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| 1 | Metabolic investigations in patients with hepatitis B and C显示文摘AIM:To investigate the similarities and dissimilarities in patients with hepatitis B and hepatitis C,clinically and metabolically. METHODS:Fifty patients with hepatitis B virus and hepatitis C virus infection were included in this study, along with fifty healthy controls for comparison purposes.Intravenous blood(10 mL)samples from patients and healthy subjects were collected and made to clot before serum was separated and immediately levels of the enzymes,alkaline phosphatase(ALK),creatinine phosphokinase(CPK),lactate dehydrogenase (LDH),serum glutamate oxaloacetate transaminase(sGOT)and serum glutamate pyruvate transaminase(sGPT)were determined by a kit method.For total con-tent of each metal the serum samples were analyzed using atomic absorption spectrophotometry.Levels of cholesterol,triglycerides,urea,creatinine and uric acid were determined using a kit method on Microlab 300. RESULTS:Serum magnesium and copper levels remained unchanged,whereas the concentration of zinc decreased and iron increased significantly in both groups of patients.Total antioxidant activity was significantly decreased in both hepatitis B and C.Among the enzymes analyzed,ALK,s-GPT,LDH and s-GOT were all significantly increased in both patients with hepatitis B and C whereas CPK was significantly decreased in patients with hepatitis B and remained unchanged in patients with hepatitis C. CONCLUSION:The information accumulated by this study will help provide a better understanding of involved metabolic processes in order to design appropriate therapeutic approaches for treating these patients,so they can recover and lead normal lives. | Abdul Aziz Mastoi Bikha Ram Devrajani Syed Zulfiquar Ali Shah Qasim Rohopoto Sikander Ali Memon Marya Baloch Ghulam Ali Qureshi Waqas Sami | 2010 | World Journal of Gastroenterology2010，16，5： | 2 |
| 2 | Lipid profile inpatients with psoriasis presenting at Liaquat University HospitalHyderabad显示文摘 | Bajaj DR Mahesar SM Devrajani BR | 2009 | J Pak Med Assoc2009，59，8： | 1 |
| 3 | Lipid profile in pa- tients with psoriasis presenting at Liaquat University Hospital Hyderabad显示文摘 | Bajaj DR Mahesar SM Devrajani BR | 2009 | J Pak Med Assoe2009，59，8： | 1 |
| 4 | Oral lichen planus:a clinical study显示文摘 | Bajaj DR Khoso NA Devrajani BR | | 0，，： | 1 |
| 5 | Type 2 diabetes melli- tus: a risk factor for Helicobacter pylori infection: a hospital based case-control study显示文摘 | Devrajani BR Shah SZ Soomro AA | 2010 | Int J Diabetes Dev Ctries2010，30，1： | 1 |
| 6 | Treatment of chronic hepatitis delta virus with peg-interferon and factors that predict sustained viral response显示文摘AIM:To observe the efficacy of peg-interferon in the treatment of hepatitis delta virus(HDV) and to identify the factors that would be predictive of the sustained viral response(SVR).METHODS:This prospective study was conducted in Medical Unit Ⅳ of the Liaquat University of Medical and Health Sciences Hospital Jamshoro from June 2008 to September 2011.This study cohort included all patients of either sex who presented during this time with hepatitis B surface antigen positivity,hepatitis B virus DNA > 20 000 IU/mL,serum glutamic pyruvic transaminase(SGPT) > 2(upper limit of normal),HDV-RNA positivity with fibrosis stage ≥ 2.Informed consent was obtained from each of these individuals.Patients were diagnosed with hepatitis D on the basis of detectable viral antibodies and the presence of HDV-RNA in their serum.A liver biopsy was performed in all cases and fibrosis staging was performed in accordance with the METAVIR scoring system.All eligible patients were administered peg-interferon at a weekly dosage of 1.5 g/kg body weight for 48 wk.HDV-RNA was assayed at the end of this treatment period and again at 24 wk later.A biochemical response was determined by a normalization of SGPT at the end of the treatment or during follow up.The end of treatment response was defined by a HDV-RNA negative status.A sustained virological response was defined by undetectable serum HDV-RNA at six months after the end of treatment.RESULTS:Among the 277 patients enrolled in our present study,238 completed a course of peg-interferon therapy of which 180(75.6%) were male and 58(24.4%) female.Biochemical responses were achieved in 122/238(51.3%) patients.End of treatment responses were achieved in 71/238(29.8%) cases.A SVR was achieved in 70 of these patients(29.4%).A strong association was found between the SVR and the end of treatment responses(P = 0.001),biochemical responses(P = 0.001) and the degree of fibrosis(P = 0.002).CONCLUSION:Peg-interferon therapy can induce remission in nearly one third of patients harboring HDV. | Shaikh Samiullah Devrajani Bikharam Nasreen | 2012 | World Journal of Gastroenterology2012，18，40： | 1 |
| 7 | Oral lichen planus:a clinical sludy显示文摘 | Bajaj DR Khoso NA Devrajani BR | 2010 | J Coll Physicians Surg Pak2010，20，3： | 1 |
| 8 | Precipitating factors of hepatic encephalopathy at a tertiary care hospital Jamshoro, Hydera- bad 显示文摘 | Devrajani BR Shah SZ Devrajani T | 2009 | J Pak Med Assoc2009，59，10： | 1 |
| 9 | Precipitating factors of hepatic encephalopathy at a tertiary care hospital Jamshoro,Hyderabad显示文摘 | Devrajani BR Shah SZ Devrajani T | | 0，，59： | 1 |
| 10 | Precipitating factors of hepatic encephalopathy at a tertiary care hospital Jamshoro, Hyderabad显示文摘 | Devrajani BR Shah SZ Devrajani T | 2009 | J Pak Med Assoc2009，59，： | 1 |
| 11 | Precipitating factors of hepatic encephalopathy at a tertiary care hospital Jamshoro,Hyderabad显示文摘 | Devrajani BR Shah SZ Devrajani T | 2009 | J Pak Med Assoc2009，59，10： | 1 |
| 12 | Lipid profile in children with coronary artery disease in Sindh,Pakistan显示文摘AIM:To evaluate lipid profile in children with coronary artery disease(CAD)in Hyderabad,Sindh,Pakistan.METHODS:The study included 100 children(6-15years),of which 43 were children of young parents(one or both)with recognized CAD,while the other 57 were children with no evidence of CAD(controls).All were evaluated for fasting blood lipid profile.Blood samples were collected from patients with CAD and healthy controls and analysis of the levels of lipid profile were carried out using a kit method on Microlab 300.RESULTS:Children with CAD had significantly higher levels of total serum cholesterol and triglycerides and decreased levels of high density lipoprotein and low density lipoprotein compared to children in the control group.Systolic and diastolic blood pressures were significantly higher,without any significant difference.CONCLUSION:CAD risk factors are significant regarding abnormal lipid levels.Genetic tendency seems to be important in the development of CAD in children. | Saira Baloch Bikha Ram Devrajani Mohsin Ali Baloch Mohammad Ali Pir | 2014 | World Journal of Cardiology2014，6，7： | 0 |
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