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| 1 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 2 | Synergistic effects between Suilllus luteus and Trichoderma virens on growth of Korean spruce seedlings and drought resistance of Scotch pine seedlings显示文摘Korean spruce(Picea koraiensis Sieb. El Zucc.)is one of the main afforestation species in northern China.Seedling quality is a critical factor at planting time. To test whether the synergistic growth enhancement of Scotch pine(P. sylvestris var. mongolica) seedlings brought by the plant beneficial fungus Trichoderma virens(J.H. Mill., Giddens and A.A. Foster) Arx and ectomycorrhizal fungus(Suillus luteus(L.) Roussel.) can also benefit Korean spruce seedlings, we examined the effects of S. luteus and T. virens on the growth of P. koraiensis seedlings and drought resistance of P. sylvestris var. mongolica in peat soils. The two fungi were added to sterilized peat soil in pots, and the plants were grown for 4 months. Seedling growth and physiological variables, including mycorrhizal colonization rate of roots,biomass, and chlorophyll content, were examined. The colonization rate of the mycorrhizal fungus on P. koraiensis exceeded 65 %, and the synergism between S. luteus and T.virens enhanced most of the variables for P. koraiensis seedlings after inoculation with S. luteus then 30 days later with T. virens as in our published results for seedlings of P.sylvestris var. mongolica. When seedlings of P. sylvestris var. mongolica were inoculated with this sequence, they became more drought tolerant. T. virens also induced S.luteus to produce-1,3-glucanase and chitinase. This inoculation sequence at planting can thus improve the quality of P. sylvestris var. mongolica and P. koraiensis seedlings and substantiates our previous results. | Dachuan Yin Xun Deng Ruiqing Song | 2016 | Journal of Forestry Research2016，27，1： | 11 |
| 3 | Hierarchically porous nitrogen-doped carbon as cathode for lithium–sulfur batteries显示文摘Porous nitrogen-doped carbon is an especially promising material energy storage due to its excellent conductivity, stable physicochemical properties, easy processability, controllable porosity and low price.Herein, we reported a novel well-designed hierarchically porous nitrogen-doped carbon(HPNC) via a combination of salt template(ZnCl_2) and hard template(SiO_2) as sulfur host for lithium–sulfur batteries. The low-melting ZnCl_2 is boiled off and leaves behind micropores and small size mesopores during pyrolysis process, while the silica spheres are removed by acid leaching to generate interconnected 3D network of macropores. The HPNC-S electrode exhibits an initial specific capacity of 1355 mAh g^(–1) at 0.1 C(1 C = 1675 m Ah g^(–1)), a high-rate capability of 623 m Ah g^(–1) at 2 C, and a small decay of 0.13% per cycle over 300 cycles at 0.2 C. This excellent rate capability and remarkable long-term cyclability of the HPNC-S electrode are attributed to its hierarchical porous structures for confining the soluble lithium polysulfide as well as the nitrogen doping for high absorbability of lithium polysulfide. | Rui Wu Siguo Chen Jianghai Deng Xun Huang Yujie Song Ruiyi Gan Xiaoju Wan Zidong Wei | 2018 | Journal of Energy Chemistry2018，27，6： | 8 |
| 4 | Ectomycorrhizal fungus enhances drought tolerance of Pinus sylvestris var.mongolica seedlings and improves soil condition显示文摘Mongolian pine is an important afforestation species widely used for ecological management in northeast China. The environment in this region is very unstable and the flora are regularly subjected to drought stress.This paper reports on the influence of inoculation with the Suillus luteus on seedlings under different water conditions.Both inoculated and non-inoculated ectomycorrhizal fungi(ECMF)-S. luteus seedlings were maintained under wellwatered or water-stress conditions for 3 months. The S.luteus colonization rate under water stress was higher than that in well-watered conditions. Under water stress, inoculated seedlings had greater growth than non-inoculated seedlings. In addition, under water stress, S. luteus-inoculated seedlings had greater superoxide dismutase and peroxidase activity, higher soluble protein content, lower proline content, and lower malondialdehyde content than non-inoculated seedlings. S. luteus colonization increased the rhizosphere soil-enzyme activity and the rhizosphere soil nutrition content under both well-watered and water-stress conditions. Given the positive impact on seedling growth and physiology, S. luteus shows potential for use in the arid and semi-arid regions of northeast China for afforestation. | Dachuan Yin Ruiqing Song Jinyu Qi Xun Deng | 2018 | Journal of Forestry Research2018，29，6： | 7 |
| 5 | Neurocognitive Graphs of First-Episode Schizophrenia and Major Depression Based on Cognitive Features显示文摘Neurocognitive deficits are frequently observed in patients with schizophrenia and major depressive disorder(MDD). The relations between cognitive features may be represented by neurocognitive graphs based on cognitive features, modeled as Gaussian Markov random fields. However, it is unclear whether it is possible to differentiate between phenotypic patterns associated with the differential diagnosis of schizophrenia and depression using this neurocognitive graph approach. In this study, we enrolled 215 first-episode patients with schizophrenia(FES), 125 with MDD, and 237 demographically-matched healthy controls(HCs). The cognitive performance of all participants was evaluated using a battery of neurocognitive tests. The graphical LASSO model was trained with aone-vs-one scenario to learn the conditional independent structure of neurocognitive features of each group. Participants in the holdout dataset were classified into different groups with the highest likelihood. A partial correlation matrix was transformed from the graphical model to further explore the neurocognitive graph for each group. The classification approach identified the diagnostic class for individuals with an average accuracy of 73.41% for FES vs HC, 67.07% for MDD vs HC, and 59.48% for FES vs MDD. Both of the neurocognitive graphs for FES and MDD had more connections and higher node centrality than those for HC. The neurocognitive graph for FES was less sparse and had more connections than that for MDD.Thus, neurocognitive graphs based on cognitive features are promising for describing endophenotypes that may discriminate schizophrenia from depression. | Sugai Liang Roberto Vega Xiangzhen Kong Wei Deng Qiang Wang Xiaohong Ma Mingli Li Xun Hu Andrew J.Greenshaw Russell Greiner Tao Li | 2018 | Neuroscience Bulletin2018，34，2： | 6 |
| 6 | Incidence and Risk Factors of Retinopathy of Prematurity in Two Neonatal Intensive Care Units in North and South China显示文摘 | Yi Chen Deng Xun Ya-Cong Wang Bin Wang Shao-Hui Geng Hui Chen Yan-Tao Li Xiao-Xin Li | 2015 | Chinese Medical Journal2015，，7： | 6 |
| 7 | Efficacy and safety of Reduqing granules in the treatment of common cold with wind-heat syndrome: a randomized, double-blind, double-dummy, positive-controlled trial显示文摘OBJECTIVE:To assess the efficacy and safety of Reduqing granules in patients with common cold with wind-heat syndrome(CCWHS).METHODS:A randomized, double-blind, double-dummy, parallel, positive-controlled trial included 72 CCWHS patients was performed.The participants were randomly assigned to two groups,Reduqing(RDQ) group and Lianhuaqingwen(LHQW) group, in a 1∶1 ratio.Patients in RDQ group received Reduqing granules and dummy Lianhuaqingwen capsules three times a day and patients in LHQW group received Lianhuaqingwen capsules and dummy Reduqing granules three times daily.The duration of treatment and follow-up were four days.RESULTS:There were no statistically significant differences in total markedly effective rate and total effective rate between RDQ group and LHQW group after treatment.Traditional Chinese Medicine(TCM) symptom score was significantly reduced after treatment in RDQ group, as well as in LHQW group.However, the difference of change in TCM symptom score between two groups was not statistically significant(P > 0.05).There were no significant differences between two groups in the median time to fever relief [RDQ group(4 ± 8) h vs LHQW group(4 ± 5) h] or the median time to fever clearance(RDQ group 47 h vs LHQW 36 h).No serious adverse events were reported during the study.CONCLUSION:Compared with Lianhuaqingwen capsules, Reduqing granules achieved similar therapeutic effect in the treatment of CCWHS and no drug-related adverse events were reported during the study.Therefore, Reduqing granules might be effective and safe in the treatment of CCWHS. | Ma Yanjiao Zhang Zhongyi Wei Lianbo He Shuai Deng Xun Ji Aimin Zhou Benjie Jiang Deqi Li Mingxing Wang Yong | 2017 | Journal of Traditional Chinese Medicine2017，37，2： | 5 |
| 8 | Shellac-coated iron oxide nanoparticles for removal of cadmium(Ⅱ) ions from aqueous solution显示文摘This study describes a new effective adsorbent for cadmium removal from aqueous solution synthesized by coating a shellac layer, a natural biodegradable and renewable resin with abundant hydroxyl and carboxylic groups, on the surface of iron oxide magnetic nanoparticles. Transmission Electron Microscopy (TEM) imaging showed shellac-coated magnetic nanoparticle (SCMN) adsorbents had a core-shell structure with a core of 20 nm and shell of 5 nm. Fourier Transform Infrared Spectroscopic analysis suggested the occurrence of reaction between carboxyl groups on the SCMN adsorbent surface and cadmium ions in aqueous solution. Kinetic data were well described by pseudo second-order model and adsorption isotherms were fitted with both Langmuir and Freundlich models with maximum adsorption capacity of 18.80 mg/g. SCMN adsorbents provided a favorable adsorption capacity under high salinity conditions, and cadmium could easily be desorbed using mild organic acid solutions at low concentration. | Jilai Gong Long Chen Guangming Zeng Fei Long Jiuhua Deng Qiuya Niu Xun He | 2012 | Journal of Environmental Sciences2012，24，7： | 5 |
| 9 | Age-Related Reduction in Cortical Thickness in First-Episode Treatment-Na?ve Patients with Schizophrenia显示文摘Substantial evidence supports the neurodevelopmental hypothesis of schizophrenia.Meanwhile,progressive neurodegenerative processes have also been reported,leading to the hypothesis that neurodegeneration is a characteristic component in the neuropathology of schizophrenia.However,a major challenge for the neurodegenerative hypothesis is that antipsychotic drugs used by patients have profound impact on brain structures.To clarify this potential confounding factor,we measured the cortical thickness across the whole brain using highresolution T1-weighted magnetic resonance imaging in 145 first-episode and treatment-naive patients with schizophrenia and 147 healthy controls.The results showed that,in the patient group,the frontal,temporal,parietal,and cingulate gyri displayed a significant age-related reduction of cortical thickness.In the control group,age-related cortical thickness reduction was mostly located in the frontal,temporal,and cingulate gyri,albeit to a lesser extent.Importantly,relative to healthy controls,patients exhibited a significantly smaller age-related cortical thickness in the anterior cingulate,inferior temporal,and insular gyri in the right hemisphere.These results provide evidence supporting the existence of neurodegenerative processes in schizophrenia and suggest that these processes already occur in the early stage of the illness. | Yin Lin Mingli Li Yi Zhou Wei Deng Xiaohong Ma Qiang Wang Wanjun Guo Yinfei Li Lijun Jiang Xun Hu Nanyin Zhang Tao Li | 2019 | Neuroscience Bulletin2019，35，4： | 5 |
| 10 | Foveal structure changes in infants treated with anti-VEGF therapy or laser therapy guided by optical coherence tomography angiography for retinopathy of prematurity显示文摘AIM: To evaluate foveal vessel density(VD) and foveal thickness using optical coherence tomography angiography(OCTA) in retinopathy of prematurity(ROP) children treated with laser photocoagulation or anti-vascular endothelial growth factor(VEGF) injection. Additionally, we assessed the relationship between foveal microvascular anomalies and different therapies in ROP children.METHODS: This was a single-center, retrospective study of patients with a diagnosis of type 1 ROP. Twenty-three eyes(14 patients) treated with anti-VEGF injection and twentynine eyes(17 patients) treated with laser coagulation were included in this study. The foveal VD, inner thickness and full thickness were measured at the central 0°, 2° to 8°, and 8° of the retina(centered on the fovea) using OCTA and cross-sectional OCT, respectively.RESULTS: Foveal VD, inner thickness and full thickness were significantly smaller within the central 8° of the retina in ROP children treated with anti-VEGF injection than in those treated with laser photocoagulation(P=0.013, 0.009, 0.036, respectively). The full thickness was also smaller in the anti-VEGF group than in the laser group at the central 0° of the retina(P=0.010). The grade of foveal hypoplasia is lower in the anti-VEGF group than in the laser group(P=0.045). Multivariable analysis did not find any risk factors associated with visual acuity in our study.CONCLUSION: In children with type 1 ROP, the better structural development of fovea in those who were treated with anti-VEGF injection compared with laser photocoagulation are identified. However, visual acuity outcomes are similar 70 mo after the treatments. | Xun Deng Yong Cheng Xue-Mei Zhu Dan-Dan Linghu Hua Xu Jian-Hong Liang | 2022 | International Journal of Ophthalmology(English edition)2022，15，1： | 4 |
| 11 | The genome of Magnolia biondii Pamp. provides insights into the evolution of Magnoliales and biosynthesis of terpenoids显示文摘Magnolia biondii Pamp.(Magnoliaceae,magnoliids)is a phylogenetically,economically,and medicinally important ornamental tree species widely grown and cultivated in the north-temperate regions of China.Determining the genome sequence of M.biondii would help resolve the phylogenetic uncertainty of magnoliids and improve the understanding of individual trait evolution within the Magnolia genus.We assembled a chromosome-level reference genome of M.biondii using~67,~175,and~154Gb of raw DNA sequences generated via Pacific Biosciences single-molecule real-time sequencing,10X Genomics Chromium,and Hi-C scaffolding strategies,respectively.The final genome assembly was~2.22Gb,with a contig N50 value of 269.11 kb and a BUSCO complete gene percentage of 91.90%.Approximately 89.17%of the genome was organized into 19 chromosomes,resulting in a scaffold N50 of 92.86Mb.The genome contained 47,547 protein-coding genes,accounting for 23.47%of the genome length,whereas 66.48%of the genome length consisted of repetitive elements.We confirmed a WGD event that occurred very close to the time of the split between the Magnoliales and Laurales.Functional enrichment of the Magnolia-specific and expanded gene families highlighted genes involved in the biosynthesis of secondary metabolites,plant–pathogen interactions,and responses to stimuli,which may improve the ecological fitness and biological adaptability of the lineage.Phylogenomic analyses revealed a sister relationship of magnoliids and Chloranthaceae,which are sister to a clade comprising monocots and eudicots.The genome sequence of M.biondii could lead to trait improvement,germplasm conservation,and evolutionary studies on the rapid radiation of early angiosperms. | Shanshan Dong Min Liu Yang Liu Fei Chen Ting Yang Lu Chen Xingtan Zhang Xing Guo Dongming Fang Linzhou Li Tian Deng Zhangxiu Yao Xiaoan Lang Yiqing Gong Ernest Wu Yaling Wang Yamei Shen Xun Gong Huan Liu Shouzhou Zhang | 2021 | Horticulture Research2021，8，1： | 4 |
| 12 | Morphological changes in gray matter volume correlate with catechol-O-methyl transferase gene Val158Met polymorphism in first-episode treatment-nave patients with schizophrenia显示文摘The catechol-O-methyltransferase(COMT) gene is a schizophrenia susceptibility gene. A common functional polymorphism of this gene,Val158/158 Met,has been proposed to influence gray matter volume(GMV). However,the effects of this polymorphism on cortical thickness/surface area in schizophrenic patients are less clear. In this study,we explored the relationship between the Val158 Met polymorphism of the COMT gene and the GMV/ cortical thickness/cortical surface area in 150 firstepisode treatment-nave patients with schizophrenia and 100 healthy controls. Main effects of diagnosis were found for GMV in the cerebellum and the visual,medial temporal,parietal,and middle frontal cortex. Patients with schizophrenia showed reduced GMVs in these regions. And main effects of genotype were detected for GMV in the left superior frontal gyrus. Moreover,a diagnosis × genotype interaction was found for the GMV of the left precuneus,and the effect of the COMT gene on GMV was due mainly to cortical thickness rather than cortical surface area. In addition,a pattern ofincreased GMV in the precuneus with increasing Met dose found in healthy controls was lost in patients with schizophrenia. These findings suggest that the COMTMet variant is associated with the disruption of dopaminergic influence on gray matter in schizophrenia,and the effect of the COMT gene on GMV in schizophrenia is mainly due to changes in cortical thickness rather than in cortical surface area. | Ming-Li Li Bo Xiang Yin-Fei Li Xun Hu Qiang Wang Wan-Jun Guo Wei Lei Chao-Hua Huang Lian-Sheng Zhao Na Li Hong-Yan Ren Hui-Yao Wang Xiao-Hong Ma Wei Deng Tao Li | 2015 | Neuroscience Bulletin2015，31，1： | 3 |
| 13 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 14 | Trending IC design directions in 2022显示文摘For the non-stop demands for a better and smarter society, the number of electronic devices keeps increasing exponentially;and the computation power, communication data rate, smart sensing capability and intelligence are always not enough. Hardware supports software, while the integrated circuit(IC) is the core of hardware. In this long review paper, we summarize and discuss recent trending IC design directions and challenges, and try to give the readers big/cool pictures on each selected small/hot topics. We divide the trends into the following six categories, namely, 1) machine learning and artificial intelligence(AI) chips, 2) communication ICs, 3) data converters, 4) power converters, 5) imagers and range sensors, 6) emerging directions. Hope you find this paper useful for your future research and works. | Chi-Hang Chan Lin Cheng Wei Deng Peng Feng Li Geng Mo Huang Haikun Jia Lu Jie Ka-Meng Lei Xihao Liu Xun Liu Yongpan Liu Yan Lu Kaiming Nie Dongfang Pan Nan Qi Sai-Weng Sin Nan Sun Wenyu Sun Jiangtao Xu Jinshan Yue Milin Zhang Zhao Zhang | 2022 | Journal of Semiconductors2022，43，7： | 3 |
| 15 | Hypoxia induces T-cell apoptosis by inhibiting chemokine C receptor 7 expression:the role of adenosine receptor A2显示文摘Hypoxia is a major characteristic of the tumor microenvironment,and its effects on immune cells are proposed to be important factors for the process of tumor immune escape.It has been reported that hypoxia affects the function of dendritic cells and the antitumor function of T cells.Here we discuss the effects of hypoxia on T-cell survival.Our results showed that hypoxia induced apoptosis of T cells.Adenosine and adenosine receptors(AR)are important to the hypoxia-related signaling pathway.Using AR agonists and antagonists,we demonstrated that hypoxia-induced apoptosis of T cells was mediated by A^(2a)and A^(2b)receptors.Furthermore,we are the first,to our knowledge,to report that hypoxia significantly inhibited the expression of chemokine C receptor 7(CCR7)of T cells via the A^(2)R signal pathway,perhaps representing a mechanism of hypoxia-induced apoptosis of T cells.Collectively,our research demonstrated that hypoxia induces T-cell apoptosis by the A^(2)R signaling pathway partly by suppressing CCR7.Blocking the A^(2)R signaling pathway and/or activation of CCR7 can increase the anti-apoptosis function of T cells and may become a new strategy to improve antitumor potential. | Jintang Sun Yan Zhang Meixiang Yang Yun Zhang Qi Xie Zewu Li Zhaogang Dong Yongmei Yang Biping Deng Alei Feng Weixu Hu Haiting Mao Xun Qu | 2010 | Cellular & Molecular Immunology2010，7，1： | 3 |
| 16 | Chemical constituents from the aerial parts of Musella lasiocarpa显示文摘Phytochemical investigation of the aerial parts of the monotypic plant,Musella lasiocarpa,led to the isolation of four rare bicyclic diarylheptanoids,musellarins B-E(2-5),two new phenylphenalenones,2-methoxy-9-(3′,4′-dihydroxyphenyl)-1H-phenalen-1-one(9),2-methoxy-9-(3′-methoxy-4′-hydroxyphenyl)-1H-phenalen-1-one(10),a new acenaphtylene derivative,trans-(1S,2S)-3-(4′-methoxyphenyl)-acenaphthene-1,2-diol(13),and two new sucrose esters,1,2′,3′,4′,6′-O-pentaacetyl-3-O-trans-p-coumaroylsucrose(16),1,2′,3′,4′,6′-O-pentaacetyl-3-O-cis-p-coumaroylsucrose(17),together with nine known compounds.In addition,(4E,6E)-1-(3′,4′-dihydroxyphenyl)-7-(4′′-hydroxyphenyl)-hepta-4,6-dien-3-one(15)was isolated for the first time from a natural source.The structures of new compounds were elucidated by analysis of their spectroscopic data.Compounds 2,6,8-10,12,and 14 were cytotoxic toward several of the human tumor cell lines(HL-60,SMMC-7721,A-549,MCF-7,and SW480).Of these,the new compound 9 was the most potent one,with IC50 values of 5.8,10.3,6.3,3.3,and 2.3μM,respectively. | Liao-Bin DONG Juan HE Xing-Yao LI Xing-De WU Xu DENG Gang XU Li-Yan PENG Yu ZHAO Yan LI Xun GONG Qin-Shi ZHAO | 2011 | Natural Products and Bioprospecting2011，1，1： | 3 |
| 17 | Terahertz synthetic aperture in-line holography with intensity correction and sparsity autofocusing reconstruction显示文摘We demonstrate high-resolution and high-quality terahertz(THz)in-line digital holography based on the synthetic aperture method.The setup is built on a self-developed THz quantum cascade laser,and a lateral resolution better than 70μm(~λ)is achieved at 4.3 THz.To correct intensity differences between sub-holograms before aperture stitching,a practical algorithm with global optimization is proposed.To address the twin-image problem for in-line holography,a sparsity-based phase retrieval algorithm is applied to perform the high-quality reconstruction.Furthermore,a new autofocusing criterion termed'reconstruction objective function'is introduced to obtain the best in-focus reconstruction distance,so the autofocusing procedure and the reconstruction are unified within the same framework.Both simulation and experiment prove its accuracy and robustness.Note that all the methods proposed here can be applied to other wavebands as well.We demonstrate the success of this THz synthetic aperture in-line holography on biological and semiconductor samples,showing its potential applications in bioimaging and materials analysis. | ZEYU LI RUIJIAO ZOU WEIPENG KONG XUEMIN WANG QINGHUA DENG QIANG YAN YU QIN WEIDONG WU XUN ZHOU | 2019 | Photonics Research2019，7，12： | 3 |
| 18 | Testing the role of genetic variation of the MC4R gene in Chinese population in antipsychotic-induced metabolic disturbance显示文摘Antipsychotic-induced metabolic disturbance(AIMD) is a common adverse effect of antipsychotics with genetics partly underpinning variation in susceptibility among schizophrenia patients. Melanocortin4 receptor(MC4 R) gene, one of the candidate genes for AIMD, has been under-studied in the Chinese patients. We conducted a pharmacogenetic study in a large cohort of Chinese patients with schizophrenia. In this study, we investigated the genetic variation of MC4 R in Chinese population by genotyping two SNPs(rs489693 and rs17782313) in 1,991 Chinese patients and examined association of these variants with the metabolic effects that were often observed to be related to AIMD. Metabolic measures, including body mass index(BMI), waist circumference(WC), glucose, triglyceride, high-density lipoprotein(HDL), and low-density lipoprotein(LDL) levels were assessed at baseline and after 6-week antipsychotic treatment. We found that interaction of SNP×medication status(drug-na?ve/medicated) was significantly associated with BMI, WC, and HDL change %, respectively. Both SNPs were significantly associated with baseline BMI and WC in the medicated group. Moderate association of rs489693 with WC, Triglyceride, and HDL change % were observed in the whole sample. In the drug-na?ve group, we found recessive effects of rs489693 on BMI gain more than 7%, WC and Triglyceride change %, with AA incurring more metabolic adverse effects. In conclusion, the association between rs489693 and the metabolic measures is ubiquitous but moderate. Rs17782313 is less involved in AIMD. Two SNPs confer risk of AIMD to patients treated with different antipsychotics in a similar way. | Yamin Zhang Hongyan Ren Qiang Wang Wei Deng Weihua Yue Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Dai Zhang Liansheng Zhao Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Science China(Life Sciences)2019，62，4： | 3 |
| 19 | A quantitative comparison of five optical coherence tomography angiography systems in clinical performance显示文摘AIM: To compare the clinical performance of 4 spectraldomain(SD) optical coherence tomography angiography(OCTA) systems: AngioVueTM, AngioPlexTM, Spectralis? OCTA, AngioScan, and 1 swept-source(SS) OCTA SS OCT AngioTM. METHODS: Twenty-seven undilated right eyes of 27 participants underwent OCTA examination using five different systems respectively for both 3×3 and 6×6 mm2 scan pattern(Spectralis OCTA for 3×3 mm2 scan only). Image quality, including vessel valid visibility and the number of motion artifacts, and acquisition time were evaluated. Repeated measures analysis of variance(ANOVA) with Bonferroni's post-test and Friedman test with Dunn's posttest were used to compare measurements.RESULTS: The age of the subjects was 28.19±5.55 y(range, 23-49 y). The spherical equivalent refraction was-2.55±1.84 D(range, 0.00 to-5.25 D). Significant difference was observed in the evaluation of vessel valid visibility(Angio Vue the highest: 0.111±0.031 for 3×3 mm2 scan and 0.128±0.020 for 6×6 mm2 scan), number of motion artifacts(AngioVue the fewest: 0.778±1.086 for 3×3 mm2 scan and 0.333±0.620 for 6×6 mm2 scan) and acquisition time(AngioPlex the shortest: 8.537±1.921 s for 3×3 mm2 scan and 8.298±1.741 s for 6×6 mm2 scan; all P<0.001). CONCLUSION: There is poor agreement of measurements among systems. AngioVue provides images with the highest vessel valid visibility and the fewest motion artifacts. AngioPlex achieves the shortest acquisition. | Xin-Xin Li Wei Wu Hao Zhou Jun-Jie Deng Meng-Ya Zhao Tian-Wei Qian Chen Yan Xun Xu Su-Qin Yu | 2018 | International Journal of Ophthalmology(English edition)2018，11，11： | 2 |
| 20 | Macular choroidal thickness in Chinese preschool children: decrease with axial length but no evident change with age显示文摘AIM: To explore the distribution pattern of macular choroidal thickness(ChT) and its association with age as well as refractive status in Chinese preschoolers.METHODS: School-based, cross-sectional study. A total of 550 healthy preschool children aged 3 to 6 years old from 6 kindergartens were enrolled. Comprehensive ocular examinations, including measurement of visual acuity, axial length, intraocular pressure and slit-lamp examination before cycloplegia, as well as refraction measurement and sweptsource optical coherence tomography(SS-OCT) examination after cycloplegia, were performed. The macular ChT in each sector of the ETDRS grid was measured by the builtin software of SS-OCT.RESULTS: The mean central ChT of the participants was 312±59 μm. The mean axial length and spherical equivalent refraction were 22.36±0.72 mm and 1.51±0.83 D, respectively. Axial length increased with age(P<0.001), while the spherical equivalent refraction was similar among different age groups. Similarly, no significant difference was observed in ChT in all sectors among different age groups(all P>0.05). The central ChT of 3-4, 5 and 6 years old children was 314±59 μm, 312±60 μm and 312±59 μm, respectively(P=0.920). No difference was observed in ChT in most of the sectors between genders. No statistical significant difference was observed among different refractive groups(all P>0.05), though the ChT of each sector seemed to be smaller in myopic children. Axial length and weight were the independent factors of central Ch T. Children with longer axial length(β=-21.184, P<0.001) and smaller weight(β=1.502, P=0.041) tended to have thinner choroid.CONCLUSION: In preschool children, the ChT remains relatively stable with age, while a negative association between ChT and axial length existed. This will be helpful to elucidate the characteristics of ChT during the early refractive development. | Xian-Gui He Jun-Jie Deng Yao Yin Bo Zhang Shu-Yu Xiong Jian-Feng Zhu Hai-Dong Zou Xun Xu Ling Wang | 2019 | International Journal of Ophthalmology(English edition)2019，12，9： | 2 |
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