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| 1 | 贝伐珠单抗联合S-1与伊立替康或mFOLF⁃OX6/CapeOX作为转移性结直肠癌一线治疗研究(TRICOLORE):一项随机、开放标签、Ⅲ期、非劣效性研究显示文摘目的:TRICOLORE研究既往报道的结果显示作为转移性结直肠癌一线治疗模式,S-1与伊立替康联合贝伐珠单抗的无疾病进展时间(PFS)非劣效于mFOLFOX6/CapeOX联合贝伐珠单抗,但首次报道时总生存期(OS)数据尚未完善。 | 邱萌 DENDA T TAKASHIMA A GAMOH M | 2021 | 结直肠肛门外科2021，27，5： | 3 |
| 2 | Phase II Study of Oral S-1 and Concurrent Radiotherapy in Patients With Unresectable Locally Advanced Pancreatic Cancer显示文摘 | Kentaro Sudo Taketo Yamaguchi Takeshi Ishihara Kazuyoshi Nakamura Taro Hara Tadamichi Denda Katsunobu Tawada Toshiyuki Imagumbai Hitoshi Araki Mitsuhiro Sakai Kazuo Hatano Hiroyuki Kawakami Takashi Uno Hisao Ito Osamu Yokosuka | 2011 | International Journal of Radiation Oncology Biology Physics2011，，1： | 2 |
| 3 | Simultaneous augmentation of muscle and bone by locomomimetism through calcium-PGC-1αsignaling显示文摘Impaired locomotion has been extensively studied worldwide because those afflicted with it have a potential risk of becoming bedridden.Physical exercise at times can be an effective remedy for frailty,but exercise therapy cannot be applied in all clinical cases.Medication is safer than exercise,but there are no drugs that reinforce both muscle and bone when administered alone.Multiple medications increase the risk of adverse events;thus,there is a need for individual drugs targeting both tissues.To this end,we established a novel sequential drug screening system and identified an aminoindazole derivative,locamidazole(LAMZ),which promotes both myogenesis and osteoblastogenesis while suppressing osteoclastogenesis.Administration of this drug enhanced locomotor function,with muscle and bone significantly strengthened.Mechanistically,LAMZ induced Mef2c and PGC-1αin a calcium signaling–dependent manner.As this signaling is activated upon physical exercise,LAMZ mimics physical exercise.Thus,LAMZ is a promising therapeutic drug for locomotor diseases,including sarcopenia and osteoporosis. | Takehito Ono Ryosuke Denda Yuta Tsukahara Takashi Nakamura Kazuo Okamoto Hiroshi Takayanagi Tomoki Nakashima | 2022 | Bone Research2022，10，4： | 2 |
| 4 | Immobilization- induced and crowded environment - induced stress delay barrier recovery in murine skin 显示文摘 | Denda M Tsuchiya T Hosoi J | 1998 | Br J Dermatol1998，138，5： | 1 |
| 5 | Prevention by inhibitors of arachidonic acid cascade of liver carcinogenesis,cirrhosis and oxidative DNA damage caused by choline deficiency, L-amino acid-defined diet in rats 显示文摘 | Denda A Endoh T Tang Q | 1998 | Mutat Res1998，402，2： | 1 |
| 6 | Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 1显示文摘 | Denda K Shimomura T Kawaguchi T | 2002 | J Biol Chem2002，277，14： | 1 |
| 7 | Stress alters cutaneous permeability barrier homeostasis 显示文摘 | Denda M Tsuchiya T Elias PM | 2000 | Am J Physiol Regul Integr Comp Physiol2000，278，2： | 1 |
| 8 | Dry environment increases mast cell num- ber and histamine content in dermis in hairless mice 显示文摘 | Ashida Y Denda M | 2003 | Br J Dermatol2003，149，： | 1 |
| 9 | Increased expression of cyclooxygenase-2 protein in rat urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine 显示文摘 | Kitayama W Denda A Okajima E | 1999 | Carcinogenesis1999，20，： | 1 |
| 10 | Expression of MUC1 mucins inversly correlated with post-surgical survival of renal cell carcinoma patients显示文摘 | Fujica K Denda K Yamamoto M | 1999 | Br J Cancer1999，80，3： | 1 |
| 11 | Visible radiation affects epidermal per- meability barrier recovery: Selective effects of red and blue light 显示文摘 | Denda M Fuzlwara S | 2008 | J Invest Dermatol2008，128，5： | 1 |
| 12 | Increased expression of cyclooxygenase-2 protein in 4-nitroquinoline-1-oxid-induced rat tongue carcinomas and chemopreventive efficacy of a specific inhibitor,nirnesulide显示文摘 | SHIOTANI H DENDA A YAMAMOTO K | 2001 | Cancer Res2001，61，4： | 1 |
| 13 | A survey on TCP-friendly congestion control显示文摘 | Widmer J Denda R Mauve M | 2001 | IEEE Network Magazine2001，15，3： | 1 |
| 14 | Development of the boundary element method for 2D piezoelectricity显示文摘 | M. Denda J. Lua | 1999 | Composites Part B1999，，7： | 1 |
| 15 | Cytotoxic effects of flavonoids against a human colon cancer derived cell line, COLO 201 : A potential natural anti-cancer substance 显示文摘 | Masahiko Imai Hidetomo Kikuchi Takanori Denda | 2009 | Cancer Letters2009，276，1： | 1 |
| 16 | Expression of MUC1 mucins inversely correlated with post-surgical survival of renal cell carcinoma patients显示文摘 | Fujita K Denda K Yamamoto M | 1999 | Br J Cancer1999，80，1： | 1 |
| 17 | Break down of distyly in a tetraploid variety of Ophiorrhiza japonica (Rubi aceae) and its phylogenetic analysis显示文摘 | Nakamura K Denda T Kameshima O | 2007 | Journal of Plant Research2007，120，： | 1 |
| 18 | Interaction between a crack and a dislocation dipole显示文摘 | Ballarini R Denda M | | 0，，： | 1 |
| 19 | A survey on TCP-friendly congestion control 显示文摘 | Widmer J Denda R Mauve M | 2001 | IEEE Network2001，15，3： | 1 |
| 20 | A phaseⅡclinical study of m FOLFOX6 plus bevacizumab as first-line therapy for Japanese advanced/recurrent colorectal cancer patients显示文摘 | Nishina T Takano Y Denda T | 2013 | Jpn J Clin Oncol2013，43，11： | 1 |
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