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| 1 | Aberrant gene methylation in the peritoneal fluid is a risk factor predicting peritoneal recurrence in gastric cancer显示文摘AIM:To investigate whether gene methylation in the peritoneal fluid (PF) predicts peritoneal recurrence in gastric cancer patients.METHODS: The gene methylation of CHFR (checkpoint with forkhead and ring finger domains), p16, RUNX3 (runt-related transcription factor 3), E-cadherin, hMLH1 (mutL homolog 1), ABCG2 (ATP-binding cassette, sub-family G, member 2) and BNIP3 (BCL2/adenovirus E1B 19 kDa interacting protein 3) were analyzed in 80 specimens of PF by quantitative methylation-specific polymerase chain reaction (PCR). Eighty patients were divided into 3 groups; Group A (n=35):the depth of cancer invasion was less than the muscularis propria; Group B (n=31): the depth of cancer invasion was beyond the muscularis propria. Both group A and B were diagnosed as no cancer cells in peritoneal cytology and histology; Group C (n=14): disseminated nodule was histologically diagnosed or cancer cells were cytologically defi ned in the peritoneal cavity.RESULTS: The positive rates of methylation in CHFR, E-cadherin and BNIP3 were significantly different among the 3 groups and increased in order of group A, B and C (0%,0% and 21% in CHFR, P<0.05; 20%, 45% and 50% in E-cadherin, P<0.05;26%,35% and 71% in BNIP3, P<0.05). In addition, the multigene methylation rate among CHFR, E-cadherin and BNIP3 was correlated with group A, B and C (9%,19% and 57%, P<0.001). Moreover, the prognosis was analyzed in group B, excluding 3 patients who underwent a non-curative resection. Two of the 5 patients with multigene methylation showed peritoneal recurrence after surgery, while those without or with a single gene methylation did not experience recurrence (P<0.05).CONCLUSION: This study suggested that gene methylation in the PF could detect occult neoplastic cells in the peritoneum and might be a risk factor for peritoneal metastasis. | Masatsugu Hiraki Yoshihiko Kitajima Seiji Sato Jun Nakamura Kazuyoshi Hashiguchi Hirokazu Noshiro Kohji Miyazaki | 2010 | World Journal of Gastroenterology2010，16，3： | 20 |
| 2 | Epithelial Cell Apoptosis and Lung Remodeling显示文摘Lung epithelium is the primary site of lung damage in various lung diseases.Epithelial cell apoptosis has been considered to be initial event in various lung diseases.Apoptosis signaling is classically composed of two principle pathways.One is a direct pathway from death receptor ligation to caspase cascade activation and cell death.The other pathway triggered by stresses such as drugs,radiation,infectious agents and reactive oxygen species is mediated by mitochondria.Endoplasmic reticulum has also been shown to be the organelle to mediate apoptosis. Epithelial cell death is followed by remodeling processes,which consist of epithelial and fibroblast activation, cytokine production,activation of coagulation pathway,neoangiogenesis,re-epithelialization and fibrosis. Epithelial and mesenchymal interaction plays important roles in these processes.Further understanding of apoptosis signaling and its regulation by novel strategies may lead to effective treatments against various lung diseases.We review the recent advances in the understanding of apoptosis signaling and discuss the involvement of apoptosis in lung remodeling. | Kazuyoshi Kuwano | 2007 | Cellular & Molecular Immunology2007，4，6： | 12 |
| 3 | S-1 in the treatment of pancreatic cancer显示文摘S-1 is an oral 5-fluorouracil(5-FU) prodrug,which is designed to improve the antitumor activity of 5-FU by inhibiting dihydropyrimidine dehydrogenase,the key enzyme of 5-FU catabolism.Recently,two important studies on the clinical use of S-1 for pancreatic cancer have been reported from Japan.In the first study(GEST study),S-1 demonstrated non-inferiority to gemcitabine(GEM) in overall survival(OS) for metastatic or locally advanced pancreatic cancer,but combination chemotherapy with GEM and S-1 did not show superiority to GEM in OS.In the second study(JASPAC-01 study),S-1 showed superiority to adjuvant chemotherapy with GEM in OS in patients with resected pancreatic cancer.In addition to GEM,S-1 is now regarded as the key drug in the management of pancreatic cancer in Japan.To date,many studies have investigated the effectiveness of S-1 in various settings,such as first-line chemotherapy for metastatic or locally advanced pancreatic cancer,second-line chemotherapy after GEM failure,and chemoradiotherapy for locally advanced disease.In this review,we focus on recent clinical trials of S-1-based chemotherapy for advanced pancreatic cancer. | Kentaro Sudo Kazuyoshi Nakamura Taketo Yamaguchi | 2014 | World Journal of Gastroenterology2014，20，41： | 9 |
| 4 | Laparoscopic cholecystectomy in situs inversus totalis with “inferior” cystic artery: A case report显示文摘A 76-year-old man with known situs inversus totalis presented with left-sided discomfort. Abdominal ultrasonography and CT scan confirmed the diagnosis of a gallstone, as well as,situs inversus; the liver and gallbladder on the left side and the spleen on the right. The biliary system was thought to be left-right reversal, mirror image in the view of drip infusion cholangiogram and MRI. Laparoscopic cholecy stectomywas safely performed, despite of unexpected aberrant cystic artery running inferior to cystic duct of situs inversus.Laparoscopic surgeon should be careful for view of reversed relationships and also existence of other anomalies. | Sumihiro Kamitani Yosihiro Tsutamoto Kazuyoshi Hanasawa Tohru Tani | 2005 | World Journal of Gastroenterology2005，11，33： | 8 |
| 5 | Prevention of aspiration of gastric contents during attempt in tracheal intubation in the semi-lateral and lateral positions显示文摘BACKGROUND:Pulmonary aspiration of gastric contents during tracheal intubation is a lifethreatening complication in emergency patients.Rapid sequence intubation is commonly performed to prevent aspiration but is not associated with low risk of intubation related complications.Although it has been considered that aspiration can be prevented in the lateral position,few studies have evaluated the ability to prevent aspiration.Moreover,this position is not always a favorable position for tracheal intubation.If aspiration can be prevented in a clinically relevant semi-lateral position,it may be advantageous.We assessed the ability to prevent aspiration in the lateral position and various degrees of the semi-lateral position using a vomiting-regurgitation manikin model.METHODS:A manikin's head was placed in the neutral,simple extension,or sniffing position.The amount of aspirated saline into the bronchi during simulated vomiting was measured at semilateral position angles of 0°to 90° in 10° increments.The difference in the vertical height between the mouth corner and the inferior border of the vocal cord was measured radiologically at each semilateral position in the three head-neck positions.RESULTS:Pulmonary aspiration was prevented at the ≥70°,≥80°,and 90° semi-lateral positions in the neutral,simple extension,and sniffing positions,respectively.The mouth was lower than the vocal cord in the semi-lateral position in which aspiration was prevented.CONCLUSION:The lateral or excessive semi-lateral position was necessary to protect the lung from aspiration in the head-neck positions commonly used for tracheal intubation.Prevention of aspiration was difficult within clinically relevant semi-lateral positions. | Ichiro Takenaka Kazuyoshi Aoyama | 2016 | World Journal of Emergency Medicine2016，7，4： | 7 |
| 6 | Pancreatitis after endoscopic retrograde cholangiopancreatography:A narrative review显示文摘Acute post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP)is a feared and potentially fatal complication that can be as high as up to 30%in high-risk patients.Pre-examination measures,during the examination and after the examination are the key to technical and clinical success with a decrease in adverse events.Several studies have debated on the subject,however,numerous topics remain controversial,such as the effectiveness of prophylactic medications and the amylase dosage time.This review was designed to provide an update on the current scientific evidence regarding PEP available in the literature. | Igor Braga Ribeiro Epifanio Silvino do Monte Junior Antonio Afonso Miranda Neto Igor Mendonça Proença Diogo Turiani Hourneaux de Moura Mauricio Kazuyoshi Minata Edson Ide Marcos Eduardo Lera dos Santos Gustavo de Oliveira Luz Sergio Eiji Matuguma Spencer Cheng Renato Baracat Eduardo Guimarães Hourneaux de Moura | 2021 | World Journal of Gastroenterology2021，27，20： | 5 |
| 7 | Y chromosome microdeletion screening using a new molecular diagnostic method in 1030 Japanese males with infertility显示文摘The azoospermia factor(AZF)region is important for spermatogenesis,and deletions within these regions are a common cause of oligozoospermia and azoospermia.Although several studies have reported this cause,the present research,to the best of our knowledge,is the first large-scale study assessing this factor in Japan.In this study,1030 male patients with infertility who were examined for Y chromosome microdeletion using the polymerase chain reaction-reverse sequence-specific oligonucleotide(PCR-rSSO)method,a newly developed method for Y chromosome microdeletion screening,were included.The study enrolled 250 patients with severe oligospermia and 717 patients with azoospermia.Among the 1030 patients,4,4,10,and 52 had AZFa,AZFb,AZFb+c,and AZFc deletions,respectively.The sperm recovery rate(SRR)of microdissection testicular sperm extraction in patients with AZFc deletions was significantly higher than that in those without AZF deletions(60.0%vs 28.7%,P=0.04).In patients with gr/gr deletion,SRR was 18.7%,which was lower than that in those without gr/gr deletion,but was not statistically significant.In conclusion,our study showed that the frequency of Y chromosome microdeletion in male patients in Japan was similar to that reported in patients from other countries,and SRR was higher in patients with AZFc deletion. | Masashi Iijima Kazuyoshi Shigehara Hideki Igarashi Koichi Kyono Yasuo Suzuki Yuji Tsuji Yoshitomo Kobori Hideyuki Kobayashi Atsushi Mizokami | 2020 | Asian Journal of Andrology2020，22，4： | 4 |
| 8 | Numerical Study on Particle Motions in Swirling Flows in a Cyclone Separator显示文摘这研究的目的是在一个气旋隔板建立粒子分离的高度精确的预言方法。在一个气旋隔板的打漩的流动的数字模拟被基于一个 Smagorinsky 模型使用大旋涡模拟(LES ) 执行。模拟和复杂流动特征的有效性被比较与试验性的结果讨论。而且,粒子运动被一个 Lagrangian 方法对待并且与一个单程的方法被计算。为粒子分离的表演从跟踪的粒子的结果被预言。作为我们的调查的结果,为气旋隔板的粒子分离的表演上的插头管子的插入的高度的影响被显示出。关键词气旋隔板 - 打漩的流动 - 粒子运动 - 大旋涡模拟 CLC 数字 | Kazuyoshi MATSUZAKI Hideaki USHIJIMA Mizue MUNEKATA Hideki OHBA | 2006 | Journal of Thermal Science2006，15，2： | 3 |
| 9 | Prediction of acute left main coronary artery obstruction by 12-lead electrocardiography显示文摘 | Hirosuke Yamaji Kohichiro Iwasaki Shozo Kusachi Takashi Murakami Ryouichi Hirami Hiromi Hamamoto Kazuyoshi Hina Toshimasa Kita Noburu Sakakibara Takao Tsuji | 2001 | Journal of the American College of Cardiology2001，，5： | 3 |
| 10 | Can magnifying endoscopy with narrow band imaging be useful for low grade adenomas in preoperative biopsy specimens?显示文摘 | Kazuhiro Miwa Hisashi Doyama Renma Ito Hiroyoshi Nakanishi Katsura Hirano Satoko Inagaki Kei Tominaga Naohiro Yoshida Kenichi Takemura Shinya Yamada Yoshibumi Kaneko Kazuyoshi Katayanagi Hiroshi Kurumaya Toshihide Okada Masakazu Yamagishi | 2012 | Gastric Cancer2012，，2： | 3 |
| 11 | Nonlinear Vibration Induced by the Water-film Whirl and Whip in a Sliding Bearing Rotor System显示文摘Many industrial applications and experiments have shown that sliding bearings often experience fluid film whip due to nonlinear fluid film forces which can cause rotor-stator rub-impact failures. The oil-film whips have attracted many studies while the water-film whips in the water lubricated sliding bearing have been little researched with the mechanism still an open problem. The dynamic fluid film forces in a water sliding bearing are investigated numerically with rotational, whirling and squeezing motions of the journal using a nonlinear model to identify the relationships between the three motions. Rotor speed-up and slow-down experiments are then conducted with the rotor system supported by a water lubricated sliding bearing to induce the water-film whirl/whip and verify the relationship. The experimental results show that the vibrations of the journal alternated between increasing and decreasing rather than continuously increasing as the rotational speed increased to twice the first critical speed, which can be explained well by the nonlinear model. The radial growth rate of the whirl motion greatly affects the whirl frequency of the journal and is responsible for the frequency lock in the water-film whip. Further analysis shows that increasing the lubricating water flow rate changes the water-film whirl/whip characteristics, reduces the first critical speed, advances the time when significant water-film whirling motion occurs, and also increases the vibration amplitude at the bearing center which may lead to the rotor-stator rub-impact. The study gives the insight into the water-film whirl and whip in the water lubricated sliding bearing. | ZHAI Liming LUO Yongyao WANG Zhengwei KITAUCHI Seishiro MIYAGAWA Kazuyoshi | 2016 | Chinese Journal of Mechanical Engineering2016，29，2： | 3 |
| 12 | Rational arrangement of measuring shear wave speed in the liver显示文摘BACKGROUND Shear wave speed has been widely applied to quantify a degree of liver fibrosis. However, there is no standardized procedure, which makes it difficult to utilize the speed universally. AIM To provide procedural standardization of shear wave speed measurement. METHODS Point shear wave elastography (pSWE) was measured in 781 patients, and twodimensional shear wave elastography (2dSWE) was measured on the same day in 18 cases. Regions-of-interest were placed at 12 sites, and the median and robust coefficient-of-variation (CVR) were calculated. A residual sum-of-square (Σdi2) was computed for bootstrap values of 1000 iterations in 18 cases with each assumption of 1 to 12 measurements. The proportion of the Σdi2 (%Σdi2) was calculated as the ratio of Σdi2 to pSWE after converting it based on the correlation between pSWE and 2dSWE. RESULTS The CVR showed a significantly broader distribution in the left lobe (P < 0.0001),and the smallest CVR in the right anterior segment that covered 95% cases was 40.4%. pSWE was significantly higher in the left lobe than in the right lobe (1.63 ± 0.78 m/s vs 1.61 ± 0.78 m/s, P = 0.0004), and the difference between the lobes became further discrete when the subjects were limited to the cases with a CVR less than 40.4% in any segment (1.76 ± 0.80 m/s vs 1.70 ± 0.82 m/s, P < 0.0001). The highest values of the CVR in every 0.1 m/s interval were plotted in convex upward along pSWE and peaked at 1.93 m/s. pSWE and 2dSWE were significantly correlated (P < 0.0001, r = 0.95). In 216000 resamples from 18 cases, the %Σdi2 of 12 sites was 8.0% and gradually increased as the acquisition sites decreased to reach a significant difference with a %Σdi2 of 7 sites (P = 0.027). CONCLUSION These data suggest that shear wave speed should be measured at 8 or more sites of spreading in both lobes. | Takeshi Yokoo Tsutomu Kanefuji Takeshi Suda Itsuo Nagayama Takahiro Hoshi Satoshi Abe Shinichi Morita Hiroteru Kamimura Kenya Kamimura Atsunori Tsuchiya Masaaki Takamura Kazuyoshi Yagi Shuji Terai | 2019 | World Journal of Gastroenterology2019，25，20： | 3 |
| 13 | Laparoscopic Appendectomy for Complicated Appendicitis: A Comparison with Open Appendectomy显示文摘 | Goutaro Katsuno Kunihiko Nagakari Seiichiro Yoshikawa Kazuyoshi Sugiyama Masaki Fukunaga | 2009 | World Journal of Surgery2009，，2： | 3 |
| 14 | Preparation of mullite monoliths with well-defined macropores and mesostructured skeletons via the sol–gel process accompanied by phase separation显示文摘 | Xingzhong Guo Wenyan Li Kazuki Nakanishi Kazuyoshi Kanamori Yang Zhu Hui Yang | 2013 | Journal of the European Ceramic Society2013，，： | 3 |
| 15 | Effects of ghrelin administration during chemotherapy with advanced esophageal cancer patients显示文摘 | Yuichiro Hiura Shuji Takiguchi Kazuyoshi Yamamoto Tsuyoshi Takahashi Yukinori Kurokawa Makoto Yamasaki Kiyokazu Nakajima Hiroshi Miyata Yoshiyuki Fujiwara Masaki Mori Kenji Kangawa Yuichiro Doki | 2012 | Cancer2012，，19： | 2 |
| 16 | Macrophage colony-stimulating factor expressed in non-cancer tissues provides predictive powers for recurrence in hepatocellular carcinoma显示文摘AIM To investigate the role of macrophage colony-stimulating factor(M-CSF) in patients with hepatocellular carcinoma(HCC) after surgery. METHODS Expression of M-CSF, distribution of M2 macrophages(Mφs), and angiogenesis were assessed in the liver, including tumors and peritumoral liver tissues. The prognostic power of these factors was assessed. Mouse isolated hepatic Mφs or monocytes were cultured with media containing M-CSF. The concentration of vascular endothelial growth factor(VEGF) in media was assessed. Furthermore, the role of the M-CSF-matured hepatic Mφs on proliferation of the vascular endothelial cell(VEC) was investigated. RESULTS A strong correlation between the expressions of M-CSF and CD163 was observed in the peritumoral area. Also, groups with high density of M-CSF, CD163 or CD31 showed a significantly shorter time to recurrence(TTR) than low density groups. Multivariate analysis revealedthe expression of M-CSF or hepatic M2Mφs in the peritumoral area as the most crucial factor responsible for shorter TTR. Moreover, the expression of M-CSF and hepatic M2Mφs in the peritumoral area had better predictable power of overall survival. Values of VEGF in culture media were significantly greater in the hepatic Mφs compared with the monocytes. Proliferation of the VEC was greatest in the cells co-cultured with hepatic Mφs when M-CSF was present in media.CONCLUSION M-CSF increases hepatocarcinogenesis, most likely by enhancing an angiogenic factor derived from hepatic Mφ and could be a useful target for therapy against HCC. | Hiroshi Kono Hideki Fujii Shinji Furuya Michio Hara Kazuyoshi Hirayama Yoshihiro Akazawa Yuuki Nakata Masato Tsuchiya Naohiro Hosomura Chao Sun | 2016 | World Journal of Gastroenterology2016，22，39： | 2 |
| 17 | Helianthus tuberosus(Jerusalem artichoke) tubers improve glucose tolerance and hepatic lipid profile in rats fed a high-fat diet显示文摘Objective:To analyze the effects of feeding Helianthus tuberosus(HT) tubers on glucose tolerance and lipid profile in rats fed a high-fat diet(HFD). Methods:A normal HFD or HFD including 10 w/w% HT tubers(HFD + HT) was fed to F334/Jcl rats. After 10 weeks,organ weights,glucose tolerance,and lipid profile were analyzed. Results:The body weight,liver weight,and epidermal fat content in the HFD group were higher than those of the normal group,and similar to those of the HFD + HT group. The oral glucose tolerance test at 10 weeks revealed that the blood glucose level 30 minutes after beginning the test in the HFD + HT group was significantly lower than that in the HFD group. Liver triglyceride and total cholesterol levels in the HFD + HT group were significantly lower than those in the HFD group. Fecal triglyceride and total cholesterol levels in the HFD + HT group were higher than those in the HFD group. Histological analyses revealed that fat and glycogen accumulation increased in the HFD group,but decreased in the HFD + HT group. Conclusions:These results indicate that HT tubers have anti-fatty liver effects based on improvements in glucose tolerance and the hepatic lipid profile. | Naoto Okada Shinya Kobayashi Kouta Moriyama Kohsuke Miyataka Shinji Abe ChiemiSato Kazuyoshi Kawazoe | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，5： | 2 |
| 18 | Interleukin-17A plays a pivotal role in cholestatic liver fibrosis in mice显示文摘 | Michio Hara Hiroshi Kono Shinji Furuya Kazuyoshi Hirayama Masato Tsuchiya Hideki Fujii | 2013 | Journal of Surgical Research2013，，2： | 2 |
| 19 | Phase II Study of Oral S-1 and Concurrent Radiotherapy in Patients With Unresectable Locally Advanced Pancreatic Cancer显示文摘 | Kentaro Sudo Taketo Yamaguchi Takeshi Ishihara Kazuyoshi Nakamura Taro Hara Tadamichi Denda Katsunobu Tawada Toshiyuki Imagumbai Hitoshi Araki Mitsuhiro Sakai Kazuo Hatano Hiroyuki Kawakami Takashi Uno Hisao Ito Osamu Yokosuka | 2011 | International Journal of Radiation Oncology Biology Physics2011，，1： | 2 |
| 20 | Sol–gel synthesis of macroporous TiO 2 from ionic precursors via phase separation route显示文摘 | Wenyan Li Xingzhong Guo Yang Zhu Yang Hui Kazuyoshi Kanamori Kazuki Nakanishi | 2013 | Journal of Sol-Gel Science and Technology2013，，： | 2 |
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