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| 1 | Beclin 1-Vps34 complex architecture: Understanding the nuts and bolts of therapeutic targets显示文摘Autophagy 是由毁坏并且再循环细胞内部的内容帮助细胞的动态平衡的维护的一条重要 lysosomal 降级小径。autophagy 的 Dysregulation 被连接到越来越多的人的疾病。Beclin 1-Vps34 蛋白质蛋白质相互作用网络为 autophagy 规定是批评的并且对细胞的正直因此必要。特别地经由 Beclin 1-Vps34 建筑群的行动的调整, autophagy 的操作被认为一条有希望的线路与 autophagy 相关的疾病作斗争。这里,我们在核心部件和 Beclin 1-Vps34 建筑群的结构的建筑学上总结最近的调查结果,并且怎么这些调查结果提供珍贵卓见进位于这些建筑群并且为设计治疗学的策略的多重函数下面的分子的机制。 | Deanna H. Morris Calvin K. Yip Yi Shi Brian T. Chait Qing Jun Wang | 2015 | Frontiers in Biology2015，10，5： | 17 |
| 2 | Interplay between intestinal alkaline phosphatase, diet, gut microbes and immunity显示文摘Intestinal alkaline phosphatase(IAP) plays an essential role in intestinal homeostasis and health through interactions with the resident microbiota, diet and the gut. IAP's role in the intestine is to dephosphorylate toxic microbial ligands such as lipopolysaccharides, unmethylated cytosine-guanosine dinucleotides and flagellin as well as extracellular nucleotides such as uridine diphosphate. IAP's ability to detoxify these ligands is essential in protecting the host from sepsis during acute inflammation and chronic inflammatory conditions such as inflammatory bowel disease. Also important in these complications is IAP's ability to regulate the microbial ecosystem by forming a complex relationship between microbiota, diet and the intestinal mucosal surface. Evidence reveals that diet alters IAP expression and activity and this in turn can influence the gut microbiota and homeostasis. IAP's ability to maintain a healthygastrointestinal tract has accelerated research on its potential use as a therapeutic agent against a multitude of diseases.Exogenous IAP has been shown to have beneficial effects when administered during ulcerative colitis,coronary bypass surgery and sepsis.There are currently a handful of human clinical trials underway investigating the effects of exogenous IAP during sepsis,rheumatoid arthritis and heart surgery.In light of these findings IAP has been marked as a novel agent to help treat a variety of other inflammatory and infectious diseases.The purpose of this review is to highlight the essential characteristics of IAP in protection and maintenance of intestinal homeostasis while addressing the intricate interplay between IAP,diet,microbiota and the intestinal epithelium. | Mehrbod Estaki Daniella DeCoffe Deanna L Gibson | 2014 | World Journal of Gastroenterology2014，20，42： | 6 |
| 3 | Reference quality assembly of the 3.5-Gb genome of Capsicum annuum from a single linked-read library显示文摘Linked-Read sequencing technology has recently been employed successfully for de novo assembly of human genomes,however,the utility of this technology for complex plant genomes is unproven.We evaluated the technology for this purpose by sequencing the 3.5-gigabase(Gb)diploid pepper(Capsicum annuum)genome with a single Linked-Read library.Plant genomes,including pepper,are characterized by long,highly similar repetitive sequences.Accordingly,significant effort is used to ensure that the sequenced plant is highly homozygous and the resulting assembly is a haploid consensus.With a phased assembly approach,we targeted a heterozygous F1 derived from a wide cross to assess the ability to derive both haplotypes and characterize a pungency gene with a large insertion/deletion.The Supernova software generated a highly ordered,more contiguous sequence assembly than all currently available C.annuum reference genomes.Over 83%of the final assembly was anchored and oriented using four publicly available de novo linkage maps.A comparison of the annotation of conserved eukaryotic genes indicated the completeness of assembly.The validity of the phased assembly is further demonstrated with the complete recovery of both 2.5-Kb insertion/deletion haplotypes of the PUN1 locus in the F1 sample that represents pungent and nonpungent peppers,as well as nearly full recovery of the BUSCO2 gene set within each of the two haplotypes.The most contiguous pepper genome assembly to date has been generated which demonstrates that Linked-Read library technology provides a tool to de novo assemble complex highly repetitive heterozygous plant genomes.This technology can provide an opportunity to cost-effectively develop high-quality genome assemblies for other complex plants and compare structural and gene differences through accurate haplotype reconstruction. | Amanda M.Hulse-Kemp Shamoni Maheshwari Kevin Stoffel Theresa A.Hill David Jaffe Stephen R.Williams Neil Weisenfeld Srividya Ramakrishnan Vijay Kumar Preyas Shah Michael C.Schatz Deanna M.Church Allen Van Deynze | 2018 | Horticulture Research2018，5，1： | 4 |
| 4 | Characterization of novel Brown midrib 6 mutations affecting lignin biosynthesis in sorghum显示文摘The presence of lignin reduces the quality of lignocellulosic biomass for forage materials and feedstock for biofuels. In C4 grasses,the brown midrib phenotype has been linked to mutations to genes in the monolignol biosynthesis pathway. For example,the Bmr6 gene in sorghum(Sorghum bicolor) has been previously shown to encode cinnamyl alcohol dehydrogenase(CAD),which catalyzes the final step of the monolignol biosynthesis pathway. Mutations in this gene have been shown to reduce the abundance of lignin,enhance digestibility,and improve saccharification efficiencies and ethanol yields. Nine sorghum lines harboring five different bmr6 alleles were identified in an EMS-mutagenized TILLING population. DNA sequencing of Bmr6 revealed that the majority of the mutations impacted evolutionarily conserved amino acids while three-dimensional structural modeling predicted that all of these alleles interfered with the enzyme's ability to bind with its NADPH cofactor. All of the new alleles reduced in vitro CAD activity levels and enhanced glucose yields following saccharification. Further,many of these lines were associated with higher reductions in acid detergent lignin compared to lines harboring the previously characterized bmr6-ref allele. These bmr6 lines represent new breeding tools for manipulating biomass composition to enhance forage and feedstock quality. | Erin D. Scully Tammy Gries Deanna L. Funnell-Harris Zhanguo Xin Frank A. Kovacs Wilfred Vermerris Scott E. Sattler | 2016 | Journal of Integrative Plant Biology2016，58，2： | 3 |
| 5 | 扁桃体鳞癌中HPV感染与EGFR、VEGF表达的相关性研究显示文摘目的:研究扁桃体鳞癌(squamous cell carcinomas of the tonsil tonsillar,SCCs)中人乳头瘤病毒(human papillomavirus,HPV)感染与血管内皮生长因子(vascular endothelial growth factor,VEGF)和表皮生长因子受体(epidermal growth factor,EGFR)表达的关系,探讨HPV与EGFR和VEGF在扁桃体鳞癌发生中的交互效应。方法:采用多重实时荧光定量聚合酶链反应(multiplex real-time polymerase chain reaction,MT-PCR)检测85例扁桃体鳞癌HPV DNA及型别,通过HPV DNA分析进行HPV感染状况的测定;同时采用半定量免疫组化检测HPV(+)组和HPV(-)组中VEGF、EGFR蛋白表达情况。结果:扁桃体鳞癌中HPV感染率为49.4%(42/85),HPV-16型占所有感染者的比例为90.5%(38/42),明显高于其他型别;HPV(+)组EGFR蛋白表达明显低于HPV(-)组(P值均<0.01);HPV(+)组与HPV(-)组VEGF蛋白表达无明显差异;此外,VEGF表达与EGFR、患者的年龄、性别、TNM分期、组织学分级均无明显相关性。结论:HPV感染与扁桃体鳞癌的发生存在相关性,HPV相关的扁桃体鳞癌中,HPV基因可能通过改变EGFR表达致癌,为HPV致癌机理进一步研究提供一个新的视角,具有重要的理论意义。 | 费继敏 Timothy A Dobbins Deanna Jones C Soon Lee Christine Loo Jonathan Clark Barbara Rose | 2015 | 现代肿瘤医学2015，23，4： | 3 |
| 6 | Maternal Age and Birth Outcomes:Data from New Jersey显示文摘 | Nancy ER Deanna LP | | 0，，06： | 1 |
| 7 | Phosphorus Indices: Why We Need to Take Stock of How We Are Doing显示文摘 | Sharpley Andrew Beegle Doug Bolster Carl Good Laura Joern Brad Ketterings Quirine Lory John Mikkelsen Rob Osmond Deanna Vadas Peter | 2012 | Journal of Environmental Quality2012，，6： | 1 |
| 8 | ACUTE RELATIVE ADRENAL INSUFFICIENCY AFTER ANEURYSMAL SUBARACHNOID HEMORRHAGE显示文摘 | Kyle A. Weant Deanna Sasaki-Adams Kathryn Dziedzic Matthew Ewend | 2008 | Neurosurgery2008，，4： | 1 |
| 9 | Fatal Hormonema dema- tioides peritionitis in a patient on continuous ambulatory pertio- neal dialysis : criteria for organism identification and review of other known fungal etiologic agents显示文摘 | Jong HS sang KL Deanna AS | 1998 | J Clin Microbiol1998，36，7： | 1 |
| 10 | Technology gets to the root of pipe welding 显示文摘 | Postlethwaite Deanna | 2007 | Welding and Cutting2007，6，5： | 1 |
| 11 | Toxoplasma tondii infection in the Unit- ed States,1999 -2000显示文摘 | Jone J1 Deanna KM Wilson W | 2003 | Emerg Infest Dis J2003，9，11： | 1 |
| 12 | Pancreas Transplantation under alemtuzumab (Campath-1H) and tacrolimus: correlation between low T-cell responses and infection显示文摘 | Ngoc LT Deanna B Kusum T | 2006 | Transplantation2006，82，： | 1 |
| 13 | CoSaMP: Iterative signal reco- very from incomplete and inaccurate samples 显示文摘 | Deanna Needell Joel Tropp | 2009 | Applied and Computational Harmonic Analysis2009，26，3： | 1 |
| 14 | Nutrition su - pport in the intensive care unit显示文摘 | Susan R R Donald A Deanna K K | 2005 | Nutr Crit Care2005，23，6： | 1 |
| 15 | Formal Operations from a Twenty - First Century Perspective 显示文摘 | Deanna Kuhn | 2008 | Human Development2008，51，： | 1 |
| 16 | Permeability for Intestinal Absorption: Caeo-2 Assay and Related Issues 显示文摘 | Barry P Deanna DG | 2008 | Current Drug Metabolism2008，9，9： | 1 |
| 17 | NMDA-induced seizures in developing rats cause long-term learning impairment and increased seizure susceptibility 显示文摘 | Carl E Deanna M Sasaki A | 2003 | Epilepsy Res2003，53，12： | 1 |
| 18 | The immediate effects of endovenousdiode 808-nm laser in the greaters aphenousvein:morphologic study and clinical implications显示文摘 | Corcos L Dini S DeAnna D | 2005 | J Vasc Surg2005，41，6： | 1 |
| 19 | The Prevalence of Hepatitis B Virus Infection in the United States in the Era of Vaccination显示文摘 | Annemarie Wasley Deanna Kruszon-- Moran Wendi Kuh- nert | 2010 | Infectious Diseases2010，202，2： | 1 |
| 20 | Post exercise protein intake enhanceswhole-body and leg protein accretion in humans 显示文摘 | DEANNA K L | 2002 | Med Sci Sports Exerc2002，34，5： | 1 |
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