kazinoki显示文摘A new isoprenylated flavonol, named broussonol A (1) was isolated from the leaves of Broussonetia kazinoki Sieb. The structure of broussonol A was characterized by chemical and spectral methods. | Pei Cheng ZHANG, Si WANG, Ying Hong WANG, Ruo Yun CHEN, De Quan YU* Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050 | 2001 | Chinese Chemical Letters2001，12，2： | 5 |
| 7 | In vitro and In vivo Evaluation of the Developed PLGA/HAp/Zein Scaffolds for Bone-Cartilage Interface Regeneration显示文摘Objective To investigate the effect of electronspun PLGA/HAp/Zein scaffolds on the repair of cartilage defects. Methods The PLGA/HAp/Zein composite scaffolds were fabricated by electrospinning method. The physiochemical properties and biocompatibility of the scaffolds were separately characterized by scanning electron microscope(SEM), transmission electron microscope(TEM), and fourier transform infrared spectroscopy(FTIR), human umbilical cord mesenchymal stem cells(h UC-MSCs) culture and animal experiments. Results The prepared PLGA/HAp/Zein scaffolds showed fibrous structure with homogenous distribution. h UC-MSCs could attach to and grow well on PLGA/HAp/Zein scaffolds, and there was no significant difference between cell proliferation on scaffolds and that without scaffolds(P>0.05). The PLGA/HAp/Zein scaffolds possessed excellent ability to promote in vivo cartilage formation. Moreover, there was a large amount of immature chondrocytes and matrix with cartilage lacuna on PLGA/HAp/Zein scaffolds. Conclusion The data suggest that the PLGA/HAp/Zein scaffolds possess good biocompatibility, which are anticipated to be potentially applied in cartilage tissue engineering and reconstruction. | LIN Yong Xin DING Zhi Yong ZHOU Xiao Bin LI Si Tao XIE De Ming LI Zhi Zhong SUN Guo Dong | 2015 | Biomedical and Environmental Sciences2015，28，1： | 5 |
| 8 | Sex-specific and Dose-response Relationship between the Incidence of Gallstones and Components of the Metabolic Syndrome in Jinchang Cohort:A Prospective Study显示文摘Gallstones is a very common gastrointestinal disease,involving the formation of masses in the gall bladder or biliary tract,due to abnormally high concentrations of cholesterol or bilirubin in the bile[1].There is a 10%–20%prevalence of gallstones worldwide,and>20%of patients with gallstones show clinical symptoms,implying a substantial disease burden[1]. | YANG Jing Li HUANG Jun Jun CHENG Ning ZHANG De Sheng LIU Si Min HUANG Wen Ya LI Na HUANG Pei Yao DING Jiao LIU Nian BAO Kai Fang DING Jie CHEN Xiao Liang ZHENG Tong Zhang BAI Ya Na | 2020 | Biomedical and Environmental Sciences2020，33，8： | 4 |
| 9 | D e novo hepatitis B virus infection from anti‐HBc‐positive donors in pediatric living donor liver transplantation显示文摘 | Zhi Feng Xi Qiang Xia Jian Jun Zhang Xiao Song Chen Long Zhi Han Jian Jun Zhu Si Yue Wang De Kai Qiu | 2013 | Journal of Digestive Diseases2013，，8： | 2 |
| 10 | Thrombocytopenia and outcome in critically ill patients with bloodstream infection显示文摘 | Vandijck DM Blot SI De Waele JJ | 2010 | Heart Lung2010，39，1： | 1 |
| 11 | Meeting the 60-min physical activity guideline:effect of operationalization显示文摘 | De Vries SI Hopman-Rock M Bakker I | | 0，，01： | 1 |
| 12 | A new genotype of hepatitis B virus:complete genome and phylogenetic relatedness 显示文摘 | LIEVEN STUYVER SI JA DE GENDT CAROLINE VAN GEYT | 2000 | Gen Virol2000，81，1： | 1 |
| 13 | Solitary thyroid nodule as presenting syndrome of pendred syndrome caused by a novel splice-site mutation in intron-8 of the SLC26A4gene显示文摘 | Massa G Jaenen N de Varebeke SI | 2003 | Eur J Pediatr2003，162，10： | 1 |
| 14 | Fat-cell changes as a mechanism of avascular necrosis of the femoral head in cortisone-treated rabbits显示文摘 | Wang GJ Sweet DE Reger SI | 1977 | J BoneJoint Surg Am1977，59，6： | 1 |
| 15 | The measles campaign in West and Central Africa: Remembering the future 显示文摘 | de Groot A Bamba SI Bougoudogo F | 2008 | Vaccine2008，26，31： | 1 |
| 16 | Experience of pergolide in the treatment of Chinese parkinsonian patients with dose-related fluctuations显示文摘 | Yeh SI | 1995 | Chin Med J (Taipei China)1995，56，5： | 1 |
| 17 | Cigarette smoke decreases pulmonary dendritic cells and impacts antiviral immune responsiveness 显示文摘 | Robbins CS I)awe DE Goncharova SI el al | 2004 | Am J Respir Cell Mol Biol2004，30，2： | 1 |
| 18 | Fat-cell changes as a mechanism of avascular necrosis of the femoral head in cortisone-treated rabbits显示文摘 | Wang GJ Sweet DE Reger SI | 1977 | J Bone Joint Surg Am1977，59，6： | 1 |
| 19 | Intra-abdominal hypertension in patients with severe acute pancreatitis显示文摘 | De Waele JJ Hoste E Blot SI | 2005 | Crit Care2005，9，4： | 1 |
| 20 | Thrombocytopeniaand outcome in critically ill patients with bloodstreaminfection显示文摘 | Vandijick DM Blot SI De Waele JJ | 2010 | Heart lung2010，39，1： | 1 |
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