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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Prospective surgical- pathological study of disease-free interval in patients with stage IB squamous cell carcinoma of the cervix : a Gyneco- logic Oncology Group study 显示文摘 | Delgado G Bundy B Zaino R | 1990 | Gynecol Oncol1990，38，3： | 1 |
| 3 | Recognition of ox-alate by a copper(11)polyaza macrobicyclic complex显示文摘 | Mateus P Delgado R Brandao P | 2011 | Chem Eur /2011，17，25： | 1 |
| 4 | PCR-DGGE assessment of the bacterial diversity of breat milk in women with lactational infec- tious mastitis显示文摘 | Delgado S Arroyo R Martin R | 2008 | BMC Infect Dis2008，8，： | 1 |
| 5 | Assessment of left ventricular dyssynchrony by speckle tracking strain imag- ing显示文摘 | Delgado V Ypenburg C yon Bommel R J | 2008 | J Am Coil Cardiol2008，51，20： | 1 |
| 6 | Methane and nitrous oxide fluxes in an acid Oxisol in western Puerto Rico: effects of tillage, liming and fertilization显示文摘 | Mosier A R Delgado J A Keller M | 1998 | Soil Biol Bioch1998，，30： | 1 |
| 7 | Use of site specific management zones to improve nitrogen man- agement for precision agriculture 显示文摘 | KHOSLA R FLEMING K DELGADO J A | 2002 | J Soil Water Con- serv2002，57，： | 1 |
| 8 | Mitigation altematives to decrease nitrous oxides emissions and urea nitrogen loss and their effect on methane flux 显示文摘 | Delgado J A Mosier A R | 1996 | Journal of Environmental Quality1996，25，5： | 1 |
| 9 | Formation of the aroma of a raw goat milk cheese during matura- tion analysed by SPME-GC-MS显示文摘 | Delgado FJ Gonzrlez-Crespo J Cava R | 2011 | Food Chemistry2011，129，3： | 1 |
| 10 | Mitigation alternatives to decrease nitrous oxides emissions and urea-nitrogen loss and their effect on methane flux显示文摘 | Delgado J A Mosier A R | 1999 | Journal of Environmental Quality1999，25，6： | 1 |
| 11 | Variants of peach latent mosaic viroid inducing peach calico:uneven distribution in infected plants and requirements of the insertion containing the pathogenicity determinant显示文摘 | Delgado S Flores R | 2006 | J Gen Virol2006，87，： | 1 |
| 12 | Long term 15N studies in a catena of the shortgrass steppe显示文摘 | Delgado J A Mosier A R Valentine D W Schimel D S Parton W J | 1996 | Biogeochemistry1996，32，： | 1 |
| 13 | Role of 06 - meth- ylguanine - DNA methyltransferase in the resistance of pancreatic tumors to DNA alkylating agents 显示文摘 | Kokkinakis DM Ahmed MM Delgado R | 1997 | Cancer Res1997，57，23： | 1 |
| 14 | MR imaging detection of cerebral microbleeds: effect of susceptibi- lity-weighted imaging, section thickness, and field strength 显示文摘 | Nandigam R N Viswanathan A Delgado P | 2009 | Am J Neuroradiol2009，30，2： | 1 |
| 15 | Glycodendritic structures: promising new antiviral drugs显示文摘 | Rojo J Delgado R | 2004 | J Antimicrob Chemother2004，54，3： | 1 |
| 16 | Prolonged QTc interval andhigh B- type natriuetic peptide levels together predict mortality inpatients with advanced heart failure 显示文摘 | Vitovec B Delgado R Zewail A | 2003 | Circulation2003，107，11： | 1 |
| 17 | Developments in the rat adjuvant arthritis model and its use in therapeutic evaluation of novelnoninvasive treatment by SOD in transfersomes 显示文摘 | Simoes S I Delgado T C Lopes R M | 2005 | J Controlled Release2005，103，2： | 1 |
| 18 | Plasma fruetosamine to evaluate metabolic control among women with gestational diabetes显示文摘 | Delgado M R Novik A V Cardemil M F | 2011 | Rev Med Chil2011，139，11： | 1 |
| 19 | Validation and comparison of advanced differential interferometry techniques: murcia metropolitan area case study显示文摘 | HERRERA G TOMAS R LOPEZ-SANCHEZ J M DELGADO J VICENTE F MULAS J COOKSLEY G SANCHEZ M DURO J ARNAUD A BLANCO P DUQUE S MALLORQUI J J DE la VEGA-PANIZO R MONSERRAT O | 2008 | ISPRS Journal of Photogrammetry and Remote Sensing2008，，： | 1 |
| 20 | Coevolutionary genetic fuzzy systems: A hierarchical collaborative approach 显示文摘 | Delgado M R Von Zuben F Gomide F | 2004 | Fuzzy Sets and Systems2004，141，1： | 1 |
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