|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer显示文摘AIM To determine the frequency and risk factors for colorectal cancer(CRC) development among individuals with resected advanced adenoma(AA)/traditional serrated adenoma(TSA)/advanced sessile serrated adenoma(ASSA). METHODS Data was collected from medical records of 14663 subjects found to have AA, TSA, or ASSA at screening or surveillance colonoscopy. Patients with inflammatory bowel disease or known genetic predisposition for CRC were excluded from the study. Factors associated with CRC developing after endoscopic management of high risk polyps were calculated in 4610 such patients who had at least one surveillance colonoscopy within 10 years following the original polypectomy of the incident advanced polyp. RESULTS84/4610(1.8%) patients developed CRC at the polypectomy site within a median of 4.2 years(mean 4.89 years), and 1.2%(54/4610) developed CRC in a region distinct from the AA/TSA/ASSA resection site within a median of 5.1 years(mean 6.67 years). Approximately, 30%(25/84) of patients who developed CRC at the AA/TSA/ASSA site and 27.8%(15/54) of patients who developed CRC at another site had colonoscopy at recommended surveillance intervals. Increasing age; polyp size; male sex; right-sided location; high degree of dysplasia; higher number of polyps resected; and piecemeal removal were associated with an increased risk for CRC developmentat the same site as the index polyp. Increasing age; right-sided location; higher number of polyps resected and sessile endoscopic appearance of the index AA/TSA/ASSA were significantly associated with an increased risk for CRC development at a different site. CONCLUSION Recognition that CRC may develop following AA/TSA/ASSA removal is one step toward improving our practice efficiency and preventing a portion of CRC related morbidity and mortality. | Mohamad A Mouchli Lidia Ouk Marianne R Scheitel Alisha P Chaudhry Donna Felmlee-Devine Diane E Grill Shahrooz Rashtak Panwen Wang Junwen Wang Rajeev Chaudhry Thomas C Smyrk Ann L Oberg Brooke R Druliner Lisa A Boardman | 2018 | World Journal of Gastroenterology2018，24，8： | 5 |
| 2 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 3 | Human enamel thickness and ENAM polymorphism显示文摘The tooth enamel development gene, enamelin(ENAM), showed evidence of positive selection during a genome-wide scan of human and primate DNA for signs of adaptive evolution. The current study examined the hypothesis that a single-nucleotide polymorphism(SNP) C14625T(rs7671281) in the ENAM gene identified in the genome-wide scan is associated with a change in enamel phenotype. African Americans were selected as the target population, as they have been reported to have a target SNP frequency of approximately 50%, whereas non-Africans are predicted to have a 96% SNP frequency. Digital radiographs and DNA samples from 244 teeth in 133 subjects were analysed, and enamel thickness was assessed in relation to SNP status,controlling for age, sex, tooth number and crown length. Crown length was found to increase with molar number, and females were found to have thicker enamel. Teeth with larger crowns also had thicker enamel, and older subjects had thinner enamel.Linear regression and generalized estimating equations were used to investigate the relationship between enamel thickness of the mandibular molars and ENAM SNP status; enamel in subjects with the derived allele was significantly thinner(P = 0.040)when the results were controlled for sex, age, tooth number and crown length. The derived allele demonstrated a recessive effect on the phenotype. The data indicate that thinner dental enamel is associated with the derived ENAM genotype. This is the first direct evidence of a dental gene implicated in human adaptive evolution as having a phenotypic effect on an oral structure. | Diane M Daubert Joanna L Kelley Yuriy G Udod Carolina Habor Chris G Kleist Ilona K Furman Igor N Tikonov Willie J Swanson Frank A Roberts | 2016 | International Journal of Oral Science2016，8，2： | 2 |
| 4 | New insights into the management of acne: An update from the Global Alliance to Improve Outcomes in Acne Group显示文摘 | Diane Thiboutot Harald Gollnick Vincenzo Bettoli Brigitte Dréno Sewon Kang James J. Leyden Alan R. Shalita Vicente Torres Lozada Diane Berson Andrew Finlay Chee Leok Goh María Isabel Herane Ana Kaminsky Raj Kubba Alison Layton Yoshiki Miyachi Montserrat P | 2009 | Journal of the American Academy of Dermatology2009，，5： | 2 |
| 5 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
| 6 | Polycyclic aromatic hydrocarbon accumulation in urban, suburban, and rural vegetation显示文摘 | WAGROWSKI DIANE M HITES R A | 1997 | Environ Sci Technol1997，31，1： | 1 |
| 7 | Genetic transformation of mouse embryos by microinjection of purified DNA显示文摘 | Gordon J W Seangos G A Diane J | 1980 | Proc Natl Acad Sci USA1980，77，： | 1 |
| 8 | Intensified regimen containing rifampicin and moxifloxacin for tuberculous meningitis: an open-label, randomised controlled phase 2 trial显示文摘 | Ruslami R Ganiem A R Dian S | 2013 | Lancet Infect Dis2013，13，1： | 1 |
| 9 | A New Mathod for Conversion of Nitriles to Primary Alcohols显示文摘ANewMathodforConversionofNitrilestoPrimaryAlcohols￥GuangDianHAN(InstituteofMateriaMedica,PekingUnionMedicalCollege,ChineseAca... | Guang Dian HAN(Institute of Materia Medica, Peking Union Medical College, Chinese Academy of Medical Sciences,Beijing 100050)Song Kee CHUNG(Department of Chemistry, Texas A&M University, College Station. Texas 77843) | 1996 | Chinese Chemical Letters1996，7，12： | 1 |
| 10 | Micromachined 1 × 2 optical fiber switch 显示文摘 | Field Leslie A Burriesci Diane L | 1996 | Sensors and Actuator A1996，，53： | 1 |
| 11 | Augmented expression of cardiotrophin-1 and its receptor component,gp130,in both left and right ventricles after myocardial infarction in the rat显示文摘 | Tsdeshi A Yoshihito T Diane P | | 0，，： | 1 |
| 12 | C-reactive protein and incident coronary heart disease in the Atherosclerosis Risk in Communities (ARIC) study显示文摘 | Nena A Diane C | 2002 | Am Heart J2002，144，： | 1 |
| 13 | Leverage and investment in diversified firms显示文摘 | Seoungpil A Denis D J Diane K D | | 0，，： | 1 |
| 14 | Sulfated zirconia catalysis:characterization by TGA/DTA/mass spectrometry显示文摘 | SRINIVSAN R KEOGH R A DIANE R | 1995 | J catal1995，153，： | 1 |
| 15 | Transthoracic discectomy withoutinterbody fusion显示文摘 | William E Krauss MD Diane A | 2005 | Surg Neurology2005，63，40： | 1 |
| 16 | Antibody-based sensors for heavy metal ions显示文摘 | Diane A Blake R.Mark Jones Robert C Blake Andrey R Pavlov Ibrahim A Darwish Haini Yu | 2001 | Biosensors and Bioelectronics2001，，9： | 1 |
| 17 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 18 | Overview of the Radiometric and Biophysical Performance of the MOD1S Vegetation Indices显示文摘 | Huele A Dian K Miura T | 2002 | Remote Sensing of Enviroment2002，83，： | 1 |
| 19 | Measuring Scholarly Outreach at Michigan State University: Definition, Challenges, Tools 显示文摘 | ROBERT L C DIANE L Z BURTON A B | 2003 | Journal 3f Higher Education Outreach and Engagement2003，，1： | 1 |
| 20 | Pharmacokinetics and safety of levofloxacin in patients with human immunodefieieney virus infection显示文摘 | Diane S Happy A Andrew T | 1994 | Antimierob Agents Chemother1994，38，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员