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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Comfort improvement of a nonlinear suspension using global optimization and in situ measurements 显示文摘 | Deprez K Moshou D Ramon H | 2005 | Journal of Sound and Vibration2005，284，： | 1 |
| 3 | The analysis of the electrical conductivity of graphite conductivity of graphite powders during compaction 显示文摘 | Deprez N McLachlan D S | 1988 | Journal of Physics D: Applied Physics1988，21，1： | 1 |
| 4 | Comfort Improvement of a Nonlinear Suspension Using Global Optimization and in Situ Measurements显示文摘 | Deprez K Moshou D Ramon H | 2005 | Journal of Sound and Vibration2005，284，： | 1 |
| 5 | Comparative study of commercially available anti-alpha-synuclein antibodies显示文摘 | Croisier E MRes D E Deprez M | 2006 | Neuropathol Appl Neurobiol2006，32，： | 1 |
| 6 | Heartburn in Belgium:prevalence,impact on daily life,and utilization of medical resources显示文摘 | Louis E DeLooze D Deprez P | 2002 | Eur J Gastroenterol Hepatol2002，14，： | 1 |
| 7 | Oxidative C--H activation/C--C bond forming reactions:synthetic scope and mechanistic insights 显示文摘 | KALYANI D DEPREZ N R DESAI L V | 2005 | J Am Chem Soc2005，127，20： | 1 |
| 8 | Comfort improvement of a nonlinear suspension using global optimization and in situ measurement 显示文摘 | DEPREZ K MOSHOU D RAMON H | 2005 | Journal of Sound and Vibration2005，284，35： | 1 |
| 9 | A novel GABRG2 mutation associated with febrile seizures显示文摘 | D Audenaert E Schwartz K G. Claeys L Claes L Deprez A Suls T Van Dyck L Lagae C Van Broeckhoven R L. Macdonald P De Jonghe | 2006 | Neurology2006，，4： | 1 |
| 10 | Heartburn in Belgium: prevalence, impact on daily life, and utilization of medical resources显示文摘 | LOUIS E DELOOZE D DEPREZ P | 2002 | Eur J Gastroenterol Hepatol2002，14，3： | 1 |
| 11 | Pharmacology and ph-armacokinetics of milnaeipran显示文摘 | Panconi E Deprez D | 2002 | Int CIin Psychopha-rmacol2002，17，1： | 1 |
| 12 | Comfort improvementof a nonlinear suspension using global optimization, andin site measurements 显示文摘 | Deprez K Moshou D Ramon H | 2005 | Journal of Sound and Vibra-tion2005，284，： | 1 |
| 13 | Phosphorylation and activation of heart phosphofructo-kinase by protein kinase B and other protein kinase of the insulin signaling cascades显示文摘 | DEPREZ J D VERTOMMEN D R | 2000 | J Biol Chem2000，272，17： | 1 |
| 14 | Evaluation of the effect of 3 probiotics on experimental Escherichia coli enterotoxaemia in weaned piglets显示文摘 | DeCupere F Deprez P Demeulenaere D | 1992 | J Vet Med Bull1992，39，： | 1 |
| 15 | Conceptual cab suspension system for a self-propelled agricultural machine, Part t 显示文摘 | Temmerman J D Deprez K Anthonis J | 2004 | Development of a Linear Mathematical Model Biosystems Engineering2004，89，4： | 1 |
| 16 | Measurement and comparative analysis of the electrical and thermal conductivities,permeability and Young's modulus of sintered nickel显示文摘 | Mclachlan D S Sigalas I | 1988 | Solid State Commun1988，66，8： | 1 |
| 17 | Long lasting anti-viral cytotoxic T lymphocytes induced in vivo with chimeric-multirestricted lipoptides显示文摘 | Sauzet Jean-Pierre Deprez Benoit Martinon Frédéric | 1995 | Vaccine1995，13，14： | 1 |
| 18 | Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades显示文摘 | Deprez J Vertommen D Alessi D R | 1997 | J Biol Chem1997，272，17： | 1 |
| 19 | Conceptual cab suspension system for a self-propelled agricuhural machine--part 1 : development of a linear mathematical model 显示文摘 | Temmerman J D Deprez K Anthoniset | 2004 | Biosystems Engineering2004，89，4： | 1 |
| 20 | N-methl-D-aspertic acid/glycine release in raphe primary cultures显示文摘 | Becquet D Hery M Deprez P | | 0，，： | 1 |
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